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Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis.

Ang CH, Hsu SH, Guo F, Tan CT, Yu VC, Visvader JE, Chow PKH, Fu NY.

Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19530-19540. doi: 10.1073/pnas.1908099116. Epub 2019 Sep 5.


Modulator of apoptosis-1 is a potential therapeutic target in acute ischemic injury.

Chan SJ, Zhao H, Hayakawa K, Chai C, Tan CT, Huang J, Tao R, Hamanaka G, Arumugam TV, Lo EH, Yu VCK, Wong PH.

J Cereb Blood Flow Metab. 2019 Dec;39(12):2406-2418. doi: 10.1177/0271678X18794839. Epub 2018 Aug 22.


Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1-Deficient Mice.

Zhao H, Mohamed NE, Chan SJ, Tan CT, Tao R, Yu VC, Wong PT.

Mol Neurobiol. 2019 Mar;56(3):2185-2201. doi: 10.1007/s12035-018-1205-7. Epub 2018 Jul 12.


RACK1/TRAF2 regulation of modulator of apoptosis-1 (MOAP-1).

Law J, Kwek I, Svystun O, Lim J, Tan CT, Luong L, Yu VC, Baksh S.

Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):684-694. doi: 10.1016/j.bbamcr.2018.02.006. Epub 2018 Feb 19.


MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria.

Tan CT, Zhou QL, Su YC, Fu NY, Chang HC, Tao RN, Sukumaran SK, Baksh S, Tan YJ, Sabapathy K, Yu CD, Yu VC.

Cell Rep. 2016 Jun 28;16(1):174-185. doi: 10.1016/j.celrep.2016.05.068. Epub 2016 Jun 16.


Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein.

Law J, Salla M, Zare A, Wong Y, Luong L, Volodko N, Svystun O, Flood K, Lim J, Sung M, Dyck JR, Tan CT, Su YC, Yu VC, Mackey J, Baksh S.

J Biol Chem. 2015 Oct 2;290(40):24100-18. doi: 10.1074/jbc.M115.648345. Epub 2015 Aug 12.


Mitochondria-acting hexokinase II peptides carried by short-length carbon nanotubes with increased cellular uptake, endosomal evasion, and enhanced bioactivity against cancer cells.

Yoong SL, Lau WL, Liu AY, Prendergast D, Ho HK, Yu VC, Lee C, Ang WH, Pastorin G.

Nanoscale. 2015 Sep 7;7(33):13907-17. doi: 10.1039/c5nr00980d. Epub 2015 Jul 29.


Thioredoxin-dependent regulation of AIF-mediated DNA damage.

Shelar SB, Kaminska KK, Reddy SA, Kumar D, Tan CT, Yu VC, Lu J, Holmgren A, Hagen T, Chew EH.

Free Radic Biol Med. 2015 Oct;87:125-36. doi: 10.1016/j.freeradbiomed.2015.06.029. Epub 2015 Jun 25.


Correction: the tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury.

Gordon M, El-Kalla M, Zhao Y, Fiteih Y, Law J, Volodko N, Mohamed A, El-Kadi AO, Liu L, Odenbach J, Thiesen A, Onyskiw C, Ghazaleh HA, Park J, Lee SB, Yu VC, Fernandez-Patron C, Alexander RT, Wine E, Baksh S.

PLoS One. 2015 Jun 24;10(6):e0131150. doi: 10.1371/journal.pone.0131150. eCollection 2015. No abstract available.


Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction.

Chen M, Zhang Y, Yu VC, Chong YS, Yoshioka T, Ge R.

Cell Death Differ. 2014 May;21(5):797-810. doi: 10.1038/cdd.2014.3. Epub 2014 Jan 24.


The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury.

Gordon M, El-Kalla M, Zhao Y, Fiteih Y, Law J, Volodko N, Anwar-Mohamed A, El-Kadi AO, Liu L, Odenbach J, Thiesen A, Onyskiw C, Ghazaleh HA, Park J, Lee SB, Yu VC, Fernandez-Patron C, Alexander RT, Wine E, Baksh S.

PLoS One. 2013 Oct 16;8(10):e75483. doi: 10.1371/journal.pone.0075483. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/0ed852a0-eb39-4a28-986f-81f28d870747. Mohamed, Anwar [corrected to Anwar-Mohamed, Anwar]. PLoS One. 2015;10(2):e0118034. PLoS One. 2015;10(6):e0131150.


RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1α)/c-Jun NH2-terminal kinase pathway.

Arshad M, Ye Z, Gu X, Wong CK, Liu Y, Li D, Zhou L, Zhang Y, Bay WP, Yu VC, Li P.

J Biol Chem. 2013 Mar 22;288(12):8726-36. doi: 10.1074/jbc.M112.368829. Epub 2013 Feb 1.


TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.

Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20937-42. doi: 10.1073/pnas.1214156110. Epub 2012 Dec 4. Erratum in: Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4148.


Modulator of Apoptosis 1: A Highly Regulated RASSF1A-Interacting BH3-Like Protein.

Law J, Yu VC, Baksh S.

Mol Biol Int. 2012;2012:536802. doi: 10.1155/2012/536802. Epub 2012 Jun 14.


A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.

Sukumaran SK, Fu NY, Tin CB, Wan KF, Lee SS, Yu VC.

Mol Cell. 2010 Mar 26;37(6):768-83. doi: 10.1016/j.molcel.2010.02.015.


Auto-FACE: an NMR based binding site mapping program for fast chemical exchange protein-ligand systems.

Krishnamoorthy J, Yu VC, Mok YK.

PLoS One. 2010 Feb 18;5(2):e8943. doi: 10.1371/journal.pone.0008943.


Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1.

Bernardo PH, Sivaraman T, Wan KF, Xu J, Krishnamoorthy J, Song CM, Tian L, Chin JS, Lim DS, Mok HY, Yu VC, Tong JC, Chai CL.

J Med Chem. 2010 Mar 11;53(5):2314-8. doi: 10.1021/jm901469p.


Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL.

Wan KF, Wang S, Brown CJ, Yu VC, Entzeroth M, Lane DP, Lee MA.

Cell Cycle. 2009 Dec;8(23):3943-52. Epub 2009 Dec 17.


RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells.

Subauste MC, Ventura-Holman T, Du L, Subauste JS, Chan SL, Yu VC, Maher JF.

Cancer Biol Ther. 2009 Dec;8(23):2297-305. Epub 2009 Dec 7.


The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1.

Mohd-Ismail NK, Deng L, Sukumaran SK, Yu VC, Hotta H, Tan YJ.

J Virol. 2009 Oct;83(19):9993-10006. doi: 10.1128/JVI.00509-09. Epub 2009 Jul 15.


Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism.

Fu NY, Sukumaran SK, Kerk SY, Yu VC.

Mol Cell. 2009 Jan 16;33(1):15-29. doi: 10.1016/j.molcel.2008.11.025.


TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process.

Lee SS, Fu NY, Sukumaran SK, Wan KF, Wan Q, Yu VC.

Exp Cell Res. 2009 Apr 15;315(7):1313-25. doi: 10.1016/j.yexcr.2008.11.021. Epub 2008 Dec 9.


Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors.

Bernardo PH, Wan KF, Sivaraman T, Xu J, Moore FK, Hung AW, Mok HY, Yu VC, Chai CL.

J Med Chem. 2008 Nov 13;51(21):6699-710. doi: 10.1021/jm8005433. Epub 2008 Oct 17.


Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl.

Janssen CO, Lim S, Lo EP, Wan KF, Yu VC, Lee MA, Ng SB, Everett MJ, Buss AD, Lane DP, Boyce RS.

Bioorg Med Chem Lett. 2008 Nov 1;18(21):5771-3. doi: 10.1016/j.bmcl.2008.09.071. Epub 2008 Sep 23.


Dynamics of RASSF1A/MOAP-1 association with death receptors.

Foley CJ, Freedman H, Choo SL, Onyskiw C, Fu NY, Yu VC, Tuszynski J, Pratt JC, Baksh S.

Mol Cell Biol. 2008 Jul;28(14):4520-35. doi: 10.1128/MCB.02011-07. Epub 2008 May 12.


SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail.

Yin Y, Yu VC, Zhu G, Chang DC.

Cell Cycle. 2008 May 15;7(10):1423-32. Epub 2008 Mar 3.


Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism.

Wan KF, Chan SL, Sukumaran SK, Lee MC, Yu VC.

J Biol Chem. 2008 Mar 28;283(13):8423-33. doi: 10.1074/jbc.M707687200. Epub 2008 Jan 29.


Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria.

Fu NY, Sukumaran SK, Yu VC.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10051-6. Epub 2007 May 29.


Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein.

Tan YX, Tan TH, Lee MJ, Tham PY, Gunalan V, Druce J, Birch C, Catton M, Fu NY, Yu VC, Tan YJ.

J Virol. 2007 Jun;81(12):6346-55. Epub 2007 Apr 11.


Signaling from p53 to NF-kappa B determines the chemotherapy responsiveness of neuroblastoma.

Armstrong MB, Bian X, Liu Y, Subramanian C, Ratanaproeksa AB, Shao F, Yu VC, Kwok RP, Opipari AW, Castle VP.

Neoplasia. 2006 Nov;8(11):964-74.


Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma.

Armstrong MB, Bian X, Liu Y, Subramanian C, Ratanaproeksa AB, Shao F, Yu VC, Kwok RP, Opipari AW Jr, Castle VP.

Neoplasia. 2006 Nov;8(11):967-77.


Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft.

Zhang YH, Bhunia A, Wan KF, Lee MC, Chan SL, Yu VC, Mok YK.

J Mol Biol. 2006 Dec 1;364(3):536-49. Epub 2006 Sep 14.


MAP-1 is a mitochondrial effector of Bax.

Tan KO, Fu NY, Sukumaran SK, Chan SL, Kang JH, Poon KL, Chen BS, Yu VC.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14623-8. Epub 2005 Sep 30.


The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.

Baksh S, Tommasi S, Fenton S, Yu VC, Martins LM, Pfeifer GP, Latif F, Downward J, Neel BG.

Mol Cell. 2005 Jun 10;18(6):637-50.


Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities.

Chan SL, Yu VC.

Clin Exp Pharmacol Physiol. 2004 Mar;31(3):119-28. Review.


Mitochondrial translocation of cofilin is an early step in apoptosis induction.

Chua BT, Volbracht C, Tan KO, Li R, Yu VC, Li P.

Nat Cell Biol. 2003 Dec;5(12):1083-9. Epub 2003 Nov 23.


Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNFalpha-induced apoptosis.

Luo KQ, Yu VC, Pu Y, Chang DC.

Biochem Biophys Res Commun. 2003 May 2;304(2):217-22.


Identification of chelerythrine as an inhibitor of BclXL function.

Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, Fu NY, Butler MS, Soejarto DD, Buss AD, Yu VC.

J Biol Chem. 2003 Jun 6;278(23):20453-6. Epub 2003 Apr 17.


Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis.

Wang H, Yeo SL, Xu J, Xu X, He H, Ronca F, Ting AE, Wang Y, Yu VC, Sim MM.

J Nat Prod. 2002 May;65(5):721-4.


MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains.

Tan KO, Tan KM, Chan SL, Yee KS, Bevort M, Ang KC, Yu VC.

J Biol Chem. 2001 Jan 26;276(4):2802-7. Epub 2000 Nov 1.


A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland.

Jiang Y, Yu VC, Buchholz F, O'Connell S, Rhodes SJ, Candeloro C, Xia YR, Lusis AJ, Rosenfeld MG.

J Biol Chem. 1996 May 3;271(18):10723-30.

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