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Items: 38


An Ex-Vivo Culture System of Ovarian Cancer Faithfully Recapitulating the Pathological Features of Primary Tumors.

Ghani FI, Dendo K, Watanabe R, Yamada K, Yoshimatsu Y, Yugawa T, Nakahara T, Tanaka K, Yoshida H, Yoshida M, Ishikawa M, Goshima N, Kato T, Kiyono T.

Cells. 2019 Jun 26;8(7). pii: E644. doi: 10.3390/cells8070644.


Induction of non-apoptotic programmed cell death by oncogenic RAS in human epithelial cells and its suppression by MYC overexpression.

Dendo K, Yugawa T, Nakahara T, Ohno SI, Goshima N, Arakawa H, Kiyono T.

Carcinogenesis. 2018 Feb 9;39(2):202-213. doi: 10.1093/carcin/bgx124.


Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes.

Yoshimatsu Y, Nakahara T, Tanaka K, Inagawa Y, Narisawa-Saito M, Yugawa T, Ohno SI, Fujita M, Nakagama H, Kiyono T.

Cancer Sci. 2017 Jul;108(7):1303-1309. doi: 10.1111/cas.13264. Epub 2017 Jun 5.


Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.

Mori S, Takeuchi T, Ishii Y, Yugawa T, Kiyono T, Nishina H, Kukimoto I.

J Virol. 2017 Feb 28;91(6). pii: e02413-16. doi: 10.1128/JVI.02413-16. Print 2017 Mar 15.


Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture.

Sugimoto N, Maehara K, Yoshida K, Yasukouchi S, Osano S, Watanabe S, Aizawa M, Yugawa T, Kiyono T, Kurumizaka H, Ohkawa Y, Fujita M.

Nucleic Acids Res. 2015 Jul 13;43(12):5898-911. doi: 10.1093/nar/gkv509. Epub 2015 May 18.


Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.

Nakahara T, Tanaka K, Ohno S, Egawa N, Yugawa T, Kiyono T.

J Virol. 2015 May;89(9):5040-59. doi: 10.1128/JVI.00389-15. Epub 2015 Feb 25.


A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.

Inagawa Y, Yamada K, Yugawa T, Ohno S, Hiraoka N, Esaki M, Shibata T, Aoki K, Saya H, Kiyono T.

Carcinogenesis. 2014 Aug;35(8):1840-6. doi: 10.1093/carcin/bgu112. Epub 2014 May 24.


ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication.

Iwahori S, Kohmon D, Kobayashi J, Tani Y, Yugawa T, Komatsu K, Kiyono T, Sugimoto N, Fujita M.

Cell Cycle. 2014;13(3):471-81. doi: 10.4161/cc.27274. Epub 2013 Nov 26.


Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.

Yugawa T, Nishino K, Ohno S, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T.

Mol Cell Biol. 2013 Nov;33(22):4434-47. doi: 10.1128/MCB.00577-13. Epub 2013 Sep 9.


Heterocomplex formation by Arp4 and β-actin is involved in the integrity of the Brg1 chromatin remodeling complex.

Nishimoto N, Watanabe M, Watanabe S, Sugimoto N, Yugawa T, Ikura T, Koiwai O, Kiyono T, Fujita M.

J Cell Sci. 2012 Aug 15;125(Pt 16):3870-82. doi: 10.1242/jcs.104349. Epub 2012 May 8.


A critical role of MYC for transformation of human cells by HPV16 E6E7 and oncogenic HRAS.

Narisawa-Saito M, Inagawa Y, Yoshimatsu Y, Haga K, Tanaka K, Egawa N, Ohno S, Ichikawa H, Yugawa T, Fujita M, Kiyono T.

Carcinogenesis. 2012 Apr;33(4):910-7. doi: 10.1093/carcin/bgs104. Epub 2012 Feb 15.


The E1 protein of human papillomavirus type 16 is dispensable for maintenance replication of the viral genome.

Egawa N, Nakahara T, Ohno S, Narisawa-Saito M, Yugawa T, Fujita M, Yamato K, Natori Y, Kiyono T.

J Virol. 2012 Mar;86(6):3276-83. doi: 10.1128/JVI.06450-11. Epub 2012 Jan 11.


An in vitro multistep carcinogenesis model for both HPV-positive and -negative human oral squamous cell carcinomas.

Zushi Y, Narisawa-Saito M, Noguchi K, Yoshimatsu Y, Yugawa T, Egawa N, Fujita M, Urade M, Kiyono T.

Am J Cancer Res. 2011;1(7):869-81. Epub 2011 Aug 18.


DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells.

Yugawa T, Narisawa-Saito M, Yoshimatsu Y, Haga K, Ohno S, Egawa N, Fujita M, Kiyono T.

Cancer Res. 2010 May 15;70(10):4034-44. doi: 10.1158/0008-5472.CAN-09-4063. Epub 2010 May 4. Erratum in: Cancer Res. 2010 Jul 1;70(13):5639.


CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.

Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M.

J Cell Sci. 2010 Jan 15;123(Pt 2):225-35. doi: 10.1242/jcs.058693.


[Molecular basis of cervical carcinogenesis by high-risk human papillomaviruses].

Yugawa T, Kiyono T.

Uirusu. 2008 Dec;58(2):141-54. Review. Japanese.


Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.

Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa-Saito M, Waga S, Kiyono T, Fujita M.

J Cell Sci. 2009 Apr 15;122(Pt 8):1184-91. doi: 10.1242/jcs.041889.


Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.

Yugawa T, Kiyono T.

Rev Med Virol. 2009 Mar;19(2):97-113. doi: 10.1002/rmv.605. Review.


Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes.

Sasaki R, Narisawa-Saito M, Yugawa T, Fujita M, Tashiro H, Katabuchi H, Kiyono T.

Carcinogenesis. 2009 Mar;30(3):423-31. doi: 10.1093/carcin/bgp007. Epub 2009 Jan 6.


Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres.

Tatsumi Y, Ezura K, Yoshida K, Yugawa T, Narisawa-Saito M, Kiyono T, Ohta S, Obuse C, Fujita M.

Genes Cells. 2008 Oct;13(10):1045-59. doi: 10.1111/j.1365-2443.2008.01224.x. Epub 2008 Aug 29.


An in vitro multistep carcinogenesis model for human cervical cancer.

Narisawa-Saito M, Yoshimatsu Y, Ohno S, Yugawa T, Egawa N, Fujita M, Hirohashi S, Kiyono T.

Cancer Res. 2008 Jul 15;68(14):5699-705. doi: 10.1158/0008-5472.CAN-07-6862.


Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.

Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa-Saito M, Matsukage A, Kiyono T, Fujita M.

Mol Biol Cell. 2008 Mar;19(3):1007-21. Epub 2007 Dec 27.


Regulation of Notch1 gene expression by p53 in epithelial cells.

Yugawa T, Handa K, Narisawa-Saito M, Ohno S, Fujita M, Kiyono T.

Mol Cell Biol. 2007 May;27(10):3732-42. Epub 2007 Mar 12.


Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.

Haga K, Ohno S, Yugawa T, Narisawa-Saito M, Fujita M, Sakamoto M, Galloway DA, Kiyono T.

Cancer Sci. 2007 Feb;98(2):147-54.


HPV16 E6-mediated stabilization of ErbB2 in neoplastic transformation of human cervical keratinocytes.

Narisawa-Saito M, Handa K, Yugawa T, Ohno S, Fujita M, Kiyono T.

Oncogene. 2007 May 10;26(21):2988-96. Epub 2006 Dec 4.


E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein.

Handa K, Yugawa T, Narisawa-Saito M, Ohno S, Fujita M, Kiyono T.

J Virol. 2007 Feb;81(3):1379-89. Epub 2006 Nov 22.


Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.

Tatsumi Y, Sugimoto N, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M.

J Cell Sci. 2006 Aug 1;119(Pt 15):3128-40. Epub 2006 Jul 11.


Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase.

Nishigaki K, Thompson D, Yugawa T, Rulli K, Hanson C, Cmarik J, Gutkind JS, Teramoto H, Ruscetti S.

J Biol Chem. 2003 Apr 11;278(15):13520-30. Epub 2003 Feb 6.


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