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Items: 1 to 50 of 86

1.

Inhibitory Effect of Berberine on Broiler P-glycoprotein Expression and Function: In Situ and In Vitro Studies.

Zhang Y, Guo L, Huang J, Sun Y, He F, Zloh M, Wang L.

Int J Mol Sci. 2019 Apr 22;20(8). pii: E1966. doi: 10.3390/ijms20081966.

2.

Relevance of Breast Cancer Resistance Protein to Pharmacokinetics of Florfenicol in Chickens: A Perspective from In Vivo and In Vitro Studies.

Liu Y, Guo L, Zloh M, Zhang Y, Huang J, Wang L.

Int J Mol Sci. 2018 Oct 15;19(10). pii: E3165. doi: 10.3390/ijms19103165.

3.

An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations.

Pandya A, Howard MJ, Zloh M, Dalby PA.

Pharmaceutics. 2018 Sep 21;10(4). pii: E165. doi: 10.3390/pharmaceutics10040165. Review.

4.

α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma.

Sainz V, Moura LIF, Peres C, Matos AI, Viana AS, Wagner AM, Vela Ramirez JE, S Barata T, Gaspar M, Brocchini S, Zloh M, Peppas NA, Satchi-Fainaro R, F Florindo H.

Acta Biomater. 2018 Aug;76:193-207. doi: 10.1016/j.actbio.2018.06.029. Epub 2018 Jun 22.

PMID:
29940370
5.

In Silico Structural Evaluation of Short Cationic Antimicrobial Peptides.

Passarini I, Rossiter S, Malkinson J, Zloh M.

Pharmaceutics. 2018 Jun 21;10(3). pii: E72. doi: 10.3390/pharmaceutics10030072.

6.

Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken.

Bhutto ZA, He F, Zloh M, Yang J, Huang J, Guo T, Wang L.

Sci Rep. 2018 Mar 13;8(1):4400. doi: 10.1038/s41598-018-22354-1.

7.

Octodrine: New Questions and Challenges in Sport Supplements.

Catalani V, Prilutskaya M, Al-Imam A, Marrinan S, Elgharably Y, Zloh M, Martinotti G, Chilcott R, Corazza O.

Brain Sci. 2018 Feb 20;8(2). pii: E34. doi: 10.3390/brainsci8020034.

8.

The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions.

Zloh M, Kirton SB.

Future Med Chem. 2018 Feb;10(4):423-432. doi: 10.4155/fmc-2017-0151. Epub 2018 Jan 30. Review.

PMID:
29380627
9.

Design, synthesis and biological evaluation of novel aryldiketo acids with enhanced antibacterial activity against multidrug resistant bacterial strains.

Cvijetić IN, Verbić TŽ, Ernesto de Resende P, Stapleton P, Gibbons S, Juranić IO, Drakulić BJ, Zloh M.

Eur J Med Chem. 2018 Jan 1;143:1474-1488. doi: 10.1016/j.ejmech.2017.10.045. Epub 2017 Nov 11.

PMID:
29133041
10.

Rational design of novel, fluorescent, tagged glutamic acid dendrimers with different terminal groups and in silico analysis of their properties.

Martinho N, Silva LC, Florindo HF, Brocchini S, Zloh M, Barata TS.

Int J Nanomedicine. 2017 Sep 25;12:7053-7073. doi: 10.2147/IJN.S135475. eCollection 2017.

11.

Practical computational toolkits for dendrimers and dendrons structure design.

Martinho N, Silva LC, Florindo HF, Brocchini S, Barata T, Zloh M.

J Comput Aided Mol Des. 2017 Sep;31(9):817-827. doi: 10.1007/s10822-017-0041-6. Epub 2017 Sep 15.

PMID:
28916961
12.

Poly-glutamic dendrimer-based conjugates for cancer vaccination - a computational design for targeted delivery of antigens.

Moura LIF, Martinho N, Silva LC, Barata TS, Brocchini S, Florindo HF, Zloh M.

J Drug Target. 2017 Nov - Dec;25(9-10):873-880. doi: 10.1080/1061186X.2017.1363213. Epub 2017 Aug 10.

PMID:
28795601
13.

Intended and unintended use of cathinone mixtures.

Guirguis A, Corkery JM, Stair JL, Kirton SB, Zloh M, Schifano F.

Hum Psychopharmacol. 2017 May;32(3). doi: 10.1002/hup.2598. Review.

PMID:
28657191
14.

4,4'-Dimethylaminorex ("4,4'-DMAR"; "Serotoni") misuse: A Web-based study.

Loi B, Zloh M, De Luca MA, Pintori N, Corkery J, Schifano F.

Hum Psychopharmacol. 2017 May;32(3). doi: 10.1002/hup.2575. Review.

PMID:
28657180
15.

Identification of Protein-Excipient Interaction Hotspots Using Computational Approaches.

Barata TS, Zhang C, Dalby PA, Brocchini S, Zloh M.

Int J Mol Sci. 2016 Jun 1;17(6). pii: E853. doi: 10.3390/ijms17060853.

16.

Small molecule recognition of mephedrone using an anthracene molecular clip.

Kellett K, Broome JH, Zloh M, Kirton SB, Fergus S, Gerhard U, Stair JL, Wallace KJ.

Chem Commun (Camb). 2016 Jun 14;52(47):7474-7. doi: 10.1039/c6cc03404g. Epub 2016 May 20.

PMID:
27198990
17.

Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists.

Zloh M, Perez-Diaz N, Tang L, Patel P, Mackenzie LS.

Life Sci. 2016 Feb 1;146:66-72. doi: 10.1016/j.lfs.2016.01.013. Epub 2016 Jan 11.

PMID:
26792060
18.

Application of diffusion-edited and solvent suppression ¹H-NMR to the direct analysis of markers in valerian-hop liquid herbal products.

Prieto JM, Mellinas-Gomez M, Zloh M.

Phytochem Anal. 2016 Mar-Apr;27(2):100-6. doi: 10.1002/pca.2603. Epub 2016 Jan 13.

PMID:
26763752
19.

In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone receptor antagonist properties.

Perez Diaz N, Zloh M, Patel P, Mackenzie LS.

Prostaglandins Other Lipid Mediat. 2016 Jan;122:18-27. doi: 10.1016/j.prostaglandins.2015.12.002. Epub 2015 Dec 11.

PMID:
26686607
20.

Correction to "Production of water-soluble few-layer graphene mesosheets by dry milling with hydrophobic drug".

Rubio N, Serra-Maia R, Kafa H, Mei KC, Pach E, Luckhurst W, Zloh M, Festy F, Richardson JP, Naglik JR, Ballesteros B, Al-Jamal KT.

Langmuir. 2015 Feb 24;31(7):2249. doi: 10.1021/acs.langmuir.5b00033. Epub 2015 Feb 6. No abstract available.

PMID:
25658657
21.

Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine.

Hochfellner C, Evangelopoulos D, Zloh M, Wube A, Guzman JD, McHugh TD, Kunert O, Bhakta S, Bucar F.

J Appl Microbiol. 2015 Apr;118(4):864-72. doi: 10.1111/jam.12753. Epub 2015 Feb 4.

22.

Molecular Modeling to Study Dendrimers for Biomedical Applications.

Martinho N, Florindo H, Silva L, Brocchini S, Zloh M, Barata T.

Molecules. 2014 Dec 8;19(12):20424-20467. Review.

23.

Computational classification models for predicting the interaction of drugs with P-glycoprotein and breast cancer resistance protein.

Erić S, Kalinić M, Ilić K, Zloh M.

SAR QSAR Environ Res. 2014;25(12):939-66. doi: 10.1080/1062936X.2014.976265. Epub 2014 Dec 1.

PMID:
25435255
24.

Production of water-soluble few-layer graphene mesosheets by dry milling with hydrophobic drug.

Rubio N, Serra-Maia R, Kafa H, Mei KC, Pach E, Luckhurst W, Zloh M, Festy F, Richardson JP, Naglik JR, Ballesteros B, Al-Jamal KT.

Langmuir. 2014 Dec 16;30(49):14999-5008. doi: 10.1021/la5038475. Epub 2014 Dec 1. Erratum in: Langmuir. 2015 Feb 24;31(7):2249.

PMID:
25409484
25.

Structural insights into binding of small molecule inhibitors to Enhancer of Zeste Homolog 2.

Kalinić M, Zloh M, Erić S.

J Comput Aided Mol Des. 2014 Nov;28(11):1109-28. doi: 10.1007/s10822-014-9788-1. Epub 2014 Aug 20.

PMID:
25139678
26.

Bioadhesive tablets containing cyclodextrin complex of itraconazole for the treatment of vaginal candidiasis.

Cevher E, Açma A, Sinani G, Aksu B, Zloh M, Mülazımoğlu L.

Int J Biol Macromol. 2014 Aug;69:124-36. doi: 10.1016/j.ijbiomac.2014.05.033. Epub 2014 May 20.

PMID:
24857873
27.

Rapid detection of sildenafil analogue in Eurycoma longifolia products using a new two-tier procedure of the near infrared (NIR) spectra database.

Said MM, Gibbons S, Moffat AC, Zloh M.

Food Chem. 2014 Sep 1;158:296-301. doi: 10.1016/j.foodchem.2014.02.125. Epub 2014 Mar 6.

PMID:
24731345
28.

A phytochemical comparison of saw palmetto products using gas chromatography and (1) H nuclear magnetic resonance spectroscopy metabolomic profiling.

Booker A, Suter A, Krnjic A, Strassel B, Zloh M, Said M, Heinrich M.

J Pharm Pharmacol. 2014 Jun;66(6):811-22. doi: 10.1111/jphp.12198. Epub 2014 Jan 13.

29.

Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex.

Wei D, Todd AK, Zloh M, Gunaratnam M, Parkinson GN, Neidle S.

J Am Chem Soc. 2013 Dec 26;135(51):19319-29. doi: 10.1021/ja4101358. Epub 2013 Dec 11.

PMID:
24295054
30.

Molecular dynamic simulations of ocular tablet dissolution.

Ru Q, Fadda HM, Li C, Paul D, Khaw PT, Brocchini S, Zloh M.

J Chem Inf Model. 2013 Nov 25;53(11):3000-8. doi: 10.1021/ci4002348. Epub 2013 Oct 21.

PMID:
24073784
31.

Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry.

Heidelberger S, Zinzalla G, Antonow D, Essex S, Basu BP, Palmer J, Husby J, Jackson PJ, Rahman KM, Wilderspin AF, Zloh M, Thurston DE.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4719-22. doi: 10.1016/j.bmcl.2013.05.066. Epub 2013 May 29.

PMID:
23810499
32.

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.

Lauinger IL, Vivas L, Perozzo R, Stairiker C, Tarun A, Zloh M, Zhang X, Xu H, Tonge PJ, Franzblau SG, Pham DH, Esguerra CV, Crawford AD, Maes L, Tasdemir D.

J Nat Prod. 2013 Jun 28;76(6):1064-70. doi: 10.1021/np400083k. Epub 2013 Jun 19.

33.

Cationic poly-L-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivo.

Al-Jamal KT, Al-Jamal WT, Wang JT, Rubio N, Buddle J, Gathercole D, Zloh M, Kostarelos K.

ACS Nano. 2013 Mar 26;7(3):1905-17. doi: 10.1021/nn305860k. Epub 2013 Mar 7.

PMID:
23527750
34.

C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes.

Fratta P, Mizielinska S, Nicoll AJ, Zloh M, Fisher EM, Parkinson G, Isaacs AM.

Sci Rep. 2012;2:1016. doi: 10.1038/srep01016. Epub 2012 Dec 21.

35.

Prediction of aqueous solubility of drug-like molecules using a novel algorithm for automatic adjustment of relative importance of descriptors implemented in counter-propagation artificial neural networks.

Erić S, Kalinić M, Popović A, Zloh M, Kuzmanovski I.

Int J Pharm. 2012 Nov 1;437(1-2):232-41. doi: 10.1016/j.ijpharm.2012.08.022. Epub 2012 Aug 23.

PMID:
22940210
36.

Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives.

Ohnmacht SA, Micco M, Petrucci V, Todd AK, Reszka AP, Gunaratnam M, Carvalho MA, Zloh M, Neidle S.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5930-5. doi: 10.1016/j.bmcl.2012.07.065. Epub 2012 Jul 23.

PMID:
22892119
37.

Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers.

Teo I, Toms SM, Marteyn B, Barata TS, Simpson P, Johnston KA, Schnupf P, Puhar A, Bell T, Tang C, Zloh M, Matthews S, Rendle PM, Sansonetti PJ, Shaunak S.

EMBO Mol Med. 2012 Sep;4(9):866-81. doi: 10.1002/emmm.201201290. Epub 2012 Aug 6.

38.

Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity.

Erić S, Ke S, Barata T, Solmajer T, Antić Stanković J, Juranić Z, Savić V, Zloh M.

Bioorg Med Chem. 2012 Sep 1;20(17):5220-8. doi: 10.1016/j.bmc.2012.06.051. Epub 2012 Jul 11.

PMID:
22841617
39.

Natural chalcones as dual inhibitors of HDACs and NF-κB.

Orlikova B, Schnekenburger M, Zloh M, Golais F, Diederich M, Tasdemir D.

Oncol Rep. 2012 Sep;28(3):797-805. doi: 10.3892/or.2012.1870. Epub 2012 Jun 15.

40.

A prodrug nanoparticle approach for the oral delivery of a hydrophilic peptide, leucine(5)-enkephalin, to the brain.

Lalatsa A, Lee V, Malkinson JP, Zloh M, Schätzlein AG, Uchegbu IF.

Mol Pharm. 2012 Jun 4;9(6):1665-80. doi: 10.1021/mp300009u. Epub 2012 May 18.

PMID:
22574705
41.

Site-specific PEGylation at histidine tags.

Cong Y, Pawlisz E, Bryant P, Balan S, Laurine E, Tommasi R, Singh R, Dubey S, Peciak K, Bird M, Sivasankar A, Swierkosz J, Muroni M, Heidelberger S, Farys M, Khayrzad F, Edwards J, Badescu G, Hodgson I, Heise C, Somavarapu S, Liddell J, Powell K, Zloh M, Choi JW, Godwin A, Brocchini S.

Bioconjug Chem. 2012 Feb 15;23(2):248-63. doi: 10.1021/bc200530x. Epub 2012 Feb 6.

PMID:
22243664
42.

Antibacterial acylphloroglucinols from Hypericum olympicum.

Shiu WK, Rahman MM, Curry J, Stapleton P, Zloh M, Malkinson JP, Gibbons S.

J Nat Prod. 2012 Mar 23;75(3):336-43. doi: 10.1021/np2003319. Epub 2011 Sep 7.

PMID:
21899267
43.

Computational design principles for bioactive dendrimer based constructs as antagonists of the TLR4-MD-2-LPS complex.

Barata T, Teo I, Lalwani S, Simanek E, Zloh M, Shaunak S.

Biomaterials. 2011 Nov;32(33):8702-11. doi: 10.1016/j.biomaterials.2011.07.085. Epub 2011 Aug 23.

44.

Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses.

Barata TS, Teo I, Brocchini S, Zloh M, Shaunak S.

PLoS Comput Biol. 2011 Jun;7(6):e1002095. doi: 10.1371/journal.pcbi.1002095. Epub 2011 Jun 30.

45.

Near-infrared spectroscopy (NIRS) and chemometric analysis of Malaysian and UK paracetamol tablets: a spectral database study.

Said MM, Gibbons S, Moffat AC, Zloh M.

Int J Pharm. 2011 Aug 30;415(1-2):102-9. doi: 10.1016/j.ijpharm.2011.05.057. Epub 2011 May 27.

PMID:
21645600
46.

Relative quantification of polyethylene glycol 400 excreted in the urine of male and female volunteers by direct injection electrospray-selected ion monitoring mass spectrometry.

Ashiru DA, Karu K, Zloh M, Patel R, Basit AW.

Int J Pharm. 2011 Jul 29;414(1-2):35-41. doi: 10.1016/j.ijpharm.2011.04.061. Epub 2011 Apr 30.

PMID:
21557993
47.

In silico screening for antibiotic escort molecules to overcome efflux.

Rahman SS, Simovic I, Gibbons S, Zloh M.

J Mol Model. 2011 Nov;17(11):2863-72. doi: 10.1007/s00894-011-0978-7. Epub 2011 Feb 8.

PMID:
21301905
48.

From sequence to 3D structure of hyperbranched molecules: application to surface modified PAMAM dendrimers.

Barata TS, Brocchini S, Teo I, Shaunak S, Zloh M.

J Mol Model. 2011 Nov;17(11):2741-9. doi: 10.1007/s00894-011-0966-y. Epub 2011 Jan 29.

PMID:
21279526
49.

Structural studies of biologically active glycosylated polyamidoamine (PAMAM) dendrimers.

Barata TS, Shaunak S, Teo I, Zloh M, Brocchini S.

J Mol Model. 2011 Aug;17(8):2051-60. doi: 10.1007/s00894-010-0907-1. Epub 2010 Dec 15.

PMID:
21161557
50.

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.

Tasdemir D, Sanabria D, Lauinger IL, Tarun A, Herman R, Perozzo R, Zloh M, Kappe SH, Brun R, Carballeira NM.

Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. doi: 10.1016/j.bmc.2010.08.055. Epub 2010 Sep 18.

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