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Items: 1 to 50 of 71

1.

Short-term effects of whole-grain wheat on appetite and food intake in healthy adults: a pilot study.

Bodinham CL, Hitchen KL, Youngman PJ, Frost GS, Robertson MD.

Br J Nutr. 2011 Aug;106(3):327-30. doi: 10.1017/S0007114511000225. Epub 2011 Apr 18.

PMID:
21554817
2.

Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.

Xu HH, Trawick JD, Haselbeck RJ, Forsyth RA, Yamamoto RT, Archer R, Patterson J, Allen M, Froelich JM, Taylor I, Nakaji D, Maile R, Kedar GC, Pilcher M, Brown-Driver V, McCarthy M, Files A, Robbins D, King P, Sillaots S, Malone C, Zamudio CS, Roemer T, Wang L, Youngman PJ, Wall D.

Antimicrob Agents Chemother. 2010 Sep;54(9):3659-70. doi: 10.1128/AAC.00308-10. Epub 2010 Jun 14.

3.

A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds.

Donald RG, Skwish S, Forsyth RA, Anderson JW, Zhong T, Burns C, Lee S, Meng X, LoCastro L, Jarantow LW, Martin J, Lee SH, Taylor I, Robbins D, Malone C, Wang L, Zamudio CS, Youngman PJ, Phillips JW.

Chem Biol. 2009 Aug 28;16(8):826-36. doi: 10.1016/j.chembiol.2009.07.004.

4.

PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

Jiang B, Xu D, Allocco J, Parish C, Davison J, Veillette K, Sillaots S, Hu W, Rodriguez-Suarez R, Trosok S, Zhang L, Li Y, Rahkhoodaee F, Ransom T, Martel N, Wang H, Gauvin D, Wiltsie J, Wisniewski D, Salowe S, Kahn JN, Hsu MJ, Giacobbe R, Abruzzo G, Flattery A, Gill C, Youngman P, Wilson K, Bills G, Platas G, Pelaez F, Diez MT, Kauffman S, Becker J, Harris G, Liberator P, Roemer T.

Chem Biol. 2008 Apr;15(4):363-74. doi: 10.1016/j.chembiol.2008.02.016.

5.

Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.

Fedorova ND, Khaldi N, Joardar VS, Maiti R, Amedeo P, Anderson MJ, Crabtree J, Silva JC, Badger JH, Albarraq A, Angiuoli S, Bussey H, Bowyer P, Cotty PJ, Dyer PS, Egan A, Galens K, Fraser-Liggett CM, Haas BJ, Inman JM, Kent R, Lemieux S, Malavazi I, Orvis J, Roemer T, Ronning CM, Sundaram JP, Sutton G, Turner G, Venter JC, White OR, Whitty BR, Youngman P, Wolfe KH, Goldman GH, Wortman JR, Jiang B, Denning DW, Nierman WC.

PLoS Genet. 2008 Apr 11;4(4):e1000046. doi: 10.1371/journal.pgen.1000046.

6.

Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus.

Rodriguez-Suarez R, Xu D, Veillette K, Davison J, Sillaots S, Kauffman S, Hu W, Bowman J, Martel N, Trosok S, Wang H, Zhang L, Huang LY, Li Y, Rahkhoodaee F, Ransom T, Gauvin D, Douglas C, Youngman P, Becker J, Jiang B, Roemer T.

Chem Biol. 2007 Oct;14(10):1163-75.

7.

Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans.

Xu D, Jiang B, Ketela T, Lemieux S, Veillette K, Martel N, Davison J, Sillaots S, Trosok S, Bachewich C, Bussey H, Youngman P, Roemer T.

PLoS Pathog. 2007 Jun;3(6):e92.

8.

Discovery of FabH/FabF inhibitors from natural products.

Young K, Jayasuriya H, Ondeyka JG, Herath K, Zhang C, Kodali S, Galgoci A, Painter R, Brown-Driver V, Yamamoto R, Silver LL, Zheng Y, Ventura JI, Sigmund J, Ha S, Basilio A, Vicente F, Tormo JR, Pelaez F, Youngman P, Cully D, Barrett JF, Schmatz D, Singh SB, Wang J.

Antimicrob Agents Chemother. 2006 Feb;50(2):519-26.

9.

Deregulation of Listeria monocytogenes virulence gene expression by two distinct and semi-independent pathways.

Milenbachs Lukowiak A, Mueller KJ, Freitag NE, Youngman P.

Microbiology. 2004 Feb;150(Pt 2):321-33.

PMID:
14766910
10.

Antimicrobials: new solutions badly needed.

Projan SJ, Youngman PJ.

Curr Opin Microbiol. 2002 Oct;5(5):463-5. No abstract available.

PMID:
12354551
11.

Identification of compounds that inhibit late steps of peptidoglycan synthesis in bacteria.

DeCenzo M, Kuranda M, Cohen S, Babiak J, Jiang ZD, Su D, Hickey M, Sancheti P, Bradford PA, Youngman P, Projan S, Rothstein DM.

J Antibiot (Tokyo). 2002 Mar;55(3):288-95.

12.

Genomics technologies and strategies for identification of novel anti-infective agents.

Youngman P, Tepper R, Moore J.

Curr Clin Top Infect Dis. 2001;21:366-90. Review. No abstract available.

PMID:
11572160
13.

Genome-wide analysis of the general stress response in Bacillus subtilis.

Price CW, Fawcett P, Cérémonie H, Su N, Murphy CK, Youngman P.

Mol Microbiol. 2001 Aug;41(4):757-74.

14.

gamma-Glutamyltransferase is a Helicobacter pylori virulence factor but is not essential for colonization.

McGovern KJ, Blanchard TG, Gutierrez JA, Czinn SJ, Krakowka S, Youngman P.

Infect Immun. 2001 Jun;69(6):4168-73.

16.

Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia.

Ravagnani A, Jennert KC, Steiner E, Grünberg R, Jefferies JR, Wilkinson SR, Young DI, Tidswell EC, Brown DP, Youngman P, Morris JG, Young M.

Mol Microbiol. 2000 Sep;37(5):1172-85.

17.

The transcriptional profile of early to middle sporulation in Bacillus subtilis.

Fawcett P, Eichenberger P, Losick R, Youngman P.

Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8063-8.

18.

A new mutation in spo0A with intragenic suppressors in the effector domain.

Schmeisser F, Brannigan JA, Lewis RJ, Wilkinson AJ, Youngman P, Barák I.

FEMS Microbiol Lett. 2000 Apr 15;185(2):123-8.

19.

Tn917-lac mutagenesis of Streptococcus mutans to identify environmentally regulated genes.

Cvitkovitch DG, Gutierrez JA, Behari J, Youngman PJ, Wetz JE, Crowley PJ, Hillman JD, Brady LJ, Bleiweis AS.

FEMS Microbiol Lett. 2000 Jan 1;182(1):149-54.

20.

Crystallization of the regulatory and effector domains of the key sporulation response regulator Spo0A.

Muchová K, Lewis RJ, Brannigan JA, Offen WA, Brown DP, Barák I, Youngman P, Wilkinson AJ.

Acta Crystallogr D Biol Crystallogr. 1999 Mar;55(Pt 3):671-6.

PMID:
10089466
21.
22.

Expression of listeriolysin O and ActA by intracellular and extracellular Listeria monocytogenes.

Moors MA, Levitt B, Youngman P, Portnoy DA.

Infect Immun. 1999 Jan;67(1):131-9.

24.

Phage display of a biologically active Bacillus thuringiensis toxin.

Kasman LM, Lukowiak AA, Garczynski SF, McNall RJ, Youngman P, Adang MJ.

Appl Environ Microbiol. 1998 Aug;64(8):2995-3003.

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29.

Carbon-source regulation of virulence gene expression in Listeria monocytogenes.

Milenbachs AA, Brown DP, Moors M, Youngman P.

Mol Microbiol. 1997 Mar;23(5):1075-85.

32.

Structure and function of the Bacillus SpoIIE protein and its localization to sites of sporulation septum assembly.

Barák I, Behari J, Olmedo G, Guzmán P, Brown DP, Castro E, Walker D, Westpheling J, Youngman P.

Mol Microbiol. 1996 Mar;19(5):1047-60.

PMID:
8830262
33.
34.

Characterization of spo0A homologues in diverse Bacillus and Clostridium species identifies a probable DNA-binding domain.

Brown DP, Ganova-Raeva L, Green BD, Wilkinson SR, Young M, Youngman P.

Mol Microbiol. 1994 Nov;14(3):411-26.

PMID:
7885226
36.
37.

Physical and functional characterization of the Bacillus subtilis spoIIM gene.

Smith K, Bayer ME, Youngman P.

J Bacteriol. 1993 Jun;175(11):3607-17.

38.
39.

Spo0A controls the sigma A-dependent activation of Bacillus subtilis sporulation-specific transcription unit spoIIE.

York K, Kenney TJ, Satola S, Moran CP Jr, Poth H, Youngman P.

J Bacteriol. 1992 Apr;174(8):2648-58.

40.

Transcriptional activation of the Listeria monocytogenes hemolysin gene in Bacillus subtilis.

Freitag NE, Youngman P, Portnoy DA.

J Bacteriol. 1992 Feb;174(4):1293-8.

41.

A genetic analysis of Spo0A structure and function.

Green BD, Olmedo G, Youngman P.

Res Microbiol. 1991 Sep-Oct;142(7-8):825-30. Review.

PMID:
1664535
44.

Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells.

Bielecki J, Youngman P, Connelly P, Portnoy DA.

Nature. 1990 May 10;345(6271):175-6.

PMID:
2110628
45.
46.

Genetic evidence that RNA polymerase associated with sigma A factor uses a sporulation-specific promoter in Bacillus subtilis.

Kenney TJ, York K, Youngman P, Moran CP Jr.

Proc Natl Acad Sci U S A. 1989 Dec;86(23):9109-13.

47.

Temporal and spatial control of the mother-cell regulatory gene spoIIID of Bacillus subtilis.

Kunkel B, Kroos L, Poth H, Youngman P, Losick R.

Genes Dev. 1989 Nov;3(11):1735-44.

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