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ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine.

Bhagwat SV, McMillen WT, Cai S, Zhao B, Whitesell M, Shen W, Kindler L, Flack RS, Wu W, Anderson B, Zhai Y, Yuan XJ, Pogue M, Van Horn RD, Rao X, McCann D, Dropsey AJ, Manro J, Walgren J, Yuen E, Rodriguez MJ, Plowman GD, Tiu RV, Joseph S, Peng SB.

Mol Cancer Ther. 2020 Feb;19(2):325-336. doi: 10.1158/1535-7163.MCT-19-0183. Epub 2019 Nov 19.


A Trigger Reduction Approach to Treatment of Paradoxical Vocal Fold Motion Disorder in the Pediatric Population.

Zalvan C, Yuen E, Geliebter J, Tiwari R.

J Voice. 2019 Sep 16. pii: S0892-1997(19)30243-7. doi: 10.1016/j.jvoice.2019.08.013. [Epub ahead of print]


Cardiopulmonary Exercise Testing, Impedance Cardiography, and Reclassification of Risk in Patients Referred for Heart Failure Evaluation.

Myers J, Christle JW, Tun A, Yilmaz B, Moneghetti KJ, Yuen E, Soofi M, Ashley E.

J Card Fail. 2019 Dec;25(12):961-968. doi: 10.1016/j.cardfail.2019.08.013. Epub 2019 Aug 24.


Measuring Nutrition and Food Literacy in Adults: A Systematic Review and Appraisal of Existing Measurement Tools.

Yuen EYN, Thomson M, Gardiner H.

Health Lit Res Pract. 2018 Aug 15;2(3):e134-e160. doi: 10.3928/24748307-20180625-01. eCollection 2018 Jul. Review.


Unintentional weight loss, its associated burden, and perceived weight status in people with cancer.

Yuen EYN, Zaleta AK, McManus S, Buzaglo JS, LeBlanc TW, Hamilton K, Stein K.

Support Care Cancer. 2020 Jan;28(1):329-339. doi: 10.1007/s00520-019-04797-y. Epub 2019 May 2.


Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma.

Even C, Lassen U, Merchan J, Le Tourneau C, Soria JC, Ferte C, Ricci F, Diener JT, Yuen E, Smith C, Oakley GJ 3rd, Benhadji KA, Massard C.

Invest New Drugs. 2019 Apr 6. doi: 10.1007/s10637-019-00739-x. [Epub ahead of print]


Transoral Penetrating Trauma to the Skull Base.

Klimczak J, Kelley A, Guthrie A, Yuen E, Lando T.

Ear Nose Throat J. 2019 Apr 4:145561319834909. doi: 10.1177/0145561319834909. [Epub ahead of print] No abstract available.


Lentiviral Vectors for the Treatment and Prevention of Cystic Fibrosis Lung Disease.

Marquez Loza LI, Yuen EC, McCray PB Jr.

Genes (Basel). 2019 Mar 14;10(3). pii: E218. doi: 10.3390/genes10030218. Review.


Evaluation of the effects of an oral notch inhibitor, crenigacestat (LY3039478), on QT interval, and bioavailability studies conducted in healthy subjects.

Yuen E, Posada M, Smith C, Thorn K, Greenwood D, Burgess M, A Benhadji K, Ortega D, Chinchen L, Suico J.

Cancer Chemother Pharmacol. 2019 Mar;83(3):483-492. doi: 10.1007/s00280-018-3750-1. Epub 2018 Dec 11.


Perioperative aspirin and long-term survival in patients undergoing coronary artery bypass graft.

Ding Q, Liu H, Zhang Z, Goldhammer J, Yuen E, Li Z, Yao L, Young N, Boyd D, Weintraub W, Morris R, Sun J.

Sci Rep. 2018 Nov 19;8(1):17051. doi: 10.1038/s41598-018-35208-7.


Notch pathway inhibition with LY3039478 in soft tissue sarcoma and gastrointestinal stromal tumours.

Mir O, Azaro A, Merchan J, Chugh R, Trent J, Rodon J, Ohnmacht U, Diener JT, Smith C, Yuen E, Oakley GJ 3rd, Le Cesne A, Soria JC, Benhadji KA, Massard C.

Eur J Cancer. 2018 Nov;103:88-97. doi: 10.1016/j.ejca.2018.08.012. Epub 2018 Sep 12.


First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer.

Massard C, Azaro A, Soria JC, Lassen U, Le Tourneau C, Sarker D, Smith C, Ohnmacht U, Oakley G, Patel BKR, Yuen ESM, Benhadji KA, Rodon J.

Ann Oncol. 2018 Sep 1;29(9):1911-1917. doi: 10.1093/annonc/mdy244.


A taxonomic signature of obesity in a large study of American adults.

Peters BA, Shapiro JA, Church TR, Miller G, Trinh-Shevrin C, Yuen E, Friedlander C, Hayes RB, Ahn J.

Sci Rep. 2018 Jun 27;8(1):9749. doi: 10.1038/s41598-018-28126-1.


Attitudes of intensive care and emergency physicians in Australia with regard to the organ donation process: A qualitative analysis.

Macvean E, Yuen EY, Tooley G, Gardiner HM, Knight T.

J Health Psychol. 2018 Apr 1:1359105318765619. doi: 10.1177/1359105318765619. [Epub ahead of print]


Measuring cancer caregiver health literacy: Validation of the Health Literacy of Caregivers Scale-Cancer (HLCS-C) in an Australian population.

Yuen E, Knight T, Dodson S, Chirgwin J, Busija L, Ricciardelli LA, Burney S, Parente P, Livingston PM.

Health Soc Care Community. 2018 May;26(3):330-344. doi: 10.1111/hsc.12524. Epub 2017 Dec 5.


Predictors of aggression in 3.322 patients with affective disorders and schizophrenia spectrum disorders evaluated in an emergency department setting.

Blanco EA, Duque LM, Rachamallu V, Yuen E, Kane JM, Gallego JA.

Schizophr Res. 2018 May;195:136-141. doi: 10.1016/j.schres.2017.10.002. Epub 2017 Nov 6.


Molecular and Epigenetic Mechanisms for the Complex Effects of Stress on Synaptic Physiology and Cognitive Functions.

Yuen EY, Wei J, Yan Z.

Int J Neuropsychopharmacol. 2017 Nov 1;20(11):948-955. doi: 10.1093/ijnp/pyx052. Review.


Prediction of human efficacious antidepressant doses using the mouse forced swim test.

Yuen E, Swanson S, Witkin JM.

Pharmacol Biochem Behav. 2017 Oct;161:22-29. doi: 10.1016/j.pbb.2017.09.002. Epub 2017 Sep 6.


Population Pharmacokinetic/ Pharmacodynamic Modelling of Auditory-Evoked Event-Related Potentials with Lorazepam.

Lombard A, Brittain C, Wishart G, Lowe S, McCarthy A, Landschulz W, Dorffner G, Anderer P, Yuen E.

Basic Clin Pharmacol Toxicol. 2018 Feb;122(2):245-252. doi: 10.1111/bcpt.12900. Epub 2017 Sep 27.


Mechanical effects of traction on lumbar intervertebral discs: A magnetic resonance imaging study.

Chow DHK, Yuen EMK, Xiao L, Leung MCP.

Musculoskelet Sci Pract. 2017 Jun;29:78-83. doi: 10.1016/j.msksp.2017.03.007. Epub 2017 Mar 20.


Erratum to: The gut microbiota in conventional and serrated precursors of colorectal cancer.

Peters BA, Dominianni C, Shapiro JA, Church TR, Wu J, Miller G, Yuen E, Freiman H, Lustbader I, Salik J, Friedlander C, Hayes RB, Ahn J.

Microbiome. 2017 Mar 6;5(1):29. doi: 10.1186/s40168-017-0238-x. No abstract available.


The gut microbiota in conventional and serrated precursors of colorectal cancer.

Peters BA, Dominianni C, Shapiro JA, Church TR, Wu J, Miller G, Yuen E, Freiman H, Lustbader I, Salik J, Friedlander C, Hayes RB, Ahn J.

Microbiome. 2016 Dec 30;4(1):69. doi: 10.1186/s40168-016-0218-6. Erratum in: Microbiome. 2017 Mar 6;5(1):29.


Communicating About Choices in Transplantation (COACH).

Traino HM, West SM, Nonterah CW, Russell J, Yuen E.

Prog Transplant. 2017 Mar;27(1):31-38. doi: 10.1177/1526924816679844. Epub 2016 Nov 25.


A Comparison of Request Process and Outcomes in Donation After Cardiac Death and Donation After Brain Death: Results From a National Study.

Siminoff LA, Alolod GP, Wilson-Genderson M, Yuen EYN, Traino HM.

Am J Transplant. 2017 May;17(5):1278-1285. doi: 10.1111/ajt.14084. Epub 2016 Nov 21.


An assessment of the central disposition of intranasally administered insulin lispro in the cerebrospinal fluid of healthy volunteers and beagle dogs.

Lowe S, Sher E, Wishart G, Jackson K, Yuen E, Brittain C, Fong SC, Clarke DO, Landschulz WH.

Drug Deliv Transl Res. 2017 Feb;7(1):11-15. doi: 10.1007/s13346-016-0325-8.


Health literacy of caregivers of adult care recipients: A systematic scoping review.

Yuen EYN, Knight T, Ricciardelli LA, Burney S.

Health Soc Care Community. 2018 Mar;26(2):e191-e206. doi: 10.1111/hsc.12368. Epub 2016 Jul 18. Review.


In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents.

Czyzewski AM, Jenssen H, Fjell CD, Waldbrook M, Chongsiriwatana NP, Yuen E, Hancock RE, Barron AE.

PLoS One. 2016 Feb 5;11(2):e0135961. doi: 10.1371/journal.pone.0135961. eCollection 2016.


A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer.

Pant S, Jones SF, Kurkjian CD, Infante JR, Moore KN, Burris HA, McMeekin DS, Benhadji KA, Patel BKR, Frenzel MJ, Kursar JD, Zamek-Gliszczynski MJ, Yuen ESM, Chan EM, Bendell JC.

Eur J Cancer. 2016 Mar;56:1-9. doi: 10.1016/j.ejca.2015.11.021. Epub 2016 Jan 19.


Changes in Brain Volume with Bapineuzumab in Mild to Moderate Alzheimer's Disease.

Novak G, Fox N, Clegg S, Nielsen C, Einstein S, Lu Y, Tudor IC, Gregg K, Di J, Collins P, Wyman BT, Yuen E, Grundman M, Brashear HR, Liu E.

J Alzheimers Dis. 2016;49(4):1123-34. doi: 10.3233/JAD-150448.


Differential Role of Social Connectedness in Geriatric Depression Among Southeast Asian Ethnic Groups.

Kim T, Nguyen ET, Yuen EJ, Nguyen T, Sorn R, Nguyen GT.

Prog Community Health Partnersh. 2015 Winter;9(4):483-93. doi: 10.1353/cpr.2015.0075.


Estrogen in prefrontal cortex blocks stress-induced cognitive impairments in female rats.

Yuen EY, Wei J, Yan Z.

J Steroid Biochem Mol Biol. 2016 Jun;160:221-6. doi: 10.1016/j.jsbmb.2015.08.028. Epub 2015 Aug 28. Review.


Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials.

Liu E, Schmidt ME, Margolin R, Sperling R, Koeppe R, Mason NS, Klunk WE, Mathis CA, Salloway S, Fox NC, Hill DL, Les AS, Collins P, Gregg KM, Di J, Lu Y, Tudor IC, Wyman BT, Booth K, Broome S, Yuen E, Grundman M, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators.

Neurology. 2015 Aug 25;85(8):692-700. doi: 10.1212/WNL.0000000000001877. Epub 2015 Jul 24.


The role of ventral striatal cAMP signaling in stress-induced behaviors.

Plattner F, Hayashi K, Hernández A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, Nishi A, Houslay MD, Bibb JA.

Nat Neurosci. 2015 Aug;18(8):1094-100. doi: 10.1038/nn.4066. Epub 2015 Jul 20.


Predictors of suicide attempts in 3.322 patients with affective disorders and schizophrenia spectrum disorders.

Gallego JA, Rachamallu V, Yuen EY, Fink S, Duque LM, Kane JM.

Psychiatry Res. 2015 Aug 30;228(3):791-796. doi: 10.1016/j.psychres.2015.05.024. Epub 2015 May 29.


Development and preliminary testing of a web-based, self-help application for disaster-affected families.

Yuen EK, Gros K, Welsh KE, McCauley J, Resnick HS, Danielson CK, Price M, Ruggiero KJ.

Health Informatics J. 2016 Sep;22(3):659-75. doi: 10.1177/1460458215579292. Epub 2015 May 1.


Randomized Controlled Trial of Home-Based Telehealth Versus In-Person Prolonged Exposure for Combat-Related PTSD in Veterans: Preliminary Results.

Yuen EK, Gros DF, Price M, Zeigler S, Tuerk PW, Foa EB, Acierno R.

J Clin Psychol. 2015 Jun;71(6):500-12. doi: 10.1002/jclp.22168. Epub 2015 Mar 25.


Development of a conceptual model of cancer caregiver health literacy.

Yuen EY, Dodson S, Batterham RW, Knight T, Chirgwin J, Livingston PM.

Eur J Cancer Care (Engl). 2016 Mar;25(2):294-306. doi: 10.1111/ecc.12284. Epub 2015 Jan 29.


Access and completion of a Web-based treatment in a population-based sample of tornado-affected adolescents.

Price M, Yuen EK, Davidson TM, Hubel G, Ruggiero KJ.

Psychol Serv. 2015 Aug;12(3):283-90. doi: 10.1037/ser0000017. Epub 2015 Jan 26.


Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?

Yuen ES, Trocóniz IF.

Seizure. 2015 Jan;24:21-7. doi: 10.1016/j.seizure.2014.11.006. Epub 2014 Nov 22.


Development of the Health Literacy of Caregivers Scale - Cancer (HLCS-C): item generation and content validity testing.

Yuen EY, Knight T, Dodson S, Ricciardelli L, Burney S, Livingston PM.

BMC Fam Pract. 2014 Dec 10;15:202. doi: 10.1186/s12875-014-0202-9.


A prediction tool for nosocomial multi-drug Resistant Gram-Negative Bacilli infections in critically ill patients - prospective observational study.

Vasudevan A, Mukhopadhyay A, Li J, Yuen EG, Tambyah PA.

BMC Infect Dis. 2014 Nov 25;14:615. doi: 10.1186/s12879-014-0615-z.


Feasibility assessment of a brief, web-based behavioral activation intervention for adolescents with depressed mood.

Davidson TM, Yuen EK, Felton JW, McCauley J, Gros KS, Ruggiero KJ.

Int J Psychiatry Med. 2014;48(1):69-82. doi: 10.2190/PM.48.1.f.


Sequential logic of polarity determination during the haploid-to-diploid transition in Saccharomyces cerevisiae.

Zapanta Rinonos S, Rai U, Vereb S, Wolf K, Yuen E, Lin C, Tartakoff AM.

Eukaryot Cell. 2014 Nov;13(11):1393-402. doi: 10.1128/EC.00161-14. Epub 2014 Aug 29.


Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons.

Yuen EY, Qin L, Wei J, Liu W, Liu A, Yan Z.

J Biol Chem. 2014 Sep 5;289(36):25177-85. doi: 10.1074/jbc.M114.567610. Epub 2014 Jul 23.


An open trial of videoconference-mediated exposure and ritual prevention for obsessive-compulsive disorder.

Goetter EM, Herbert JD, Forman EM, Yuen EK, Thomas JG.

J Anxiety Disord. 2014 Jun;28(5):460-2. doi: 10.1016/j.janxdis.2014.05.004. Epub 2014 May 17.


Handling missing data in a duloxetine population pharmacokinetic/pharmacodynamic model - imputation methods and selection models.

Yuen E, Gueorguieva I, Aarons L.

Pharm Res. 2014 Oct;31(10):2829-43. doi: 10.1007/s11095-014-1380-9. Epub 2014 May 3.


How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy?

Yuen ES, Sims JR.

Seizure. 2014 Jun;23(6):490-3. doi: 10.1016/j.seizure.2014.03.011. Epub 2014 Mar 28.


Memory enhancement by targeting Cdk5 regulation of NR2B.

Plattner F, Hernández A, Kistler TM, Pozo K, Zhong P, Yuen EY, Tan C, Hawasli AH, Cooke SF, Nishi A, Guo A, Wiederhold T, Yan Z, Bibb JA.

Neuron. 2014 Mar 5;81(5):1070-1083. doi: 10.1016/j.neuron.2014.01.022.


Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators.

N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839.

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