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Improved bone regeneration using bone anabolic drug conjugates (C3 and C6) with deproteinized bovine bone mineral as a carrier in rat mandibular defects.

Sheikh Z, Abdallah MN, Al-Jaf F, Chen G, Hamdan N, Young RN, Grynpas MD, Glogauer M.

J Periodontol. 2020 Feb 25. doi: 10.1002/JPER.19-0645. [Epub ahead of print]


Robotic-assisted complete mesocolic excision, central vascular ligation and para-aortic lymph node dissection in multifocal carcinoid: A case report and technical description.

Young R, Rajkomar A, Smart P, Warrier S.

Int J Surg Case Rep. 2020 Feb 11;67:262-266. doi: 10.1016/j.ijscr.2020.02.018. [Epub ahead of print]


Splicing of enhancer-associated lincRNAs contributes to enhancer activity.

Tan JY, Biasini A, Young RS, Marques AC.

Life Sci Alliance. 2020 Feb 21;3(4). pii: e202000663. doi: 10.26508/lsa.202000663. Print 2020 Apr.


The sarcoma diagnostic interval: a systematic review on length, contributing factors and patient outcomes.

Soomers V, Husson O, Young R, Desar I, Van der Graaf W.

ESMO Open. 2020 Feb;5(1). pii: e000592. doi: 10.1136/esmoopen-2019-000592. Review.


Validated Living Worldwide Supercentenarians 112+, Living and Recently Deceased: February 2020.

Young RD, Kroczek WJ.

Rejuvenation Res. 2020 Feb;23(1):65-67. doi: 10.1089/rej.2020.29002.rdy. No abstract available.


Data for engineering lipid metabolism of Chinese hamster ovary (CHO) cells for enhanced recombinant protein production.

Budge JD, Knight TJ, Povey J, Roobol J, Brown IR, Singh G, Dean A, Turner S, Jaques CM, Young RJ, Racher AJ, Smales CM.

Data Brief. 2020 Jan 31;29:105217. doi: 10.1016/j.dib.2020.105217. eCollection 2020 Apr.


Single residue in CD28-costimulated CAR T cells limits long-term persistence and antitumor durability.

Guedan S, Madar A, Casado-Medrano V, Shaw CE, Wing A, Liu F, Young RM, June CH, Posey AD Jr.

J Clin Invest. 2020 Feb 18. pii: 133215. doi: 10.1172/JCI133215. [Epub ahead of print]


Correlation between percutaneous biopsy and final histopathology for retroperitoneal sarcoma: a single-centre study.

Young R, Snow H, Hendry S, Mitchell C, Slavin J, Schlicht S, Na L, Hofman MS, Gyorki DE.

ANZ J Surg. 2020 Feb 16. doi: 10.1111/ans.15723. [Epub ahead of print]


Impact of a nutritional supplement during gestation and early childhood on child salivary cortisol, hair cortisol, and telomere length at 4-6 years of age: a follow-up of a randomized controlled trial.

Oaks BM, Adu-Afarwuah S, Kumordzie S, Laudenslager ML, Smith DL, Lin J, Young RR, Arnold CD, Bentil H, Okronipa H, Ocansey M, Dewey KG.

Stress. 2020 Feb 24:1-10. doi: 10.1080/10253890.2020.1728528. [Epub ahead of print]


Phase II trial of eribulin in patients who do not achieve pathologic complete response (pCR) following neoadjuvant chemotherapy.

Yardley DA, Peacock N, Daniel B, Anz B, Molthrop DC Jr, Shroff SK, Young R, Jankov A, Vander Woude A, Shastry M, Pasek J, DeBusk LM, Hainsworth JD.

Breast Cancer Res Treat. 2020 Feb 14. doi: 10.1007/s10549-020-05563-z. [Epub ahead of print]


Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity.

Hamad AE, Moinuddin O, Blair MP, Schechet SA, Shapiro MJ, Quiram PA, Mammo DA, Berrocal AM, Prakhunhungsit S, Cernichiaro-Espinosa LA, Mukai S, Yonekawa Y, Ung C, Holz ER, Harper CA 3rd, Young RC, Besirli CG, Nagiel A, Lee TC, Gupta MP, Walsh MK, Khawly JA, Campbell JP, Kychenthal A, Nudleman ED, Robinson JE, Hartnett ME, Calvo CM, Chang EY.

Ophthalmol Retina. 2019 Dec 24. pii: S2468-6530(19)30687-6. doi: 10.1016/j.oret.2019.12.015. [Epub ahead of print]


Inhaled nicotine and lung cancer: Potential role of the nicotinic acetylcholine receptor.

Young RP, Scott RJ.

Proc Natl Acad Sci U S A. 2020 Feb 11. pii: 201921567. doi: 10.1073/pnas.1921567117. [Epub ahead of print] No abstract available.


Increasing Spending on Primary Care to Reduce Health Care Costs.

Young RA.

JAMA. 2020 Feb 11;323(6):571. doi: 10.1001/jama.2019.20634. No abstract available.


Role of Human Galectins in Inflammation and Cancers Associated with Endometriosis.

Hisrich BV, Young RB, Sansone AM, Bowens Z, Green LJ, Lessey BA, Blenda AV.

Biomolecules. 2020 Feb 4;10(2). pii: E230. doi: 10.3390/biom10020230. Review.


CRISPR-engineered T cells in patients with refractory cancer.

Stadtmauer EA, Fraietta JA, Davis MM, Cohen AD, Weber KL, Lancaster E, Mangan PA, Kulikovskaya I, Gupta M, Chen F, Tian L, Gonzalez VE, Xu J, Jung IY, Melenhorst JJ, Plesa G, Shea J, Matlawski T, Cervini A, Gaymon AL, Desjardins S, Lamontagne A, Salas-Mckee J, Fesnak A, Siegel DL, Levine BL, Jadlowsky JK, Young RM, Chew A, Hwang WT, Hexner EO, Carreno BM, Nobles CL, Bushman FD, Parker KR, Qi Y, Satpathy AT, Chang HY, Zhao Y, Lacey SF, June CH.

Science. 2020 Feb 6. pii: eaba7365. doi: 10.1126/science.aba7365. [Epub ahead of print]


Disease risk and GVHD biomarkers can stratify patients for risk of relapse and nonrelapse mortality post hematopoietic cell transplant.

Aziz MD, Shah J, Kapoor U, Dimopoulos C, Anand S, Augustine A, Ayuk F, Chaudhry M, Chen YB, Choe HK, Etra A, Gergoudis S, Hartwell MJ, Hexner EO, Hogan WJ, Kitko CL, Kowalyk S, Kröger N, Merli P, Morales G, Nakamura R, Ordemann R, Pulsipher MA, Qayed M, Reshef R, Rösler W, Schechter T, Schreiner E, Srinagesh H, Wölfl M, Wudhikarn K, Yanik G, Young R, Özbek U, Ferrara JLM, Levine JE.

Leukemia. 2020 Feb 4. doi: 10.1038/s41375-020-0726-z. [Epub ahead of print]


GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder.

Young RC, Mulsant BH, Sajatovic M, Gildengers AG, Gyulai L, Al Jurdi RK, Beyer J, Evans J, Banerjee S, Greenberg R, Marino P, Kunik ME, Chen P, Barrett M, Schulberg HC, Bruce ML, Reynolds CF, Alexopoulos GS; GERI-BD Study Group.

Focus (Am Psychiatr Publ). 2019 Jul;17(3):314-321. doi: 10.1176/appi.focus.17308. Epub 2019 Jul 16. Review.


Prognostic and radiographic correlates of a prospectively collected molecularly profiled cohort of IDH1/2-wildtype astrocytomas.

Lin AL, Rosenblum M, Mellinghoff IK, Tabar VS, Ogilvie S, Schaff L, Yang TJ, Young RJ, Taylor BS, Jonsson P, Bale TA.

Brain Pathol. 2020 Jan 26. doi: 10.1111/bpa.12826. [Epub ahead of print]


Realising biaxial reinforcement via orientation-induced anisotropic swelling in graphene-based elastomers.

Liu M, Kinloch IA, Young RJ, Papageorgiou DG.

Nanoscale. 2020 Feb 7;12(5):3377-3386. doi: 10.1039/c9nr09988c. Epub 2020 Jan 27.


Bacteriophage P1 does not show spatial preference when infecting Escherichia coli.

Zhang K, Young R, Zeng L.

Virology. 2020 Mar;542:1-7. doi: 10.1016/j.virol.2019.12.012. Epub 2020 Jan 7.


Direction of the relationship between methamphetamine use and positive psychotic symptoms in regular methamphetamine users: evidence from a prospective cohort study.

Hides L, Chan G, Dawe S, McKetin R, Kavanagh DJ, Young RM, Teesson M, Saunders JB.

Br J Psychiatry. 2020 Jan 17:1-7. doi: 10.1192/bjp.2019.263. [Epub ahead of print]


Edible unclonable functions.

Leem JW, Kim MS, Choi SH, Kim SR, Kim SW, Song YM, Young RJ, Kim YL.

Nat Commun. 2020 Jan 16;11(1):328. doi: 10.1038/s41467-019-14066-5.


Frustrated Lewis-Pair-Meditated Selective Single Fluoride Substitution in Trifluoromethyl Groups.

Mandal D, Gupta R, Jaiswal AK, Young RD.

J Am Chem Soc. 2020 Feb 5;142(5):2572-2578. doi: 10.1021/jacs.9b12167. Epub 2020 Jan 23.


A Phase II Open Label Study of Everolimus in Combination With Endocrine Therapy in Resistant Hormone Receptor-Positive HER2-Negative Advanced Breast Cancer.

Yardley DA, Liggett W, Mainwaring M, Castrellon A, Blakely L, Hemphill B, Anz B 3rd, Young RR, Shastry M, DeBusk LM, Hainsworth JD, Burris HA 3rd.

Clin Breast Cancer. 2019 Jun 26. pii: S1526-8209(19)30164-8. doi: 10.1016/j.clbc.2019.06.005. [Epub ahead of print]


Mechanisms of mechanical reinforcement by graphene and carbon nanotubes in polymer nanocomposites.

Papageorgiou DG, Li Z, Liu M, Kinloch IA, Young RJ.

Nanoscale. 2020 Jan 28;12(4):2228-2267. doi: 10.1039/c9nr06952f. Epub 2020 Jan 13.


If Jeanne Calment Were 122, That Is All the More Reason for Biosampling.

Young R.

Rejuvenation Res. 2020 Feb;23(1):48-64. doi: 10.1089/rej.2020.2303.


Mycobacterium tuberculosis Decaprenylphosphoryl-β-d-ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity.

Borthwick JA, Alemparte C, Wall I, Whitehurst BC, Argyrou A, Burley G, de Dios-Anton P, Guijarro L, Monteiro MC, Ortega F, Suckling CJ, Pichel JC, Cacho M, Young RJ.

J Med Chem. 2020 Jan 22. doi: 10.1021/acs.jmedchem.9b01561. [Epub ahead of print]


Provision of Lipid-Based Nutrient Supplements to Mothers During Pregnancy and 6 Months Postpartum and to Their Infants from 6 to 18 Months Promotes Infant Gut Microbiota Diversity at 18 Months of Age but Not Microbiota Maturation in a Rural Malawian Setting: Secondary Outcomes of a Randomized Trial.

Kamng'ona AW, Young R, Arnold CD, Patson N, Jorgensen JM, Kortekangas E, Chaima D, Malamba C, Ashorn U, Cheung YB, Ashorn P, Maleta K, Dewey KG.

J Nutr. 2020 Jan 7. pii: nxz298. doi: 10.1093/jn/nxz298. [Epub ahead of print]


The mixed effects of a package of multilevel interventions on the health and care of pregnant women in Zinder, Niger.

Ouedraogo CT, Wessells KR, Young RR, Bamba IF, Faye MT, Banda N, Hess SY.

BMJ Glob Health. 2019 Dec 10;4(6):e001200. doi: 10.1136/bmjgh-2018-001200. eCollection 2019.


Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload.

Bartoli F, Bailey MA, Rode B, Mateo P, Antigny F, Bedouet K, Gerbaud P, Gosain R, Plante J, Norman K, Gomez S, Lefebvre F, Rucker-Martin C, Ainscough JFX, Kearney MT, Bruns AF, Shi J, Appleby HL, Young RS, Shawer HM, Debant M, Gomez AM, Beech DJ, Foster R, Benitah JP, Sabourin J.

Circulation. 2020 Jan 21;141(3):199-216. doi: 10.1161/CIRCULATIONAHA.118.038891. Epub 2020 Jan 7.


Captive-born collared peccaries learning about their predators: Lessons learnt but not remembered.

de Faria CM, de Souza Sá F, Lovenstain Costa DD, da Silva MM, da Silva BC, Young RJ, de Azevedo CS.

Behav Processes. 2020 Feb;171:104031. doi: 10.1016/j.beproc.2019.104031. Epub 2019 Dec 31.


Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma.

Tribble JR, Vasalauskaite A, Redmond T, Young RD, Hassan S, Fautsch MP, Sengpiel F, Williams PA, Morgan JE.

Brain Commun. 2019;1(1):fcz035. doi: 10.1093/braincomms/fcz035. Epub 2019 Nov 28.


Applying circuit theory and landscape linkage maps to reintroduction planning for California Condors.

D'Elia J, Brandt J, Burnett LJ, Haig SM, Hollenbeck J, Kirkland S, Marcot BG, Punzalan A, West CJ, Williams-Claussen T, Wolstenholme R, Young R.

PLoS One. 2019 Dec 31;14(12):e0226491. doi: 10.1371/journal.pone.0226491. eCollection 2019.


A framework for evaluating the impact of the IUCN Red List of threatened species.

Betts J, Young RP, Hilton-Taylor C, Hoffmann M, Rodríguez JP, Stuart SN, Milner-Gulland EJ.

Conserv Biol. 2019 Dec 25. doi: 10.1111/cobi.13454. [Epub ahead of print]


DCE-MRI perfusion predicts pseudoprogression in metastatic melanoma treated with immunotherapy.

Umemura Y, Wang D, Peck KK, Flynn J, Zhang Z, Fatovic R, Anderson ES, Beal K, Shoushtari AN, Kaley T, Young RJ.

J Neurooncol. 2020 Jan;146(2):339-346. doi: 10.1007/s11060-019-03379-6. Epub 2019 Dec 24.


18F-Fluorocholine PET uptake correlates with pathologic evidence of recurrent tumor after stereotactic radiosurgery for brain metastases.

Grkovski M, Kohutek ZA, Schöder H, Brennan CW, Tabar VS, Gutin PH, Zhang Z, Young RJ, Beattie BJ, Zanzonico PB, Huse JT, Rosenblum MK, Blasberg RG, Humm JL, Beal K.

Eur J Nucl Med Mol Imaging. 2019 Dec 21. doi: 10.1007/s00259-019-04628-6. [Epub ahead of print]


Gaps in terrestrial soundscape research: It's time to focus on tropical wildlife.

Scarpelli MDA, Ribeiro MC, Teixeira FZ, Young RJ, Teixeira CP.

Sci Total Environ. 2020 Mar 10;707:135403. doi: 10.1016/j.scitotenv.2019.135403. Epub 2019 Nov 23. Review.


In Vivo Bone Effects of a Novel Bisphosphonate-EP4a Conjugate Drug (C3) for Reversing Osteoporotic Bone Loss in an Ovariectomized Rat Model.

Sheikh Z, Chen G, Al-Jaf F, Thévenin M, Banks K, Glogauer M, Young RN, Grynpas MD.

JBMR Plus. 2019 Nov 9;3(12):e10237. doi: 10.1002/jbm4.10237. eCollection 2019 Dec.


Validation and characterisation of prognostically significant PD-L1+ immune cells in HPV+ oropharyngeal squamous cell carcinoma.

Young RJ, Bressel M, Porceddu S, Cernelc J, Savas P, Liu H, Urban D, Thai AA, Cooper C, Fua T, Neeson P, Rischin D, Solomon B.

Oral Oncol. 2020 Feb;101:104516. doi: 10.1016/j.oraloncology.2019.104516. Epub 2019 Dec 12.


Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation.

Young RM, Ewan KB, Ferrer VP, Allende ML, Godovac-Zimmermann J, Dale TC, Wilson SW.

Elife. 2019 Dec 12;8. pii: e51447. doi: 10.7554/eLife.51447.


ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry.

Wang L, Tan TK, Durbin AD, Zimmerman MW, Abraham BJ, Tan SH, Ngoc PCT, Weichert-Leahey N, Akahane K, Lawton LN, Rokita JL, Maris JM, Young RA, Look AT, Sanda T.

Nat Commun. 2019 Dec 9;10(1):5622. doi: 10.1038/s41467-019-13515-5.


The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease.

Srinagesh HK, Özbek U, Kapoor U, Ayuk F, Aziz M, Ben-David K, Choe HK, DeFilipp Z, Etra A, Grupp SA, Hartwell MJ, Hexner EO, Hogan WJ, Karol AB, Kasikis S, Kitko CL, Kowalyk S, Lin JY, Major-Monfried H, Mielke S, Merli P, Morales G, Ordemann R, Pulsipher MA, Qayed M, Reddy P, Reshef R, Rösler W, Sandhu KS, Schechter T, Shah J, Sigel K, Weber D, Wölfl M, Wudhikarn K, Young R, Levine JE, Ferrara JLM.

Blood Adv. 2019 Dec 10;3(23):4034-4042. doi: 10.1182/bloodadvances.2019000791.


Extinction filters mediate the global effects of habitat fragmentation on animals.

Betts MG, Wolf C, Pfeifer M, Banks-Leite C, Arroyo-Rodríguez V, Ribeiro DB, Barlow J, Eigenbrod F, Faria D, Fletcher RJ Jr, Hadley AS, Hawes JE, Holt RD, Klingbeil B, Kormann U, Lens L, Levi T, Medina-Rangel GF, Melles SL, Mezger D, Morante-Filho JC, Orme CDL, Peres CA, Phalan BT, Pidgeon A, Possingham H, Ripple WJ, Slade EM, Somarriba E, Tobias JA, Tylianakis JM, Urbina-Cardona JN, Valente JJ, Watling JI, Wells K, Wearn OR, Wood E, Young R, Ewers RM.

Science. 2019 Dec 6;366(6470):1236-1239. doi: 10.1126/science.aax9387.


Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production.

Budge JD, Knight TJ, Povey J, Roobol J, Brown IR, Singh G, Dean A, Turner S, Jaques CM, Young RJ, Racher AJ, Smales CM.

Metab Eng. 2020 Jan;57:203-216. doi: 10.1016/j.ymben.2019.11.007. Epub 2019 Dec 2.


Filling the Gap for Obsessive-Compulsive Disorder Services in Canada: Implementing an Intensive Care Program.

Taube-Schiff M, Rector NA, Young R, Larkin P, Richter MA.

J Nerv Ment Dis. 2020 Jan;208(1):38-47. doi: 10.1097/NMD.0000000000001075.


The phosphite oxidoreductase gene, ptxD as a bio-contained chloroplast marker and crop-protection tool for algal biotechnology using Chlamydomonas.

Changko S, Rajakumar PD, Young REB, Purton S.

Appl Microbiol Biotechnol. 2020 Jan;104(2):675-686. doi: 10.1007/s00253-019-10258-7. Epub 2019 Dec 2.


Impact of Plerixafor Use at Different Peripheral Blood CD34+ Thresholds on Autologous Stem Cell Collection in Patients with Multiple Myeloma.

Shah EE, Young RP, Wong SW, Damon LE, Wolf JL, Shah ND, Leavitt AD, Loeffler P, Martin TG 3rd.

Biol Blood Marrow Transplant. 2019 Nov 27. pii: S1083-8791(19)30830-4. doi: 10.1016/j.bbmt.2019.11.024. [Epub ahead of print]


The north is not all the same: comparing health system performance in 18 northern regions of Canada.

Young TK, Chatwood S, Ng C, Young RW, Marchildon GP.

Int J Circumpolar Health. 2019 Dec;78(1):1697474. doi: 10.1080/22423982.2019.1697474.


Telemedicine for Diabetic Retinopathy Screening in an Urban, Insured Population Using Fundus Cameras in a Primary Care Office Setting.

Martinez JA, Parikh PD, Wong RW, Harper CA, Dooner JW, Levitan M, Nixon PA, Young RC, Ghafoori SD.

Ophthalmic Surg Lasers Imaging Retina. 2019 Nov 1;50(11):e274-e277. doi: 10.3928/23258160-20191031-14.


Steric Interactions Impact Vibronic and Vibrational Coherences in Perylenediimide Cyclophanes.

Schultz JD, Coleman AF, Mandal A, Shin JY, Ratner MA, Young RM, Wasielewski MR.

J Phys Chem Lett. 2019 Dec 5;10(23):7498-7504. doi: 10.1021/acs.jpclett.9b02923. Epub 2019 Nov 25.


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