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Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy.

Gupta V, Yull F, Khabele D.

Cancers (Basel). 2018 Sep 29;10(10). pii: E366. doi: 10.3390/cancers10100366. Review.


Immunity drives TET1 regulation in cancer through NF-κB.

Collignon E, Canale A, Al Wardi C, Bizet M, Calonne E, Dedeurwaerder S, Garaud S, Naveaux C, Barham W, Wilson A, Bouchat S, Hubert P, Van Lint C, Yull F, Sotiriou C, Willard-Gallo K, Noel A, Fuks F.

Sci Adv. 2018 Jun 20;4(6):eaap7309. doi: 10.1126/sciadv.aap7309. eCollection 2018 Jun.


p52 expression enhances lung cancer progression.

Saxon JA, Yu H, Polosukhin VV, Stathopoulos GT, Gleaves LA, McLoed AG, Massion PP, Yull FE, Zhao Z, Blackwell TS.

Sci Rep. 2018 Apr 17;8(1):6078. doi: 10.1038/s41598-018-24488-8.


IκB Kinase α Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma.

Vreka M, Lilis I, Papageorgopoulou M, Giotopoulou GA, Lianou M, Giopanou I, Kanellakis NI, Spella M, Agalioti T, Armenis V, Goldmann T, Marwitz S, Yull FE, Blackwell TS, Pasparakis M, Marazioti A, Stathopoulos GT.

Cancer Res. 2018 Jun 1;78(11):2939-2951. doi: 10.1158/0008-5472.CAN-17-1944. Epub 2018 Mar 27.


Epithelial NF-κB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment.

Saxon JA, Sherrill TP, Polosukhin VV, Sai J, Zaynagetdinov R, McLoed AG, Gulleman PM, Barham W, Cheng DS, Hunt RP, Gleaves LA, Richmond A, Young LR, Yull FE, Blackwell TS.

Oncoimmunology. 2016 Mar 30;5(6):e1168549. doi: 10.1080/2162402X.2016.1168549. eCollection 2016 Jun.


Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer.

McLoed AG, Sherrill TP, Cheng DS, Han W, Saxon JA, Gleaves LA, Wu P, Polosukhin VV, Karin M, Yull FE, Stathopoulos GT, Georgoulias V, Zaynagetdinov R, Blackwell TS.

Cell Rep. 2016 Jun 28;16(1):120-132. doi: 10.1016/j.celrep.2016.05.085. Epub 2016 Jun 16.


Manipulating the NF-κB pathway in macrophages using mannosylated, siRNA-delivering nanoparticles can induce immunostimulatory and tumor cytotoxic functions.

Ortega RA, Barham W, Sharman K, Tikhomirov O, Giorgio TD, Yull FE.

Int J Nanomedicine. 2016 May 18;11:2163-77. doi: 10.2147/IJN.S93483. eCollection 2016.


IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development.

Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS.

J Immunol. 2016 Apr 15;196(8):3411-20. doi: 10.4049/jimmunol.1500906. Epub 2016 Mar 7.


Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment.

Hill AA, Anderson-Baucum EK, Kennedy AJ, Webb CD, Yull FE, Hasty AH.

Mol Metab. 2015 Jul 28;4(10):665-77. doi: 10.1016/j.molmet.2015.07.005. eCollection 2015 Oct.


p52 Overexpression Increases Epithelial Apoptosis, Enhances Lung Injury, and Reduces Survival after Lipopolysaccharide Treatment.

Saxon JA, Cheng DS, Han W, Polosukhin VV, McLoed AG, Richmond BW, Gleaves LA, Tanjore H, Sherrill TP, Barham W, Yull FE, Blackwell TS.

J Immunol. 2016 Feb 15;196(4):1891-9. doi: 10.4049/jimmunol.1501555. Epub 2016 Jan 15.


Microenvironmental effects limit efficacy of thymoquinone treatment in a mouse model of ovarian cancer.

Wilson AJ, Saskowski J, Barham W, Khabele D, Yull F.

Mol Cancer. 2015 Nov 9;14:192. doi: 10.1186/s12943-015-0463-5.


Aberrant activation of NF-κB signaling in mammary epithelium leads to abnormal growth and ductal carcinoma in situ.

Barham W, Chen L, Tikhomirov O, Onishko H, Gleaves L, Stricker TP, Blackwell TS, Yull FE.

BMC Cancer. 2015 Sep 30;15:647. doi: 10.1186/s12885-015-1652-8.


NF-κB-dependent airway inflammation triggers systemic insulin resistance.

Cyphert TJ, Morris RT, House LM, Barnes TM, Otero YF, Barham WJ, Hunt RP, Zaynagetdinov R, Yull FE, Blackwell TS, McGuinness OP.

Am J Physiol Regul Integr Comp Physiol. 2015 Nov 1;309(9):R1144-52. doi: 10.1152/ajpregu.00442.2014. Epub 2015 Sep 16.


Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancer.

Wilson AJ, Saskowski J, Barham W, Yull F, Khabele D.

J Ovarian Res. 2015 Jul 28;8:46. doi: 10.1186/s13048-015-0177-8.


Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment.

Zaynagetdinov R, Sherrill TP, Gleaves LA, McLoed AG, Saxon JA, Habermann AC, Connelly L, Dulek D, Peebles RS Jr, Fingleton B, Yull FE, Stathopoulos GT, Blackwell TS.

Cancer Res. 2015 Apr 15;75(8):1624-1634. doi: 10.1158/0008-5472.CAN-14-2379. Epub 2015 Feb 17.


Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice.

Buckman LB, Thompson MM, Lippert RN, Blackwell TS, Yull FE, Ellacott KL.

Mol Metab. 2014 Oct 16;4(1):58-63. doi: 10.1016/j.molmet.2014.10.001. eCollection 2015 Jan.


Biocompatible mannosylated endosomal-escape nanoparticles enhance selective delivery of short nucleotide sequences to tumor associated macrophages.

Ortega RA, Barham WJ, Kumar B, Tikhomirov O, McFadden ID, Yull FE, Giorgio TD.

Nanoscale. 2015 Jan 14;7(2):500-10. doi: 10.1039/c4nr03962a.


Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation.

Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS.

Am J Respir Cell Mol Biol. 2015 Jul;53(1):50-9. doi: 10.1165/rcmb.2014-0289OC.


Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response.

Yang J, Hawkins OE, Barham W, Gilchuk P, Boothby M, Ayers GD, Joyce S, Karin M, Yull FE, Richmond A.

Cancer Res. 2014 Dec 15;74(24):7274-84. doi: 10.1158/0008-5472.CAN-14-1091. Epub 2014 Oct 21.


IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.

Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, Slaughter JC, Yull FE, Hoffman HM, Blackwell TS, Prince LS.

J Immunol. 2014 Aug 1;193(3):1184-93. doi: 10.4049/jimmunol.1302516. Epub 2014 Jun 30.


NF-κB gene signature predicts prostate cancer progression.

Jin R, Yi Y, Yull FE, Blackwell TS, Clark PE, Koyama T, Smith JA Jr, Matusik RJ.

Cancer Res. 2014 May 15;74(10):2763-72. doi: 10.1158/0008-5472.CAN-13-2543. Epub 2014 Mar 31.


Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction.

Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL.

Lab Invest. 2014 Apr;94(4):409-21. doi: 10.1038/labinvest.2014.10. Epub 2014 Feb 17.


NF-κB inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense.

Li H, Han W, Polosukhin V, Yull FE, Segal BH, Xie CM, Blackwell TS.

Mediators Inflamm. 2013;2013:503213. doi: 10.1155/2013/503213. Epub 2013 Nov 18.


Tracking NF-κB activity in tumor cells during ovarian cancer progression in a syngeneic mouse model.

Wilson AJ, Barham W, Saskowski J, Tikhomirov O, Chen L, Lee HJ, Yull F, Khabele D.

J Ovarian Res. 2013 Sep 10;6(1):63. doi: 10.1186/1757-2215-6-63.


Targeting the Wnt pathway in synovial sarcoma models.

Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE.

Cancer Discov. 2013 Nov;3(11):1286-301. doi: 10.1158/2159-8290.CD-13-0138. Epub 2013 Aug 6.


Increased dietary sodium induces COX2 expression by activating NFκB in renal medullary interstitial cells.

He W, Zhang M, Zhao M, Davis LS, Blackwell TS, Yull F, Breyer MD, Hao CM.

Pflugers Arch. 2014 Feb;466(2):357-367. doi: 10.1007/s00424-013-1328-7. Epub 2013 Jul 31.


NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity.

Han W, Li H, Cai J, Gleaves LA, Polosukhin VV, Segal BH, Yull FE, Blackwell TS.

J Immunol. 2013 May 1;190(9):4786-94. doi: 10.4049/jimmunol.1201809. Epub 2013 Mar 25.


Macrophage-specific RNA interference targeting via "click", mannosylated polymeric micelles.

Yu SS, Lau CM, Barham WJ, Onishko HM, Nelson CE, Li H, Smith CA, Yull FE, Duvall CL, Giorgio TD.

Mol Pharm. 2013 Mar 4;10(3):975-87. doi: 10.1021/mp300434e. Epub 2013 Feb 12.


Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling.

Edwards JR, Perrien DS, Fleming N, Nyman JS, Ono K, Connelly L, Moore MM, Lwin ST, Yull FE, Mundy GR, Elefteriou F.

J Bone Miner Res. 2013 Apr;28(4):960-9. doi: 10.1002/jbmr.1824.


Intraductal injection of LPS as a mouse model of mastitis: signaling visualized via an NF-κB reporter transgenic.

Barham W, Sherrill T, Connelly L, Blackwell TS, Yull FE.

J Vis Exp. 2012 Sep 4;(67):e4030. doi: 10.3791/4030.


Mother-daughter communication about breast cancer risk: interpersonal and biological stress processes.

Berlin KL, Andreotti C, Yull F, Grau AM, Compas BE.

J Behav Med. 2013 Jun;36(3):328-39. doi: 10.1007/s10865-012-9418-0. Epub 2012 May 9.


Tumor microenvironment complexity: emerging roles in cancer therapy.

Swartz MA, Iida N, Roberts EW, Sangaletti S, Wong MH, Yull FE, Coussens LM, DeClerck YA.

Cancer Res. 2012 May 15;72(10):2473-80. doi: 10.1158/0008-5472.CAN-12-0122. Epub 2012 Mar 13.


Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.

Arima Y, Harada M, Kamimura D, Park JH, Kawano F, Yull FE, Kawamoto T, Iwakura Y, Betz UA, Márquez G, Blackwell TS, Ohira Y, Hirano T, Murakami M.

Cell. 2012 Feb 3;148(3):447-57. doi: 10.1016/j.cell.2012.01.022.


Opposing effects of bortezomib-induced nuclear factor-κB inhibition on chemical lung carcinogenesis.

Karabela SP, Psallidas I, Sherrill TP, Kairi CA, Zaynagetdinov R, Cheng DS, Vassiliou S, McMahon F, Gleaves LA, Han W, Stathopoulos I, Zakynthinos SG, Yull FE, Roussos C, Kalomenidis I, Blackwell TS, Stathopoulos GT.

Carcinogenesis. 2012 Apr;33(4):859-67. doi: 10.1093/carcin/bgs024. Epub 2012 Jan 27.


A critical role for macrophages in promotion of urethane-induced lung carcinogenesis.

Zaynagetdinov R, Sherrill TP, Polosukhin VV, Han W, Ausborn JA, McLoed AG, McMahon FB, Gleaves LA, Degryse AL, Stathopoulos GT, Yull FE, Blackwell TS.

J Immunol. 2011 Dec 1;187(11):5703-11. doi: 10.4049/jimmunol.1100558. Epub 2011 Nov 2.


Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes.

Zaynagetdinov R, Stathopoulos GT, Sherrill TP, Cheng DS, McLoed AG, Ausborn JA, Polosukhin VV, Connelly L, Zhou W, Fingleton B, Peebles RS, Prince LS, Yull FE, Blackwell TS.

Oncogene. 2012 Jun 28;31(26):3164-76. doi: 10.1038/onc.2011.480. Epub 2011 Oct 17.


NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.

Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I.

PLoS One. 2011;6(8):e23488. doi: 10.1371/journal.pone.0023488. Epub 2011 Aug 24.


NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model.

Connelly L, Barham W, Onishko HM, Chen L, Sherrill TP, Zabuawala T, Ostrowski MC, Blackwell TS, Yull FE.

Breast Cancer Res. 2011 Aug 31;13(4):R83. doi: 10.1186/bcr2935.


Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts.

Chen AC, Arany PR, Huang YY, Tomkinson EM, Sharma SK, Kharkwal GB, Saleem T, Mooney D, Yull FE, Blackwell TS, Hamblin MR.

PLoS One. 2011;6(7):e22453. doi: 10.1371/journal.pone.0022453. Epub 2011 Jul 21.


NF-κB signaling in fetal lung macrophages disrupts airway morphogenesis.

Blackwell TS, Hipps AN, Yamamoto Y, Han W, Barham WJ, Ostrowski MC, Yull FE, Prince LS.

J Immunol. 2011 Sep 1;187(5):2740-7. doi: 10.4049/jimmunol.1101495. Epub 2011 Jul 20.


Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs.

Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, Newcomb DC, Jones BR, Roldan J, Lane KB, Morrisey EE, Beers MF, Yull FE, Blackwell TS.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10562-7. doi: 10.1073/pnas.1107559108. Epub 2011 Jun 13.


Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden.

Connelly L, Barham W, Onishko HM, Sherrill T, Chodosh LA, Blackwell TS, Yull FE.

Oncogene. 2011 Mar 24;30(12):1402-12. doi: 10.1038/onc.2010.521. Epub 2010 Nov 15.


Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion.

Stathopoulos GT, Sherrill TP, Karabela SP, Goleniewska K, Kalomenidis I, Roussos C, Fingleton B, Yull FE, Peebles RS Jr, Blackwell TS.

Am J Respir Crit Care Med. 2010 Nov 15;182(10):1273-81. doi: 10.1164/rccm.201001-0001OC. Epub 2010 Jul 1.


Conditional ablation of Ikkb inhibits melanoma tumor development in mice.

Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A.

J Clin Invest. 2010 Jul;120(7):2563-74. doi: 10.1172/JCI42358. Epub 2010 Jun 7.


NADPH oxidase limits innate immune responses in the lungs in mice.

Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS.

PLoS One. 2010 Mar 16;5(3):e9631. doi: 10.1371/journal.pone.0009631.


Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection.

Connelly L, Barham W, Pigg R, Saint-Jean L, Sherrill T, Cheng DS, Chodosh LA, Blackwell TS, Yull FE.

J Cell Physiol. 2010 Jan;222(1):73-81. doi: 10.1002/jcp.21922.


The protein kinase IKKepsilon regulates energy balance in obese mice.

Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR.

Cell. 2009 Sep 4;138(5):961-75. doi: 10.1016/j.cell.2009.06.046.


Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart.

Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME.

J Clin Invest. 2009 Apr;119(4):986-96. doi: 10.1172/JCI35814. Epub 2009 Mar 9.


Myeloid cells control termination of lung inflammation through the NF-kappaB pathway.

Han W, Joo M, Everhart MB, Christman JW, Yull FE, Blackwell TS.

Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L320-7. doi: 10.1152/ajplung.90485.2008. Epub 2008 Dec 19.


The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth.

Jin RJ, Lho Y, Connelly L, Wang Y, Yu X, Saint Jean L, Case TC, Ellwood-Yen K, Sawyers CL, Bhowmick NA, Blackwell TS, Yull FE, Matusik RJ.

Cancer Res. 2008 Aug 15;68(16):6762-9. doi: 10.1158/0008-5472.CAN-08-0107.

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