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Items: 36

1.

Phase I clinical trial and human pharmacokinetics of 2,4-diamino-5-adamantyl-6-methyl pyrimidine ethane sulfonate (DAMP-ES): a lipid-soluble antifolate.

Creaven PJ, Zakrzewski SF, Greco WR, Madajewicz S, Mittelman A, Pontes JE, Karakousis C, Takita H, Proefrock A.

Cancer Chemother Pharmacol. 1988;21(2):122-8.

PMID:
2832091
2.

Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.

Rustum YM, Trave F, Zakrzewski SF, Petrelli N, Herrera L, Mittelman A, Arbuck SG, Creaven PJ.

NCI Monogr. 1987;(5):165-70.

PMID:
2448653
4.

Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil.

Yin MB, Zakrzewski SF, Hakala MT.

Mol Pharmacol. 1983 Jan;23(1):190-7. No abstract available.

PMID:
6688119
5.

Toxicity and pharmacokinetics of a new antifolate, 2,4-diamino-5-adamantyl-6-methylpyrimidine, in dogs.

Zakrzewski SF, Pavelic Z, Greco WR, Bullard G, Creaven PJ, Mihich E.

Cancer Res. 1982 Jun;42(6):2177-83.

6.

Molecular structures of 2,4-diaminopyrimidine antifolates with antineoplastic activity.

Cody V, Zakrzewski SF.

J Med Chem. 1982 Apr;25(4):427-30.

PMID:
7069721
7.

Preparation of tritiated dihydrofolic acid of high specific activity.

Zakrzewski SF.

Methods Enzymol. 1980;66:529-33. No abstract available.

PMID:
7374494
10.
11.

Synthesis and antifolate activity of new diaminopyrimidines and diaminopurines in enzymatic and cellular systems.

Kavai I, Mead LH, Drobniak J, Zakrzewski SF.

J Med Chem. 1975 Mar;18(3):272-5.

PMID:
1169322
12.

Uptake and metabolism of folate by a folate-utilizing mutant of Pediococcus cerevisiae (8081-S) and the parent strain (8081).

Zakrzewski SF, Grzelakowska-Sztabert B.

J Biol Chem. 1973 Apr 25;248(8):2684-90. No abstract available.

13.

Hydrophobic interactions between the 5-alkyl group of 2,4-diamino-6-methylpyrimidines and dihydrofolate reductase.

Ho YK, Zakrzewski SF, Mead LH.

Biochemistry. 1973 Feb 27;12(5):1003-5. No abstract available.

PMID:
4734458
14.

Synthesis and biological activity of 2,4-diamino-6- and -7-(1-adamantyl)pteridines.

Jonak JP, Zakrzewski SF, Mead LH, Allshouse LD.

J Med Chem. 1972 Dec;15(12):1331-2. No abstract available.

PMID:
4629014
15.

Synthesis and biological activity of some 5-substituted 2,4-diamino-6-alkylpyrimidines. 3.

Jonak JP, Zakrzewski SF, Mead LH.

J Med Chem. 1972 Jun;15(6):662-5. No abstract available.

PMID:
5063997
16.

5-(1-Adamantyl) pyrimidines as inhibitors of folate metabolism.

Ho YK, Hakala MT, Zakrzewski SF.

Cancer Res. 1972 May;32(5):1023-8. No abstract available.

17.

Synthesis and biological activity of some 5-(1-adamantyl)pyrimidines. 2.

Jonak JP, Zakrzewski SF, Mead LH.

J Med Chem. 1971 May;14(5):408-11. No abstract available.

PMID:
5117687
18.

Preparation of tritiated dihydrofolate and its use in the assay of dihydrofolate reductase.

Zakrzewski SF, Himberg JJ.

Anal Biochem. 1971 Apr;40(2):336-44. No abstract available.

PMID:
5551544
19.

Synthesis and biological activity of some 5-(1-adamantyl)pyrimidines. 1.

Jonak JP, Zakrzewski SF, Mead LH, Hakala MT.

J Med Chem. 1970 Nov;13(6):1170-2. No abstract available.

PMID:
5529583
20.

On the specificity of labeling in tritiated folic acid.

Zakrzewski SF, Evans EA, Phillips RF.

Anal Biochem. 1970 Jul;36(1):197-206. No abstract available.

PMID:
5482627
21.

Adamantane derivatives of p-aminobenzamide and sulfanilamide.

Zakrzewski SF, Bloch A, Nichol CA.

J Med Chem. 1968 Jul;11(4):885-6. No abstract available.

PMID:
5671263
22.

Mechanism of reduction of dihydrofolate to tetrahydrofolate. Studies with 7-methyldihydrofolate as a model compound.

Zakrzewski SF, Sansone A.

J Biol Chem. 1967 Dec 25;242(24):5661-6. No abstract available.

23.

Inhibition of thymidylate synthetase by some analogs of tetrahydrofolic acid.

Slavik K, Zakrzewski SF.

Mol Pharmacol. 1967 Jul;3(4):370-7. No abstract available.

PMID:
6033635
24.

Evidence for the chemical interaction between 2-mercaptoethanol and tetrahydrofolate.

Zakrzewski SF.

J Biol Chem. 1966 Jun 25;241(12):2957-61. No abstract available.

25.

RELATIONSHIP BETWEEN BASICITY OF CERTAIN FOLATE ANALOGUES AND THEIR AFFINITIES FOR FOLATE REDUCTASE.

ZAKRZEWSKI SF.

J Biol Chem. 1963 Dec;238:4002-4. No abstract available.

26.

The mechanism of binding of folate analogues by folate reductase.

ZAKRZEWSKI SF.

J Biol Chem. 1963 Apr;238:1485-90. No abstract available.

27.

Assay for 4-amino folic acid analogues by inhibition of folic acid reductase.

WERKHEISER WC, ZAKRZEWSKI SF, NICHOL CA.

J Pharmacol Exp Ther. 1962 Aug;137:162-6. No abstract available.

PMID:
14006195
28.

Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.

HAKALA MT, ZAKRZEWSKI SF, NICHOL CA.

J Biol Chem. 1961 Mar;236:952-8. No abstract available.

29.

Evidence for a single enzyme reducing folate and dihydrofolate.

ZAKRZEWSKI SF, NICHOL CA.

J Biol Chem. 1960 Oct;235:2984-8. No abstract available.

30.

Studies on the substrate specificity of folic acid reductase.

ZAKRZEWSKI SF.

J Biol Chem. 1960 Jun;235:1780-4. No abstract available.

31.

Purification and properties of folic acid reductase from chicken liver.

ZAKRZEWSKI SF.

J Biol Chem. 1960 Jun;235:1776-9. No abstract available.

32.

On the enzymic reduction of folic acid by a purified hydrogenase.

ZAKRZEWSKI SF, NICHOL CA.

Biochim Biophys Acta. 1958 Feb;27(2):425-6. No abstract available.

PMID:
13522752
33.

The incorporation of formate-C14 into citrovorum factor.

ZAKRZEWSKI SF, NICHOL CA.

J Biol Chem. 1955 Apr;213(2):697-704. No abstract available.

34.

A labile precursor of citrovorum factor.

NICHOL CA, ANTON AH, ZAKRZEWSKI SF.

Science. 1955 Feb 25;121(3139):275-9. No abstract available.

PMID:
13237976
35.

The separation and determination of pteroylglutamic acid and related compounds.

ZAKRZEWSKI SF, NICHOL CA.

J Biol Chem. 1953 Nov;205(1):361-8. No abstract available.

36.

Resistance to folic acid analogues in a strain of Streptococcus faecalis.

NICHOL CA, ZAKRZEWSKI SF, WELCH AD.

Proc Soc Exp Biol Med. 1953 Jun;83(2):272-7. No abstract available.

PMID:
13064243

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