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Items: 1 to 50 of 118


A bilobal model of Ca2+-dependent inactivation to probe the physiology of L-type Ca2+ channels.

Limpitikul WB, Greenstein JL, Yue DT, Dick IE, Winslow RL.

J Gen Physiol. 2018 Dec 3;150(12):1688-1701. doi: 10.1085/jgp.201812115. Epub 2018 Nov 23.


Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels.

Niu J, Dick IE, Yang W, Bamgboye MA, Yue DT, Tomaselli G, Inoue T, Ben-Johny M.

Elife. 2018 Sep 10;7. pii: e35222. doi: 10.7554/eLife.35222.


Duplex signaling by CaM and Stac3 enhances CaV1.1 function and provides insights into congenital myopathy.

Niu J, Yang W, Yue DT, Inoue T, Ben-Johny M.

J Gen Physiol. 2018 Aug 6;150(8):1145-1161. doi: 10.1085/jgp.201812005. Epub 2018 Jun 27.


Conservation of cardiac L-type Ca2+ channels and their regulation in Drosophila: A novel genetically-pliable channelopathic model.

Limpitikul WB, Viswanathan MC, O'Rourke B, Yue DT, Cammarato A.

J Mol Cell Cardiol. 2018 Jun;119:64-74. doi: 10.1016/j.yjmcc.2018.04.010. Epub 2018 Apr 21.


Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels.

Banerjee R, Yoder JB, Yue DT, Amzel LM, Tomaselli GF, Gabelli SB, Ben-Johny M.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E3026-E3035. doi: 10.1073/pnas.1716381115. Epub 2018 Mar 12.


Multiscale mapping of frequency sweep rate in mouse auditory cortex.

Issa JB, Haeffele BD, Young ED, Yue DT.

Hear Res. 2017 Feb;344:207-222. doi: 10.1016/j.heares.2016.11.018. Epub 2016 Dec 21.


Detecting stoichiometry of macromolecular complexes in live cells using FRET.

Ben-Johny M, Yue DN, Yue DT.

Nat Commun. 2016 Dec 6;7:13709. doi: 10.1038/ncomms13709.


Quantifying macromolecular interactions in living cells using FRET two-hybrid assays.

Butz ES, Ben-Johny M, Shen M, Yang PS, Sang L, Biel M, Yue DT, Wahl-Schott C.

Nat Protoc. 2016 Dec;11(12):2470-2498. doi: 10.1038/nprot.2016.128. Epub 2016 Nov 10.


A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome.

Limpitikul WB, Dick IE, Tester DJ, Boczek NJ, Limphong P, Yang W, Choi MH, Babich J, DiSilvestre D, Kanter RJ, Tomaselli GF, Ackerman MJ, Yue DT.

Circ Res. 2017 Jan 6;120(1):39-48. doi: 10.1161/CIRCRESAHA.116.309283. Epub 2016 Oct 20.


Protein kinase A modulation of CaV1.4 calcium channels.

Sang L, Dick IE, Yue DT.

Nat Commun. 2016 Jul 26;7:12239. doi: 10.1038/ncomms12239.


An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca(2+)-dependent regulation.

Limpitikul WB, Dick IE, Ben-Johny M, Yue DT.

Sci Rep. 2016 Jun 3;6:27235. doi: 10.1038/srep27235.


Uncovering Aberrant Mutant PKA Function with Flow Cytometric FRET.

Lee SR, Sang L, Yue DT.

Cell Rep. 2016 Mar 29;14(12):3019-29. doi: 10.1016/j.celrep.2016.02.077. Epub 2016 Mar 17.


Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca(2+)-dependent inactivation.

Dick IE, Joshi-Mukherjee R, Yang W, Yue DT.

Nat Commun. 2016 Jan 29;7:10370. doi: 10.1038/ncomms10370.


Novel fluorescence resonance energy transfer-based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes.

Bazzazi H, Sang L, Dick IE, Joshi-Mukherjee R, Yang W, Yue DT.

J Physiol. 2015 Sep 1;593(17):3865-84. doi: 10.1113/JP270510. Epub 2015 Jul 22.


Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels.

Ben-Johny M, Dick IE, Sang L, Limpitikul WB, Kang PW, Niu J, Banerjee R, Yang W, Babich JS, Issa JB, Lee SR, Namkung H, Li J, Zhang M, Yang PS, Bazzazi H, Adams PJ, Joshi-Mukherjee R, Yue DN, Yue DT.

Curr Mol Pharmacol. 2015;8(2):188-205. Review.


Large Ca²⁺-dependent facilitation of Ca(V)2.1 channels revealed by Ca²⁺ photo-uncaging.

Lee SR, Adams PJ, Yue DT.

J Physiol. 2015 Jul 1;593(13):2753-78. doi: 10.1113/JP270091.


Apocalmodulin itself promotes ion channel opening and Ca(2+) regulation.

Adams PJ, Ben-Johny M, Dick IE, Inoue T, Yue DT.

Cell. 2014 Oct 23;159(3):608-22. doi: 10.1016/j.cell.2014.09.047.


Optical mapping of optogenetically shaped cardiac action potentials.

Park SA, Lee SR, Tung L, Yue DT.

Sci Rep. 2014 Aug 19;4:6125. doi: 10.1038/srep06125.


Calcineurin determines toxic versus beneficial responses to α-synuclein.

Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Ben-Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, Lindquist S.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3544-52. doi: 10.1073/pnas.1413201111. Epub 2014 Aug 13.


Multiscale optical Ca2+ imaging of tonal organization in mouse auditory cortex.

Issa JB, Haeffele BD, Agarwal A, Bergles DE, Young ED, Yue DT.

Neuron. 2014 Aug 20;83(4):944-59. doi: 10.1016/j.neuron.2014.07.009. Epub 2014 Jul 31.


Conservation of Ca2+/calmodulin regulation across Na and Ca2+ channels.

Ben-Johny M, Yang PS, Niu J, Yang W, Joshi-Mukherjee R, Yue DT.

Cell. 2014 Jun 19;157(7):1657-70. doi: 10.1016/j.cell.2014.04.035.


Calmodulin regulation (calmodulation) of voltage-gated calcium channels.

Ben-Johny M, Yue DT.

J Gen Physiol. 2014 Jun;143(6):679-92. doi: 10.1085/jgp.201311153. Review.


Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.

Limpitikul WB, Dick IE, Joshi-Mukherjee R, Overgaard MT, George AL Jr, Yue DT.

J Mol Cell Cardiol. 2014 Sep;74:115-24. doi: 10.1016/j.yjmcc.2014.04.022. Epub 2014 May 8.


Allostery in Ca²⁺ channel modulation by calcium-binding proteins.

Yang PS, Johny MB, Yue DT.

Nat Chem Biol. 2014 Mar;10(3):231-8. doi: 10.1038/nchembio.1436. Epub 2014 Jan 19.


Continuously tunable Ca(2+) regulation of RNA-edited CaV1.3 channels.

Bazzazi H, Ben Johny M, Adams PJ, Soong TW, Yue DT.

Cell Rep. 2013 Oct 31;5(2):367-77. doi: 10.1016/j.celrep.2013.09.006. Epub 2013 Oct 10.


Structural and functional plasticity in long-term cultures of adult ventricular myocytes.

Joshi-Mukherjee R, Dick IE, Liu T, O'Rourke B, Yue DT, Tung L.

J Mol Cell Cardiol. 2013 Dec;65:76-87. doi: 10.1016/j.yjmcc.2013.09.009. Epub 2013 Sep 25.


Ca2+ channel nanodomains boost local Ca2+ amplitude.

Tadross MR, Tsien RW, Yue DT.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15794-9. doi: 10.1073/pnas.1313898110. Epub 2013 Sep 9.


Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels.

Ben Johny M, Yang PS, Bazzazi H, Yue DT.

Nat Commun. 2013;4:1717. doi: 10.1038/ncomms2727.


Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5.

Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH.

Neuron. 2012 Aug 23;75(4):675-87. doi: 10.1016/j.neuron.2012.06.023.


Calcium-channel number critically influences synaptic strength and plasticity at the active zone.

Sheng J, He L, Zheng H, Xue L, Luo F, Shin W, Sun T, Kuner T, Yue DT, Wu LG.

Nat Neurosci. 2012 Jun 10;15(7):998-1006. doi: 10.1038/nn.3129.


Nanodomain Ca²⁺ of Ca²⁺ channels detected by a tethered genetically encoded Ca²⁺ sensor.

Tay LH, Dick IE, Yang W, Mank M, Griesbeck O, Yue DT.

Nat Commun. 2012 Apr 10;3:778. doi: 10.1038/ncomms1777.


RNA editing of the IQ domain in Ca(v)1.3 channels modulates their Ca²⁺-dependent inactivation.

Huang H, Tan BZ, Shen Y, Tao J, Jiang F, Sung YY, Ng CK, Raida M, Köhr G, Higuchi M, Fatemi-Shariatpanahi H, Harden B, Yue DT, Soong TW.

Neuron. 2012 Jan 26;73(2):304-16. doi: 10.1016/j.neuron.2011.11.022.


The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses.

Sun T, Wu XS, Xu J, McNeil BD, Pang ZP, Yang W, Bai L, Qadri S, Molkentin JD, Yue DT, Wu LG.

J Neurosci. 2010 Sep 1;30(35):11838-47. doi: 10.1523/JNEUROSCI.1481-10.2010.


Systematic mapping of the state dependence of voltage- and Ca2+-dependent inactivation using simple open-channel measurements.

Tadross MR, Yue DT.

J Gen Physiol. 2010 Mar;135(3):217-27. doi: 10.1085/jgp.200910309. Epub 2010 Feb 8.


Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels.

Tadross MR, Ben Johny M, Yue DT.

J Gen Physiol. 2010 Mar;135(3):197-215. doi: 10.1085/jgp.200910308. Epub 2010 Feb 8.


Enzyme-inhibitor-like tuning of Ca(2+) channel connectivity with calmodulin.

Liu X, Yang PS, Yang W, Yue DT.

Nature. 2010 Feb 18;463(7283):968-72. doi: 10.1038/nature08766. Epub 2010 Feb 7. Erratum in: Nature. 2010 Apr 29;464(7293):1390.


Robust approaches to quantitative ratiometric FRET imaging of CFP/YFP fluorophores under confocal microscopy.

Tadross MR, Park SA, Veeramani B, Yue DT.

J Microsc. 2009 Jan;233(1):192-204. doi: 10.1111/j.1365-2818.2008.03109.x.


Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel.

Tadross MR, Dick IE, Yue DT.

Cell. 2008 Jun 27;133(7):1228-40. doi: 10.1016/j.cell.2008.05.025.


Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+.

Mori MX, Vander Kooi CW, Leahy DJ, Yue DT.

Structure. 2008 Apr;16(4):607-20. doi: 10.1016/j.str.2008.01.011.


Role of CaVbeta subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV1.2 channels.

Miriyala J, Nguyen T, Yue DT, Colecraft HM.

Circ Res. 2008 Apr 11;102(7):e54-64. doi: 10.1161/CIRCRESAHA.108.171736. Epub 2008 Mar 20.


A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels.

Dick IE, Tadross MR, Liang H, Tay LH, Yang W, Yue DT.

Nature. 2008 Feb 14;451(7180):830-4. doi: 10.1038/nature06529. Epub 2008 Jan 30.


Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.

Samuels BA, Hsueh YP, Shu T, Liang H, Tseng HC, Hong CJ, Su SC, Volker J, Neve RL, Yue DT, Tsai LH.

Neuron. 2007 Dec 6;56(5):823-37.


Live-cell transforms between Ca2+ transients and FRET responses for a troponin-C-based Ca2+ sensor.

Tay LH, Griesbeck O, Yue DT.

Biophys J. 2007 Dec 1;93(11):4031-40. Epub 2007 Aug 17.


Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels.

Chaudhuri D, Issa JB, Yue DT.

J Gen Physiol. 2007 May;129(5):385-401. Epub 2007 Apr 16.


Mechanism of Ca(v)1.2 channel modulation by the amino terminus of cardiac beta2-subunits.

Herzig S, Khan IF, Gründemann D, Matthes J, Ludwig A, Michels G, Hoppe UC, Chaudhuri D, Schwartz A, Yue DT, Hullin R.

FASEB J. 2007 May;21(7):1527-38. Epub 2007 Feb 8.


Alternative splicing of the Ca(v)1.3 channel IQ domain, a molecular switch for Ca2+-dependent inactivation within auditory hair cells.

Shen Y, Yu D, Hiel H, Liao P, Yue DT, Fuchs PA, Soong TW.

J Neurosci. 2006 Oct 18;26(42):10690-9.


Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells.

Yang PS, Alseikhan BA, Hiel H, Grant L, Mori MX, Yang W, Fuchs PA, Yue DT.

J Neurosci. 2006 Oct 18;26(42):10677-89.


A CaVbeta SH3/guanylate kinase domain interaction regulates multiple properties of voltage-gated Ca2+ channels.

Takahashi SX, Miriyala J, Tay LH, Yue DT, Colecraft HM.

J Gen Physiol. 2005 Oct;126(4):365-77.


Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current.

Chaudhuri D, Alseikhan BA, Chang SY, Soong TW, Yue DT.

J Neurosci. 2005 Sep 7;25(36):8282-94.


Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles.

Liao P, Yong TF, Liang MC, Yue DT, Soong TW.

Cardiovasc Res. 2005 Nov 1;68(2):197-203. Epub 2005 Jul 27. Review.


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