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Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.

Petrie EJ, Sandow JJ, Lehmann WIL, Liang LY, Coursier D, Young SN, Kersten WJA, Fitzgibbon C, Samson AL, Jacobsen AV, Lowes KN, Au AE, Jousset Sabroux H, Lalaoui N, Webb AI, Lessene G, Manning G, Lucet IS, Murphy JM.

Cell Rep. 2019 Sep 24;28(13):3309-3319.e5. doi: 10.1016/j.celrep.2019.08.055.


A Framework for Evaluating Field-Based, High-Throughput Phenotyping Systems: A Meta-Analysis.

Young SN.

Sensors (Basel). 2019 Aug 17;19(16). pii: E3582. doi: 10.3390/s19163582.


Factors Affecting PhD Student Success.

Young SN, Vanwye WR, Schafer MA, Robertson TA, Poore AV.

Int J Exerc Sci. 2019 Jan 1;12(1):34-45. eCollection 2019. Review.


Community Engagement in Academic Health Centers: A Model for Capturing and Advancing Our Successes.

Vitale K, Newton GL, Abraido-Lanza AF, Aguirre AN, Ahmed S, Esmond SL, Evans J, Gelmon SB, Hart C, Hendricks D, McClinton-Brown R, Young SN, Stewart MK, Tumiel-Berhalter LM.

J Community Engagem Scholarsh. 2018;10(1):81-90. Epub 2018 Feb 14.


Sport simulation as a form of implicit motor training in a geriatric athlete after stroke: a case report.

Young SN, VanWye WR, Wallmann HW.

Physiother Theory Pract. 2018 Jun 25:1-9. doi: 10.1080/09593985.2018.1488322. [Epub ahead of print]


Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Petrie EJ, Sandow JJ, Jacobsen AV, Smith BJ, Griffin MDW, Lucet IS, Dai W, Young SN, Tanzer MC, Wardak A, Liang LY, Cowan AD, Hildebrand JM, Kersten WJA, Lessene G, Silke J, Czabotar PE, Webb AI, Murphy JM.

Nat Commun. 2018 Jun 21;9(1):2422. doi: 10.1038/s41467-018-04714-7.


Relative and Absolute Reliability of the Professionalism in Physical Therapy Core Values Self-Assessment Tool.

Furgal KE, Norris ES, Young SN, Wallmann HW.

J Allied Health. 2018 Spring;47(1):e45-e48.


The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis.

Davies KA, Tanzer MC, Griffin MDW, Mok YF, Young SN, Qin R, Petrie EJ, Czabotar PE, Silke J, Murphy JM.

Cell Death Differ. 2018 Sep;25(9):1567-1580. doi: 10.1038/s41418-018-0061-3. Epub 2018 Feb 14.


Evaluation of a pilot of nurse practitioner led, GP supported rural palliative care provision.

Mitchell GK, Senior HE, Bibo MP, Makoni B, Young SN, Rosenberg JP, Yates P.

BMC Palliat Care. 2016 Nov 9;15(1):93.


The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain.

Chen K, Dobson RC, Lucet IS, Young SN, Pearce FG, Blewitt ME, Murphy JM.

Biochem J. 2016 Jun 15;473(12):1733-44. doi: 10.1042/BCJ20160189. Epub 2016 Apr 8.


Opening the Black Box: Conceptualizing Community Engagement From 109 Community-Academic Partnership Programs.

Ahmed SM, Maurana C, Nelson D, Meister T, Young SN, Lucey P.

Prog Community Health Partnersh. 2016 Spring;10(1):51-61. doi: 10.1353/cpr.2016.0019.


Evolutionary divergence of the necroptosis effector MLKL.

Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM.

Cell Death Differ. 2016 Jul;23(7):1185-97. doi: 10.1038/cdd.2015.169. Epub 2016 Feb 12.


Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop.

Tanzer MC, Tripaydonis A, Webb AI, Young SN, Varghese LN, Hall C, Alexander WS, Hildebrand JM, Silke J, Murphy JM.

Biochem J. 2015 Oct 15;471(2):255-65. doi: 10.1042/BJ20150678. Epub 2015 Aug 17.


Eating a meal is associated with elevations in agreeableness and reductions in dominance and submissiveness.

aan het Rot M, Moskowitz DS, Hsu ZY, Young SN.

Physiol Behav. 2015 May 15;144:103-9. doi: 10.1016/j.physbeh.2015.03.014. Epub 2015 Mar 12.


Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.

Hildebrand JM, Tanzer MC, Lucet IS, Young SN, Spall SK, Sharma P, Pierotti C, Garnier JM, Dobson RC, Webb AI, Tripaydonis A, Babon JJ, Mulcair MD, Scanlon MJ, Alexander WS, Wilks AF, Czabotar PE, Lessene G, Murphy JM, Silke J.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. doi: 10.1073/pnas.1408987111. Epub 2014 Oct 6.


Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha-[(11) C]methyl-l-tryptophan study.

Booij L, Soucy JP, Young SN, Regoli M, Gravel P, Diksic M, Leyton M, Pihl RO, Benkelfat C.

J Neurochem. 2014 Dec;131(5):634-44. doi: 10.1111/jnc.12826. Epub 2014 Aug 21.


RIPK1- and RIPK3-induced cell death mode is determined by target availability.

Cook WD, Moujalled DM, Ralph TJ, Lock P, Young SN, Murphy JM, Vaux DL.

Cell Death Differ. 2014 Oct;21(10):1600-12. doi: 10.1038/cdd.2014.70. Epub 2014 Jun 6.


Impulsive behaviour in interpersonal encounters: associations with quarrelsomeness and agreeableness.

aan Het Rot M, Moskowitz DS, Young SN.

Br J Psychol. 2015 Feb;106(1):152-61. doi: 10.1111/bjop.12070. Epub 2014 Mar 7.


Tryptophan and inhibitors of tryptophan 2,3-dioxygenase as antidepressants.

Young SN.

J Psychopharmacol. 2014 Feb;28(2):168-9. doi: 10.1177/0269881113512043. No abstract available.


Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.

Varghese LN, Zhang JG, Young SN, Willson TA, Alexander WS, Nicola NA, Babon JJ, Murphy JM.

Growth Factors. 2014 Feb;32(1):18-26. doi: 10.3109/08977194.2013.874347. Epub 2014 Jan 20.


Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses.

Varghese LN, Ungureanu D, Liau NP, Young SN, Laktyushin A, Hammaren H, Lucet IS, Nicola NA, Silvennoinen O, Babon JJ, Murphy JM.

Biochem J. 2014 Mar 1;458(2):395-405. doi: 10.1042/BJ20131516.


Prospective associations of depression with survival: a population-based cohort study in patients with newly diagnosed breast cancer.

Vodermaier A, Linden W, Rnic K, Young SN, Ng A, Ditsch N, Olson R.

Breast Cancer Res Treat. 2014 Jan;143(2):373-84. doi: 10.1007/s10549-013-2795-4. Epub 2013 Dec 13.


Possible role of more positive social behaviour in the clinical effect of antidepressant drugs.

Young SN, Moskowitz DS, aan het Rot M.

J Psychiatry Neurosci. 2014 Jan;39(1):60-5. doi: 10.1503/jpn.130165. Review.


Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.

Murphy JM, Lucet IS, Hildebrand JM, Tanzer MC, Young SN, Sharma P, Lessene G, Alexander WS, Babon JJ, Silke J, Czabotar PE.

Biochem J. 2014 Feb 1;457(3):369-77. doi: 10.1042/BJ20131270.


Methodology and interpretation of acute tryptophan depletion studies.

Young SN.

Acta Psychiatr Scand. 2014 Feb;129(2):156. doi: 10.1111/acps.12214. Epub 2013 Nov 11. No abstract available.


The effect of acute tryptophan depletion on mood and impulsivity in polydrug ecstasy users.

Young SN, Regoli M, Leyton M, Pihl RO, Benkelfat C.

Psychopharmacology (Berl). 2014 Feb;231(4):707-16. doi: 10.1007/s00213-013-3287-2. Epub 2013 Oct 19.


A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS.

Biochem J. 2014 Jan 15;457(2):323-34. doi: 10.1042/BJ20131174.


The influence of light administration on interpersonal behavior and affect in people with mild to moderate seasonality.

Hsu ZY, Moskowitz DS, Young SN.

Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:92-101. doi: 10.1016/j.pnpbp.2013.09.004. Epub 2013 Sep 14.


The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS.

Immunity. 2013 Sep 19;39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5.


Antidepressant effects of botulinum toxin A: scientific rationale; author response.

Young SN.

J Psychiatry Neurosci. 2013 Sep;38(5):E29. doi: 10.1503/jpn.130109. No abstract available.


Appropriate amino acid mixtures for tryptophan depletion and tyrosine/phenylalanine depletion and the safety of long-term amino acid depletion in humans.

Young SN.

Psychopharmacology (Berl). 2013 Sep;229(2):377-8. doi: 10.1007/s00213-013-3237-z. Epub 2013 Aug 13. No abstract available.


Dopamine and light: dissecting effects on mood and motivational states in women with subsyndromal seasonal affective disorder.

Cawley EI, Park S, aan het Rot M, Sancton K, Benkelfat C, Young SN, Boivin DB, Leyton M.

J Psychiatry Neurosci. 2013 Nov;38(6):388-97. doi: 10.1503/jpn.120181.


The effect of raising and lowering tryptophan levels on human mood and social behaviour.

Young SN.

Philos Trans R Soc Lond B Biol Sci. 2013 Feb 25;368(1615):20110375. doi: 10.1098/rstb.2011.0375. Print 2013. Review.


Acute tryptophan depletion in humans: a review of theoretical, practical and ethical aspects.

Young SN.

J Psychiatry Neurosci. 2013 Sep;38(5):294-305. doi: 10.1503/jpn.120209. Review.


Salivary cortisol and interpersonal functioning: an event-contingent recording study in the offspring of parents with bipolar disorder.

Ellenbogen MA, Linnen AM, Santo JB, aan het Rot M, Hodgins S, Young SN.

Psychoneuroendocrinology. 2013 Jul;38(7):997-1006. doi: 10.1016/j.psyneuen.2012.10.005. Epub 2012 Nov 4.


Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity.

Babon JJ, Kershaw NJ, Murphy JM, Varghese LN, Laktyushin A, Young SN, Lucet IS, Norton RS, Nicola NA.

Immunity. 2012 Feb 24;36(2):239-50. doi: 10.1016/j.immuni.2011.12.015.


Bright light for nonseasonal depression?

Young SN.

J Psychiatry Neurosci. 2011 Sep;36(5):E37-8. doi: 10.1503/jpn.110056. No abstract available.


My 21 years with the Journal of Psychiatry and Neuroscience, with observations on editors, editorial boards, authors and reviewers.

Young SN.

J Psychiatry Neurosci. 2011 Jul;36(4):E30-4. doi: 10.1503/jpn.110044. No abstract available.


Serotonergic contribution to boys' behavioral regulation.

Nantel-Vivier A, Pihl RO, Young SN, Parent S, Bélanger SA, Sutton R, Dubois ME, Tremblay RE, Séguin JR.

PLoS One. 2011;6(6):e20304. doi: 10.1371/journal.pone.0020304. Epub 2011 Jun 1.


Biologic effects of mindfulness meditation: growing insights into neurobiologic aspects of the prevention of depression.

Young SN.

J Psychiatry Neurosci. 2011 Mar;36(2):75-7. doi: 10.1503/jpn.110010. No abstract available.


Possible directions for the discovery of new antidepressant treatments.

Young SN.

J Psychiatry Neurosci. 2011 Jan;36(1):3-5. doi: 10.1503/jpn.100169. No abstract available.


Estrogen treatment impairs cognitive performance after psychosocial stress and monoamine depletion in postmenopausal women.

Newhouse PA, Dumas J, Wilkins H, Coderre E, Sites CK, Naylor M, Benkelfat C, Young SN.

Menopause. 2010 Jul;17(4):860-73. doi: 10.1097/gme.0b013e3181e15df4.


Anxiety, emotional security and the interpersonal behavior of individuals with social anxiety disorder.

Russell JJ, Moskowitz DS, Zuroff DC, Bleau P, Pinard G, Young SN.

Psychol Med. 2011 Mar;41(3):545-54. doi: 10.1017/S0033291710000863. Epub 2010 May 12.


Bioanalytical inaccuracy: a threat to the integrity and efficiency of research.

Young SN, Anderson GN.

J Psychiatry Neurosci. 2010 Jan;35(1):3-6. No abstract available.


Recognizing emotions in faces: effects of acute tryptophan depletion and bright light.

aan het Rot M, Coupland N, Boivin DB, Benkelfat C, Young SN.

J Psychopharmacol. 2010 Oct;24(10):1447-54. doi: 10.1177/0269881109348169. Epub 2009 Nov 25.


Impact of acute tryptophan depletion on mood and eating-related urges in bulimic and nonbulimic women.

Bruce KR, Steiger H, Young SN, Kin NM, Israël M, Lévesque M.

J Psychiatry Neurosci. 2009 Sep;34(5):376-82.


Rethinking scientific meetings: an imperative in an era of climate change.

Young SN.

J Psychiatry Neurosci. 2009 Sep;34(5):341-2. No abstract available.

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