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Development of a model for anemia of inflammation that is relevant to critical care.

Boshuizen M, van Bruggen R, Zaat SA, Schultz MJ, Aguilera E, Motos A, Senussi T, Idone FA, Pelosi P, Torres A, Bassi GL, Juffermans NP.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):47. doi: 10.1186/s40635-019-0261-2.


A dual functional bone-defect-filling material with sequential antibacterial and osteoinductive properties for infected bone defect repair.

Wang D, Liu Y, Liu Y, Yan L, Zaat SAJ, Wismeijer D, Pathak JL, Wu G.

J Biomed Mater Res A. 2019 Oct;107(10):2360-2370. doi: 10.1002/jbm.a.36744. Epub 2019 Jun 17.


C-Reactive Protein Promotes Inflammation through FcγR-Induced Glycolytic Reprogramming of Human Macrophages.

Newling M, Sritharan L, van der Ham AJ, Hoepel W, Fiechter RH, de Boer L, Zaat SAJ, Bisoendial RJ, Baeten DLP, Everts B, den Dunnen J.

J Immunol. 2019 Jul 1;203(1):225-235. doi: 10.4049/jimmunol.1900172. Epub 2019 May 22.


Evaluating Efficacy of Antimicrobial and Antifouling Materials for Urinary Tract Medical Devices: Challenges and Recommendations.

Ramstedt M, Ribeiro IAC, Bujdakova H, Mergulhão FJM, Jordao L, Thomsen P, Alm M, Burmølle M, Vladkova T, Can F, Reches M, Riool M, Barros A, Reis RL, Meaurio E, Kikhney J, Moter A, Zaat SAJ, Sjollema J.

Macromol Biosci. 2019 May;19(5):e1800384. doi: 10.1002/mabi.201800384. Epub 2019 Mar 18. Review.


Recommendations for design and conduct of preclinical in vivo studies of orthopedic device-related infection.

Moriarty TF, Harris LG, Mooney RA, Wenke JC, Riool M, Zaat SAJ, Moter A, Schaer TP, Khanna N, Kuehl R, Alt V, Montali A, Liu J, Zeiter S, Busscher HJ, Grainger DW, Richards RG.

J Orthop Res. 2019 Feb;37(2):271-287. doi: 10.1002/jor.24230. Epub 2019 Feb 21. Review.


A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection.

Zhang X, de Boer L, Stockhammer OW, Grijpma DW, Spaink HP, Zaat SAJ.

J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/58523.


Antimicrobial peptide modification of biomaterials using supramolecular additives.

Zaccaria S, van Gaal RC, Riool M, Zaat SAJ, Dankers PYW.

J Polym Sci A Polym Chem. 2018 Sep 1;56(17):1926-1934. doi: 10.1002/pola.29078. Epub 2018 Aug 9.


Cationic Amphipathic Antimicrobial Peptides Perturb the Inner Membrane of Germinated Spores Thus Inhibiting Their Outgrowth.

Omardien S, Drijfhout JW, Zaat SA, Brul S.

Front Microbiol. 2018 Sep 26;9:2277. doi: 10.3389/fmicb.2018.02277. eCollection 2018.


Synergistic microbicidal effect of cationic antimicrobial peptides and teicoplanin against planktonic and biofilm-encased Staphylococcus aureus.

Koppen BC, Mulder PPG, de Boer L, Riool M, Drijfhout JW, Zaat SAJ.

Int J Antimicrob Agents. 2019 Feb;53(2):143-151. doi: 10.1016/j.ijantimicag.2018.10.002. Epub 2018 Oct 10.


Monitoring local delivery of vancomycin from gelatin nanospheres in zebrafish larvae.

Zhang X, Song J, Klymov A, Zhang Y, de Boer L, Jansen JA, van den Beucken JJ, Yang F, Zaat SA, Leeuwenburgh SC.

Int J Nanomedicine. 2018 Sep 13;13:5377-5394. doi: 10.2147/IJN.S168959. eCollection 2018.


Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms.

Van Dijck P, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, Cantón E, Coenye T, Cos P, Cowen LE, Edgerton M, Espinel-Ingroff A, Filler SG, Ghannoum M, Gow NAR, Haas H, Jabra-Rizk MA, Johnson EM, Lockhart SR, Lopez-Ribot JL, Maertens J, Munro CA, Nett JE, Nobile CJ, Pfaller MA, Ramage G, Sanglard D, Sanguinetti M, Spriet I, Verweij PE, Warris A, Wauters J, Yeaman MR, Zaat SAJ, Thevissen K.

Microb Cell. 2018 Jun 14;5(7):300-326. doi: 10.15698/mic2018.07.638. Review.


Bactericidal activity of amphipathic cationic antimicrobial peptides involves altering the membrane fluidity when interacting with the phospholipid bilayer.

Omardien S, Drijfhout JW, Vaz FM, Wenzel M, Hamoen LW, Zaat SAJ, Brul S.

Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2404-2415. doi: 10.1016/j.bbamem.2018.06.004. Epub 2018 Jun 11.


Synthetic antimicrobial peptides delocalize membrane bound proteins thereby inducing a cell envelope stress response.

Omardien S, Drijfhout JW, van Veen H, Schachtschabel S, Riool M, Hamoen LW, Brul S, Zaat SAJ.

Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2416-2427. doi: 10.1016/j.bbamem.2018.06.005. Epub 2018 Jun 9.


Photochemical internalization enhances cytosolic release of antibiotic and increases its efficacy against staphylococcal infection.

Zhang X, de Boer L, Heiliegers L, Man-Bovenkerk S, Selbo PK, Drijfhout JW, Høgset A, Zaat SAJ.

J Control Release. 2018 Aug 10;283:214-222. doi: 10.1016/j.jconrel.2018.06.004. Epub 2018 Jun 5.


Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices.

Münker TJAG, van de Vijfeijken SECM, Mulder CS, Vespasiano V, Becking AG, Kleverlaan CJ; CranioSafe Group; CranioSafe Group, Becking AG, Dubois L, Karssemakers LHE, Milstein DMJ, van de Vijfeijken SECM, Depauw PRAM, Hoefnagels FWA, Vandertop WP, Kleverlaan CJ, Münker TJAG, Maal TJJ, Nout E, Riool M, Zaat SAJ.

J Mech Behav Biomed Mater. 2018 May;81:168-172. doi: 10.1016/j.jmbbm.2018.01.033. Epub 2018 Jan 31.


FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming.

Hansen IS, Krabbendam L, Bernink JH, Loayza-Puch F, Hoepel W, van Burgsteden JA, Kuijper EC, Buskens CJ, Bemelman WA, Zaat SAJ, Agami R, Vidarsson G, van den Brink GR, de Jong EC, Wildenberg ME, Baeten DLP, Everts B, den Dunnen J.

Nat Commun. 2018 Feb 28;9(1):863. doi: 10.1038/s41467-018-03318-5.


Poly(trimethylene carbonate) and poly(D,L-lactic acid) modify human dendritic cell responses to staphylococci but do not affect Th1 and Th2 cell development.

Balraadjsing PP, de Jong EC, Grijpma DW, Tanck MW, Zaat SA.

Eur Cell Mater. 2018 Feb 19;35:103-116. doi: 10.22203/eCM.v035a08.


In vitro methods for the evaluation of antimicrobial surface designs.

Sjollema J, Zaat SAJ, Fontaine V, Ramstedt M, Luginbuehl R, Thevissen K, Li J, van der Mei HC, Busscher HJ.

Acta Biomater. 2018 Apr 1;70:12-24. doi: 10.1016/j.actbio.2018.02.001. Epub 2018 Feb 10. Review.


The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms.

de Breij A, Riool M, Cordfunke RA, Malanovic N, de Boer L, Koning RI, Ravensbergen E, Franken M, van der Heijde T, Boekema BK, Kwakman PHS, Kamp N, El Ghalbzouri A, Lohner K, Zaat SAJ, Drijfhout JW, Nibbering PH.

Sci Transl Med. 2018 Jan 10;10(423). pii: eaan4044. doi: 10.1126/scitranslmed.aan4044. Erratum in: Sci Transl Med. 2018 Mar 21;10 (433):.


Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through FcαRI-TLR Cross-Talk.

Hansen IS, Hoepel W, Zaat SAJ, Baeten DLP, den Dunnen J.

J Immunol. 2017 Dec 15;199(12):4124-4131. doi: 10.4049/jimmunol.1700883. Epub 2017 Nov 8.


Antimicrobial Peptides in Biomedical Device Manufacturing.

Riool M, de Breij A, Drijfhout JW, Nibbering PH, Zaat SAJ.

Front Chem. 2017 Aug 24;5:63. doi: 10.3389/fchem.2017.00063. eCollection 2017. Review.


Data on the surface morphology of additively manufactured Ti-6Al-4V implants during processing by plasma electrolytic oxidation.

van Hengel IAJ, Riool M, Fratila-Apachitei LE, Witte-Bouma J, Farrell E, Zadpoor AA, Zaat SAJ, Apachitei I.

Data Brief. 2017 Jun 9;13:385-389. doi: 10.1016/j.dib.2017.06.015. eCollection 2017 Aug.


Selective laser melting porous metallic implants with immobilized silver nanoparticles kill and prevent biofilm formation by methicillin-resistant Staphylococcus aureus.

van Hengel IAJ, Riool M, Fratila-Apachitei LE, Witte-Bouma J, Farrell E, Zadpoor AA, Zaat SAJ, Apachitei I.

Biomaterials. 2017 Sep;140:1-15. doi: 10.1016/j.biomaterials.2017.02.030. Epub 2017 Feb 28.


The zebrafish embryo as a model to quantify early inflammatory cell responses to biomaterials.

Zhang X, Stockhammer OW, de Boer L, Vischer NOE, Spaink HP, Grijpma DW, Zaat SAJ.

J Biomed Mater Res A. 2017 Sep;105(9):2522-2532. doi: 10.1002/jbm.a.36110. Epub 2017 Jun 6.


Orthopaedic device-related infection: current and future interventions for improved prevention and treatment.

Moriarty TF, Kuehl R, Coenye T, Metsemakers WJ, Morgenstern M, Schwarz EM, Riool M, Zaat SAJ, Khana N, Kates SL, Richards RG.

EFORT Open Rev. 2017 Mar 13;1(4):89-99. doi: 10.1302/2058-5241.1.000037. eCollection 2016 Apr.


A chlorhexidine-releasing epoxy-based coating on titanium implants prevents Staphylococcus aureus experimental biomaterial-associated infection.

Riool M, Dirks AJ, Jaspers V, de Boer L, Loontjens TJ, van der Loos CM, Florquin S, Apachitei I, Rijk LN, Keul HA, Zaat SA.

Eur Cell Mater. 2017 Feb 14;33:143-157. doi: 10.22203/eCM.v033a11.


Fabrication of oxide layer on zirconium by micro-arc oxidation: Structural and antimicrobial characteristics.

Fidan S, Muhaffel F, Riool M, Cempura G, de Boer L, Zaat SAJ, Filemonowicz AC, Cimenoglu H.

Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:565-569. doi: 10.1016/j.msec.2016.11.035. Epub 2016 Nov 10.


Nebulized Recombinant Human Tissue Factor Pathway Inhibitor Attenuates Coagulation and Exerts Modest Anti-inflammatory Effects in Rat Models of Lung Injury.

van den Boogaard FE, Hofstra JJ, Brands X, Levi MM, Roelofs JJ, Zaat SA, Van't Veer C, van der Poll T, Schultz MJ.

J Aerosol Med Pulm Drug Deliv. 2017 Apr;30(2):91-99. doi: 10.1089/jamp.2016.1317. Epub 2016 Dec 15.


Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145.

de Breij A, Riool M, Kwakman PH, de Boer L, Cordfunke RA, Drijfhout JW, Cohen O, Emanuel N, Zaat SA, Nibbering PH, Moriarty TF.

J Control Release. 2016 Jan 28;222:1-8. doi: 10.1016/j.jconrel.2015.12.003. Epub 2015 Dec 3.


Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections.

Liu Y, Qin R, Zaat SAJ, Breukink E, Heger M.

J Clin Transl Res. 2015 Dec 1;1(3):140-167. eCollection 2015 Dec 30. Review.


Silver-coated endotracheal tubes for prevention of ventilator-associated pneumonia in critically ill patients.

Tokmaji G, Vermeulen H, Müller MC, Kwakman PH, Schultz MJ, Zaat SA.

Cochrane Database Syst Rev. 2015 Aug 12;(8):CD009201. doi: 10.1002/14651858.CD009201.pub2. Review.


A doxycycline-loaded polymer-lipid encapsulation matrix coating for the prevention of implant-related osteomyelitis due to doxycycline-resistant methicillin-resistant Staphylococcus aureus.

Metsemakers WJ, Emanuel N, Cohen O, Reichart M, Potapova I, Schmid T, Segal D, Riool M, Kwakman PH, de Boer L, de Breij A, Nibbering PH, Richards RG, Zaat SA, Moriarty TF.

J Control Release. 2015 Jul 10;209:47-56. doi: 10.1016/j.jconrel.2015.04.022. Epub 2015 Apr 21.


Staphylococcus epidermidis originating from titanium implants infects surrounding tissue and immune cells.

Riool M, de Boer L, Jaspers V, van der Loos CM, van Wamel WJB, Wu G, Kwakman PHS, Zaat SAJ.

Acta Biomater. 2014 Dec;10(12):5202-5212. doi: 10.1016/j.actbio.2014.08.012. Epub 2014 Aug 18.


Real-time quantification of matrix metalloproteinase and integrin αvβ3 expression during biomaterial-associated infection in a murine model.

Daghighi S, Sjollema J, Dijkstra RJ, Jaspers V, Zaat SA, van der Mei HC, Busscher HJ.

Eur Cell Mater. 2014 Jan 25;27:26-37; discussion 37-8.


Critical factors in the translation of improved antimicrobial strategies for medical implants and devices.

Grainger DW, van der Mei HC, Jutte PC, van den Dungen JJ, Schultz MJ, van der Laan BF, Zaat SA, Busscher HJ.

Biomaterials. 2013 Dec;34(37):9237-43. doi: 10.1016/j.biomaterials.2013.08.043. Epub 2013 Sep 11.


A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery.

Veneman WJ, Stockhammer OW, de Boer L, Zaat SA, Meijer AH, Spaink HP.

BMC Genomics. 2013 Apr 15;14:255. doi: 10.1186/1471-2164-14-255.


Antibiotic prophylaxis in (sub)normothermic organ preservation: in vitro efficacy and toxicity of cephalosporins.

Bruinsma BG, Post IC, van Rijssen LB, de Boer L, Heger M, Zaat SA, van Gulik TM.

Transplantation. 2013 Apr 27;95(8):1064-9. doi: 10.1097/TP.0b013e318284c17a.


Bacterial infection as a likely cause of adverse reactions to polyacrylamide hydrogel fillers in cosmetic surgery.

Christensen L, Breiting V, Bjarnsholt T, Eickhardt S, Høgdall E, Janssen M, Pallua N, Zaat SA.

Clin Infect Dis. 2013 May;56(10):1438-44. doi: 10.1093/cid/cit067. Epub 2013 Feb 7.


Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells.

van der Aar AM, Picavet DI, Muller FJ, de Boer L, van Capel TM, Zaat SA, Bos JD, Janssen H, George TC, Kapsenberg ML, van Ham SM, Teunissen MB, de Jong EC.

J Invest Dermatol. 2013 May;133(5):1240-9. doi: 10.1038/jid.2012.500. Epub 2013 Feb 7.


Medical-grade honey does not reduce skin colonization at central venous catheter-insertion sites of critically ill patients: a randomized controlled trial.

Kwakman PH, Müller MC, Binnekade JM, van den Akker JP, de Borgie CA, Schultz MJ, Zaat SA.

Crit Care. 2012 Oct 30;16(5):R214. doi: 10.1186/cc11849.


Biomaterial-associated infection: locating the finish line in the race for the surface.

Busscher HJ, van der Mei HC, Subbiahdoss G, Jutte PC, van den Dungen JJ, Zaat SA, Schultz MJ, Grainger DW.

Sci Transl Med. 2012 Sep 26;4(153):153rv10. Review.


Persistence of a bioluminescent Staphylococcus aureus strain on and around degradable and non-degradable surgical meshes in a murine model.

Daghighi S, Sjollema J, Jaspers V, de Boer L, Zaat SA, Dijkstra RJ, van Dam GM, van der Mei HC, Busscher HJ.

Acta Biomater. 2012 Nov;8(11):3991-6. doi: 10.1016/j.actbio.2012.07.017. Epub 2012 Jul 21.


In vitro cytotoxicity evaluation of porous TiO₂-Ag antibacterial coatings for human fetal osteoblasts.

Necula BS, van Leeuwen JP, Fratila-Apachitei LE, Zaat SA, Apachitei I, Duszczyk J.

Acta Biomater. 2012 Nov;8(11):4191-7. doi: 10.1016/j.actbio.2012.07.005. Epub 2012 Jul 17.


IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and FcγRIIa in human dendritic cells.

den Dunnen J, Vogelpoel LT, Wypych T, Muller FJ, de Boer L, Kuijpers TW, Zaat SA, Kapsenberg ML, de Jong EC.

Blood. 2012 Jul 5;120(1):112-21. doi: 10.1182/blood-2011-12-399931. Epub 2012 May 30.


Antibacterial components of honey.

Kwakman PH, Zaat SA.

IUBMB Life. 2012 Jan;64(1):48-55. doi: 10.1002/iub.578. Epub 2011 Nov 17.


Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements.

Kwakman PH, Krijgsveld J, de Boer L, Nguyen LT, Boszhard L, Vreede J, Dekker HL, Speijer D, Drijfhout JW, te Velde AA, Crielaard W, Vogel HJ, Vandenbroucke-Grauls CM, Zaat SA.

J Biol Chem. 2011 Dec 16;286(50):43506-14. doi: 10.1074/jbc.M111.248641. Epub 2011 Oct 24.


Accumulation of human EGF in nectar of transformed plants of Nicotiana langsdorffii x N. sanderae and transfer to honey by bees.

Helsper JP, Ruyter-Spira CP, Kwakman PH, Bleeker WK, Keizer LC, Bade JB, Te Velde AA, Zaat SA, Verbeek M, Creemers-Molenaar J.

Plant Biol (Stuttg). 2011 Sep;13(5):740-6. doi: 10.1111/j.1438-8677.2010.00440.x. Epub 2011 Jan 28.


Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells.

Huibregtse IL, Zaat SA, Kapsenberg ML, Sartori da Silva MA, Peppelenbosch MP, van Deventer SJ, Braat H.

Gastroenterol Res Pract. 2012;2012:639291. doi: 10.1155/2012/639291. Epub 2011 Jul 27.


Investigating the cationic side chains of the antimicrobial peptide tritrpticin: hydrogen bonding properties govern its membrane-disruptive activities.

Nguyen LT, de Boer L, Zaat SA, Vogel HJ.

Biochim Biophys Acta. 2011 Sep;1808(9):2297-303. doi: 10.1016/j.bbamem.2011.05.015. Epub 2011 May 24.

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