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Items: 15


Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse.

Crick PJ, Yutuc E, Abdel-Khalik J, Saeed A, Betsholtz C, Genove G, Björkhem I, Wang Y, Griffiths WJ.

J Steroid Biochem Mol Biol. 2019 Dec;195:105475. doi: 10.1016/j.jsbmb.2019.105475. Epub 2019 Sep 18.


Mining for Oxysterols in Cyp7b1-/- Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5.

Meljon A, Crick PJ, Yutuc E, Yau JL, Seckl JR, Theofilopoulos S, Arenas E, Wang Y, Griffiths WJ.

Biomolecules. 2019 Apr 13;9(4). pii: E149. doi: 10.3390/biom9040149.


Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders.

Griffiths WJ, Yutuc E, Abdel-Khalik J, Crick PJ, Hearn T, Dickson A, Bigger BW, Hoi-Yee Wu T, Goenka A, Ghosh A, Jones SA, Covey DF, Ory DS, Wang Y.

Free Radic Biol Med. 2019 Nov 20;144:124-133. doi: 10.1016/j.freeradbiomed.2019.04.020. Epub 2019 Apr 19.


Developing an Enzyme-Assisted Derivatization Method for Analysis of C27 Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry.

Abdel-Khalik J, Crick PJ, Yutuc E, Wang Y, Griffiths WJ.

Molecules. 2019 Feb 7;24(3). pii: E597. doi: 10.3390/molecules24030597.


24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo.

Theofilopoulos S, Abreu de Oliveira WA, Yang S, Yutuc E, Saeed A, Abdel-Khalik J, Ullgren A, Cedazo-Minguez A, Björkhem I, Wang Y, Griffiths WJ, Arenas E.

J Biol Chem. 2019 Mar 15;294(11):4169-4176. doi: 10.1074/jbc.RA118.005639. Epub 2019 Jan 17.


Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients.

Griffiths WJ, Abdel-Khalik J, Yutuc E, Roman G, Warner M, Gustafsson JÅ, Wang Y.

Free Radic Biol Med. 2019 Apr;134:42-52. doi: 10.1016/j.freeradbiomed.2018.12.020. Epub 2018 Dec 19.


Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.

Griffiths WJ, Crick PJ, Meljon A, Theofilopoulos S, Abdel-Khalik J, Yutuc E, Parker JE, Kelly DE, Kelly SL, Arenas E, Wang Y.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):191-211. doi: 10.1016/j.bbalip.2018.11.006. Epub 2018 Nov 22.


Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma.

Abdel-Khalik J, Crick PJ, Yutuc E, DeBarber AE, Duell PB, Steiner RD, Laina I, Wang Y, Griffiths WJ.

Biochimie. 2018 Oct;153:86-98. doi: 10.1016/j.biochi.2018.06.020. Epub 2018 Jun 28.


Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation.

Griffiths WJ, Gilmore I, Yutuc E, Abdel-Khalik J, Crick PJ, Hearn T, Dickson A, Bigger BW, Wu TH, Goenka A, Ghosh A, Jones SA, Wang Y.

J Lipid Res. 2018 Jun;59(6):1058-1070. doi: 10.1194/jlr.D083246. Epub 2018 Apr 6.


Charge-tagging liquid chromatography-mass spectrometry methodology targeting oxysterol diastereoisomers.

Griffiths WJ, Hearn T, Crick PJ, Abdel-Khalik J, Dickson A, Yutuc E, Wang Y.

Chem Phys Lipids. 2017 Oct;207(Pt B):69-80. doi: 10.1016/j.chemphyslip.2017.04.004. Epub 2017 Apr 12.


Cholesterolomics: An update.

Griffiths WJ, Abdel-Khalik J, Yutuc E, Morgan AH, Gilmore I, Hearn T, Wang Y.

Anal Biochem. 2017 May 1;524:56-67. doi: 10.1016/j.ab.2017.01.009. Epub 2017 Jan 10. Review.


Defective cholesterol metabolism in amyotrophic lateral sclerosis.

Abdel-Khalik J, Yutuc E, Crick PJ, Gustafsson JÅ, Warner M, Roman G, Talbot K, Gray E, Griffiths WJ, Turner MR, Wang Y.

J Lipid Res. 2017 Jan;58(1):267-278. doi: 10.1194/jlr.P071639. Epub 2016 Nov 3.


Current trends in oxysterol research.

Griffiths WJ, Abdel-Khalik J, Hearn T, Yutuc E, Morgan AH, Wang Y.

Biochem Soc Trans. 2016 Apr 15;44(2):652-8. doi: 10.1042/BST20150255. Review.


An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.

Robertson KA, Hsieh WY, Forster T, Blanc M, Lu H, Crick PJ, Yutuc E, Watterson S, Martin K, Griffiths SJ, Enright AJ, Yamamoto M, Pradeepa MM, Lennox KA, Behlke MA, Talbot S, Haas J, Dölken L, Griffiths WJ, Wang Y, Angulo A, Ghazal P.

PLoS Biol. 2016 Mar 3;14(3):e1002364. doi: 10.1371/journal.pbio.1002364. eCollection 2016 Mar.


New methods for analysis of oxysterols and related compounds by LC-MS.

Griffiths WJ, Abdel-Khalik J, Crick PJ, Yutuc E, Wang Y.

J Steroid Biochem Mol Biol. 2016 Sep;162:4-26. doi: 10.1016/j.jsbmb.2015.11.017. Epub 2015 Nov 27. Review.

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