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Items: 1 to 50 of 147

1.

Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output.

Ivanova H, Wagner LE 2nd, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K, De Smedt H, Martens L, Yule DI, Parys JB, Bultynck G.

Cell Mol Life Sci. 2019 Apr 16. doi: 10.1007/s00018-019-03091-8. [Epub ahead of print]

PMID:
30989245
2.

Bok regulates mitochondrial fusion and morphology.

Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE 2nd, Yule DI, Wojcikiewicz RJH.

Cell Death Differ. 2019 Apr 11. doi: 10.1038/s41418-019-0327-4. [Epub ahead of print]

PMID:
30976095
3.

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F.

Sci Rep. 2019 Feb 14;9(1):2096. doi: 10.1038/s41598-018-38312-w.

4.

Acetylcholine Inhibits Platelet Activation.

Bennett JA, Ture SK, Schmidt RA, Mastrangelo MA, Cameron SJ, Terry LE, Yule DI, Morrell CN, Lowenstein CJ.

J Pharmacol Exp Ther. 2019 May;369(2):182-187. doi: 10.1124/jpet.118.253583. Epub 2019 Feb 14.

PMID:
30765424
5.

Expression of BK channels and Na+-K+ pumps in the apical membrane of lacrimal acinar cells suggests a new molecular mechanism for primary tear-secretion.

Almássy J, Diszházi G, Skaliczki M, Márton I, Magyar ZÉ, Nánási PP, Yule DI.

Ocul Surf. 2019 Apr;17(2):272-277. doi: 10.1016/j.jtos.2019.01.007. Epub 2019 Jan 24.

PMID:
30685438
6.

A Model of [Formula: see text] Dynamics in an Accurate Reconstruction of Parotid Acinar Cells.

Pages N, Vera-Sigüenza E, Rugis J, Kirk V, Yule DI, Sneyd J.

Bull Math Biol. 2019 May;81(5):1394-1426. doi: 10.1007/s11538-018-00563-z. Epub 2019 Jan 14.

PMID:
30644065
7.

All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics.

Lock JT, Alzayady KJ, Yule DI, Parker I.

Sci Signal. 2018 Dec 18;11(561). pii: eaau0344. doi: 10.1126/scisignal.aau0344.

8.

A Mathematical Model of Fluid Transport in an Accurate Reconstruction of Parotid Acinar Cells.

Vera-Sigüenza E, Pages N, Rugis J, Yule DI, Sneyd J.

Bull Math Biol. 2019 Mar;81(3):699-721. doi: 10.1007/s11538-018-0534-z. Epub 2018 Nov 27.

PMID:
30484039
9.

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells.

Joseph SK, Young MP, Alzayady K, Yule DI, Ali M, Booth DM, Hajnóczky G.

J Biol Chem. 2018 Nov 9;293(45):17464-17476. doi: 10.1074/jbc.RA118.005624. Epub 2018 Sep 18.

PMID:
30228182
10.

Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.

de Rubio RG, Ransom RF, Malik S, Yule DI, Anantharam A, Smrcka AV.

Sci Signal. 2018 Sep 11;11(547). pii: eaan1210. doi: 10.1126/scisignal.aan1210.

11.

Inositol 1,4,5-trisphosphate Receptor Mutations associated with Human Disease.

Terry LE, Alzayady KJ, Furati E, Yule DI.

Messenger (Los Angel). 2018 Jun;6(1-2):29-44.

12.

Carbohydrate Loading to Combat Acute Pancreatitis.

Vervliet T, Yule DI, Bultynck G.

Trends Biochem Sci. 2018 Oct;43(10):741-744. doi: 10.1016/j.tibs.2018.08.001. Epub 2018 Aug 28.

PMID:
30170888
13.

Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP.

Nurbaeva MK, Eckstein M, Devotta A, Saint-Jeannet JP, Yule DI, Hubbard MJ, Lacruz RS.

Front Physiol. 2018 Jul 2;9:801. doi: 10.3389/fphys.2018.00801. eCollection 2018.

14.

Differential regulation of ion channels function by proteolysis.

Wang L, Yule DI.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1698-1706. doi: 10.1016/j.bbamcr.2018.07.004. Epub 2018 Jul 17. Review.

PMID:
30009861
15.

Region-specific proteolysis differentially modulates type 2 and type 3 inositol 1,4,5-trisphosphate receptor activity in models of acute pancreatitis.

Wang L, Wagner LE 2nd, Alzayady KJ, Yule DI.

J Biol Chem. 2018 Aug 24;293(34):13112-13124. doi: 10.1074/jbc.RA118.003421. Epub 2018 Jul 3.

PMID:
29970616
16.

Can pancreatitis be treated by inhibiting Ca2+ signaling?

Williams JA, Yule DI.

Ann Transl Med. 2018 Apr;6(7):124. doi: 10.21037/atm.2017.06.07. No abstract available.

17.

New saliva secretion model based on the expression of Na+-K+ pump and K+ channels in the apical membrane of parotid acinar cells.

Almássy J, Siguenza E, Skaliczki M, Matesz K, Sneyd J, Yule DI, Nánási PP.

Pflugers Arch. 2018 Apr;470(4):613-621. doi: 10.1007/s00424-018-2109-0. Epub 2018 Jan 17.

PMID:
29344775
18.

Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity.

Wang L, Wagner LE 2nd, Alzayady KJ, Yule DI.

J Biol Chem. 2017 Jul 14;292(28):11714-11726. doi: 10.1074/jbc.M117.789917. Epub 2017 May 19.

19.

Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2.

Luyten T, Welkenhuyzen K, Roest G, Kania E, Wang L, Bittremieux M, Yule DI, Parys JB, Bultynck G.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):947-956. doi: 10.1016/j.bbamcr.2017.02.013. Epub 2017 Feb 28.

20.

DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store.

Bittremieux M, Gerasimenko JV, Schuermans M, Luyten T, Stapleton E, Alzayady KJ, De Smedt H, Yule DI, Mikoshiba K, Vangheluwe P, Gerasimenko OV, Parys JB, Bultynck G.

Cell Calcium. 2017 Mar;62:60-70. doi: 10.1016/j.ceca.2017.01.015. Epub 2017 Feb 1.

PMID:
28196740
21.

On the dynamical structure of calcium oscillations.

Sneyd J, Han JM, Wang L, Chen J, Yang X, Tanimura A, Sanderson MJ, Kirk V, Yule DI.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1456-1461. doi: 10.1073/pnas.1614613114. Epub 2017 Feb 1.

22.

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.

Concepcion AR, Vaeth M, Wagner LE 2nd, Eckstein M, Hecht L, Yang J, Crottes D, Seidl M, Shin HP, Weidinger C, Cameron S, Turvey SE, Issekutz T, Meyts I, Lacruz RS, Cuk M, Yule DI, Feske S.

J Clin Invest. 2016 Nov 1;126(11):4303-4318. doi: 10.1172/JCI89056. Epub 2016 Oct 10.

23.

The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.

Ivanova H, Ritaine A, Wagner L, Luyten T, Shapovalov G, Welkenhuyzen K, Seitaj B, Monaco G, De Smedt H, Prevarskaya N, Yule DI, Parys JB, Bultynck G.

Oncotarget. 2016 Aug 23;7(34):55704-55720. doi: 10.18632/oncotarget.11005.

24.

Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell.

Sneyd J, Means S, Zhu D, Rugis J, Won JH, Yule DI.

J Theor Biol. 2017 Apr 21;419:383-393. doi: 10.1016/j.jtbi.2016.04.030. Epub 2016 May 4.

25.

Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome.

Gerber S, Alzayady KJ, Burglen L, Brémond-Gignac D, Marchesin V, Roche O, Rio M, Funalot B, Calmon R, Durr A, Gil-da-Silva-Lopes VL, Ribeiro Bittar MF, Orssaud C, Héron B, Ayoub E, Berquin P, Bahi-Buisson N, Bole C, Masson C, Munnich A, Simons M, Delous M, Dollfus H, Boddaert N, Lyonnet S, Kaplan J, Calvas P, Yule DI, Rozet JM, Fares Taie L.

Am J Hum Genet. 2016 May 5;98(5):971-980. doi: 10.1016/j.ajhg.2016.03.004. Epub 2016 Apr 21.

26.

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.

Alzayady KJ, Wang L, Chandrasekhar R, Wagner LE 2nd, Van Petegem F, Yule DI.

Sci Signal. 2016 Apr 5;9(422):ra35. doi: 10.1126/scisignal.aad6281.

27.

Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs.

Chandrasekhar R, Alzayady KJ, Wagner LE 2nd, Yule DI.

J Biol Chem. 2016 Mar 4;291(10):4846-60. doi: 10.1074/jbc.M115.705301. Epub 2016 Jan 11.

28.

Proteolytic fragmentation of inositol 1,4,5-trisphosphate receptors: a novel mechanism regulating channel activity?

Wang L, Alzayady KJ, Yule DI.

J Physiol. 2016 Jun 1;594(11):2867-76. doi: 10.1113/JP271140. Epub 2015 Dec 7. Review.

29.

IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome.

Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I.

Sci Rep. 2015 Sep 14;5:13953. doi: 10.1038/srep13953.

30.

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

Chandrasekhar R, Alzayady KJ, Yule DI.

Biochem Soc Trans. 2015 Jun;43(3):364-70. doi: 10.1042/BST20140287. Review.

31.

Tracing the Evolutionary History of Inositol, 1, 4, 5-Trisphosphate Receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs.

Alzayady KJ, Sebé-Pedrós A, Chandrasekhar R, Wang L, Ruiz-Trillo I, Yule DI.

Mol Biol Evol. 2015 Sep;32(9):2236-53. doi: 10.1093/molbev/msv098. Epub 2015 Apr 23.

32.

The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release.

Hedgepeth SC, Garcia MI, Wagner LE 2nd, Rodriguez AM, Chintapalli SV, Snyder RR, Hankins GD, Henderson BR, Brodie KM, Yule DI, van Rossum DB, Boehning D.

J Biol Chem. 2015 Mar 13;290(11):7304-13. doi: 10.1074/jbc.M114.611186. Epub 2015 Feb 2.

33.

The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel.

Vervloessem T, Yule DI, Bultynck G, Parys JB.

Biochim Biophys Acta. 2015 Sep;1853(9):1992-2005. doi: 10.1016/j.bbamcr.2014.12.006. Epub 2014 Dec 10. Review.

34.

Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.

Wagner LE 2nd, Groom LA, Dirksen RT, Yule DI.

Cell Calcium. 2014 Aug;56(2):96-107. doi: 10.1016/j.ceca.2014.05.004. Epub 2014 Jun 6.

35.

Cell Calcium. Special issue: Ca²⁺ signaling and secretory function. Preface.

Yule DI.

Cell Calcium. 2014 Jun;55(6):281. doi: 10.1016/j.ceca.2014.04.001. Epub 2014 Apr 18. No abstract available.

36.

Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species.

Bánsághi S, Golenár T, Madesh M, Csordás G, RamachandraRao S, Sharma K, Yule DI, Joseph SK, Hajnóczky G.

J Biol Chem. 2014 Mar 21;289(12):8170-81. doi: 10.1074/jbc.M113.504159. Epub 2014 Jan 27.

37.

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor.

Monaco G, Decrock E, Nuyts K, Wagner LE 2nd, Luyten T, Strelkov SV, Missiaen L, De Borggraeve WM, Leybaert L, Yule DI, De Smedt H, Parys JB, Bultynck G.

PLoS One. 2013 Aug 30;8(8):e73386. doi: 10.1371/journal.pone.0073386. eCollection 2013.

38.

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

Alzayady KJ, Wagner LE 2nd, Chandrasekhar R, Monteagudo A, Godiska R, Tall GG, Joseph SK, Yule DI.

J Biol Chem. 2013 Oct 11;288(41):29772-84. doi: 10.1074/jbc.M113.502203. Epub 2013 Aug 16.

39.

Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts.

Kemény LV, Schnúr A, Czepán M, Rakonczay Z Jr, Gál E, Lonovics J, Lázár G, Simonka Z, Venglovecz V, Maléth J, Judák L, Németh IB, Szabó K, Almássy J, Virág L, Geisz A, Tiszlavicz L, Yule DI, Wittmann T, Varró A, Hegyi P.

Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15;305(8):G552-63. doi: 10.1152/ajpgi.00394.2012. Epub 2013 Aug 1.

40.

Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV.

Cell. 2013 Mar 28;153(1):216-27. doi: 10.1016/j.cell.2013.02.047.

41.

Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels.

Alzayady KJ, Chandrasekhar R, Yule DI.

J Biol Chem. 2013 Apr 19;288(16):11122-34. doi: 10.1074/jbc.M113.453241. Epub 2013 Mar 11.

42.

Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity.

Wei-LaPierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W.

J Biol Chem. 2013 Apr 12;288(15):10567-77. doi: 10.1074/jbc.M113.455709. Epub 2013 Mar 1.

43.

Analyzing Ca(2+) dynamics in intact epithelial cells using spatially limited flash photolysis.

Almassy J, Yule DI.

Cold Spring Harb Protoc. 2013 Jan 1;2013(1). pii: pdb.prot072777. doi: 10.1101/pdb.prot072777.

PMID:
23282645
44.

Investigating ion channel distribution using a combination of spatially limited photolysis, Ca(2+) imaging, and patch clamp recording.

Almassy J, Yule DI.

Cold Spring Harb Protoc. 2013 Jan 1;2013(1). pii: pdb.prot072769. doi: 10.1101/pdb.prot072769.

PMID:
23282644
45.

Studying the activation of epithelial ion channels using global whole-field photolysis.

Almassy J, Yule DI.

Cold Spring Harb Protoc. 2013 Jan 1;2013(1). pii: pdb.prot072751. doi: 10.1101/pdb.prot072751.

PMID:
23282643
46.

Photolysis of caged compounds: studying Ca(2+) signaling and activation of Ca(2+)-dependent ion channels.

Almassy J, Yule DI.

Cold Spring Harb Protoc. 2013 Jan 1;2013(1). pii: pdb.top066076. doi: 10.1101/pdb.top066076.

PMID:
23282631
47.

Manganese transport via the transferrin mechanism.

Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, Yule DI.

Neurotoxicology. 2013 Jan;34:118-27. doi: 10.1016/j.neuro.2012.10.018. Epub 2012 Nov 9.

48.

A quantitative analysis of electrolyte exchange in the salivary duct.

Patterson K, Catalán MA, Melvin JE, Yule DI, Crampin EJ, Sneyd J.

Am J Physiol Gastrointest Liver Physiol. 2012 Nov 15;303(10):G1153-63. doi: 10.1152/ajpgi.00364.2011. Epub 2012 Aug 16.

49.

Differential regulation of the InsP₃ receptor type-1 and -2 single channel properties by InsP₃, Ca²⁺ and ATP.

Wagner LE 2nd, Yule DI.

J Physiol. 2012 Jul 15;590(14):3245-59. doi: 10.1113/jphysiol.2012.228320. Epub 2012 Apr 30.

50.

Modelling the effects of calcium waves and oscillations on saliva secretion.

Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ.

J Theor Biol. 2012 Jul 21;305:45-53. doi: 10.1016/j.jtbi.2012.04.009. Epub 2012 Apr 14.

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