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Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart.

Lowe V, Wisniewski L, Sayers J, Evans I, Frankel P, Mercader-Huber N, Zachary IC, Pellet-Many C.

Development. 2019 Jun 5. pii: dev.174482. doi: 10.1242/dev.174482. [Epub ahead of print]


Public health delivery in the information age: the role of informatics and technology.

Williams F, Oke A, Zachary I.

Perspect Public Health. 2019 Feb 13:1757913918802308. doi: 10.1177/1757913918802308. [Epub ahead of print]


Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation.

Mahmoud M, Evans IM, Mehta V, Pellet-Many C, Paliashvili K, Zachary I.

Am J Physiol Cell Physiol. 2019 Mar 1;316(3):C424-C433. doi: 10.1152/ajpcell.00405.2018. Epub 2019 Jan 16.


Endothelial C-Type Natriuretic Peptide Is a Critical Regulator of Angiogenesis and Vascular Remodeling.

Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC, Abraham DJ, Tsui J, Hobbs AJ.

Circulation. 2019 Mar 26;139(13):1612-1628. doi: 10.1161/CIRCULATIONAHA.118.036344.


VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy-Terminal NRP1 Fragments That Regulate Angiogenic Signaling.

Mehta V, Fields L, Evans IM, Yamaji M, Pellet-Many C, Jones T, Mahmoud M, Zachary I.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1845-1858. doi: 10.1161/ATVBAHA.118.311118.


Perinatal and long-term effects of maternal uterine artery adenoviral VEGF-A165 gene therapy in the growth-restricted guinea pig fetus.

Vaughan OR, Rossi CA, Ginsberg Y, White A, Hristova M, Sebire NJ, Martin J, Zachary IC, Peebles DM, David AL.

Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R344-R353. doi: 10.1152/ajpregu.00210.2017. Epub 2018 May 30.


Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells.

Powell J, Mota F, Steadman D, Soudy C, Miyauchi JT, Crosby S, Jarvis A, Reisinger T, Winfield N, Evans G, Finniear A, Yelland T, Chou YT, Chan AWE, O'Leary A, Cheng L, Liu D, Fotinou C, Milagre C, Martin JF, Jia H, Frankel P, Djordjevic S, Tsirka SE, Zachary IC, Selwood DL.

J Med Chem. 2018 May 10;61(9):4135-4154. doi: 10.1021/acs.jmedchem.8b00210. Epub 2018 Apr 24.


Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.

Critchley WR, Pellet-Many C, Ringham-Terry B, Harrison MA, Zachary IC, Ponnambalam S.

Cells. 2018 Mar 15;7(3). pii: E22. doi: 10.3390/cells7030022. Review.


Architecture and hydration of the arginine-binding site of neuropilin-1.

Mota F, Fotinou C, Rana RR, Chan AWE, Yelland T, Arooz MT, O'Leary AP, Hutton J, Frankel P, Zachary I, Selwood D, Djordjevic S.

FEBS J. 2018 Apr;285(7):1290-1304. doi: 10.1111/febs.14405. Epub 2018 Feb 25.


Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis.

Evans IM, Kennedy SA, Paliashvili K, Santra T, Yamaji M, Lovering RC, Britton G, Frankel P, Kolch W, Zachary IC.

Mol Cell Proteomics. 2017 Feb;16(2):168-180. doi: 10.1074/mcp.M116.064428. Epub 2016 Dec 22.


Maternal Therapy with Ad.VEGF-A165 Increases Fetal Weight at Term in a Guinea-Pig Model of Fetal Growth Restriction.

Swanson AM, Rossi CA, Ofir K, Mehta V, Boyd M, Barker H, Ledwozyw A, Vaughan O, Martin J, Zachary I, Sebire N, Peebles DM, David AL.

Hum Gene Ther. 2016 Dec;27(12):997-1007. doi: 10.1089/hum.2016.046. Epub 2016 Aug 16.


Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling.

Frolov A, Evans IM, Li N, Sidlauskas K, Paliashvili K, Lockwood N, Barrett A, Brandner S, Zachary IC, Frankel P.

Sci Rep. 2016 Jun 13;6:27378. doi: 10.1038/srep27378.


Peri- and Postnatal Effects of Prenatal Adenoviral VEGF Gene Therapy in Growth-Restricted Sheep.

Carr DJ, Wallace JM, Aitken RP, Milne JS, Martin JF, Zachary IC, Peebles DM, David AL.

Biol Reprod. 2016 Jun;94(6):142. doi: 10.1095/biolreprod.115.133744. Epub 2016 Apr 20.


VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis.

Fearnley GW, Smith GA, Abdul-Zani I, Yuldasheva N, Mughal NA, Homer-Vanniasinkam S, Kearney MT, Zachary IC, Tomlinson DC, Harrison MA, Wheatcroft SB, Ponnambalam S.

Biol Open. 2016 May 15;5(5):571-83. doi: 10.1242/bio.017434.


Structural studies of neuropilin-2 reveal a zinc ion binding site remote from the vascular endothelial growth factor binding pocket.

Tsai YC, Fotinou C, Rana R, Yelland T, Frankel P, Zachary I, Djordjevic S.

FEBS J. 2016 May;283(10):1921-34. doi: 10.1111/febs.13711. Epub 2016 Apr 1.


Perspectives of HIV agencies on improving HIV prevention, treatment, and care services in the USA.

Khosla N, Zachary I.

AIDS Care. 2016 Oct;28(10):1249-54. doi: 10.1080/09540121.2015.1124977. Epub 2016 Feb 10.


Gene Targeting to the Uteroplacental Circulation of Pregnant Guinea Pigs.

Mehta V, Ofir K, Swanson A, Kloczko E, Boyd M, Barker H, Avdic-Belltheus A, Martin J, Zachary I, Peebles D, David AL.

Reprod Sci. 2016 Aug;23(8):1087-95. doi: 10.1177/1933719116630411. Epub 2016 Feb 10.


Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression.

Miyauchi JT, Chen D, Choi M, Nissen JC, Shroyer KR, Djordevic S, Zachary IC, Selwood D, Tsirka SE.

Oncotarget. 2016 Mar 1;7(9):9801-14. doi: 10.18632/oncotarget.6877.


Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury.

Pellet-Many C, Mehta V, Fields L, Mahmoud M, Lowe V, Evans I, Ruivo J, Zachary I.

Cardiovasc Res. 2015 Nov 1;108(2):288-98. doi: 10.1093/cvr/cvv229. Epub 2015 Sep 25.


Information Management in Cancer Registries: Evaluating the Needs for Cancer Data Collection and Cancer Research.

Zachary I, Boren SA, Simoes E, Jackson-Thompson J, Davis JW, Hicks L.

Online J Public Health Inform. 2015 Jul 1;7(2):e213. doi: 10.5210/ojphi.v7i2.5664. eCollection 2015.


NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells.

Fantin A, Lampropoulou A, Gestri G, Raimondi C, Senatore V, Zachary I, Ruhrberg C.

Cell Rep. 2015 Jun 16;11(10):1577-90. doi: 10.1016/j.celrep.2015.05.018. Epub 2015 Jun 4. Erratum in: Cell Rep. 2015 Dec 1;13(9):2037.


Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice.

Yamaji M, Mahmoud M, Evans IM, Zachary IC.

PLoS One. 2015 Feb 6;10(2):e0115563. doi: 10.1371/journal.pone.0115563. eCollection 2015.


Local over-expression of VEGF-DΔNΔC in the uterine arteries of pregnant sheep results in long-term changes in uterine artery contractility and angiogenesis.

Mehta V, Abi-Nader KN, Shangaris P, Shaw SW, Filippi E, Benjamin E, Boyd M, Peebles DM, Martin J, Zachary I, David AL.

PLoS One. 2014 Jun 30;9(6):e100021. doi: 10.1371/journal.pone.0100021. eCollection 2014.


VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions.

Fearnley GW, Odell AF, Latham AM, Mughal NA, Bruns AF, Burgoyne NJ, Homer-Vanniasinkam S, Zachary IC, Hollstein MC, Wheatcroft SB, Ponnambalam S.

Mol Biol Cell. 2014 Aug 15;25(16):2509-21. doi: 10.1091/mbc.E14-05-0962. Epub 2014 Jun 25.


Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation.

Jopling HM, Odell AF, Pellet-Many C, Latham AM, Frankel P, Sivaprasadarao A, Walker JH, Zachary IC, Ponnambalam S.

Cells. 2014 Apr 29;3(2):363-85. doi: 10.3390/cells3020363.


N-terminal modification of VEGF-A C terminus-derived peptides delineates structural features involved in neuropilin-1 binding and functional activity.

Jia H, Aqil R, Cheng L, Chapman C, Shaikh S, Jarvis A, Chan AW, Hartzoulakis B, Evans IM, Frolov A, Martin J, Frankel P, Djordevic S, Zachary IC, Selwood DL.

Chembiochem. 2014 May 26;15(8):1161-70. doi: 10.1002/cbic.201300658. Epub 2014 Apr 25.


A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling.

Barrett A, Evans IM, Frolov A, Britton G, Pellet-Many C, Yamaji M, Mehta V, Bandopadhyay R, Li N, Brandner S, Zachary IC, Frankel P.

J Cell Sci. 2014 Jun 15;127(Pt 12):2647-58. doi: 10.1242/jcs.135988. Epub 2014 Apr 24. Erratum in: J Cell Sci. 2014 Aug 1;127(Pt 15):3397.


Uteroplacental adenovirus vascular endothelial growth factor gene therapy increases fetal growth velocity in growth-restricted sheep pregnancies.

Carr DJ, Wallace JM, Aitken RP, Milne JS, Mehta V, Martin JF, Zachary IC, Peebles DM, David AL.

Hum Gene Ther. 2014 Apr;25(4):375-84. doi: 10.1089/hum.2013.214. Epub 2014 Apr 7.


Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis.

Fantin A, Herzog B, Mahmoud M, Yamaji M, Plein A, Denti L, Ruhrberg C, Zachary I.

Development. 2014 Feb;141(3):556-62. doi: 10.1242/dev.103028. Epub 2014 Jan 8.


Neuropilins: role in signalling, angiogenesis and disease.

Zachary I.

Chem Immunol Allergy. 2014;99:37-70. doi: 10.1159/000354169. Epub 2013 Oct 17. Review.


Production of soluble human vascular endothelial growth factor VEGF-A165-heparin binding domain in Escherichia coli.

Seyedarabi A, Cheng L, Zachary I, Djordjevic S.

PLoS One. 2013;8(2):e55690. doi: 10.1371/journal.pone.0055690. Epub 2013 Feb 8.


p130Cas: a key signalling node in health and disease.

Barrett A, Pellet-Many C, Zachary IC, Evans IM, Frankel P.

Cell Signal. 2013 Apr;25(4):766-77. doi: 10.1016/j.cellsig.2012.12.019. Epub 2012 Dec 29. Review.


A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.

Bruns AF, Yuldasheva N, Latham AM, Bao L, Pellet-Many C, Frankel P, Stephen SL, Howell GJ, Wheatcroft SB, Kearney MT, Zachary IC, Ponnambalam S.

PLoS One. 2012;7(11):e48539. doi: 10.1371/journal.pone.0048539. Epub 2012 Nov 6.


How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns.

Zachary IC.

Biochem Soc Trans. 2011 Dec;39(6):1583-91. doi: 10.1042/BST20110697. Review.


Long-term increase in uterine blood flow is achieved by local overexpression of VEGF-A(165) in the uterine arteries of pregnant sheep.

Mehta V, Abi-Nader KN, Peebles DM, Benjamin E, Wigley V, Torondel B, Filippi E, Shaw SW, Boyd M, Martin J, Zachary I, David AL.

Gene Ther. 2012 Sep;19(9):925-35. doi: 10.1038/gt.2011.158. Epub 2011 Oct 20.


VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation.

Herzog B, Pellet-Many C, Britton G, Hartzoulakis B, Zachary IC.

Mol Biol Cell. 2011 Aug 1;22(15):2766-76. doi: 10.1091/mbc.E09-12-1061. Epub 2011 Jun 8.


Protein kinase D in vascular biology and angiogenesis.

Evans IM, Zachary IC.

IUBMB Life. 2011 Apr;63(4):258-63. doi: 10.1002/iub.456. Review.


Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas.

Pellet-Many C, Frankel P, Evans IM, Herzog B, Jünemann-Ramírez M, Zachary IC.

Biochem J. 2011 May 1;435(3):609-18. doi: 10.1042/BJ20100580.


Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells.

Evans IM, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary IC, Frankel P.

Mol Cell Biol. 2011 Mar;31(6):1174-85. doi: 10.1128/MCB.00903-10. Epub 2011 Jan 18.


Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects.

Zachary I, Morgan RD.

Heart. 2011 Feb;97(3):181-9. doi: 10.1136/hrt.2009.180414. Epub 2010 Sep 30. Review.


Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells.

Evans IM, Bagherzadeh A, Charles M, Raynham T, Ireson C, Boakes A, Kelland L, Zachary IC.

Biochem J. 2010 Aug 1;429(3):565-72. doi: 10.1042/BJ20100578.


Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.

Jarvis A, Allerston CK, Jia H, Herzog B, Garza-Garcia A, Winfield N, Ellard K, Aqil R, Lynch R, Chapman C, Hartzoulakis B, Nally J, Stewart M, Cheng L, Menon M, Tickner M, Djordjevic S, Driscoll PC, Zachary I, Selwood DL.

J Med Chem. 2010 Mar 11;53(5):2215-26. doi: 10.1021/jm901755g.


Hostility and physiological responses to laboratory stress in acute coronary syndrome patients.

Brydon L, Strike PC, Bhattacharyya MR, Whitehead DL, McEwan J, Zachary I, Steptoe A.

J Psychosom Res. 2010 Feb;68(2):109-16. doi: 10.1016/j.jpsychores.2009.06.007. Epub 2009 Sep 23.


Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity.

Jia H, Cheng L, Tickner M, Bagherzadeh A, Selwood D, Zachary I.

Br J Cancer. 2010 Feb 2;102(3):541-52. doi: 10.1038/sj.bjc.6605539. Epub 2010 Jan 19.


A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation.

Maffucci T, Raimondi C, Abu-Hayyeh S, Dominguez V, Sala G, Zachary I, Falasca M.

PLoS One. 2009 Dec 14;4(12):e8285. doi: 10.1371/journal.pone.0008285.


The role of neuropilins in cell signalling.

Zachary IC, Frankel P, Evans IM, Pellet-Many C.

Biochem Soc Trans. 2009 Dec;37(Pt 6):1171-8. doi: 10.1042/BST0371171.


Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis.

Bruns AF, Herbert SP, Odell AF, Jopling HM, Hooper NM, Zachary IC, Walker JH, Ponnambalam S.

Traffic. 2010 Jan;11(1):161-74. doi: 10.1111/j.1600-0854.2009.01001.x.


The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis.

Fiedler LR, Bachetti T, Leiper J, Zachary I, Chen L, Renné T, Wojciak-Stothard B.

Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2117-24. doi: 10.1161/ATVBAHA.109.194035. Epub 2009 Sep 24.


Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells.

Jopling HM, Odell AF, Hooper NM, Zachary IC, Walker JH, Ponnambalam S.

Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1119-24. doi: 10.1161/ATVBAHA.109.186239. Epub 2009 Apr 16.


VEGFR1 receptor tyrosine kinase localization to the Golgi apparatus is calcium-dependent.

Mittar S, Ulyatt C, Howell GJ, Bruns AF, Zachary I, Walker JH, Ponnambalam S.

Exp Cell Res. 2009 Mar 10;315(5):877-89. doi: 10.1016/j.yexcr.2008.12.020. Epub 2009 Jan 6.


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