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Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism.

Kristensen KK, Leth-Espensen KZ, Mertens HDT, Birrane G, Meiyappan M, Olivecrona G, Jørgensen TJD, Young SG, Ploug M.

Proc Natl Acad Sci U S A. 2020 Feb 7. pii: 201920202. doi: 10.1073/pnas.1920202117. [Epub ahead of print]


Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores.

Heizer PJ, Yang Y, Tu Y, Kim PH, Chen NY, Hu Y, Yoshinaga Y, de Jong PJ, Vergnes L, Morales JE, Li RL, Jackson NJ, Reue K, Young SG, Fong LG.

J Lipid Res. 2020 Jan 15. pii: jlr.RA119000593. doi: 10.1194/jlr.RA119000593. [Epub ahead of print]


An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death.

Chen NY, Yang Y, Weston TA, Belling JN, Heizer P, Tu Y, Kim P, Edillo L, Jonas SJ, Weiss PS, Fong LG, Young SG.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25870-25879. doi: 10.1073/pnas.1917225116. Epub 2019 Dec 3.


Active surveillance and genetic evolution of avian influenza viruses in Egypt, 2016-2018.

Kandeil A, Hicks JT, Young SG, El Taweel AN, Kayed AS, Moatasim Y, Kutkat O, Bagato O, McKenzie PP, Cai Z, Badra R, Kutkat M, Bahl J, Webby RJ, Kayali G, Ali MA.

Emerg Microbes Infect. 2019;8(1):1370-1382. doi: 10.1080/22221751.2019.1663712.


Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia.

Hu X, Weston TA, He C, Jung RS, Heizer PJ, Young BD, Tu Y, Tontonoz P, Wohlschlegel JA, Jiang H, Young SG, Fong LG.

Elife. 2019 Sep 5;8. pii: e50231. doi: 10.7554/eLife.50231.


DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces.

Gill NK, Ly C, Kim PH, Saunders CA, Fong LG, Young SG, Luxton GWG, Rowat AC.

Front Cell Dev Biol. 2019 Jun 26;7:103. doi: 10.3389/fcell.2019.00103. eCollection 2019.


GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism.

Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M.

Cell Metab. 2019 Jul 2;30(1):51-65. doi: 10.1016/j.cmet.2019.05.023. Review.


Evolution and Medical Significance of LU Domain-Containing Proteins.

Leth JM, Leth-Espensen KZ, Kristensen KK, Kumari A, Lund Winther AM, Young SG, Ploug M.

Int J Mol Sci. 2019 Jun 5;20(11). pii: E2760. doi: 10.3390/ijms20112760. Review.


GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients.

Hu X, Matsumoto K, Jung RS, Weston TA, Heizer PJ, He C, Sandoval NP, Allan CM, Tu Y, Vinters HV, Liau LM, Ellison RM, Morales JE, Baufeld LJ, Bayley NA, He L, Betsholtz C, Beigneux AP, Nathanson DA, Gerhardt H, Young SG, Fong LG, Jiang H.

Elife. 2019 Jun 6;8. pii: e47178. doi: 10.7554/eLife.47178.


Doctor hopping and doctor shopping for prescription opioids associated with increased odds of high-risk use.

Young SG, Hayes CJ, Aram J, Tait MA.

Pharmacoepidemiol Drug Saf. 2019 Aug;28(8):1117-1124. doi: 10.1002/pds.4838. Epub 2019 Jun 5.


Lipoprotein lipase is active as a monomer.

Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE 4th, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6319-6328. doi: 10.1073/pnas.1900983116. Epub 2019 Mar 8.


Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina.

Nmezi B, Xu J, Fu R, Armiger TJ, Rodriguez-Bey G, Powell JS, Ma H, Sullivan M, Tu Y, Chen NY, Young SG, Stolz DB, Dahl KN, Liu Y, Padiath QS.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4307-4315. doi: 10.1073/pnas.1810070116. Epub 2019 Feb 14.


An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner.

Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG.

J Lipid Res. 2019 Apr;60(4):869-879. doi: 10.1194/jlr.M091322. Epub 2018 Dec 31.


Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis.

Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1723-1732. doi: 10.1073/pnas.1817984116. Epub 2018 Dec 17.


Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.

Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K.

J Clin Invest. 2019 Jan 2;129(1):281-295. doi: 10.1172/JCI122595. Epub 2018 Dec 3.


GPIHBP1 autoantibody syndrome during interferon β1a treatment.

Eguchi J, Miyashita K, Fukamachi I, Nakajima K, Murakami M, Kawahara Y, Yamashita T, Ohta Y, Abe K, Nakatsuka A, Mino M, Takase S, Okazaki H, Hegele RA, Ploug M, Hu X, Wada J, Young SG, Beigneux AP.

J Clin Lipidol. 2019 Jan - Feb;13(1):62-69. doi: 10.1016/j.jacl.2018.10.004. Epub 2018 Oct 24.


The workforce trends of physician assistants in Iowa (1995-2015).

Gruca TS, Nelson GC, Thiesen L, Asprey DP, Young SG.

PLoS One. 2018 Oct 8;13(10):e0204813. doi: 10.1371/journal.pone.0204813. eCollection 2018.


An ELISA for quantifying GPIHBP1 autoantibodies and making a diagnosis of the GPIHBP1 autoantibody syndrome.

Miyashita K, Fukamachi I, Machida T, Nakajima K, Young SG, Murakami M, Beigneux AP, Nakajima K.

Clin Chim Acta. 2018 Dec;487:174-178. doi: 10.1016/j.cca.2018.09.039. Epub 2018 Oct 1.


Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness.

Levy Y, Ross JA, Niglas M, Snetkov VA, Lynham S, Liao CY, Puckelwartz MJ, Hsu YM, McNally EM, Alsheimer M, Harridge SD, Young SG, Fong LG, Español Y, Lopez-Otin C, Kennedy BK, Lowe DA, Ochala J.

JCI Insight. 2018 Oct 4;3(19). pii: 120920. doi: 10.1172/jci.insight.120920.


Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome.

Kim PH, Luu J, Heizer P, Tu Y, Weston TA, Chen N, Lim C, Li RL, Lin PY, Dunn JCY, Hodzic D, Young SG, Fong LG.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaat7163. doi: 10.1126/scitranslmed.aat7163.


Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures.

Chen NY, Kim P, Weston TA, Edillo L, Tu Y, Fong LG, Young SG.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10100-10105. doi: 10.1073/pnas.1812622115. Epub 2018 Sep 17.


NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes.

He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H.

Biochem Biophys Res Commun. 2018 Oct 12;504(4):899-902. doi: 10.1016/j.bbrc.2018.09.051. Epub 2018 Sep 15.


Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P.

Cell. 2018 Oct 4;175(2):514-529.e20. doi: 10.1016/j.cell.2018.08.033. Epub 2018 Sep 13.


Macrophages release plasma membrane-derived particles rich in accessible cholesterol.

He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8499-E8508. doi: 10.1073/pnas.1810724115. Epub 2018 Aug 20.


Face color facilitates the disambiguation of confusing emotion expressions: Toward a social functional account of face color in emotion communication.

Thorstenson CA, Pazda AD, Young SG, Elliot AJ.

Emotion. 2019 Aug;19(5):799-807. doi: 10.1037/emo0000485. Epub 2018 Aug 6.


Unlocking pandemic potential: prevalence and spatial patterns of key substitutions in avian influenza H5N1 in Egyptian isolates.

Young SG, Kitchen A, Kayali G, Carrel M.

BMC Infect Dis. 2018 Jul 6;18(1):314. doi: 10.1186/s12879-018-3222-6.


Configural face processing impacts race disparities in humanization and trust.

Cassidy BS, Krendl AC, Stanko KA, Rydell RJ, Young SG, Hugenberg K.

J Exp Soc Psychol. 2017 Nov;73:111-124. doi: 10.1016/j.jesp.2017.06.018. Epub 2017 Jul 5.


A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase.

Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E6020-E6029. doi: 10.1073/pnas.1806774115. Epub 2018 Jun 13.


NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes.

He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H.

Cell Metab. 2018 May 1;27(5):1055-1066.e3. doi: 10.1016/j.cmet.2018.03.017.


Correction: High prevalence of elevated blood lead levels in both rural and urban Iowa newborns: Spatial patterns and area-level covariates.

Carrel M, Zahrieh D, Young SG, Oleson J, Ryckman KK, Wels B, Simmons DL, Saftlas A.

PLoS One. 2018 Apr 12;13(4):e0196002. doi: 10.1371/journal.pone.0196002. eCollection 2018.


Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure.

Larsson M, Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Walzem RL, Beigneux AP, Young SG, Fong LG.

J Lipid Res. 2018 Apr;59(4):706-713. doi: 10.1194/jlr.M083832. Epub 2018 Feb 15.


IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure.

Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P.

Cell. 2018 Jan 11;172(1-2):218-233.e17. doi: 10.1016/j.cell.2017.11.019. Epub 2017 Dec 14.


An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum.

Miyashita K, Fukamachi I, Nagao M, Ishida T, Kobayashi J, Machida T, Nakajima K, Murakami M, Ploug M, Beigneux AP, Young SG, Nakajima K.

J Clin Lipidol. 2018 Jan - Feb;12(1):203-210.e1. doi: 10.1016/j.jacl.2017.10.022. Epub 2017 Nov 1.


Perceiving Sophisticated Minds Influences Perceptual Individuation.

Almaraz SM, Hugenberg K, Young SG.

Pers Soc Psychol Bull. 2018 Feb;44(2):143-157. doi: 10.1177/0146167217733070. Epub 2017 Nov 2.


Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1.

He C, Hu X, Jung RS, Larsson M, Tu Y, Duarte-Vogel S, Kim P, Sandoval NP, Price TR, Allan CM, Raney B, Jiang H, Bensadoun A, Walzem RL, Kuo RI, Beigneux AP, Fong LG, Young SG.

JCI Insight. 2017 Oct 19;2(20). pii: 96783. doi: 10.1172/jci.insight.96783.


Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice.

Allan CM, Heizer PJ, Jung CJ, Tu Y, Tran D, Young LC, Fong LG, de Jong PJ, Beigneux AP, Young SG.

J Dermatol Sci. 2018 Jan;89(1):85-87. doi: 10.1016/j.jdermsci.2017.08.014. Epub 2017 Sep 28. No abstract available.


Feral Swine in the United States Have Been Exposed to both Avian and Swine Influenza A Viruses.

Martin BE, Sun H, Carrel M, Cunningham FL, Baroch JA, Hanson-Dorr KC, Young SG, Schmit B, Nolting JM, Yoon KJ, Lutman MW, Pedersen K, Lager K, Bowman AS, Slemons RD, Smith DR, DeLiberto T, Wan XF.

Appl Environ Microbiol. 2017 Sep 15;83(19). pii: e01346-17. doi: 10.1128/AEM.01346-17. Print 2017 Oct 1.


Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL.

Larsson M, Allan CM, Jung RS, Heizer PJ, Beigneux AP, Young SG, Fong LG.

J Lipid Res. 2017 Sep;58(9):1893-1902. doi: 10.1194/jlr.M078220. Epub 2017 Jul 10.


GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia.

Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP.

J Clin Lipidol. 2017 Jul - Aug;11(4):964-971. doi: 10.1016/j.jacl.2017.05.017. Epub 2017 Jun 13.


High prevalence of elevated blood lead levels in both rural and urban Iowa newborns: Spatial patterns and area-level covariates.

Carrel M, Zahrieh D, Young SG, Oleson J, Ryckman KK, Wels B, Simmons DL, Saftlas A.

PLoS One. 2017 May 16;12(5):e0177930. doi: 10.1371/journal.pone.0177930. eCollection 2017. Erratum in: PLoS One. 2018 Apr 12;13(4):e0196002.


Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding.

Allan CM, Jung CJ, Larsson M, Heizer PJ, Tu Y, Sandoval NP, Dang TLP, Jung RS, Beigneux AP, de Jong PJ, Fong LG, Young SG.

J Lipid Res. 2017 Jul;58(7):1453-1461. doi: 10.1194/jlr.M076943. Epub 2017 May 5.


Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation.

Gigante CM, Dibattista M, Dong FN, Zheng X, Yue S, Young SG, Reisert J, Zheng Y, Zhao H.

Nat Commun. 2017 Apr 20;8:15098. doi: 10.1038/ncomms15098.


A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency.

Allan CM, Tran D, Tu Y, Heizer PJ, Young LC, Fong LG, Beigneux AP, Young SG.

Exp Dermatol. 2017 Nov;26(11):1134-1136. doi: 10.1111/exd.13363. Epub 2017 Jul 27.


Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.

Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG.

N Engl J Med. 2017 Apr 27;376(17):1647-1658. doi: 10.1056/NEJMoa1611930. Epub 2017 Apr 5.


RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.

Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P.

J Clin Invest. 2017 Mar 1;127(3):987-1004. doi: 10.1172/JCI89484. Epub 2017 Feb 13.


How's the Flu Getting Through? Landscape genetics suggests both humans and birds spread H5N1 in Egypt.

Young SG, Carrel M, Kitchen A, Malanson GP, Tamerius J, Ali M, Kayali G.

Infect Genet Evol. 2017 Apr;49:293-299. doi: 10.1016/j.meegid.2017.02.005. Epub 2017 Feb 4.


High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS.

He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2000-2005. doi: 10.1073/pnas.1621432114. Epub 2017 Feb 6.


Facial redness, expression, and masculinity influence perceptions of anger and health.

Young SG, Thorstenson CA, Pazda AD.

Cogn Emot. 2018 Feb;32(1):49-60. doi: 10.1080/02699931.2016.1273201. Epub 2016 Dec 29.


A minimal ingroup advantage in emotion identification confidence.

Young SG, Wilson JP.

Cogn Emot. 2018 Feb;32(1):192-199. doi: 10.1080/02699931.2016.1273199. Epub 2016 Dec 28.


Stimulus Threat and Exposure Context Modulate the Effect of Mere Exposure on Approach Behaviors.

Young SG, Jones IF, Claypool HM.

Front Psychol. 2016 Nov 29;7:1881. eCollection 2016.

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