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Items: 18


Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS.

Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21.


Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.

Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Travers J, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, Kaelin WG Jr.

Cancer Discov. 2019 Feb;9(2):230-247. doi: 10.1158/2159-8290.CD-18-0389. Epub 2018 Oct 29.


Pooled Lentiviral-Delivery Genetic Screens.

Piccioni F, Younger ST, Root DE.

Curr Protoc Mol Biol. 2018 Jan 16;121:32.1.1-32.1.21. doi: 10.1002/cpmb.52.


Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens.

Najm FJ, Strand C, Donovan KF, Hegde M, Sanson KR, Vaimberg EW, Sullender ME, Hartenian E, Kalani Z, Fusi N, Listgarten J, Younger ST, Bernstein BE, Root DE, Doench JG.

Nat Biotechnol. 2018 Feb;36(2):179-189. doi: 10.1038/nbt.4048. Epub 2017 Dec 18.


p53 regulates enhancer accessibility and activity in response to DNA damage.

Younger ST, Rinn JL.

Nucleic Acids Res. 2017 Sep 29;45(17):9889-9900. doi: 10.1093/nar/gkx577.


Silent pericentromeric repeats speak out.

Younger ST, Rinn JL.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15008-9. doi: 10.1073/pnas.1520341112. Epub 2015 Nov 18. No abstract available.


Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display.

Shechner DM, Hacisuleyman E, Younger ST, Rinn JL.

Nat Methods. 2015 Jul;12(7):664-70. doi: 10.1038/nmeth.3433. Epub 2015 Jun 1.


Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage.

Younger ST, Kenzelmann-Broz D, Jung H, Attardi LD, Rinn JL.

Nucleic Acids Res. 2015 May 19;43(9):4447-62. doi: 10.1093/nar/gkv284. Epub 2015 Apr 16.


Identification and validation of miRNA target sites within nontraditional miRNA targets.

Younger ST, Corey DR.

Methods Mol Biol. 2015;1206:53-67. doi: 10.1007/978-1-4939-1369-5_5.


'Lnc'-ing enhancers to MYC regulation.

Younger ST, Rinn JL.

Cell Res. 2014 Jun;24(6):643-4. doi: 10.1038/cr.2014.54. Epub 2014 Apr 29.


Transcriptional regulation by miRNA mimics that target sequences downstream of gene termini.

Younger ST, Corey DR.

Mol Biosyst. 2011 Aug;7(8):2383-8. doi: 10.1039/c1mb05090g. Epub 2011 May 18.


Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters.

Younger ST, Corey DR.

Nucleic Acids Res. 2011 Jul;39(13):5682-91. doi: 10.1093/nar/gkr155. Epub 2011 Mar 22.


Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter.

Chu Y, Yue X, Younger ST, Janowski BA, Corey DR.

Nucleic Acids Res. 2010 Nov;38(21):7736-48. doi: 10.1093/nar/gkq648. Epub 2010 Jul 30.


Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini.

Yue X, Schwartz JC, Chu Y, Younger ST, Gagnon KT, Elbashir S, Janowski BA, Corey DR.

Nat Chem Biol. 2010 Aug;6(8):621-9. doi: 10.1038/nchembio.400. Epub 2010 Jun 27.


Predicting potential miRNA target sites within gene promoters.

Younger ST, Pertsemlidis A, Corey DR.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3791-4. doi: 10.1016/j.bmcl.2009.04.032. Epub 2009 Apr 18.


The puzzle of RNAs that target gene promoters.

Younger ST, Corey DR.

Chembiochem. 2009 May 4;10(7):1135-9. doi: 10.1002/cbic.200900015.


Antisense transcripts are targets for activating small RNAs.

Schwartz JC, Younger ST, Nguyen NB, Hardy DB, Monia BP, Corey DR, Janowski BA.

Nat Struct Mol Biol. 2008 Aug;15(8):842-8. doi: 10.1038/nsmb.1444. Epub 2008 Jul 6.


Activating gene expression in mammalian cells with promoter-targeted duplex RNAs.

Janowski BA, Younger ST, Hardy DB, Ram R, Huffman KE, Corey DR.

Nat Chem Biol. 2007 Mar;3(3):166-73. Epub 2007 Jan 28.


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