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Items: 41

1.

Sharing pharma compounds with academia: experiences with providing vitamin D receptor ligands.

Schmitz AA, Hackethal S, Schulz A, May E, Steinmeyer A, Zügel U, Asadullah K.

Nat Rev Drug Discov. 2015 Apr;14(4):294. doi: 10.1038/nrd4008-c1. Epub 2015 Mar 6. No abstract available.

PMID:
25743082
2.

The vitamin D analog ZK191784 normalizes decreased bone matrix mineralization in mice lacking the calcium channel TRPV5.

van der Eerden BC, Fratzl-Zelman N, Nijenhuis T, Roschger P, Zügel U, Steinmeyer A, Hoenderop JG, Bindels RJ, Klaushofer K, van Leeuwen JP.

J Cell Physiol. 2013 Feb;228(2):402-7. doi: 10.1002/jcp.24144.

PMID:
22740316
3.

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.

Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL.

Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

4.

Vitamin D receptor activation improves allergen-triggered eczema in mice.

Hartmann B, Riedel R, Jörss K, Loddenkemper C, Steinmeyer A, Zügel U, Babina M, Radbruch A, Worm M.

J Invest Dermatol. 2012 Feb;132(2):330-6. doi: 10.1038/jid.2011.296. Epub 2011 Sep 22.

5.

Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases.

von Bonin A, Rausch A, Mengel A, Hitchcock M, Krüger M, von Ahsen O, Merz C, Röse L, Stock C, Martin SF, Leder G, Döcke WD, Asadullah K, Zügel U.

Exp Dermatol. 2011 Jan;20(1):41-7. doi: 10.1111/j.1600-0625.2010.01198.x.

PMID:
21158938
6.

Targeting the vitamin D receptor inhibits the B cell-dependent allergic immune response.

Hartmann B, Heine G, Babina M, Steinmeyer A, Zügel U, Radbruch A, Worm M.

Allergy. 2011 Apr;66(4):540-8. doi: 10.1111/j.1398-9995.2010.02513.x. Epub 2010 Dec 1.

PMID:
21121929
7.

Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation.

Dernedde J, Rausch A, Weinhart M, Enders S, Tauber R, Licha K, Schirner M, Zügel U, von Bonin A, Haag R.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19679-84. doi: 10.1073/pnas.1003103107. Epub 2010 Nov 1.

8.

Calcitriol down-regulates human ether a go-go 1 potassium channel expression in cervical cancer cells.

Avila E, García-Becerra R, Rodríguez-Rasgado JA, Díaz L, Ordaz-Rosado D, Zügel U, Steinmeyer A, Barrera D, Halhali A, Larrea F, Camacho J.

Anticancer Res. 2010 Jul;30(7):2667-72.

PMID:
20682996
9.

Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells.

Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zügel U, Roman J.

J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):142-50. doi: 10.1016/j.jsbmb.2009.11.004. Epub 2009 Nov 17.

10.

The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-alpha pathway of systemic and cutaneous inflammation.

Schottelius AJ, Zügel U, Döcke WD, Zollner TM, Röse L, Mengel A, Buchmann B, Becker A, Grütz G, Naundorf S, Friedrich A, Gaestel M, Asadullah K.

J Invest Dermatol. 2010 Feb;130(2):481-91. doi: 10.1038/jid.2009.218. Epub 2009 Aug 6.

11.

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis.

Peric M, Koglin S, Dombrowski Y, Gross K, Bradac E, Büchau A, Steinmeyer A, Zügel U, Ruzicka T, Schauber J.

PLoS One. 2009 Jul 22;4(7):e6340. doi: 10.1371/journal.pone.0006340.

12.

Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses.

Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL.

PLoS One. 2009 Jun 5;4(6):e5810. doi: 10.1371/journal.pone.0005810.

13.

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases.

Schäcke H, Zollner TM, Döcke WD, Rehwinkel H, Jaroch S, Skuballa W, Neuhaus R, May E, Zügel U, Asadullah K.

Br J Pharmacol. 2009 Oct;158(4):1088-103. doi: 10.1111/j.1476-5381.2009.00238.x. Epub 2009 May 6.

14.

Immunomodulation by a novel, dissociated Vitamin D analogue.

Zügel U, Steinmeyer A, May E, Lehmann M, Asadullah K.

Exp Dermatol. 2009 Jul;18(7):619-27. doi: 10.1111/j.1600-0625.2009.00845.x. Epub 2009 Feb 23.

PMID:
19239489
15.

RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genes.

Gust TC, Neubrandt L, Merz C, Asadullah K, Zügel U, von Bonin A.

Cell Commun Signal. 2008 Aug 6;6:3. doi: 10.1186/1478-811X-6-3.

16.

1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells.

Heine G, Niesner U, Chang HD, Steinmeyer A, Zügel U, Zuberbier T, Radbruch A, Worm M.

Eur J Immunol. 2008 Aug;38(8):2210-8. doi: 10.1002/eji.200838216.

17.

Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype.

Strauch UG, Obermeier F, Grunwald N, Dunger N, Rath HC, Schölmerich J, Steinmeyer A, Zügel U, Herfarth HH.

World J Gastroenterol. 2007 Dec 28;13(48):6529-37.

18.

Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3.

Schauber J, Oda Y, Büchau AS, Yun QC, Steinmeyer A, Zügel U, Bikle DD, Gallo RL.

J Invest Dermatol. 2008 Apr;128(4):816-24. Epub 2007 Oct 18.

19.

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.

Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL.

J Clin Invest. 2007 Mar;117(3):803-11. Epub 2007 Feb 8.

20.

The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist.

Nijenhuis T, van der Eerden BC, Zügel U, Steinmeyer A, Weinans H, Hoenderop JG, van Leeuwen JP, Bindels RJ.

FASEB J. 2006 Oct;20(12):2171-3.

PMID:
17012263
21.

Characterization of vitamin D receptor ligands with cell-specific and dissociated activity.

Castillo AI, Sánchez-Martínez R, Jiménez-Lara AM, Steinmeyer A, Zügel U, Aranda A.

Mol Endocrinol. 2006 Dec;20(12):3093-104. Epub 2006 Aug 10.

22.

The immunological synapse: kinases in T cell signalling as potential drug targets.

Baier G, Asadullah K, Zügel U.

Immunol Lett. 2006 May 15;105(1):3-5.

PMID:
16580735
23.

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.

Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL.

Science. 2006 Mar 24;311(5768):1770-3. Epub 2006 Feb 23.

24.

Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns.

Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J, Zügel U, Steinmeyer A, Pollak A, Roth E, Boltz-Nitulescu G, Spittler A.

Eur J Immunol. 2006 Feb;36(2):361-70.

25.

Inhibition of apolipoprotein AI gene expression by 1, 25-dihydroxyvitamin D3.

Wehmeier K, Beers A, Haas MJ, Wong NC, Steinmeyer A, Zugel U, Mooradian AD.

Biochim Biophys Acta. 2005 Oct 15;1737(1):16-26. Epub 2005 Sep 26.

PMID:
16236546
26.

22-ene-25-oxa-vitamin D: a new vitamin D analogue with profound immunosuppressive capacities.

Daniel C, Schlauch T, Zügel U, Steinmeyer A, Radeke HH, Steinhilber D, Stein J.

Eur J Clin Invest. 2005 May;35(5):343-9.

PMID:
15860047
27.

Immunoregulation through 1,25-dihydroxyvitamin D3 and its analogs.

May E, Asadullah K, Zügel U.

Curr Drug Targets Inflamm Allergy. 2004 Dec;3(4):377-93. Review.

PMID:
15584887
28.

A novel immunosuppressive 1alpha,25-dihydroxyvitamin D3 analog with reduced hypercalcemic activity.

Zügel U, Steinmeyer A, Giesen C, Asadullah K.

J Invest Dermatol. 2002 Dec;119(6):1434-42.

29.

gp96-peptide vaccination of mice against intracellular bacteria.

Zügel U, Sponaas AM, Neckermann J, Schoel B, Kaufmann SH.

Infect Immun. 2001 Jun;69(6):4164-7.

30.

Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety.

Marczak S, Przezdziecka A, Wicha J, Steinmeyer A, Zügel U.

Bioorg Med Chem Lett. 2001 Jan 8;11(1):63-6.

PMID:
11140735
31.

Participation of group 2 CD1 molecules in the control of murine tuberculosis.

Szalay G, Zügel U, Ladel CH, Kaufmann SH.

Microbes Infect. 1999 Dec;1(14):1153-7.

PMID:
10580269
32.

Immune response against heat shock proteins in infectious diseases.

Zügel U, Kaufmann SH.

Immunobiology. 1999 Sep;201(1):22-35. Review.

PMID:
10532278
33.

Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells.

Steinhoff U, Brinkmann V, Klemm U, Aichele P, Seiler P, Brandt U, Bland PW, Prinz I, Zügel U, Kaufmann SH.

Immunity. 1999 Sep;11(3):349-58.

34.

Role of heat shock proteins in protection from and pathogenesis of infectious diseases.

Zügel U, Kaufmann SH.

Clin Microbiol Rev. 1999 Jan;12(1):19-39. Review.

35.

Termination of peripheral tolerance to a T cell epitope by heteroclitic antigen analogues.

Zügel U, Wang R, Shih G, Sette A, Alexander J, Grey HM.

J Immunol. 1998 Aug 15;161(4):1705-9.

37.

Relative roles of natural killer- and T cell-mediated anti-leukemia effects in chronic myelogenous leukemia patients treated with interferon-alpha.

Pawelec G, Da Silva P, Max H, Kalbacher H, Schmidt H, Bruserud O, Zügel U, Baier W, Rehbein A, Pohla H.

Leuk Lymphoma. 1995 Aug;18(5-6):471-8.

PMID:
8528055
38.
41.

Prevention of autoimmune lysis by T cells with specificity for a heat shock protein by antisense oligonucleotide treatment.

Steinhoff U, Zügel U, Wand-Württenberger A, Hengel H, Rösch R, Munk ME, Kaufmann SH.

Proc Natl Acad Sci U S A. 1994 May 24;91(11):5085-8.

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