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Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.

Fujii T, Luethi N, Young PJ, Frei DR, Eastwood GM, French CJ, Deane AM, Shehabi Y, Hajjar LA, Oliveira G, Udy AA, Orford N, Edney SJ, Hunt AL, Judd HL, Bitker L, Cioccari L, Naorungroj T, Yanase F, Bates S, McGain F, Hudson EP, Al-Bassam W, Dwivedi DB, Peppin C, McCracken P, Orosz J, Bailey M, Bellomo R; VITAMINS Trial Investigators.

JAMA. 2020 Jan 17. doi: 10.1001/jama.2019.22176. [Epub ahead of print]


Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial.

PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group, Young PJ, Bagshaw SM, Forbes AB, Nichol AD, Wright SE, Bailey M, Bellomo R, Beasley R, Brickell K, Eastwood GM, Gattas DJ, van Haren F, Litton E, Mackle DM, McArthur CJ, McGuinness SP, Mouncey PR, Navarra L, Opgenorth D, Pilcher D, Saxena MK, Webb SA, Wiley D, Rowan KM.

JAMA. 2020 Jan 17. doi: 10.1001/jama.2019.22190. [Epub ahead of print]


O2, do we know what to do?

Young PJ, Bagshaw SM, Bailey M, Bellomo R, Mackle D, Pilcher D, Landoni G, Nichol A, Martin D.

Crit Care Resusc. 2019 Dec;21(4):230-32. No abstract available.


Vitamin C therapy for patients with sepsis or septic shock: a protocol for a systematic review and a network meta-analysis.

Fujii T, Belletti A, Carr A, Furukawa TA, Luethi N, Putzu A, Sartini C, Salanti G, Tsujimoto Y, Udy AA, Young PJ, Bellomo R.

BMJ Open. 2019 Nov 12;9(11):e033458. doi: 10.1136/bmjopen-2019-033458.


Randomised evaluation of active control of temperature versus ordinary temperature management (REACTOR) trial.

Young PJ, Bailey MJ, Bass F, Beasley RW, Freebairn RC, Hammond NE, van Haren FMP, Harward ML, Henderson SJ, Mackle DM, McArthur CJ, McGuinness SP, Myburgh JA, Saxena MK, Turner AM, Webb SAR, Bellomo R; REACTOR investigators; ANZICS Clinical Trials Group.

Intensive Care Med. 2019 Oct;45(10):1382-1391. doi: 10.1007/s00134-019-05729-4. Epub 2019 Oct 1.


A Pilot, Double-Blind, Randomized, Controlled Trial of High-Dose Intravenous Vitamin C for Vasoplegia After Cardiac Surgery.

Yanase F, Bitker L, Hessels L, Osawa E, Naorungroj T, Cutuli SL, Young PJ, Ritzema J, Hill G, Latimer-Bell C, Hunt A, Eastwood GM, Hilton A, Bellomo R.

J Cardiothorac Vasc Anesth. 2020 Feb;34(2):409-416. doi: 10.1053/j.jvca.2019.08.034. Epub 2019 Aug 24.


The Risk of Hyperoxemia in ICU Patients. Much Ado About O2.

Young PJ, Bellomo R.

Am J Respir Crit Care Med. 2019 Dec 1;200(11):1333-1335. doi: 10.1164/rccm.201909-1751ED. No abstract available.


Balanced Crystalloids or 0.9% Saline in Sepsis. Beyond Reasonable Doubt?

Young PJ.

Am J Respir Crit Care Med. 2019 Dec 15;200(12):1456-1458. doi: 10.1164/rccm.201908-1669ED. No abstract available.


Preventing Colonization by Lung Isolation: Primum Non Nocere.

Young PJ.

Respir Care. 2019 Sep;64(9):1170-1172. doi: 10.4187/respcare.07340. No abstract available.


Interview date trends for dermatology residency from 2012-2017.

Kwon CD, Liao RS, Young PJ, Lee AH, Zuo RC, Yi PH, Grossberg AL.

Dermatol Online J. 2019 May 15;25(5). pii: 13030/qt4pr742jj.


When less is more in the active management of elevated body temperature of ICU patients.

Young PJ, Prescott HC.

Intensive Care Med. 2019 Sep;45(9):1275-1278. doi: 10.1007/s00134-019-05668-0. Epub 2019 Jun 19. No abstract available.


A pathway for bed-side innovation.

Young PJ.

Anaesthesia. 2019 Nov;74(11):1357-1360. doi: 10.1111/anae.14725. Epub 2019 Jun 3. No abstract available.


Vitamin C, Hydrocortisone and Thiamine in Patients with Septic Shock (VITAMINS) trial: study protocol and statistical analysis plan.

Fujii T, Udy AA, Deane AM, Luethi N, Bailey M, Eastwood GM, Frei D, French C, Orford N, Shehabi Y, Young PJ, Bellomo R; VITAMINS trial investigators.

Crit Care Resusc. 2019 Jun;21(2):119-125.


Is sepsis treatment heating up?

Young PJ.

Crit Care Resusc. 2019 Jun;21(2):85-86. No abstract available.


Practice patterns and perceptions of Australian and New Zealand anaesthetists towards perioperative oxygen therapy.

Frei DR, Beasley R, Campbell D, Leslie K, Merry AF, Moore M, Myles PS, Ruawai-Hamilton L, Short TG, Young PJ.

Anaesth Intensive Care. 2019 May;47(3):288-294. doi: 10.1177/0310057X19842245. Epub 2019 May 24. No abstract available.


Vasopressin in septic shock: what we know and where to next?

Young PJ, Delaney A, Venkatesh B.

Intensive Care Med. 2019 Jun;45(6):902-903. doi: 10.1007/s00134-019-05642-w. Epub 2019 May 13. No abstract available.


Climate policy implications of nonlinear decline of Arctic land permafrost and other cryosphere elements.

Yumashev D, Hope C, Schaefer K, Riemann-Campe K, Iglesias-Suarez F, Jafarov E, Burke EJ, Young PJ, Elshorbany Y, Whiteman G.

Nat Commun. 2019 Apr 23;10(1):1900. doi: 10.1038/s41467-019-09863-x.


Preventing lives affected by hemophilia: A mixed methods study of the views of adults with hemophilia and their families toward genetic screening.

Boardman FK, Hale R, Gohel R, Young PJ.

Mol Genet Genomic Med. 2019 May;7(5):e618. doi: 10.1002/mgg3.618. Epub 2019 Mar 5.


Newborn screening for haemophilia: The views of families and adults living with haemophilia in the UK.

Boardman FK, Hale R, Young PJ.

Haemophilia. 2019 Mar;25(2):276-282. doi: 10.1111/hae.13706. Epub 2019 Feb 28.


Ozone-climate interactions and effects on solar ultraviolet radiation.

Bais AF, Bernhard G, McKenzie RL, Aucamp PJ, Young PJ, Ilyas M, Jöckel P, Deushi M.

Photochem Photobiol Sci. 2019 Mar 1;18(3):602-640. doi: 10.1039/c8pp90059k. Epub 2019 Feb 27.


Fever control in critically ill adults. An individual patient data meta-analysis of randomised controlled trials.

Young PJ, Bellomo R, Bernard GR, Niven DJ, Schortgen F, Saxena M, Beasley R, Weatherall M.

Intensive Care Med. 2019 Apr;45(4):468-476. doi: 10.1007/s00134-019-05553-w. Epub 2019 Feb 11.


Unintentional endotracheal tube cuff deflation during routine checks: a simulation study.

Patel V, Hodges EJ, Mariyaselvam MZ, Peutherer C, Young PJ.

Nurs Crit Care. 2019 Mar;24(2):83-88. doi: 10.1111/nicc.12397. Epub 2018 Dec 2.


What should we target after TARGET?

Young PJ, Bellomo R, Chapman MJ, Deane AM, Peake SL.

Crit Care Resusc. 2018 Dec;20(4):252-253. No abstract available.


When Checklists Fail: Human Factors Learning from Aviation and Safety by Design.

Mariyaselvam MZA, Young PJ.

Anesthesiology. 2018 Dec;129(6):1192-1193. doi: 10.1097/ALN.0000000000002470. No abstract available.


Mean arterial pressure and mortality in patients with distributive shock: a retrospective analysis of the MIMIC-III database.

Vincent JL, Nielsen ND, Shapiro NI, Gerbasi ME, Grossman A, Doroff R, Zeng F, Young PJ, Russell JA.

Ann Intensive Care. 2018 Nov 8;8(1):107. doi: 10.1186/s13613-018-0448-9.


Why do multicenter randomized controlled trials not confirm the positive findings of single center randomized controlled trials in acute care?

Landoni G, Pieri M, Young PJ, Bellomo R.

Minerva Anestesiol. 2019 Feb;85(2):194-200. doi: 10.23736/S0375-9393.18.13070-7. Epub 2018 Oct 30.


Drought-induced Amazonian wildfires instigate a decadal-scale disruption of forest carbon dynamics.

Silva CVJ, Aragão LEOC, Barlow J, Espirito-Santo F, Young PJ, Anderson LO, Berenguer E, Brasil I, Foster Brown I, Castro B, Farias R, Ferreira J, França F, Graça PMLA, Kirsten L, Lopes AP, Salimon C, Scaranello MA, Seixas M, Souza FC, Xaud HAM.

Philos Trans R Soc Lond B Biol Sci. 2018 Oct 8;373(1760). pii: 20180043. doi: 10.1098/rstb.2018.0043.


Oxygen therapy in acute resuscitation.

Frei DR, Young PJ.

Curr Opin Crit Care. 2018 Dec;24(6):506-511. doi: 10.1097/MCC.0000000000000549. Review.


Body temperature measurement methods and targets in Australian and New Zealand intensive care units.

Cutuli SL, Osawa EA, Glassford NJ, Marshall D, Eyeington CT, Eastwood GM, Young PJ, Bellomo R.

Crit Care Resusc. 2018 Sep;20(3):241-244.


A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol.

Young PJ, Bagshaw SM, Forbes A, Nichol A, Wright SE, Bellomo R, Bailey MJ, Beasley RW, Eastwood GM, Festa M, Gattas D, van Haren F, Litton E, Mouncey PR, Navarra L, Pilcher D, Mackle DM, McArthur CJ, McGuinness SP, Saxena MK, Webb S, Rowan KM; Australian and New Zealand Intensive Care Society Clinical Trials Group on behalf of the PEPTIC investigators.

Crit Care Resusc. 2018 Sep;20(3):182-189.


Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery.

Mazer CD, Whitlock RP, Fergusson DA, Belley-Cote E, Connolly K, Khanykin B, Gregory AJ, de Médicis É, Carrier FM, McGuinness S, Young PJ, Byrne K, Villar JC, Royse A, Grocott HP, Seeberger MD, Mehta C, Lellouche F, Hare GMT, Painter TW, Fremes S, Syed S, Bagshaw SM, Hwang NC, Royse C, Hall J, Dai D, Mistry N, Thorpe K, Verma S, Jüni P, Shehata N; TRICS Investigators and Perioperative Anesthesia Clinical Trials Group.

N Engl J Med. 2018 Sep 27;379(13):1224-1233. doi: 10.1056/NEJMoa1808561. Epub 2018 Aug 26.


The future of hyperdiverse tropical ecosystems.

Barlow J, França F, Gardner TA, Hicks CC, Lennox GD, Berenguer E, Castello L, Economo EP, Ferreira J, Guénard B, Gontijo Leal C, Isaac V, Lees AC, Parr CL, Wilson SK, Young PJ, Graham NAJ.

Nature. 2018 Jul;559(7715):517-526. doi: 10.1038/s41586-018-0301-1. Epub 2018 Jul 25. Review.


In Reply.

Mariyaselvam MZA, Young PJ.

Anesthesiology. 2018 Aug;129(2):372-373. doi: 10.1097/ALN.0000000000002310. No abstract available.


Accidental dual humidification in intensive care units: Repeated alerts and system changes are not enough.

Patel V, Mariyaselvam MZA, Peutherer C, Young PJ.

J Crit Care. 2018 Oct;47:159-163. doi: 10.1016/j.jcrc.2018.06.024. Epub 2018 Jun 30.


Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis.

Chu DK, Kim LH, Young PJ, Zamiri N, Almenawer SA, Jaeschke R, Szczeklik W, Schünemann HJ, Neary JD, Alhazzani W.

Lancet. 2018 Apr 28;391(10131):1693-1705. doi: 10.1016/S0140-6736(18)30479-3. Epub 2018 Apr 26. Review.


A two centre observational study of simultaneous pulse oximetry and arterial oxygen saturation recordings in intensive care unit patients.

Ebmeier SJ, Barker M, Bacon M, Beasley RC, Bellomo R, Knee Chong C, Eastwood GM, Gilchrist J, Kagaya H, Pilcher J, Reddy SK, Ridgeon E, Sarma N, Sprogis S, Tanaka A, Tweedie M, Weatherall M, Young PJ.

Anaesth Intensive Care. 2018 May;46(3):297-303. Erratum in: Anaesth Intensive Care. 2018 Jul;46(4):432.


A Modified Tie Technique for Securing Endotracheal Tubes.

Walters HR, Young HE, Young PJ.

Respir Care. 2018 Apr;63(4):424-429. doi: 10.4187/respcare.05655. Epub 2018 Mar 6.


Protocol summary and statistical analysis plan for the intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX).

Mackle DM, Bailey MJ, Beasley RW, Bellomo R, Bennett VL, Deane AM, Eastwood GM, Finfer S, Freebairn RC, Litton E, Linke NJ, McArthur CJ, McGuinness SP, Panwar R, Young PJ; Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Resusc. 2018 Mar;20(1):22-32.


Intensive care unit randomised trial comparing two approaches to oxygen therapy (ICU-ROX): results of the pilot phase.

Young PJ, Mackle DM, Bailey MJ, Beasley RW, Bennett VL, Deane AM, Eastwood GM, Finfer S, Freebairn RC, Litton E, Linke NJ, McArthur CJ, McGuinness SP, Panwar R, Bellomo R; The ICU-ROX pilot investigators ; The Australian and New Zealand Intensive Care Society Clinical Trials Group .

Crit Care Resusc. 2017 Dec;19(4):344-354.


Learning Healthcare Systems Will Protect Patients from Unscientific Practice Variation.

Young PJ.

Ann Am Thorac Soc. 2018 Feb;15(2):131-133. doi: 10.1513/AnnalsATS.201709-717IP. No abstract available.


Newborn genetic screening for spinal muscular atrophy in the UK: The views of the general population.

Boardman FK, Sadler C, Young PJ.

Mol Genet Genomic Med. 2018 Jan;6(1):99-108. doi: 10.1002/mgg3.353. Epub 2017 Nov 23.


Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery.

Mazer CD, Whitlock RP, Fergusson DA, Hall J, Belley-Cote E, Connolly K, Khanykin B, Gregory AJ, de Médicis É, McGuinness S, Royse A, Carrier FM, Young PJ, Villar JC, Grocott HP, Seeberger MD, Fremes S, Lellouche F, Syed S, Byrne K, Bagshaw SM, Hwang NC, Mehta C, Painter TW, Royse C, Verma S, Hare GMT, Cohen A, Thorpe KE, Jüni P, Shehata N; TRICS Investigators and Perioperative Anesthesia Clinical Trials Group.

N Engl J Med. 2017 Nov 30;377(22):2133-2144. doi: 10.1056/NEJMoa1711818. Epub 2017 Nov 12.


Fever control.

Young PJ, Nielsen N, Saxena M.

Intensive Care Med. 2018 Feb;44(2):227-230. doi: 10.1007/s00134-017-4969-8. Epub 2017 Oct 22. No abstract available.


Preventing Retained Central Venous Catheter Guidewires: A Randomized Controlled Simulation Study Using a Human Factors Approach.

Mariyaselvam MZA, Catchpole KR, Menon DK, Gupta AK, Young PJ.

Anesthesiology. 2017 Oct;127(4):658-665. doi: 10.1097/ALN.0000000000001797.


Probing Interligand Electron Transfer in the 1MLCT S1 Excited State of trans-Mo2L2L'2 Compounds: A Comparative Study of Auxiliary Ligands and Solvents.

Jiang C, Young PJ, Brown-Xu SE, Kender WT, Hamilton EJM, Gallucci JC, Chisholm MH.

Inorg Chem. 2017 Aug 21;56(16):9660-9668. doi: 10.1021/acs.inorgchem.7b01164. Epub 2017 Aug 7.


Effect of 0.9% Saline or Plasma-Lyte 148 as Crystalloid Fluid Therapy in the Intensive Care Unit on Blood Product Use and Postoperative Bleeding After Cardiac Surgery.

Reddy SK, Bailey MJ, Beasley RW, Bellomo R, Mackle DM, Psirides AJ, Young PJ.

J Cardiothorac Vasc Anesth. 2017 Oct;31(5):1630-1638. doi: 10.1053/j.jvca.2017.04.023. Epub 2017 Apr 15.


The role of experiential knowledge within attitudes towards genetic carrier screening: A comparison of people with and without experience of spinal muscular atrophy.

Boardman FK, Young PJ, Warren O, Griffiths FE.

Health Expect. 2018 Feb;21(1):201-211. doi: 10.1111/hex.12602. Epub 2017 Jul 13.


Impairment Experiences, Identity and Attitudes Towards Genetic Screening: the Views of People with Spinal Muscular Atrophy.

Boardman FK, Young PJ, Griffiths FE.

J Genet Couns. 2018 Feb;27(1):69-84. doi: 10.1007/s10897-017-0122-7. Epub 2017 Jun 30.


Effect sizes in ongoing randomized controlled critical care trials.

Ridgeon EE, Bellomo R, Aberegg SK, Sweeney RM, Varughese RS, Landoni G, Young PJ.

Crit Care. 2017 Jun 5;21(1):132. doi: 10.1186/s13054-017-1726-x. Review.


Angiotensin II for the Treatment of Vasodilatory Shock.

Khanna A, English SW, Wang XS, Ham K, Tumlin J, Szerlip H, Busse LW, Altaweel L, Albertson TE, Mackey C, McCurdy MT, Boldt DW, Chock S, Young PJ, Krell K, Wunderink RG, Ostermann M, Murugan R, Gong MN, Panwar R, Hästbacka J, Favory R, Venkatesh B, Thompson BT, Bellomo R, Jensen J, Kroll S, Chawla LS, Tidmarsh GF, Deane AM; ATHOS-3 Investigators.

N Engl J Med. 2017 Aug 3;377(5):419-430. doi: 10.1056/NEJMoa1704154. Epub 2017 May 21.

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