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Items: 1 to 50 of 485

1.

Long noncoding RNAs of single hematopoietic stem and progenitor cells in healthy and dysplastic human bone marrow.

Wu Z, Gao S, Zhao X, Chen J, Keyvanfar K, Feng X, Kajigaya S, Young NS.

Haematologica. 2018 Dec 13. pii: haematol.2018.208926. doi: 10.3324/haematol.2018.208926. [Epub ahead of print]

2.

Pathogenic TERT promoter variants in telomere diseases.

Gutierrez-Rodrigues F, Donaires FS, Pinto A, Vicente A, Dillon LW, Clé DV, Santana BA, Pirooznia M, Ibanez MDPF, Townsley DM, Kajigaya S, Hourigan CS, Cooper JN, Calado RT, Young NS.

Genet Med. 2018 Dec 7. doi: 10.1038/s41436-018-0385-x. [Epub ahead of print]

PMID:
30523342
3.

Macrophage TNF-α licenses donor T cells in murine bone marrow failure and can be implicated in human aplastic anemia.

Sun W, Wu Z, Lin Z, Hollinger M, Chen J, Feng X, Young NS.

Blood. 2018 Dec 27;132(26):2730-2743. doi: 10.1182/blood-2018-05-844928. Epub 2018 Oct 25.

PMID:
30361263
4.

Aplastic Anemia.

Young NS.

N Engl J Med. 2018 Oct 25;379(17):1643-1656. doi: 10.1056/NEJMra1413485. Review. No abstract available.

PMID:
30354958
5.

Interleukin-18 plays a dispensable role in murine and likely also human bone marrow failure.

Wu Z, Giudice V, Chen J, Sun W, Lin Z, Keyvanfar K, Talasani N, Kajigaya S, Feng X, Young NS.

Exp Hematol. 2019 Jan;69:54-64.e2. doi: 10.1016/j.exphem.2018.10.003. Epub 2018 Oct 12.

PMID:
30316805
6.

Aptamer-based proteomics of serum and plasma in acquired aplastic anemia.

Giudice V, Biancotto A, Wu Z, Cheung F, Candia J, Fantoni G, Kajigaya S, Rios O, Townsley D, Feng X, Young NS.

Exp Hematol. 2018 Dec;68:38-50. doi: 10.1016/j.exphem.2018.09.008. Epub 2018 Oct 9.

PMID:
30312735
7.

Donor-derived MDS/AML in families with germline GATA2 mutation.

Galera P, Hsu AP, Wang W, Droll S, Chen R, Schwartz JR, Klco JM, Arai S, Maese L, Zerbe C, Parta MJ, Young NS, Holland SM, Hickstein DD, Calvo KR.

Blood. 2018 Nov 1;132(18):1994-1998. doi: 10.1182/blood-2018-07-861070. Epub 2018 Sep 19. No abstract available.

PMID:
30232126
8.

Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria Detection.

Dulau-Florea AE, Young NS, Maric I, Calvo KR, Dunbar CE, Townsley DM, Winkler T, Monreal M, Jiang C, Jordan EK, Braylan RC.

Am J Clin Pathol. 2018 Jul 5. doi: 10.1093/ajcp/aqy053. [Epub ahead of print]

PMID:
29982419
9.

Circulating S100A8 and S100A9 protein levels in plasma of patients with acquired aplastic anemia and myelodysplastic syndromes.

Giudice V, Wu Z, Kajigaya S, Fernandez Ibanez MDP, Rios O, Cheung F, Ito S, Young NS.

Cytokine. 2019 Jan;113:462-465. doi: 10.1016/j.cyto.2018.06.025. Epub 2018 Jun 27.

10.

Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes.

Giudice V, Banaszak LG, Gutierrez-Rodrigues F, Kajigaya S, Panjwani R, Ibanez MDPF, Rios O, Bleck CK, Stempinski ES, Raffo DQ, Townsley DM, Young NS.

Haematologica. 2018 Jul;103(7):1150-1159. doi: 10.3324/haematol.2017.182824. Epub 2018 Apr 19.

11.

Eltrombopag mobilizes iron in patients with aplastic anemia.

Zhao Z, Sun Q, Sokoll LJ, Streiff M, Cheng Z, Grasmeder S, Townsley DM, Young NS, Dunbar CE, Winkler T.

Blood. 2018 May 24;131(21):2399-2402. doi: 10.1182/blood-2018-01-826784. Epub 2018 Apr 9. No abstract available. Erratum in: Blood. 2018 Jul 26;132(4):459.

PMID:
29632023
12.

CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation.

Wu ZJ, Zhao X, Banaszak LG, Gutierrez-Rodrigues F, Keyvanfar K, Gao SG, Quinones Raffo D, Kajigaya S, Young NS.

Int J Oncol. 2018 Apr;52(4):1209-1223. doi: 10.3892/ijo.2018.4290. Epub 2018 Feb 28.

13.

PD-1 deficiency augments bone marrow failure in a minor-histocompatibility antigen mismatch lymphocyte infusion model.

Hollinger MK, Giudice V, Cummings NA, Rivell G, Zhang H, Kajigaya S, Keyvanfar K, Chen J, Feng X, Young NS.

Exp Hematol. 2018 Jun;62:17-23. doi: 10.1016/j.exphem.2018.03.001. Epub 2018 Mar 7.

PMID:
29524567
14.

Deep sequencing and flow cytometric characterization of expanded effector memory CD8+CD57+ T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia.

Giudice V, Feng X, Lin Z, Hu W, Zhang F, Qiao W, Ibanez MDPF, Rios O, Young NS.

Haematologica. 2018 May;103(5):759-769. doi: 10.3324/haematol.2017.176701. Epub 2018 Feb 1.

15.

Heterozygous RTEL1 variants in bone marrow failure and myeloid neoplasms.

Marsh JCW, Gutierrez-Rodrigues F, Cooper J, Jiang J, Gandhi S, Kajigaya S, Feng X, Ibanez MDPF, Donaires FS, Lopes da Silva JP, Li Z, Das S, Ibanez M, Smith AE, Lea N, Best S, Ireland R, Kulasekararaj AG, McLornan DP, Pagliuca A, Callebaut I, Young NS, Calado RT, Townsley DM, Mufti GJ.

Blood Adv. 2018 Jan 4;2(1):36-48. doi: 10.1182/bloodadvances.2017008110. eCollection 2018 Jan 9.

16.

Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.

Banaszak LG, Giudice V, Zhao X, Wu Z, Gao S, Hosokawa K, Keyvanfar K, Townsley DM, Gutierrez-Rodrigues F, Fernandez Ibanez MDP, Kajigaya S, Young NS.

Blood Cells Mol Dis. 2018 Mar;69:10-22. doi: 10.1016/j.bcmd.2017.12.002. Epub 2018 Jan 4.

PMID:
29324392
17.

Clonality in context: hematopoietic clones in their marrow environment.

Cooper JN, Young NS.

Blood. 2017 Nov 30;130(22):2363-2372. doi: 10.1182/blood-2017-07-794362. Epub 2017 Oct 18.

18.

Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells.

Zhao X, Gao S, Wu Z, Kajigaya S, Feng X, Liu Q, Townsley DM, Cooper J, Chen J, Keyvanfar K, Fernandez Ibanez MDP, Wang X, Young NS.

Blood. 2017 Dec 21;130(25):2762-2773. doi: 10.1182/blood-2017-08-803353. Epub 2017 Oct 13.

19.

Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia.

Zhao X, Feng X, Wu Z, Winkler T, Desmond R, Olnes M, Dumitriu B, Townsley DM, Dunbar CE, Young NS.

Exp Hematol. 2018 Feb;58:39-43. doi: 10.1016/j.exphem.2017.09.006. Epub 2017 Sep 20.

20.

Prevalence of somatic mutations in patients with aplastic anemia using peripheral blood cfDNA as compared with BM.

Albitar A, Townsley D, Ma W, De Dios I, Funari V, Young NS, Albitar M.

Leukemia. 2018 Jan;32(1):227-229. doi: 10.1038/leu.2017.271. Epub 2017 Aug 23. No abstract available.

21.

Parvovirus B19 integration into human CD36+ erythroid progenitor cells.

Janovitz T, Wong S, Young NS, Oliveira T, Falck-Pedersen E.

Virology. 2017 Nov;511:40-48. doi: 10.1016/j.virol.2017.08.011. Epub 2017 Aug 12.

22.

Telomerase enzyme deficiency promotes metabolic dysfunction in murine hepatocytes upon dietary stress.

Alves-Paiva RM, Kajigaya S, Feng X, Chen J, Desierto M, Wong S, Townsley DM, Donaires FS, Bertola A, Gao B, Young NS, Calado RT.

Liver Int. 2018 Jan;38(1):144-154. doi: 10.1111/liv.13529. Epub 2017 Aug 19.

23.

Rapamycin is highly effective in murine models of immune-mediated bone marrow failure.

Feng X, Lin Z, Sun W, Hollinger MK, Desierto MJ, Keyvanfar K, Malide D, Muranski P, Chen J, Young NS.

Haematologica. 2017 Oct;102(10):1691-1703. doi: 10.3324/haematol.2017.163675. Epub 2017 Jul 20.

24.

Optimization and standardization of fluorescent cell barcoding for multiplexed flow cytometric phenotyping.

Giudice V, Feng X, Kajigaya S, Young NS, Biancotto A.

Cytometry A. 2017 Jul;91(7):694-703. doi: 10.1002/cyto.a.23162. Epub 2017 Jul 10.

25.

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways.

Hosokawa K, Kajigaya S, Keyvanfar K, Qiao W, Xie Y, Townsley DM, Feng X, Young NS.

J Immunol. 2017 Jul 15;199(2):477-488. doi: 10.4049/jimmunol.1601299. Epub 2017 Jun 19.

26.

Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice.

Lin Z, Kajigaya S, Feng X, Chen J, Young NS.

J Aging Sci. 2017 Apr;5(1). pii: 169. doi: 10.4172/2329-8847.1000169. Epub 2017 Feb 6.

27.

Saccharomyces cerevisiae-derived virus-like particle parvovirus B19 vaccine elicits binding and neutralizing antibodies in a mouse model for sickle cell disease.

Penkert RR, Young NS, Surman SL, Sealy RE, Rosch J, Dormitzer PR, Settembre EC, Chandramouli S, Wong S, Hankins JS, Hurwitz JL.

Vaccine. 2017 Jun 22;35(29):3615-3620. doi: 10.1016/j.vaccine.2017.05.022. Epub 2017 May 26.

28.

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.

Townsley DM, Scheinberg P, Winkler T, Desmond R, Dumitriu B, Rios O, Weinstein B, Valdez J, Lotter J, Feng X, Desierto M, Leuva H, Bevans M, Wu C, Larochelle A, Calvo KR, Dunbar CE, Young NS.

N Engl J Med. 2017 Apr 20;376(16):1540-1550. doi: 10.1056/NEJMoa1613878.

29.

Allogeneic transplantation using CD34+ selected peripheral blood progenitor cells combined with non-mobilized donor T cells for refractory severe aplastic anaemia.

Purev E, Tian X, Aue G, Pantin J, Vo P, Shalabi R, Reger RN, Cook L, Ramos C, Cho E, Worthy T, Khuu H, Stroncek D, Young NS, Childs RW.

Br J Haematol. 2017 Mar;176(6):950-960. doi: 10.1111/bjh.14448. Epub 2017 Feb 7.

PMID:
28169418
30.

Whole transcriptome sequencing identifies increased CXCR2 expression in PNH granulocytes.

Hosokawa K, Kajigaya S, Keyvanfar K, Qiao W, Xie Y, Biancotto A, Townsley DM, Feng X, Young NS.

Br J Haematol. 2017 Apr;177(1):136-141. doi: 10.1111/bjh.14502. Epub 2017 Feb 1.

31.

Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes.

Guidugli L, Johnson AK, Alkorta-Aranburu G, Nelakuditi V, Arndt K, Churpek JE, Godley LA, Townsley D, Young NS, Fitzpatrick C, Del Gaudio D, Das S, Li Z.

Leukemia. 2017 May;31(5):1226-1229. doi: 10.1038/leu.2017.28. Epub 2017 Jan 20. No abstract available.

32.

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs.

Corat MA, Schlums H, Wu C, Theorell J, Espinoza DA, Sellers SE, Townsley DM, Young NS, Bryceson YT, Dunbar CE, Winkler T.

Blood. 2017 Apr 6;129(14):1940-1946. doi: 10.1182/blood-2016-08-734285. Epub 2016 Nov 30.

33.

Pulmonary arteriovenous malformations: an uncharacterised phenotype of dyskeratosis congenita and related telomere biology disorders.

Khincha PP, Bertuch AA, Agarwal S, Townsley DM, Young NS, Keel S, Shimamura A, Boulad F, Simoneau T, Justino H, Kuo C, Artandi S, McCaslin C, Cox DW, Chaffee S, Collins BF, Giri N, Alter BP, Raghu G, Savage SA.

Eur Respir J. 2017 Jan 25;49(1). pii: 1601640. doi: 10.1183/13993003.01640-2016. Print 2017 Jan. No abstract available.

34.

Human Parvoviruses.

Qiu J, Söderlund-Venermo M, Young NS.

Clin Microbiol Rev. 2017 Jan;30(1):43-113. Review.

35.

Epigenetic landscape of the TERT promoter: a potential biomarker for high risk AML/MDS.

Zhao X, Tian X, Kajigaya S, Cantilena CR, Strickland S, Savani BN, Mohan S, Feng X, Keyvanfar K, Dunavin N, Townsley DM, Dumitriu B, Battiwalla M, Rezvani K, Young NS, Barrett AJ, Ito S.

Br J Haematol. 2016 Nov;175(3):427-439. doi: 10.1111/bjh.14244. Epub 2016 Jul 19.

36.

Telomere content measurement in human hematopoietic cells: Comparative analysis of qPCR and Flow-FISH techniques.

Wand T, Fang M, Chen C, Hardy N, McCoy JP Jr, Dumitriu B, Young NS, Biancotto A.

Cytometry A. 2016 Oct;89(10):914-921. doi: 10.1002/cyto.a.22982. Epub 2016 Sep 22.

37.

A plasma microRNA signature as a biomarker for acquired aplastic anemia.

Hosokawa K, Kajigaya S, Feng X, Desierto MJ, Fernandez Ibanez MD, Rios O, Weinstein B, Scheinberg P, Townsley DM, Young NS.

Haematologica. 2017 Jan;102(1):69-78. doi: 10.3324/haematol.2016.151076. Epub 2016 Sep 22.

38.

Telomere Length Recovery: A Strong Predictor of Overall Survival in Acute Promyelocytic Leukemia.

Baljevic M, Dumitriu B, Lee JW, Paietta EM, Wiernik PH, Racevskis J, Chen C, Stein EM, Gallagher RE, Rowe JM, Appelbaum FR, Powell BL, Larson RA, Coutré SE, Lancet J, Litzow MR, Luger SM, Young NS, Tallman MS.

Acta Haematol. 2016;136(4):210-218. Epub 2016 Sep 16.

39.

Danazol Treatment for Telomere Diseases.

Townsley DM, Dumitriu B, Young NS.

N Engl J Med. 2016 Sep 15;375(11):1095-6. doi: 10.1056/NEJMc1607752. No abstract available.

PMID:
27626528
40.

Reducing Health Inequities in the U.S.: Recommendations From the NHLBI's Health Inequities Think Tank Meeting.

Sampson UKA, Kaplan RM, Cooper RS, Diez Roux AV, Marks JS, Engelgau MM, Peprah E, Mishoe H, Boulware LE, Felix KL, Califf RM, Flack JM, Cooper LA, Gracia JN, Henderson JA, Davidson KW, Krishnan JA, Lewis TT, Sanchez E, Luban NL, Vaccarino V, Wong WF, Wright JT Jr, Meyers D, Ogedegbe OG, Presley-Cantrell L, Chambers DA, Belis D, Bennett GC, Boyington JE, Creazzo TL, de Jesus JM, Krishnamurti C, Lowden MR, Punturieri A, Shero ST, Young NS, Zou S, Mensah GA.

J Am Coll Cardiol. 2016 Aug 2;68(5):517-524. doi: 10.1016/j.jacc.2016.04.059. Review.

41.

Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research.

Engelgau MM, Peprah E, Sampson UKA, Mishoe H, Benjamin IJ, Douglas PS, Hochman JS, Ridker PM, Brandes N, Checkley W, El-Saharty S, Ezzati M, Hennis A, Jiang L, Krumholz HM, Lamourelle G, Makani J, Narayan KMV, Ohene-Frempong K, Straus SE, Stuckler D, Chambers DA, Belis D, Bennett GC, Boyington JE, Creazzo TL, de Jesus JM, Krishnamurti C, Lowden MR, Punturieri A, Shero ST, Young NS, Zou S, Mensah GA.

Glob Heart. 2017 Dec;12(4):341-348. doi: 10.1016/j.gheart.2016.03.640. Epub 2016 Jul 21. Review.

PMID:
27452772
42.

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment.

Kordasti S, Costantini B, Seidl T, Perez Abellan P, Martinez Llordella M, McLornan D, Diggins KE, Kulasekararaj A, Benfatto C, Feng X, Smith A, Mian SA, Melchiotti R, de Rinaldis E, Ellis R, Petrov N, Povoleri GA, Chung SS, Thomas NS, Farzaneh F, Irish JM, Heck S, Young NS, Marsh JC, Mufti GJ.

Blood. 2016 Sep 1;128(9):1193-205. doi: 10.1182/blood-2016-03-703702. Epub 2016 Jun 8.

43.

Danazol Treatment for Telomere Diseases.

Townsley DM, Dumitriu B, Liu D, Biancotto A, Weinstein B, Chen C, Hardy N, Mihalek AD, Lingala S, Kim YJ, Yao J, Jones E, Gochuico BR, Heller T, Wu CO, Calado RT, Scheinberg P, Young NS.

N Engl J Med. 2016 May 19;374(20):1922-31. doi: 10.1056/NEJMoa1515319.

44.

Long-term adaptation to hypoxia preserves hematopoietic stem cell function.

Chen J, Kang JG, Keyvanfar K, Young NS, Hwang PM.

Exp Hematol. 2016 Sep;44(9):866-873.e4. doi: 10.1016/j.exphem.2016.04.010. Epub 2016 Apr 23.

PMID:
27118043
45.

Alemtuzumab in T-cell large granular lymphocytic leukaemia: interim results from a single-arm, open-label, phase 2 study.

Dumitriu B, Ito S, Feng X, Stephens N, Yunce M, Kajigaya S, Melenhorst JJ, Rios O, Scheinberg P, Chinian F, Keyvanfar K, Battiwalla M, Wu CO, Maric I, Xi L, Raffeld M, Muranski P, Townsley DM, Young NS, Barrett AJ, Scheinberg P.

Lancet Haematol. 2016 Jan;3(1):e22-9. doi: 10.1016/S2352-3026(15)00227-6. Epub 2015 Dec 17.

46.

Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia.

Hosokawa K, Muranski P, Feng X, Townsley DM, Liu B, Knickelbein J, Keyvanfar K, Dumitriu B, Ito S, Kajigaya S, Taylor JG 6th, Kaplan MJ, Nussenblatt RB, Barrett AJ, O'Shea J, Young NS.

J Immunol. 2016 Feb 15;196(4):1568-78. doi: 10.4049/jimmunol.1501739. Epub 2016 Jan 13.

47.

PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function.

Sato K, Feng X, Chen J, Li J, Muranski P, Desierto MJ, Keyvanfar K, Malide D, Kajigaya S, Young NS.

Haematologica. 2016 Jan;101(1):57-67. doi: 10.3324/haematol.2014.121632. Epub 2015 Nov 20.

48.

Hematopoietic lineage skewing and intestinal epithelia degeneration in aged mice with telomerase RNA component deletion.

Chen J, Bryant MA, Dent JJ, Sun Y, Desierto MJ, Young NS.

Exp Gerontol. 2015 Dec;72:251-60. doi: 10.1016/j.exger.2015.10.016. Epub 2015 Oct 30.

49.

IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure.

Chen J, Feng X, Desierto MJ, Keyvanfar K, Young NS.

Blood. 2015 Dec 10;126(24):2621-31. doi: 10.1182/blood-2015-06-652453. Epub 2015 Oct 21.

50.

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

Young NS, Ogawa S.

N Engl J Med. 2015 Oct 22;373(17):1675-6. doi: 10.1056/NEJMc1509703. No abstract available.

PMID:
26488702

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