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GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL.

Elife. 2019 May 21;8. pii: e43038. doi: 10.7554/eLife.43038.


GPCR-Hippo Signaling in Cancer.

Luo J, Yu FX.

Cells. 2019 May 8;8(5). pii: E426. doi: 10.3390/cells8050426. Review.


An alternatively transcribed TAZ variant negatively regulates JAK-STAT signaling.

Fang C, Li J, Qi S, Lei Y, Zeng Y, Yu P, Hu Z, Zhou Y, Wang Y, Dai R, Li J, Huang S, Xu P, Chen K, Ding C, Yu FX.

EMBO Rep. 2019 Jun;20(6). pii: e47227. doi: 10.15252/embr.201847227. Epub 2019 Apr 11.


Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis.

Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J, Tang F, Liu GH.

PLoS Biol. 2019 Apr 1;17(4):e3000201. doi: 10.1371/journal.pbio.3000201. eCollection 2019 Apr.


Precise Detection of Gene Mutations in Fine-Needle Aspiration Specimens of the Papillary Thyroid Microcarcinoma Using Next-Generation Sequencing.

Yu FX, Hu MX, Zhao HX, Niu LJ, Rong XY, Li WH, Zhu Q, Ying JM, Lyu N.

Int J Endocrinol. 2019 Feb 19;2019:4723958. doi: 10.1155/2019/4723958. eCollection 2019.


Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy.

Lee PS, Gao N, Dike M, Shkilnyy O, Me R, Zhang Y, Yu FX.

Diabetes. 2019 Apr;68(4):807-818. doi: 10.2337/db18-1172. Epub 2019 Jan 24.


Rosiglitazone Inhibits Activation of Hepatic Stellate Cells via Up-Regulating Micro-RNA-124-3p to Alleviate Hepatic Fibrosis.

Zhi SC, Chen SZ, Li YY, Li JJ, Zheng YH, Yu FX.

Dig Dis Sci. 2019 Jun;64(6):1560-1570. doi: 10.1007/s10620-019-5462-8. Epub 2019 Jan 23.


Integration of Neural Reward Processing and Appetite-Related Signaling in Obese Females: Evidence From Resting-State fMRI.

Zhang P, Liu Y, Lv H, Li MY, Yu FX, Wang Z, Ding HY, Wang LX, Zhao KX, Zhang ZY, Zhao PF, Li J, Yang ZH, Zhang ZT, Wang ZC.

J Magn Reson Imaging. 2019 Aug;50(2):541-551. doi: 10.1002/jmri.26576. Epub 2019 Jan 17.


Follow-up study of high-dose praziquantel therapy for cerebral sparganosis.

Zhang P, Zou Y, Yu FX, Wang Z, Lv H, Liu XH, Ding HY, Zhang TT, Zhao PF, Yin HX, Yang ZH, Wang ZC.

PLoS Negl Trop Dis. 2019 Jan 14;13(1):e0007018. doi: 10.1371/journal.pntd.0007018. eCollection 2019 Jan.


Microarray Expression Profiles of lncRNAs and mRNAs in Postoperative Cognitive Dysfunction.

Zhang Y, Liu YX, Xiao QX, Liu Q, Deng R, Bian J, Deng IB, Al-Hawwas M, Yu FX.

Front Neurosci. 2018 Oct 8;12:694. doi: 10.3389/fnins.2018.00694. eCollection 2018.


Fine Particulate Matter-Induced Exacerbation of Allergic Asthma via Activation of T-cell Immunoglobulin and Mucin Domain 1.

Zhao YX, Zhang HR, Yang XN, Zhang YH, Feng S, Yu FX, Yan XX.

Chin Med J (Engl). 2018 Oct 20;131(20):2461-2473. doi: 10.4103/0366-6999.243551.


RAP2 mediates mechanoresponses of the Hippo pathway.

Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL.

Nature. 2018 Aug;560(7720):655-660. doi: 10.1038/s41586-018-0444-0. Epub 2018 Aug 22.


TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway.

Cui X, Gao N, Me R, Xu J, Yu FX.

Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4228-4237. doi: 10.1167/iovs.18-24672.


Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6 Mouse Corneas.

Gao N, Me R, Dai C, Seyoum B, Yu FX.

J Immunol. 2018 Jul 15;201(2):688-699. doi: 10.4049/jimmunol.1800046. Epub 2018 Jun 11.


The clinical presentation and collateral pathway development of congenital absence of the internal carotid artery.

Zhang P, Wang Z, Yu FX, Lv H, Liu XH, Feng WH, Ma J, Yang ZH, Wang ZC.

J Vasc Surg. 2018 Oct;68(4):1054-1061. doi: 10.1016/j.jvs.2018.01.043. Epub 2018 May 19. Review.


Staurosporine targets the Hippo pathway to inhibit cell growth.

Ma X, Li P, Chen P, Li J, Huang H, Wang C, Li W, Ding J, Zhao Y, Yu FX, Qi X, Zhang L.

J Mol Cell Biol. 2018 Jun 1;10(3):267-269. doi: 10.1093/jmcb/mjy016. No abstract available.


Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.

Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z.

J Clin Invest. 2018 Mar 1;128(3):970-984. doi: 10.1172/JCI90429. Epub 2018 Feb 5.


Functions and regulations of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis.

Gu Y, Zhang L, Yu FX.

Yi Chuan. 2017 Jul 20;39(7):588-596. doi: 10.16288/j.yczz.17-048. Review.


Incidental papillary fibroelastoma of the tricuspid valve.

Xie XJ, Yu FX, Liu HD.

J Card Surg. 2017 Jul;32(7):416-417. doi: 10.1111/jocs.13167. Epub 2017 Jun 20. No abstract available.


CXCL10 suppression of hem- and lymph-angiogenesis in inflamed corneas through MMP13.

Gao N, Liu X, Wu J, Li J, Dong C, Wu X, Xiao X, Yu FX.

Angiogenesis. 2017 Nov;20(4):505-518. doi: 10.1007/s10456-017-9561-x. Epub 2017 Jun 16.


A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp. M336.

Yu FX, Chen Y, Yang YH, Li GH, Zhao PJ.

Nat Prod Res. 2018 Mar;32(6):689-694. doi: 10.1080/14786419.2017.1338285. Epub 2017 Jun 12.


ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis.

Dong C, Gao N, Ross BX, Yu FX.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2948-2958. doi: 10.1167/iovs.17-21476.


IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas.

Ross BX, Gao N, Cui X, Standiford TJ, Xu J, Yu FX.

J Immunol. 2017 May 1;198(9):3536-3547. doi: 10.4049/jimmunol.1602087. Epub 2017 Mar 22.


The Hippo pathway in tissue homeostasis and regeneration.

Wang Y, Yu A, Yu FX.

Protein Cell. 2017 May;8(5):349-359. doi: 10.1007/s13238-017-0371-0. Epub 2017 Jan 27. Review.


Four new steroids from the endophytic fungus Chaetomium sp. M453 derived of Chinese herbal medicine Huperzia serrata.

Yu FX, Li Z, Chen Y, Yang YH, Li GH, Zhao PJ.

Fitoterapia. 2017 Mar;117:41-46. doi: 10.1016/j.fitote.2016.12.012. Epub 2016 Dec 29.


Pestalotic acids A-I, antibacterial ambuic acid analogues, from a mycoparasite (Pestalotipsis sp. cr014) of Cronartium ribicola.

Li J, Xie J, Yu FX, Chen YH, Zhao PJ.

Arch Pharm Res. 2016 Sep 19. [Epub ahead of print]


Production of germline transgenic pigs co-expressing double fluorescent proteins by lentiviral vector.

Chen XY, Zhu ZW, Yu FX, Huang J, Hu XR, Pan JZ.

Anim Reprod Sci. 2016 Nov;174:11-19. doi: 10.1016/j.anireprosci.2016.05.009. Epub 2016 Jun 28.


Expressed sequence tag analysis of functional genes associated with adventitious rooting in Liriodendron hybrids.

Zhong YD, Sun XY, Liu EY, Li YQ, Gao Z, Yu FX.

Genet Mol Res. 2016 Jun 24;15(2). doi: 10.4238/gmr.15027606.


[The multicenter study on the registration and follow-up of low anticoagulation therapy for the heart valve operation in China].

Dong L, Shi YK, Xu JP, Zhang EY, Liu JC, Li YX, Ni YM, Yang Q, Han T, Fu B, Chen J, Ren L, Wei SL, Chen H, Liu KX, Yu FX, Liu JS, Xiao MD, Wu SM, Zhang KL, Huang HL, Jiang SL, Qiao CH, Wang CS, Xu ZY, Zhou XM, Wang DJ, Ni LX, Xiao YB, Jiang SL, Zhang GM, Liang GY, Yang SY, Bo P, Zhong QJ, Zhang JB, Zhang X, Zhu YB, Teng X, Zhu P, Huang F, Xiao YM, Cao GQ, Tian H, Xia LM, Lu FL, Liu YQ, Liu DX, Xu H, Yuan Y, Li M, Chang C, Wu XC, Xu Z, Guo P, Bai YJ, Xue WB, Jiang XY, Na ZH, Zeng QY, Cai H, Wang YL, Xiong R, Jin S, Zheng XM, Wu D.

Zhonghua Yi Xue Za Zhi. 2016 May 24;96(19):1489-94. doi: 10.3760/cma.j.issn.0376-2491.2016.19.006. Chinese.


Development and characterization of novel microsatellite markers for Ginkgo biloba using 454 pyrosequencing.

Zhou Q, Wang XX, Xu M, Cao FL, Yu FX, Xu LA.

Genet Mol Res. 2016 Mar 28;15(1). doi: 10.4238/gmr.15017385.


Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein.

Hong SY, Yu FX, Luo Y, Hagen T.

Cell Signal. 2016 May;28(5):377-383. doi: 10.1016/j.cellsig.2016.01.011. Epub 2016 Jan 28.


NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.

Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL.

Genes Dev. 2015 Nov 15;29(22):2362-76. doi: 10.1101/gad.265116.115.


Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.

Yu FX, Zhao B, Guan KL.

Cell. 2015 Nov 5;163(4):811-28. doi: 10.1016/j.cell.2015.10.044. Review.


MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway.

Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, Park HW, Mo JS, Lu W, Lu S, Flores F, Yu FX, Halder G, Guan KL.

Nat Commun. 2015 Oct 5;6:8357. doi: 10.1038/ncomms9357.


Targeting the Hippo Pathway for Anti-cancer Therapies.

Gong R, Yu FX.

Curr Med Chem. 2015;22(35):4104-17. Review.


Alternative Wnt Signaling Activates YAP/TAZ.

Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan KL.

Cell. 2015 Aug 13;162(4):780-94. doi: 10.1016/j.cell.2015.07.013.


Development of novel chloroplast microsatellite markers for Ginkgo biloba.

Xu M, Xu LA, Cao FL, Zhang HJ, Yu FX.

Genet Mol Res. 2015 Jul 13;14(3):7715-20. doi: 10.4238/2015.July.13.17.


Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation.

Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX, Xu Y, Guan KL.

Cell Res. 2015 Aug;25(8):985-8. doi: 10.1038/cr.2015.88. Epub 2015 Jul 24. No abstract available.


A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.

Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL.

Genes Dev. 2015 Jun 15;29(12):1271-84. doi: 10.1101/gad.262816.115.


Estrogen regulates Hippo signaling via GPER in breast cancer.

Zhou X, Wang S, Wang Z, Feng X, Liu P, Lv XB, Li F, Yu FX, Sun Y, Yuan H, Zhu H, Xiong Y, Lei QY, Guan KL.

J Clin Invest. 2015 May;125(5):2123-35. doi: 10.1172/JCI79573. Epub 2015 Apr 20.


Bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion.

Yu FX, Hu WJ, He B, Zheng YH, Zhang QY, Chen L.

World J Surg Oncol. 2015 Feb 15;13:52. doi: 10.1186/s12957-015-0465-1.


Protective effect of proanthocyanidin against oxidative ovarian damage induced by 3-nitropropionic acid in mice.

Zhang JQ, Xing BS, Zhu CC, Shen M, Yu FX, Liu HL.

Genet Mol Res. 2015 Mar 30;14(1):2484-94. doi: 10.4238/2015.March.30.6.


Inhibition of pancreatic stellate cell activity by adipose-derived stem cells.

Yu FX, Su LF, Dai CL, Wang Y, Teng YY, Fu JH, Zhang QY, Tang YH.

Hepatobiliary Pancreat Dis Int. 2015 Apr;14(2):215-21.


A gp130-Src-YAP module links inflammation to epithelial regeneration.

Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M.

Nature. 2015 Mar 5;519(7541):57-62. doi: 10.1038/nature14228. Epub 2015 Feb 25.


YAP as oncotarget in uveal melanoma.

Yu FX, Zhang K, Guan KL.

Oncoscience. 2014 Jun 22;1(7):480-1. eCollection 2014. No abstract available.


Metabolism. Differential regulation of mTORC1 by leucine and glutamine.

Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL.

Science. 2015 Jan 9;347(6218):194-8. doi: 10.1126/science.1259472. Epub 2015 Jan 7.


YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations.

Lyubasyuk V, Ouyang H, Yu FX, Guan KL, Zhang K.

Mol Cell Oncol. 2014 Dec 1;2(1):e970957. doi: 10.4161/23723548.2014.970957. eCollection 2015 Jan-Mar.


Hippo pathway regulation of gastrointestinal tissues.

Yu FX, Meng Z, Plouffe SW, Guan KL.

Annu Rev Physiol. 2015;77:201-27. doi: 10.1146/annurev-physiol-021014-071733. Epub 2014 Sep 29. Review.


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