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Items: 1 to 50 of 337

1.

Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine.

Kharenko OA, Patel RG, Brown SD, Calosing C, White A, Lakshminarasimhan D, Suto RK, Duffy BC, Kitchen DB, McLure KG, Hansen HC, van der Horst EH, Young PR.

J Med Chem. 2018 Sep 27;61(18):8202-8211. doi: 10.1021/acs.jmedchem.8b00666. Epub 2018 Sep 13.

PMID:
30165024
2.

Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion.

Löber U, Hobbs M, Dayaram A, Tsangaras K, Jones K, Alquezar-Planas DE, Ishida Y, Meers J, Mayer J, Quedenau C, Chen W, Johnson RN, Timms P, Young PR, Roca AL, Greenwood AD.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8609-8614. doi: 10.1073/pnas.1807598115. Epub 2018 Aug 6.

3.

Communication Ambassadors-an Australian Social Media Initiative to Develop Communication Skills in Early Career Scientists.

Wang JTH, Power CJ, Kahler CM, Lyras D, Young PR, Iredell J, Robins-Browne R.

J Microbiol Biol Educ. 2018 Mar 30;19(1). pii: 19.1.25. doi: 10.1128/jmbe.v19i1.1428. eCollection 2018.

4.

Viral Entry and NS1 as Potential Antiviral Drug Targets.

de Silva AM, Rey FA, Young PR, Hilgenfeld R, Vasudevan SG.

Adv Exp Med Biol. 2018;1062:107-113. doi: 10.1007/978-981-10-8727-1_8. Review.

PMID:
29845528
5.

Plugging the Leak in Dengue Shock.

Watterson D, Modhiran N, Muller DA, Stacey KJ, Young PR.

Adv Exp Med Biol. 2018;1062:89-106. doi: 10.1007/978-981-10-8727-1_7. Review.

PMID:
29845527
6.

Arboviruses: A Family on the Move.

Young PR.

Adv Exp Med Biol. 2018;1062:1-10. doi: 10.1007/978-981-10-8727-1_1. Review.

PMID:
29845521
7.

Antibody-Binding, Antifouling Surface Coatings Based on Recombinant Expression of Zwitterionic EK Peptides.

Walker JA, Robinson KJ, Munro C, Gengenbach T, Muller DA, Young PR, Lua LHL, Corrie SR.

Langmuir. 2019 Feb 5;35(5):1266-1272. doi: 10.1021/acs.langmuir.8b00810. Epub 2018 Jun 19.

PMID:
29801414
8.

Cell division and turgor mediate enhanced plant growth in Arabidopsis plants treated with the bacterial signalling molecule lumichrome.

Pholo M, Coetzee B, Maree HJ, Young PR, Lloyd JR, Kossmann J, Hills PN.

Planta. 2018 Aug;248(2):477-488. doi: 10.1007/s00425-018-2916-8. Epub 2018 May 17.

PMID:
29777364
9.

Complete genome of Aedes aegypti anphevirus in the Aag2 mosquito cell line.

Di Giallonardo F, Audsley MD, Shi M, Young PR, McGraw EA, Holmes EC.

J Gen Virol. 2018 Jun;99(6):832-836. doi: 10.1099/jgv.0.001079. Epub 2018 May 9.

PMID:
29741476
10.

Multispecialty retrospective review of the clinical utility of pelvic magnetic resonance imaging in the setting of pelvic pain.

Moore JR, Pathak RA, Snowden C, Bolan CW, Young PR, Broderick GA.

Transl Androl Urol. 2017 Dec;6(6):1155-1158. doi: 10.21037/tau.2017.10.02.

11.

Structural and Functional Characterization of a Cross-Reactive Dengue Virus Neutralizing Antibody that Recognizes a Cryptic Epitope.

Li J, Watterson D, Chang CW, Che XY, Li XQ, Ericsson DJ, Qiu LW, Cai JP, Chen J, Fry SR, Cheung STM, Cooper MA, Young PR, Kobe B.

Structure. 2018 Jan 2;26(1):51-59.e4. doi: 10.1016/j.str.2017.11.017. Epub 2017 Dec 14.

12.

The Heptad Repeat C Domain of the Respiratory Syncytial Virus Fusion Protein Plays a Key Role in Membrane Fusion.

Bermingham IM, Chappell KJ, Watterson D, Young PR.

J Virol. 2018 Jan 30;92(4). pii: e01323-17. doi: 10.1128/JVI.01323-17. Print 2018 Feb 15.

13.

High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responses.

Muller DA, Fernando GJP, Owens NS, Agyei-Yeboah C, Wei JCJ, Depelsenaire ACI, Forster A, Fahey P, Weldon WC, Oberste MS, Young PR, Kendall MAF.

Sci Rep. 2017 Oct 3;7(1):12644. doi: 10.1038/s41598-017-13011-0.

14.

RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease.

Jahagirdar R, Attwell S, Marusic S, Bendele A, Shenoy N, McLure KG, Gilham D, Norek K, Hansen HC, Yu R, Tobin J, Wagner GS, Young PR, Wong NCW, Kulikowski E.

Mol Pharmacol. 2017 Dec;92(6):694-706. doi: 10.1124/mol.117.110379. Epub 2017 Sep 29.

PMID:
28974538
15.

Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children.

Brealey JC, Chappell KJ, Galbraith S, Fantino E, Gaydon J, Tozer S, Young PR, Holt PG, Sly PD.

Respirology. 2018 Feb;23(2):220-227. doi: 10.1111/resp.13179. Epub 2017 Sep 15.

PMID:
28913912
16.

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein.

Jaberolansar N, Chappell KJ, Watterson D, Bermingham IM, Toth I, Young PR, Skwarczynski M.

Sci Rep. 2017 Sep 11;7(1):11130. doi: 10.1038/s41598-017-10415-w.

17.

The Transcriptional Responses and Metabolic Consequences of Acclimation to Elevated Light Exposure in Grapevine Berries.

du Plessis K, Young PR, Eyéghé-Bickong HA, Vivier MA.

Front Plant Sci. 2017 Jul 20;8:1261. doi: 10.3389/fpls.2017.01261. eCollection 2017.

18.

Reduction of Zika virus infectivity in platelet concentrates after treatment with ultraviolet C light and in plasma after treatment with methylene blue and visible light.

Fryk JJ, Marks DC, Hobson-Peters J, Watterson D, Hall RA, Young PR, Reichenberg S, Tolksdorf F, Sumian C, Gravemann U, Seltsam A, Faddy HM.

Transfusion. 2017 Nov;57(11):2677-2682. doi: 10.1111/trf.14256. Epub 2017 Jul 17.

PMID:
28718518
19.

Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay.

Lebani K, Jones ML, Watterson D, Ranzoni A, Traves RJ, Young PR, Mahler SM.

PLoS One. 2017 Jul 6;12(7):e0180669. doi: 10.1371/journal.pone.0180669. eCollection 2017.

20.

Clinical and Laboratory Diagnosis of Dengue Virus Infection.

Muller DA, Depelsenaire AC, Young PR.

J Infect Dis. 2017 Mar 1;215(suppl_2):S89-S95. doi: 10.1093/infdis/jiw649. Review.

PMID:
28403441
21.

Computational Identification of Antibody Epitopes on the Dengue Virus NS1 Protein.

Jones ML, Legge FS, Lebani K, Mahler SM, Young PR, Watterson D, Treutlein HR, Zeng J.

Molecules. 2017 Apr 10;22(4). pii: E607. doi: 10.3390/molecules22040607.

22.

Impact of Direction of Unloading Influence on Template Rate of Perceived Exertion.

Greer BK, Young PR, Thompson B, Rickert BJ, Moran MF.

J Strength Cond Res. 2018 Dec;32(12):3398-3404. doi: 10.1519/JSC.0000000000001846.

PMID:
28346316
23.

Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6.

Modhiran N, Watterson D, Blumenthal A, Baxter AG, Young PR, Stacey KJ.

Immunol Cell Biol. 2017 May;95(5):491-495. doi: 10.1038/icb.2017.5. Epub 2017 Feb 21.

PMID:
28220810
24.

Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG.

Pyankov OV, Setoh YX, Bodnev SA, Edmonds JH, Pyankova OG, Pyankov SA, Pali G, Belford S, Lu L, La M, Lovrecz G, Volchkova VA, Chappell KJ, Watterson D, Marsh G, Young PR, Agafonov AA, Farmer JF, Volchkov VE, Suhrbier A, Khromykh AA.

Sci Rep. 2017 Feb 3;7:41537. doi: 10.1038/srep41537.

25.

Investigating the Effect of Substrate Materials on Wearable Immunoassay Performance.

Lee KT, Coffey JW, Robinson KJ, Muller DA, Grøndahl L, Kendall MA, Young PR, Corrie SR.

Langmuir. 2017 Jan 24;33(3):773-782. doi: 10.1021/acs.langmuir.6b03933. Epub 2017 Jan 11.

PMID:
28006902
26.

Product release is rate-limiting for catalytic processing by the Dengue virus protease.

Shannon AE, Pedroso MM, Chappell KJ, Watterson D, Liebscher S, Kok WM, Fairlie DP, Schenk G, Young PR.

Sci Rep. 2016 Nov 29;6:37539. doi: 10.1038/srep37539.

27.

Phylogenetic Diversity of Koala Retrovirus within a Wild Koala Population.

Chappell KJ, Brealey JC, Amarilla AA, Watterson D, Hulse L, Palmieri C, Johnston SD, Holmes EC, Meers J, Young PR.

J Virol. 2017 Jan 18;91(3). pii: e01820-16. doi: 10.1128/JVI.01820-16. Print 2017 Feb 1.

28.

Impact of Minimally Invasive Benign Prostatic Hyperplasia Therapies on 30- and 90-Day Postoperative Office Encounters.

Pathak RA, Broderick GA, Igel TC, Petrou SP, Young PR, Wehle MJ, Heckman MG, Diehl NN, Vargas ER, Shah K, Thiel DD.

Urology. 2017 Jan;99:186-191. doi: 10.1016/j.urology.2016.10.015. Epub 2016 Oct 19.

PMID:
27771424
29.

Riboflavin and ultraviolet light: impact on dengue virus infectivity.

Faddy HM, Fryk JJ, Watterson D, Young PR, Modhiran N, Muller DA, Keil SD, Goodrich RP, Marks DC.

Vox Sang. 2016 Oct;111(3):235-241. doi: 10.1111/vox.12414. Epub 2016 Jun 9.

PMID:
27281512
30.

Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes.

Wasiak S, Gilham D, Tsujikawa LM, Halliday C, Norek K, Patel RG, McLure KG, Young PR, Gordon A, Kulikowski E, Johansson J, Sweeney M, Wong NC.

Data Brief. 2016 Jul 29;8:1280-8. doi: 10.1016/j.dib.2016.07.047. eCollection 2016 Sep.

31.

How Can the Health System Retain Women in HIV Treatment for a Lifetime? A Discrete Choice Experiment in Ethiopia and Mozambique.

Kruk ME, Riley PL, Palma AM, Adhikari S, Ahoua L, Arnaldo C, Belo DF, Brusamento S, Cumba LI, Dziuban EJ, El-Sadr WM, Gutema Y, Habtamu Z, Heller T, Kidanu A, Langa J, Mahagaja E, McCarthy CF, Melaku Z, Shodell D, Tsiouris F, Young PR, Rabkin M.

PLoS One. 2016 Aug 23;11(8):e0160764. doi: 10.1371/journal.pone.0160764. eCollection 2016.

32.

Dengue and chikungunya viruses in plasma are effectively inactivated after treatment with methylene blue and visible light.

Fryk JJ, Marks DC, Hobson-Peters J, Prow NA, Watterson D, Hall RA, Young PR, Reichenberg S, Sumian C, Faddy HM.

Transfusion. 2016 Sep;56(9):2278-85. doi: 10.1111/trf.13729. Epub 2016 Jul 25.

PMID:
27456861
33.

Field-Grown Grapevine Berries Use Carotenoids and the Associated Xanthophyll Cycles to Acclimate to UV Exposure Differentially in High and Low Light (Shade) Conditions.

Joubert C, Young PR, Eyéghé-Bickong HA, Vivier MA.

Front Plant Sci. 2016 Jun 10;7:786. doi: 10.3389/fpls.2016.00786. eCollection 2016.

34.

RVX-297- a novel BD2 selective inhibitor of BET bromodomains.

Kharenko OA, Gesner EM, Patel RG, Norek K, White A, Fontano E, Suto RK, Young PR, McLure KG, Hansen HC.

Biochem Biophys Res Commun. 2016 Aug 12;477(1):62-7. doi: 10.1016/j.bbrc.2016.06.021. Epub 2016 Jun 6.

PMID:
27282480
35.

Notice of Retraction and Replacement. Hollon et al. Effect of cognitive therapy with antidepressant medications vs antidepressants alone on the rate of recovery in major depressive disorder: a randomized clinical trial. JAMA Psychiatry. 2014;71(10):1157-1164.

Hollon SD, DeRubeis RJ, Fawcett J, Amsterdam JD, Shelton RC, Zajecka J, Young PR, Gallop R.

JAMA Psychiatry. 2016 Jun 1;73(6):639-40. doi: 10.1001/jamapsychiatry.2016.0756. No abstract available.

36.

The NPC2 protein: A novel dog allergen.

Khurana T, Newman-Lindsay S, Young PR, Slater JE.

Ann Allergy Asthma Immunol. 2016 May;116(5):440-446.e2. doi: 10.1016/j.anai.2016.02.006. Epub 2016 Mar 17.

PMID:
26995145
37.

A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance.

Watterson D, Robinson J, Chappell KJ, Butler MS, Edwards DJ, Fry SR, Bermingham IM, Cooper MA, Young PR.

Sci Rep. 2016 Mar 15;6:22791. doi: 10.1038/srep22791.

38.

The many faces of the flavivirus NS1 protein offer a multitude of options for inhibitor design.

Watterson D, Modhiran N, Young PR.

Antiviral Res. 2016 Jun;130:7-18. doi: 10.1016/j.antiviral.2016.02.014. Epub 2016 Mar 2. Review.

PMID:
26944216
39.

Inactivation of dengue, chikungunya, and Ross River viruses in platelet concentrates after treatment with ultraviolet C light.

Faddy HM, Fryk JJ, Prow NA, Watterson D, Young PR, Hall RA, Tolksdorf F, Sumian C, Gravemann U, Seltsam A, Marks DC.

Transfusion. 2016 Jun;56(6 Pt 2):1548-55. doi: 10.1111/trf.13519. Epub 2016 Mar 1.

PMID:
26926832
40.

Inactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responses.

Muller DA, Pearson FE, Fernando GJ, Agyei-Yeboah C, Owens NS, Corrie SR, Crichton ML, Wei JC, Weldon WC, Oberste MS, Young PR, Kendall MA.

Sci Rep. 2016 Feb 25;6:22094. doi: 10.1038/srep22094.

42.

Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.

Shannon AE, Chappell KJ, Stoermer MJ, Chow SY, Kok WM, Fairlie DP, Young PR.

Protein Expr Purif. 2016 Mar;119:124-9. doi: 10.1016/j.pep.2015.11.022. Epub 2015 Dec 2.

PMID:
26647367
43.

Grapevine Plasticity in Response to an Altered Microclimate: Sauvignon Blanc Modulates Specific Metabolites in Response to Increased Berry Exposure.

Young PR, Eyeghe-Bickong HA, du Plessis K, Alexandersson E, Jacobson DA, Coetzee Z, Deloire A, Vivier MA.

Plant Physiol. 2016 Mar;170(3):1235-54. doi: 10.1104/pp.15.01775. Epub 2015 Dec 1.

44.

Urologic-Induced Complications of Prophylactic Ureteral Localization Stent Placement for Colorectal Surgery Cases.

Pathak RA, Taylor AS, Alford S, Broderick GA, Igel TC, Petrou SP, Wehle MJ, Young PR, Thiel DD.

J Laparoendosc Adv Surg Tech A. 2015 Dec;25(12):966-70. doi: 10.1089/lap.2015.0345. Epub 2015 Nov 19.

PMID:
26583763
45.

Recent advances in the development of subunit-based RSV vaccines.

Jaberolansar N, Toth I, Young PR, Skwarczynski M.

Expert Rev Vaccines. 2016;15(1):53-68. doi: 10.1586/14760584.2016.1105134. Epub 2015 Oct 27. Review.

PMID:
26506139
46.

Comparison between polyethylene glycol and zwitterionic polymers as antifouling coatings on wearable devices for selective antigen capture from biological tissue.

Robinson KJ, Coffey JW, Muller DA, Young PR, Kendall MA, Thurecht KJ, Grøndahl L, Corrie SR.

Biointerphases. 2015 Dec 7;10(4):04A305. doi: 10.1116/1.4932055.

PMID:
26446192
47.

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity.

Modhiran N, Watterson D, Muller DA, Panetta AK, Sester DP, Liu L, Hume DA, Stacey KJ, Young PR.

Sci Transl Med. 2015 Sep 9;7(304):304ra142. doi: 10.1126/scitranslmed.aaa3863.

PMID:
26355031
48.

A rapid qualitative and quantitative evaluation of grape berries at various stages of development using Fourier-transform infrared spectroscopy and multivariate data analysis.

Musingarabwi DM, Nieuwoudt HH, Young PR, Eyéghè-Bickong HA, Vivier MA.

Food Chem. 2016 Jan 1;190:253-262. doi: 10.1016/j.foodchem.2015.05.080. Epub 2015 May 18.

PMID:
26212968
49.

Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.

Duffy BC, Liu S, Martin GS, Wang R, Hsia MM, Zhao H, Guo C, Ellis M, Quinn JF, Kharenko OA, Norek K, Gesner EM, Young PR, McLure KG, Wagner GS, Lakshminarasimhan D, White A, Suto RK, Hansen HC, Kitchen DB.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2818-23. doi: 10.1016/j.bmcl.2015.04.107. Epub 2015 May 11.

PMID:
26022843
50.

The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation.

Setoh YX, Tan CS, Prow NA, Hobson-Peters J, Young PR, Khromykh AA, Hall RA.

Virol J. 2015 May 7;12:72. doi: 10.1186/s12985-015-0303-7.

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