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Items: 1 to 50 of 147

1.

6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum.

Saepua S, Sadorn K, Vanichtanankul J, Anukunwithaya T, Rattanajak R, Vitsupakorn D, Kamchonwongpaisan S, Yuthavong Y, Thongpanchang C.

Bioorg Med Chem. 2019 Oct 28:115158. doi: 10.1016/j.bmc.2019.115158. [Epub ahead of print]

PMID:
31685330
2.

Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine.

Jaruwat A, Riangrungroj P, Ubonprasert S, Sae-Ueng U, Kuaprasert B, Yuthavong Y, Leartsakulpanich U, Chitnumsub P.

Arch Biochem Biophys. 2019 May 30;667:6-13. doi: 10.1016/j.abb.2019.04.002. Epub 2019 Apr 16.

PMID:
31002765
3.

Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.

Tarnchompoo B, Chitnumsub P, Jaruwat A, Shaw PJ, Vanichtanankul J, Poen S, Rattanajak R, Wongsombat C, Tonsomboon A, Decharuangsilp S, Anukunwithaya T, Arwon U, Kamchonwongpaisan S, Yuthavong Y.

ACS Med Chem Lett. 2018 Nov 7;9(12):1235-1240. doi: 10.1021/acsmedchemlett.8b00389. eCollection 2018 Dec 13.

4.

Characterization of Plasmodium knowlesi dihydrofolate reductase-thymidylate synthase and sensitivity to antifolates.

Ittarat W, Pornthanakasem W, Mungthin M, Suwandittakul N, Leelayoova S, Tarnchompoo B, Yuthavong Y, Kongkasuriyachai D, Leartsakulpanich U.

Parasitol Int. 2018 Dec;67(6):787-792. doi: 10.1016/j.parint.2018.08.004. Epub 2018 Aug 14.

PMID:
30114522
5.

Cytochrome c and c1 heme lyases are essential in Plasmodium berghei.

Posayapisit N, Songsungthong W, Koonyosying P, Falade MO, Uthaipibull C, Yuthavong Y, Shaw PJ, Kamchonwongpaisan S.

Mol Biochem Parasitol. 2016 Nov - Dec;210(1-2):32-36. doi: 10.1016/j.molbiopara.2016.08.003. Epub 2016 Aug 9.

PMID:
27520480
6.

Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates.

Lourens AC, Gravestock D, van Zyl RL, Hoppe HC, Kolesnikova N, Taweechai S, Yuthavong Y, Kamchonwongpaisan S, Rousseau AL.

Org Biomol Chem. 2016 Aug 16;14(33):7899-911. doi: 10.1039/c6ob01350c.

PMID:
27477595
7.

Role of Plasmodium vivax Dihydropteroate Synthase Polymorphisms in Sulfa Drug Resistance.

Pornthanakasem W, Riangrungroj P, Chitnumsub P, Ittarat W, Kongkasuriyachai D, Uthaipibull C, Yuthavong Y, Leartsakulpanich U.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4453-63. doi: 10.1128/AAC.01835-15. Print 2016 Aug.

8.

Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling.

Aroonsri A, Akinola O, Posayapisit N, Songsungthong W, Uthaipibull C, Kamchonwongpaisan S, Gbotosho GO, Yuthavong Y, Shaw PJ.

Int J Parasitol. 2016 Jul;46(8):527-35. doi: 10.1016/j.ijpara.2016.04.002. Epub 2016 May 2.

PMID:
27150044
9.

Estimating mRNA lengths from Plasmodium falciparum genes by Virtual Northern RNA-seq analysis.

Shaw PJ, Kaewprommal P, Piriyapongsa J, Wongsombat C, Yuthavong Y, Kamchonwongpaisan S.

Int J Parasitol. 2016 Jan;46(1):7-12. doi: 10.1016/j.ijpara.2015.09.007. Epub 2015 Nov 10.

PMID:
26548960
10.

Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study.

Shaw PJ, Chaotheing S, Kaewprommal P, Piriyapongsa J, Wongsombat C, Suwannakitti N, Koonyosying P, Uthaipibull C, Yuthavong Y, Kamchonwongpaisan S.

BMC Genomics. 2015 Oct 21;16:830. doi: 10.1186/s12864-015-2040-0.

11.

Use of bacterial surrogates as a tool to explore antimalarial drug interaction: Synergism between inhibitors of malarial dihydrofolate reductase and dihydropteroate synthase.

Talawanich Y, Kamchonwongpaisan S, Sirawaraporn W, Yuthavong Y.

Acta Trop. 2015 Sep;149:64-9. doi: 10.1016/j.actatropica.2015.05.011. Epub 2015 May 18.

PMID:
25997881
12.

Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.

Witschel MC, Rottmann M, Schwab A, Leartsakulpanich U, Chitnumsub P, Seet M, Tonazzi S, Schwertz G, Stelzer F, Mietzner T, McNamara C, Thater F, Freymond C, Jaruwat A, Pinthong C, Riangrungroj P, Oufir M, Hamburger M, Mäser P, Sanz-Alonso LM, Charman S, Wittlin S, Yuthavong Y, Chaiyen P, Diederich F.

J Med Chem. 2015 Apr 9;58(7):3117-30. doi: 10.1021/jm501987h. Epub 2015 Mar 18.

PMID:
25785478
13.

Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase.

Maenpuen S, Amornwatcharapong W, Krasatong P, Sucharitakul J, Palfey BA, Yuthavong Y, Chitnumsub P, Leartsakulpanich U, Chaiyen P.

J Biol Chem. 2015 Mar 27;290(13):8656-65. doi: 10.1074/jbc.M114.612275. Epub 2015 Feb 12.

14.

Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control.

Chitnumsub P, Jaruwat A, Riangrungroj P, Ittarat W, Noytanom K, Oonanant W, Vanichthanankul J, Chuankhayan P, Maenpuen S, Chen CJ, Chaiyen P, Yuthavong Y, Leartsakulpanich U.

Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3177-86. doi: 10.1107/S1399004714023128. Epub 2014 Nov 22.

15.

Molecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins.

Wongsombat C, Aroonsri A, Kamchonwongpaisan S, Morgan HP, Walkinshaw MD, Yuthavong Y, Shaw PJ.

Mol Biochem Parasitol. 2014 Nov;198(1):1-10. doi: 10.1016/j.molbiopara.2014.10.005. Epub 2014 Nov 3.

PMID:
25447287
16.

Application of loop-mediated isothermal amplification assay combined with lateral flow dipstick for detection of Plasmodium falciparum and Plasmodium vivax.

Yongkiettrakul S, Jaroenram W, Arunrut N, Chareanchim W, Pannengpetch S, Suebsing R, Kiatpathomchai W, Pornthanakasem W, Yuthavong Y, Kongkasuriyachai D.

Parasitol Int. 2014 Dec;63(6):777-84. doi: 10.1016/j.parint.2014.06.004. Epub 2014 Jul 17.

PMID:
25038579
17.

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities.

Chitnumsub P, Ittarat W, Jaruwat A, Noytanom K, Amornwatcharapong W, Pornthanakasem W, Chaiyen P, Yuthavong Y, Leartsakulpanich U.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1517-27. doi: 10.1107/S1399004714005598. Epub 2014 May 23.

18.

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I.

Kümpornsin K, Kotanan N, Chobson P, Kochakarn T, Jirawatcharadech P, Jaru-ampornpan P, Yuthavong Y, Chookajorn T.

Malar J. 2014 Apr 19;13:150. doi: 10.1186/1475-2875-13-150.

19.

Origin of robustness in generating drug-resistant malaria parasites.

Kümpornsin K, Modchang C, Heinberg A, Ekland EH, Jirawatcharadech P, Chobson P, Suwanakitti N, Chaotheing S, Wilairat P, Deitsch KW, Kamchonwongpaisan S, Fidock DA, Kirkman LA, Yuthavong Y, Chookajorn T.

Mol Biol Evol. 2014 Jul;31(7):1649-60. doi: 10.1093/molbev/msu140. Epub 2014 Apr 16.

20.

Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.

Mokmak W, Chunsrivirot S, Hannongbua S, Yuthavong Y, Tongsima S, Kamchonwongpaisan S.

Chem Biol Drug Des. 2014 Oct;84(4):450-61. doi: 10.1111/cbdd.12334. Epub 2014 Jun 4.

PMID:
24716467
21.

Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition.

Pinthong C, Maenpuen S, Amornwatcharapong W, Yuthavong Y, Leartsakulpanich U, Chaiyen P.

FEBS J. 2014 Jun;281(11):2570-83. doi: 10.1111/febs.12803. Epub 2014 Apr 28.

22.

Anticancer properties of distinct antimalarial drug classes.

Hooft van Huijsduijnen R, Guy RK, Chibale K, Haynes RK, Peitz I, Kelter G, Phillips MA, Vennerstrom JL, Yuthavong Y, Wells TN.

PLoS One. 2013 Dec 31;8(12):e82962. doi: 10.1371/journal.pone.0082962. eCollection 2013.

23.

Inducible knockdown of Plasmodium gene expression using the glmS ribozyme.

Prommana P, Uthaipibull C, Wongsombat C, Kamchonwongpaisan S, Yuthavong Y, Knuepfer E, Holder AA, Shaw PJ.

PLoS One. 2013 Aug 30;8(8):e73783. doi: 10.1371/journal.pone.0073783. eCollection 2013.

24.

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization.

Pornthanakasem W, Kongkasuriyachai D, Uthaipibull C, Yuthavong Y, Leartsakulpanich U.

Malar J. 2012 Nov 22;11:387. doi: 10.1186/1475-2875-11-387.

25.

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.

Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E, Thongphanchang C, Taweechai S, Vanichtanankul J, Rattanajak R, Arwon U, Fantauzzi P, Yuvaniyama J, Charman WN, Matthews D.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8. doi: 10.1073/pnas.1204556109. Epub 2012 Oct 3.

26.

Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay.

Sopitthummakhun K, Thongpanchang C, Vilaivan T, Yuthavong Y, Chaiyen P, Leartsakulpanich U.

Malar J. 2012 Jun 12;11:194. doi: 10.1186/1475-2875-11-194.

27.

Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil.

Vanichtanankul J, Taweechai S, Uttamapinant C, Chitnumsub P, Vilaivan T, Yuthavong Y, Kamchonwongpaisan S.

Antimicrob Agents Chemother. 2012 Jul;56(7):3928-35. doi: 10.1128/AAC.00301-12. Epub 2012 Apr 23.

28.

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene.

Tirakarn S, Riangrungroj P, Kongsaeree P, Imwong M, Yuthavong Y, Leartsakulpanich U.

Parasitol Int. 2012 Jun;61(2):324-32. doi: 10.1016/j.parint.2011.12.004. Epub 2012 Jan 2.

29.

Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I.

Somsak V, Srichairatanakool S, Yuthavong Y, Kamchonwongpaisan S, Uthaipibull C.

Acta Trop. 2012 Apr;122(1):113-8. doi: 10.1016/j.actatropica.2011.12.010. Epub 2011 Dec 29.

PMID:
22222185
30.

Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening.

Somsak V, Uthaipibull C, Prommana P, Srichairatanakool S, Yuthavong Y, Kamchonwongpaisan S.

Malar J. 2011 Oct 7;10:291. doi: 10.1186/1475-2875-10-291.

31.

Trypanosomal dihydrofolate reductase reveals natural antifolate resistance.

Vanichtanankul J, Taweechai S, Yuvaniyama J, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Yuthavong Y.

ACS Chem Biol. 2011 Sep 16;6(9):905-11. doi: 10.1021/cb200124r. Epub 2011 Jun 16.

PMID:
21650210
32.

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model.

Tipsuwan W, Srichairatanakool S, Kamchonwongpaisan S, Yuthavong Y, Uthaipibull C.

Malar J. 2011 May 10;10:119. doi: 10.1186/1475-2875-10-119.

33.

Small-scale in vitro culture and purification of Plasmodium berghei for transfection experiment.

Somsak V, Srichairatanakool S, Kamchonwongpaisan S, Yuthavong Y, Uthaipibull C.

Mol Biochem Parasitol. 2011 Jun;177(2):156-9. doi: 10.1016/j.molbiopara.2011.01.013. Epub 2011 Feb 1.

PMID:
21291917
34.

Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax.

Chanama M, Chanama S, Shaw PJ, Chitnumsub P, Leartsakulpanich U, Yuthavong Y.

Mol Biol Rep. 2011 Feb;38(2):1029-37. doi: 10.1007/s11033-010-0199-7. Epub 2010 Jun 25.

PMID:
20577818
35.

Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT.

Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. doi: 10.1128/AAC.01526-09. Epub 2010 Mar 29.

36.

Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen.

Chitnumsub P, Yuvaniyama J, Chahomchuen T, Vilaivan T, Yuthavong Y.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1175-8. doi: 10.1107/S1744309109041979. Epub 2009 Oct 30.

37.

Characterization of Plasmodium falciparum serine hydroxymethyltransferase-A potential antimalarial target.

Maenpuen S, Sopitthummakhun K, Yuthavong Y, Chaiyen P, Leartsakulpanich U.

Mol Biochem Parasitol. 2009 Nov;168(1):63-73. doi: 10.1016/j.molbiopara.2009.06.010. Epub 2009 Jul 8.

PMID:
19591881
38.

Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues.

Sopitthummakhun K, Maenpuen S, Yuthavong Y, Leartsakulpanich U, Chaiyen P.

FEBS J. 2009 Aug;276(15):4023-36. doi: 10.1111/j.1742-4658.2009.07111.x. Epub 2009 Jun 22.

39.

Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases.

Maitarad P, Kamchonwongpaisan S, Vanichtanankul J, Vilaivan T, Yuthavong Y, Hannongbua S.

J Comput Aided Mol Des. 2009 Apr;23(4):241-52. doi: 10.1007/s10822-008-9254-z. Epub 2009 Jan 21.

PMID:
19156529
40.

Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.

Dasgupta T, Chitnumsub P, Kamchonwongpaisan S, Maneeruttanarungroj C, Nichols SE, Lyons TM, Tirado-Rives J, Jorgensen WL, Yuthavong Y, Anderson KS.

ACS Chem Biol. 2009 Jan 16;4(1):29-40. doi: 10.1021/cb8002804.

41.

Avian influenza A/H5N1 neuraminidase expressed in yeast with a functional head domain.

Yongkiettrakul S, Boonyapakron K, Jongkaewwattana A, Wanitchang A, Leartsakulpanich U, Chitnumsub P, Eurwilaichitr L, Yuthavong Y.

J Virol Methods. 2009 Mar;156(1-2):44-51. doi: 10.1016/j.jviromet.2008.10.025. Epub 2008 Dec 11.

PMID:
19038288
42.

A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates.

Ganesan K, Ponmee N, Jiang L, Fowble JW, White J, Kamchonwongpaisan S, Yuthavong Y, Wilairat P, Rathod PK.

PLoS Pathog. 2008 Nov;4(11):e1000214. doi: 10.1371/journal.ppat.1000214. Epub 2008 Nov 21.

43.

Particular interaction between pyrimethamine derivatives and quadruple mutant type dihydrofolate reductase of Plasmodium falciparum: CoMFA and quantum chemical calculations studies.

Maitarad P, Saparpakorn P, Hannongbua S, Kamchonwongpaisan S, Tarnchompoo B, Yuthavong Y.

J Enzyme Inhib Med Chem. 2009 Apr;24(2):471-9. doi: 10.1080/14756360802201223 .

PMID:
18608776
44.

Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase.

Leartsakulpanich U, Kongkasuriyachai D, Imwong M, Chotivanich K, Yuthavong Y.

Parasitol Int. 2008 Jun;57(2):223-8. Epub 2007 Nov 12.

PMID:
18096429
45.

Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination.

Japrung D, Leartsakulpanich U, Chusacultanachai S, Yuthavong Y.

Antimicrob Agents Chemother. 2007 Dec;51(12):4356-60. Epub 2007 Sep 17.

46.

Characterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5' cap status.

Shaw PJ, Ponmee N, Karoonuthaisiri N, Kamchonwongpaisan S, Yuthavong Y.

Mol Biochem Parasitol. 2007 Oct;155(2):146-55. Epub 2007 Jul 10.

PMID:
17692399
47.

Folate metabolism as a source of molecular targets for antimalarials.

Yuthavong Y, Kamchonwongpaisan S, Leartsakulpanich U, Chitnumsub P.

Future Microbiol. 2006 Jun;1(1):113-25. Review.

PMID:
17661690
48.

Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library.

Thongpanchang C, Taweechai S, Kamchonwongpaisan S, Yuthavong Y, Thebtaranonth Y.

Anal Chem. 2007 Jul 1;79(13):5006-12. Epub 2007 May 26.

PMID:
17530740
49.

Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins.

Ponmee N, Chuchue T, Wilairat P, Yuthavong Y, Kamchonwongpaisan S.

Biochem Pharmacol. 2007 Jun 30;74(1):153-60. Epub 2007 Mar 15.

50.

The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.

Kamchonwongpaisan S, Vanichtanankul J, Taweechai S, Chitnumsub P, Yuthavong Y.

Int J Parasitol. 2007 Jun;37(7):787-93. Epub 2007 Jan 14.

PMID:
17320089

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