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Items: 16


Stem, Effector, and Hybrid States of Memory CD8+ T Cells.

Lugli E, Galletti G, Boi SK, Youngblood BA.

Trends Immunol. 2020 Jan;41(1):17-28. doi: 10.1016/ Epub 2019 Dec 4. Review.


Defining 'T cell exhaustion'.

Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, Wherry EJ, Youngblood BA, Zehn D.

Nat Rev Immunol. 2019 Nov;19(11):665-674. doi: 10.1038/s41577-019-0221-9. Epub 2019 Sep 30. Review.


Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis.

Youngblood BA, Brock EC, Leung J, Falahati R, Bochner BS, Rasmussen HS, Peterson K, Bebbington C, Tomasevic N.

JCI Insight. 2019 Oct 3;4(19). pii: 126219. doi: 10.1172/jci.insight.126219.


AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.

Youngblood BA, Brock EC, Leung J, Falahati R, Bryce PJ, Bright J, Williams J, Shultz LD, Greiner DL, Brehm MA, Bebbington C, Tomasevic N.

Int Arch Allergy Immunol. 2019;180(2):91-102. doi: 10.1159/000501637. Epub 2019 Aug 9.


Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses.

Zamora AE, Crawford JC, Allen EK, Guo XJ, Bakke J, Carter RA, Abdelsamed HA, Moustaki A, Li Y, Chang TC, Awad W, Dallas MH, Mullighan CG, Downing JR, Geiger TL, Chen T, Green DR, Youngblood BA, Zhang J, Thomas PG.

Sci Transl Med. 2019 Jun 26;11(498). pii: eaat8549. doi: 10.1126/scitranslmed.aat8549.


Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies.

Legrand F, Cao Y, Wechsler JB, Zhu X, Zimmermann N, Rampertaap S, Monsale J, Romito K, Youngblood BA, Brock EC, Makiya MA, Tomasevic N, Bebbington C, Maric I, Metcalfe DD, Bochner BS, Klion AD.

J Allergy Clin Immunol. 2019 Jun;143(6):2227-2237.e10. doi: 10.1016/j.jaci.2018.10.066. Epub 2018 Dec 10.


Origin and differentiation of human memory CD8 T cells after vaccination.

Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, Youngblood BA, Abdelsamed HA, McGuire DJ, Cohen KW, Alexe G, Nagar S, McCausland MM, Gupta S, Tata P, Haining WN, McElrath MJ, Zhang D, Hu B, Greenleaf WJ, Goronzy JJ, Mulligan MJ, Hellerstein M, Ahmed R.

Nature. 2017 Dec 21;552(7685):362-367. doi: 10.1038/nature24633. Epub 2017 Dec 13.


Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent.

Shwetank, Abdelsamed HA, Frost EL, Schmitz HM, Mockus TE, Youngblood BA, Lukacher AE.

Immunol Cell Biol. 2017 Nov;95(10):953-959. doi: 10.1038/icb.2017.62. Epub 2017 Aug 22.


Cell-Intrinsic Barriers of T Cell-Based Immunotherapy.

Ghoneim HE, Zamora AE, Thomas PG, Youngblood BA.

Trends Mol Med. 2016 Dec;22(12):1000-1011. doi: 10.1016/j.molmed.2016.10.002. Epub 2016 Nov 4. Review.


CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defects.

Youngblood BA, MacDonald CC.

Stem Cell Res. 2014 Nov;13(3 Pt A):413-21. doi: 10.1016/j.scr.2014.09.005. Epub 2014 Sep 28.


CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3' end processing.

Youngblood BA, Grozdanov PN, MacDonald CC.

Nucleic Acids Res. 2014 Jul;42(13):8330-42. doi: 10.1093/nar/gku551. Epub 2014 Jun 23.


Human leukemia inhibitory factor produced by the ExpressTec method from rice (Oryza sativa L.) is active in human neural stem cells and mouse induced pluripotent stem cells.

Alfano R, Youngblood BA, Zhang D, Huang N, MacDonald CC.

Bioengineered. 2014 May-Jun;5(3):180-5. doi: 10.4161/bioe.28996. Epub 2014 Apr 28.


Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection.

Lu P, Youngblood BA, Austin JW, Mohammed AU, Butler R, Ahmed R, Boss JM.

J Exp Med. 2014 Mar 10;211(3):515-27. doi: 10.1084/jem.20130208. Epub 2014 Mar 3.


Application of recombinant human leukemia inhibitory factor (LIF) produced in rice (Oryza sativa L.) for maintenance of mouse embryonic stem cells.

Youngblood BA, Alfano R, Pettit SC, Zhang D, Dallmann HG, Huang N, Macdonald CC.

J Biotechnol. 2014 Feb 20;172:67-72. doi: 10.1016/j.jbiotec.2013.12.012. Epub 2013 Dec 29.


Global DNA methylation remodeling accompanies CD8 T cell effector function.

Scharer CD, Barwick BG, Youngblood BA, Ahmed R, Boss JM.

J Immunol. 2013 Sep 15;191(6):3419-29. doi: 10.4049/jimmunol.1301395. Epub 2013 Aug 16.


CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments.

Zinzow-Kramer WM, Long AB, Youngblood BA, Rosenthal KM, Butler R, Mohammed AU, Skountzou I, Ahmed R, Evavold BD, Boss JM.

Genes Immun. 2012 Jun;13(4):299-310. doi: 10.1038/gene.2011.86. Epub 2012 Jan 5.

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