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Items: 34


Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways.

Nan X, Wang J, Cheng H, Yin Z, Sheng J, Qiu B, Lau CC, Yustein JT, Zhao H, Wong STC.

Cancer Lett. 2019 Oct 28. pii: S0304-3835(19)30537-3. doi: 10.1016/j.canlet.2019.10.034. [Epub ahead of print]


Development of a Novel Humanized Monoclonal Antibody to Secreted Frizzled-Related Protein-2 That Inhibits Triple-Negative Breast Cancer and Angiosarcoma Growth In Vivo.

Garcia D, Nasarre P, Bonilla IV, Hilliard E, Peterson YK, Spruill L, Broome AM, Hill EG, Yustein JT, Mehrotra S, Klauber-DeMore N.

Ann Surg Oncol. 2019 Sep 12. doi: 10.1245/s10434-019-07800-2. [Epub ahead of print]


Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) New Agents for Ewing Sarcoma Task Force.

Bailey K, Cost C, Davis I, Glade-Bender J, Grohar P, Houghton P, Isakoff M, Stewart E, Laack N, Yustein J, Reed D, Janeway K, Gorlick R, Lessnick S, DuBois S, Hingorani P.

F1000Res. 2019 Apr 15;8. pii: F1000 Faculty Rev-493. doi: 10.12688/f1000research.18139.1. eCollection 2019. Review.


Tegavivint and the β-catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma.

Nomura M, Rainusso N, Lee YC, Dawson B, Coarfa C, Han R, Larson JL, Shuck R, Kurenbekova L, Yustein JT.

J Natl Cancer Inst. 2019 Feb 21. pii: djz026. doi: 10.1093/jnci/djz026. [Epub ahead of print]


Generation of patient-derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas.

Rainusso N, Cleveland H, Hernandez JA, Quintanilla NM, Hicks J, Vasudevan S, Marco RAW, Allen-Rhoades W, Wang LL, Yustein JT.

Pediatr Blood Cancer. 2019 Apr;66(4):e27579. doi: 10.1002/pbc.27579. Epub 2018 Dec 11.


Transglutaminase-2 promotes metastatic and stem-like phenotypes in osteosarcoma.

Fuja DG, Rainusso NC, Shuck RL, Kurenbekova L, Donehower LA, Yustein JT.

Am J Cancer Res. 2018 Sep 1;8(9):1752-1763. eCollection 2018.


Fluorinated EuII-based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging.

Basal LA, Bailey MD, Romero J, Ali MM, Kurenbekova L, Yustein J, Pautler RG, Allen MJ.

Chem Sci. 2017 Dec 1;8(12):8345-8350. doi: 10.1039/c7sc03142d. Epub 2017 Oct 26.


In Vitro and In Vivo Characterization of a Preclinical Irradiation-Adapted Model for Ewing Sarcoma.

Shapiro MC, Tang T, Dasgupta A, Kurenbekova L, Shuck R, Gaber MW, Yustein JT.

Int J Radiat Oncol Biol Phys. 2018 May 1;101(1):118-127. doi: 10.1016/j.ijrobp.2018.01.095. Epub 2018 Feb 5.


Biomarker significance of plasma and tumor miR-21, miR-221, and miR-106a in osteosarcoma.

Nakka M, Allen-Rhoades W, Li Y, Kelly AJ, Shen J, Taylor AM, Barkauskas DA, Yustein JT, Andrulis IL, Wunder JS, Gorlick R, Meltzer PS, Lau CC, Man TK; TARGET osteosarcoma consortium.

Oncotarget. 2017 May 27;8(57):96738-96752. doi: 10.18632/oncotarget.18236. eCollection 2017 Nov 14.


Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties.

Dasgupta A, Trucco M, Rainusso N, Bernardi RJ, Shuck R, Kurenbekova L, Loeb DM, Yustein JT.

Oncotarget. 2017 Aug 24;8(44):77292-77308. doi: 10.18632/oncotarget.20467. eCollection 2017 Sep 29.


Detection of Plasma MicroRNA Signature in Osteosarcoma Patients.

Allen-Rhoades W, Yustein JT.

Methods Mol Biol. 2018;1699:113-118. doi: 10.1007/978-1-4939-7435-1_9.


miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.

Satterfield L, Shuck R, Kurenbekova L, Allen-Rhoades W, Edwards D, Huang S, Rajapakshe K, Coarfa C, Donehower LA, Yustein JT.

Int J Cancer. 2017 Nov 15;141(10):2062-2075. doi: 10.1002/ijc.30909. Epub 2017 Aug 8.


Cancer's Achilles' Heel: Apoptosis and Necroptosis to the Rescue.

Dasgupta A, Nomura M, Shuck R, Yustein J.

Int J Mol Sci. 2016 Dec 23;18(1). pii: E23. doi: 10.3390/ijms18010023. Review.


Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential.

Techavichit P, Gao Y, Kurenbekova L, Shuck R, Donehower LA, Yustein JT.

BMC Cancer. 2016 Nov 8;16(1):869.


Glycolysis determines dichotomous regulation of T cell subsets in hypoxia.

Xu Y, Chaudhury A, Zhang M, Savoldo B, Metelitsa LS, Rodgers J, Yustein JT, Neilson JR, Dotti G.

J Clin Invest. 2016 Jul 1;126(7):2678-88. doi: 10.1172/JCI85834. Epub 2016 Jun 13.


Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis.

Roos A, Satterfield L, Zhao S, Fuja D, Shuck R, Hicks MJ, Donehower LA, Yustein JT.

Br J Cancer. 2015 Nov 3;113(9):1289-97. doi: 10.1038/bjc.2015.305. Epub 2015 Oct 15.


Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma.

Rao PH, Zhao S, Zhao YJ, Yu A, Rainusso N, Trucco M, Allen-Rhoades W, Satterfield L, Fuja D, Borra VJ, Man TK, Donehower LA, Yustein JT.

Genes Chromosomes Cancer. 2015 Dec;54(12):796-808. doi: 10.1002/gcc.22291. Epub 2015 Sep 10.


Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma.

Allen-Rhoades W, Kurenbekova L, Satterfield L, Parikh N, Fuja D, Shuck RL, Rainusso N, Trucco M, Barkauskas DA, Jo E, Ahern C, Hilsenbeck S, Donehower LA, Yustein JT.

Cancer Med. 2015 Jul;4(7):977-88. doi: 10.1002/cam4.438. Epub 2015 Mar 17.


NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.

Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, Yustein JT.

Oncogene. 2015 Sep 24;34(39):5069-79. doi: 10.1038/onc.2014.429. Epub 2015 Jan 12.


The adolescent and young adult with cancer: state of the art -- bone tumors.

Rainusso N, Wang LL, Yustein JT.

Curr Oncol Rep. 2013 Aug;15(4):296-307. doi: 10.1007/s11912-013-0321-9. Review.


Proteoglycan 4 expression protects against the development of osteoarthritis.

Ruan MZ, Erez A, Guse K, Dawson B, Bertin T, Chen Y, Jiang MM, Yustein J, Gannon F, Lee BH.

Sci Transl Med. 2013 Mar 13;5(176):176ra34. doi: 10.1126/scitranslmed.3005409.


ChIP-PED enhances the analysis of ChIP-seq and ChIP-chip data.

Wu G, Yustein JT, McCall MN, Zilliox M, Irizarry RA, Zeller K, Dang CV, Ji H.

Bioinformatics. 2013 May 1;29(9):1182-9. doi: 10.1093/bioinformatics/btt108. Epub 2013 Mar 1.


Multiple target-specific molecular agents for detection and image analysis of breast cancer characteristics in mice.

Ke S, Wang W, Qiu X, Zhang F, Yustein JT, Cameron AG, Zhang S, Yu D, Zou C, Gao X, Lin J, Yallampalli S, Li M.

Curr Mol Med. 2013 Mar;13(3):446-58.


High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition.

Awad O, Yustein JT, Shah P, Gul N, Katuri V, O'Neill A, Kong Y, Brown ML, Toretsky JA, Loeb DM.

PLoS One. 2010 Nov 11;5(11):e13943. doi: 10.1371/journal.pone.0013943.


Abdominal undifferentiated small round cell tumor with unique translocation (X;19)(q13;q13.3).

Yustein JT, Rednam S, Bertuch AA, Goss JA, Brandt ML, Eldin K, Lu X, Hicks J.

Pediatr Blood Cancer. 2010 Jul 1;54(7):1041-4. doi: 10.1002/pbc.22437.


Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model.

Yustein JT, Liu YC, Gao P, Jie C, Le A, Vuica-Ross M, Chng WJ, Eberhart CG, Bergsagel PL, Dang CV.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3534-9. doi: 10.1073/pnas.0901230107. Epub 2010 Feb 2.


The interplay between MYC and HIF in cancer.

Dang CV, Kim JW, Gao P, Yustein J.

Nat Rev Cancer. 2008 Jan;8(1):51-6. Review.


Biology and treatment of Burkitt's lymphoma.

Yustein JT, Dang CV.

Curr Opin Hematol. 2007 Jul;14(4):375-81. Review.


Global mapping of c-Myc binding sites and target gene networks in human B cells.

Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT, Ooi HS, Orlov YL, Shahab A, Yong HC, Fu Y, Weng Z, Kuznetsov VA, Sung WK, Ruan Y, Dang CV, Wei CL.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17834-9. Epub 2006 Nov 8.


Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis.

Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, Kim JW, Yustein JT, Lee LA, Dang CV.

Mol Cell Biol. 2005 Jul;25(14):6225-34.


Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication.

Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU.

Mol Cell Biol. 2003 Nov;23(22):8282-94.


Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.

Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ.

Oncogene. 2003 Sep 18;22(40):6129-41.


KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway.

Yustein JT, Li D, Robinson D, Kung HJ.

Oncogene. 2000 Feb 3;19(5):710-8.


Tyrosine kinase expression profiles of chicken erythro-progenitor cells and oncogene-transformed erythroblasts.

Robinson D, Chen HC, Li D, Yustein JT, He F, Lin WC, Hayman MJ, Kung HJ.

J Biomed Sci. 1998;5(2):93-100.


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