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Items: 1 to 50 of 138

1.

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening.

Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ.

Nat Commun. 2019 May 16;10(1):2198. doi: 10.1038/s41467-019-09940-1.

2.

Genome-wide CRISPR-Cas9 screening in mammalian cells.

Yu JSL, Yusa K.

Methods. 2019 Jul 15;164-165:29-35. doi: 10.1016/j.ymeth.2019.04.015. Epub 2019 Apr 26. Review.

PMID:
31034882
3.

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.

Nature. 2019 Apr;568(7753):511-516. doi: 10.1038/s41586-019-1103-9. Epub 2019 Apr 10.

PMID:
30971826
4.

CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors.

Yu JSL, Palano G, Lim C, Moggio A, Drowley L, Plowright AT, Bohlooly-Y M, Rosen BS, Hansson EM, Wang QD, Yusa K.

Stem Cells. 2019 Jul;37(7):958-972. doi: 10.1002/stem.3012. Epub 2019 Apr 23.

PMID:
30932271
5.

Estimation of birth year by radiocarbon dating of tooth enamel: Approach to obtaining enamel powder.

Saitoh H, Moriya T, Takeyama M, Yusa K, Sakuma A, Chiba F, Torimitsu S, Ishii N, Sakurada K, Iino M, Iwase H, Tokanai F.

J Forensic Leg Med. 2019 Feb;62:97-102. doi: 10.1016/j.jflm.2019.01.013. Epub 2019 Jan 29.

PMID:
30731391
6.

Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects.

Gonçalves E, Behan FM, Louzada S, Arnol D, Stronach EA, Yang F, Yusa K, Stegle O, Iorio F, Garnett MJ.

Genome Biol. 2019 Feb 5;20(1):27. doi: 10.1186/s13059-019-1637-z.

7.

JACKS: joint analysis of CRISPR/Cas9 knockout screens.

Allen F, Behan F, Khodak A, Iorio F, Yusa K, Garnett M, Parts L.

Genome Res. 2019 Mar;29(3):464-471. doi: 10.1101/gr.238923.118. Epub 2019 Jan 23.

8.

A case of multiple osseous choristomas arising on the medial side of the lateral pterygoid muscle.

Ozaki H, Yusa K, Hamamoto Y, Iino M.

Oral Radiol. 2019 Jan 16. doi: 10.1007/s11282-019-00368-3. [Epub ahead of print]

PMID:
30649706
9.

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.

Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA.

Cell. 2019 Feb 7;176(4):882-896.e18. doi: 10.1016/j.cell.2018.11.044. Epub 2019 Jan 10.

10.

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.

Balmus G, Pilger D, Coates J, Demir M, Sczaniecka-Clift M, Barros AC, Woods M, Fu B, Yang F, Chen E, Ostermaier M, Stankovic T, Ponstingl H, Herzog M, Yusa K, Martinez FM, Durant ST, Galanty Y, Beli P, Adams DJ, Bradley A, Metzakopian E, Forment JV, Jackson SP.

Nat Commun. 2019 Jan 8;10(1):87. doi: 10.1038/s41467-018-07729-2.

11.

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS.

Nat Commun. 2018 Dec 19;9(1):5378. doi: 10.1038/s41467-018-07620-0.

12.

Pooled extracellular receptor-ligand interaction screening using CRISPR activation.

Chong ZS, Ohnishi S, Yusa K, Wright GJ.

Genome Biol. 2018 Nov 26;19(1):205. doi: 10.1186/s13059-018-1581-3.

13.

Comparison of Complications With Semisolid Versus Liquid Diet Via Nasogastric Feeding Tube After Orthognathic Surgery.

Ishikawa S, Matsumura H, Tomitsuka S, Yusa K, Sato Y, Iino M.

J Oral Maxillofac Surg. 2019 Feb;77(2):410.e1-410.e9. doi: 10.1016/j.joms.2018.10.012. Epub 2018 Oct 25.

PMID:
30458127
14.

External dosimetry audit for quality assurance of carbon-ion radiation therapy clinical trials.

Mizuno H, Fukumura A, Kanematsu N, Yonai S, Shirai T, Yusa K, Yanou T, Suga M, Mizota M, Minohara S, Kanai T, Kamada T.

J Appl Clin Med Phys. 2019 Jan;20(1):31-36. doi: 10.1002/acm2.12465. Epub 2018 Nov 1.

15.

Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting.

Iorio F, Behan FM, Gonçalves E, Bhosle SG, Chen E, Shepherd R, Beaver C, Ansari R, Pooley R, Wilkinson P, Harper S, Butler AP, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.

BMC Genomics. 2018 Aug 13;19(1):604. doi: 10.1186/s12864-018-4989-y.

16.

Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution.

Li M, Yu JSL, Tilgner K, Ong SH, Koike-Yusa H, Yusa K.

Cell Rep. 2018 Jul 10;24(2):489-502. doi: 10.1016/j.celrep.2018.06.027.

17.

Genome-scale identification of cellular pathways required for cell surface recognition.

Sharma S, Bartholdson SJ, Couch ACM, Yusa K, Wright GJ.

Genome Res. 2018 Sep;28(9):1372-1382. doi: 10.1101/gr.231183.117. Epub 2018 Jun 18.

18.

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ.

Nat Commun. 2018 May 10;9(1):1849. doi: 10.1038/s41467-018-03917-2.

19.

A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.

Fukuda K, Okuda A, Yusa K, Shinkai Y.

Genome Res. 2018 Jun;28(6):846-858. doi: 10.1101/gr.227280.117. Epub 2018 May 4.

20.

Author Correction: Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries.

Ong SH, Li Y, Koike-Yusa H, Yusa K.

Sci Rep. 2018 Apr 12;8(1):6136. doi: 10.1038/s41598-018-24092-w.

21.

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.

Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian TV, Kaemena DF, Tosti L, Tan W, Manning JR, Chantzoura E, Ottosson DR, Collombet S, Johnsson A, Cohen E, Yusa K, Linnarsson S, Graf T, Parmar M, Kaji K.

Cell Stem Cell. 2017 Dec 7;21(6):791-805.e9. doi: 10.1016/j.stem.2017.10.013. Epub 2017 Nov 22.

22.

Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.

Dovey OM, Cooper JL, Mupo A, Grove CS, Lynn C, Conte N, Andrews RM, Pacharne S, Tzelepis K, Vijayabaskar MS, Green P, Rad R, Arends M, Wright P, Yusa K, Bradley A, Varela I, Vassiliou GS.

Blood. 2017 Oct 26;130(17):1911-1922. doi: 10.1182/blood-2017-01-760595. Epub 2017 Aug 23.

23.

Successful Outcome of Low-Dose S-1 Used to Treat Buccal Squamous Cell Carcinoma.

Yusa K, Yamanouchi H, Sugano A, Iino M.

Case Rep Oncol Med. 2017;2017:4537631. doi: 10.1155/2017/4537631. Epub 2017 Jul 18.

24.

Three-Dimensional Printing Model as a Tool to Assist in Surgery for Large Mandibular Tumour: a Case Report.

Yusa K, Yamanochi H, Takagi A, Iino M.

J Oral Maxillofac Res. 2017 Jun 30;8(2):e4. doi: 10.5037/jomr.2017.8204. eCollection 2017 Apr-Jun.

25.

Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries.

Ong SH, Li Y, Koike-Yusa H, Yusa K.

Sci Rep. 2017 Aug 7;7(1):7384. doi: 10.1038/s41598-017-07827-z. Erratum in: Sci Rep. 2018 Apr 12;8(1):6136.

26.

Applications of CRISPR genome editing technology in drug target identification and validation.

Lu Q, Livi GP, Modha S, Yusa K, Macarrón R, Dow DJ.

Expert Opin Drug Discov. 2017 Jun;12(6):541-552. doi: 10.1080/17460441.2017.1317244. Epub 2017 Apr 23. Review.

PMID:
28388235
27.

Effect of timing of collection of salivary metabolomic biomarkers on oral cancer detection.

Ishikawa S, Sugimoto M, Kitabatake K, Tu M, Sugano A, Yamamori I, Iba A, Yusa K, Kaneko M, Ota S, Hiwatari K, Enomoto A, Masaru T, Iino M.

Amino Acids. 2017 Apr;49(4):761-770. doi: 10.1007/s00726-017-2378-5. Epub 2017 Jan 18.

PMID:
28101653
28.

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

Tzelepis K, Koike-Yusa H, De Braekeleer E, Li Y, Metzakopian E, Dovey OM, Mupo A, Grinkevich V, Li M, Mazan M, Gozdecka M, Ohnishi S, Cooper J, Patel M, McKerrell T, Chen B, Domingues AF, Gallipoli P, Teichmann S, Ponstingl H, McDermott U, Saez-Rodriguez J, Huntly BJP, Iorio F, Pina C, Vassiliou GS, Yusa K.

Cell Rep. 2016 Oct 18;17(4):1193-1205. doi: 10.1016/j.celrep.2016.09.079.

29.

Eluted zinc ions stimulate osteoblast differentiation and mineralization in human dental pulp stem cells for bone tissue engineering.

Yusa K, Yamamoto O, Iino M, Takano H, Fukuda M, Qiao Z, Sugiyama T.

Arch Oral Biol. 2016 Nov;71:162-169. doi: 10.1016/j.archoralbio.2016.07.010. Epub 2016 Aug 5.

PMID:
27521529
30.

Zinc-modified titanium surface enhances osteoblast differentiation of dental pulp stem cells in vitro.

Yusa K, Yamamoto O, Takano H, Fukuda M, Iino M.

Sci Rep. 2016 Jul 8;6:29462. doi: 10.1038/srep29462.

31.

Disseminated Intravascular Coagulation after Surgery for Facial Injury.

Ozaki H, Tachibana H, Ishikawa S, Yusa K, Kitabatake K, Iino M.

Case Rep Dent. 2016;2016:6053652. doi: 10.1155/2016/6053652. Epub 2016 May 30.

32.

Changes in Rectal Dose Due to Alterations in Beam Angles for Setup Uncertainty and Range Uncertainty in Carbon-Ion Radiotherapy for Prostate Cancer.

Kubota Y, Kawamura H, Sakai M, Tsumuraya R, Tashiro M, Yusa K, Kubo N, Sato H, Kawahara M, Katoh H, Kanai T, Ohno T, Nakano T.

PLoS One. 2016 Apr 20;11(4):e0153894. doi: 10.1371/journal.pone.0153894. eCollection 2016.

33.

Mandibular Reconstruction With Fibula Bone Graft Followed by Particulate Cancellous Bone and Marrow Graft With Titanium Mesh Tray.

Ozaki H, Sakurai H, Yusa K, Kitabatake K, Kobayashi T, Iino M.

J Oral Implantol. 2016 Aug;42(4):381-4. doi: 10.1563/aaid-joi-D-16-00009. Epub 2016 Apr 14. No abstract available.

PMID:
27077954
34.

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

Rouhani FJ, Nik-Zainal S, Wuster A, Li Y, Conte N, Koike-Yusa H, Kumasaka N, Vallier L, Yusa K, Bradley A.

PLoS Genet. 2016 Apr 7;12(4):e1005932. doi: 10.1371/journal.pgen.1005932. eCollection 2016 Apr.

35.

Facilitation of bone resorption activities in synovial lavage fluid patients with mandibular condyle fractures.

Takano H, Takahashi T, Nakata A, Nogami S, Yusa K, Kuwajima S, Yamazaki M, Fukuda M.

J Oral Rehabil. 2016 May;43(5):333-9. doi: 10.1111/joor.12388. Epub 2016 Mar 6.

PMID:
26946239
36.

A Case of Simultaneous Unilateral Anterior and Posterior Stafne Bone Defects.

Ozaki H, Ishikawa S, Kitabatake K, Yusa K, Tachibana H, Iino M.

Case Rep Dent. 2015;2015:983956. doi: 10.1155/2015/983956. Epub 2015 Oct 29.

37.

Functional and aesthetic rehabilitation with maxillary prosthesis supported by two zygomatic implants for maxillary defect resulting from cancer ablative surgery: a case report/technique article.

Ozaki H, Ishikawa S, Kitabatake K, Yusa K, Sakurai H, Iino M.

Odontology. 2016 May;104(2):233-8. doi: 10.1007/s10266-015-0222-5. Epub 2015 Oct 26.

PMID:
26497725
38.

Evaluation of an empirical monitor output estimation in carbon ion radiotherapy.

Matsumura A, Yusa K, Kanai T, Mizota M, Ohno T, Nakano T.

Med Phys. 2015 Sep;42(9):5188-94. doi: 10.1118/1.4928145.

PMID:
26328969
39.

piggyBac Transposon.

Yusa K.

Microbiol Spectr. 2015 Apr;3(2):MDNA3-0028-2014. doi: 10.1128/microbiolspec.MDNA3-0028-2014. Review.

PMID:
26104701
40.

Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.

Tokunaga M, Kokubu C, Maeda Y, Sese J, Horie K, Sugimoto N, Kinoshita T, Yusa K, Takeda J.

BMC Genomics. 2014 Nov 24;15:1016. doi: 10.1186/1471-2164-15-1016.

41.

piggyBac transposon-based insertional mutagenesis in mouse haploid embryonic stem cells.

Pettitt SJ, Tan EP, Yusa K.

Methods Mol Biol. 2015;1239:15-28. doi: 10.1007/978-1-4939-1862-1_2.

PMID:
25408399
42.

Off-target assessment of CRISPR-Cas9 guiding RNAs in human iPS and mouse ES cells.

Tan EP, Li Y, Velasco-Herrera Mdel C, Yusa K, Bradley A.

Genesis. 2015 Feb;53(2):225-36. doi: 10.1002/dvg.22835. Epub 2014 Dec 10.

PMID:
25378133
43.

Separate cellular localizations of human T-lymphotropic virus 1 (HTLV-1) Env and glucose transporter type 1 (GLUT1) are required for HTLV-1 Env-mediated fusion and infection.

Maeda Y, Terasawa H, Tanaka Y, Mitsuura C, Nakashima K, Yusa K, Harada S.

J Virol. 2015 Jan;89(1):502-11. doi: 10.1128/JVI.02686-14. Epub 2014 Oct 22.

44.

Removal of reprogramming transgenes improves the tissue reconstitution potential of keratinocytes generated from human induced pluripotent stem cells.

Igawa K, Kokubu C, Yusa K, Horie K, Yoshimura Y, Yamauchi K, Suemori H, Yokozeki H, Toyoda M, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Umezawa A, Katayama I, Takeda J.

Stem Cells Transl Med. 2014 Sep;3(9):992-1001. doi: 10.5966/sctm.2013-0179. Epub 2014 Jul 14.

45.

Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1.

Nakano Y, Monde K, Terasawa H, Yuan Y, Yusa K, Harada S, Maeda Y.

Virology. 2014 Mar;452-453:117-24. doi: 10.1016/j.virol.2013.12.034. Epub 2014 Jan 31.

46.

V3-independent competitive resistance of a dual-X4 HIV-1 to the CXCR4 inhibitor AMD3100.

Maeda Y, Terasawa H, Nakano Y, Monde K, Yusa K, Oka S, Takiguchi M, Harada S.

PLoS One. 2014 Feb 19;9(2):e89515. doi: 10.1371/journal.pone.0089515. eCollection 2014.

47.

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library.

Koike-Yusa H, Li Y, Tan EP, Velasco-Herrera Mdel C, Yusa K.

Nat Biotechnol. 2014 Mar;32(3):267-73. doi: 10.1038/nbt.2800. Epub 2013 Dec 23.

PMID:
24535568
48.

[Evaluation of the safety of innovative drugs against viruses and infectious agents].

Kobayashi T, Yusa K, Kawasaki N.

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2013;(131):7-15. Review. Japanese.

PMID:
24340664
49.

Seamless genome editing in human pluripotent stem cells using custom endonuclease-based gene targeting and the piggyBac transposon.

Yusa K.

Nat Protoc. 2013 Oct;8(10):2061-78. doi: 10.1038/nprot.2013.126. Epub 2013 Sep 26.

PMID:
24071911
50.

Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development.

Miyamoto K, Teperek M, Yusa K, Allen GE, Bradshaw CR, Gurdon JB.

Science. 2013 Aug 30;341(6149):1002-5. doi: 10.1126/science.1240376.

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