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Applications of stable isotope-based metabolomics and fluxomics toward synthetic biology of cyanobacteria.

Babele PK, Young JD.

Wiley Interdiscip Rev Syst Biol Med. 2019 Dec 9:e1472. doi: 10.1002/wsbm.1472. [Epub ahead of print] Review.


Conditional Survival With Increasing Duration of ICU Admission: An Observational Study of Three Intensive Care Databases.

Marshall DC, Hatch RA, Gerry S, Young JD, Watkinson P.

Crit Care Med. 2020 Jan;48(1):91-97. doi: 10.1097/CCM.0000000000004082.


Does Universal Insurance and Access to Care Influence Disparities in Outcomes for Pediatric Patients with Osteomyelitis?

Young JD, Dee EC, Levine A, Sturgeon DJ, Koehlmoos TP, Schoenfeld AJ.

Clin Orthop Relat Res. 2019 Oct 15. doi: 10.1097/CORR.0000000000000994. [Epub ahead of print]


Genome-scale model-based identification of metabolite indicators for early detection of kidney toxicity.

Pannala VR, Vinnakota KC, Estes SK, Trenary I, OˈBrien TP, Printz RL, Papin JA, Reifman J, Oyama T, Shiota M, Young JD, Wallqvist A.

Toxicol Sci. 2019 Nov 13. pii: kfz228. doi: 10.1093/toxsci/kfz228. [Epub ahead of print]


Real-world evaluation of the safety and tolerability of abacavir/dolutegravir/lamivudine in an incarcerated population.

Brizzi MB, Chiampas TD, Michienzi SM, Young JD, Patel MC, Badowski ME.

Int J STD AIDS. 2019 Oct;30(12):1163-1168. doi: 10.1177/0956462419863925. Epub 2019 Sep 27. No abstract available.


Protocolised non-invasive compared with invasive weaning from mechanical ventilation for adults in intensive care: the Breathe RCT.

Perkins GD, Mistry D, Lall R, Gao-Smith F, Snelson C, Hart N, Camporota L, Varley J, Carle C, Paramasivam E, Hoddell B, de Paeztron A, Dosanjh S, Sampson J, Blair L, Couper K, McAuley D, Young JD, Walsh T, Blackwood B, Rose L, Lamb SE, Dritsaki M, Maredza M, Khan I, Petrou S, Gates S.

Health Technol Assess. 2019 Sep;23(48):1-114. doi: 10.3310/hta23480.


The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study.

Palmer E, Post B, Klapaukh R, Marra G, MacCallum NS, Brealey D, Ercole A, Jones A, Ashworth S, Watkinson P, Beale R, Brett SJ, Young JD, Black C, Rashan A, Martin D, Singer M, Harris S.

Am J Respir Crit Care Med. 2019 Dec 1;200(11):1373-1380. doi: 10.1164/rccm.201904-0849OC.


The Purinome and the preBötzinger Complex - A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response.

Reklow RJ, Alvares TS, Zhang Y, Miranda Tapia AP, Biancardi V, Katzell AK, Frangos SM, Hansen MA, Toohey AW, Cass CE, Young JD, Pagliardini S, Boison D, Funk GD.

Front Cell Neurosci. 2019 Aug 21;13:365. doi: 10.3389/fncel.2019.00365. eCollection 2019.


Using real-time location devices (RTLD) to quantify off-unit adult intensive care registrar workload: a 1-year tertiary NHS hospital prospective observational study.

Malycha J, Murphy D, Barker G, Ludbrook G, Young JD, Watkinson PJ.

J Clin Monit Comput. 2019 Sep 5. doi: 10.1007/s10877-019-00383-z. [Epub ahead of print]


Chaplain care in pediatric oncology: Insight for interprofessional collaboration.

Lion AH, Skiles JL, Watson BN, Young JD, Torke AM.

Pediatr Blood Cancer. 2019 Dec;66(12):e27971. doi: 10.1002/pbc.27971. Epub 2019 Aug 20.


Cross-Cultural Comparison of Postoperative Discharge Opioid Prescribing After Orthopaedic Trauma Surgery.

Young JD, Bhashyam AR, Qudsi RA, Parisien RL, Shrestha S, van der Vliet QMJ, Fils J, Losina E, Dyer GSM.

J Bone Joint Surg Am. 2019 Jul 17;101(14):1286-1293. doi: 10.2106/JBJS.18.01022.


Investigation of foreign materials in gingival lesions: a clinicopathologic, energy-dispersive microanalysis of the lesions and in vitro confirmation of pro-inflammatory effects of the foreign materials.

Ferreira L, Peng HH, Cox DP, Chambers DW, Bhula A, Young JD, Ojcius DM, Ramos-Junior ES, Morandini AC.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Sep;128(3):250-267. doi: 10.1016/j.oooo.2019.04.009. Epub 2019 Apr 20.


Risk factors for new-onset atrial fibrillation on the general adult ICU: A systematic review.

Bedford JP, Harford M, Petrinic T, Young JD, Watkinson PJ.

J Crit Care. 2019 Oct;53:169-175. doi: 10.1016/j.jcrc.2019.06.015. Epub 2019 Jun 18.


Unilateral hamstrings static stretching can impair the affected and contralateral knee extension force but improve unilateral drop jump height.

Caldwell SL, Bilodeau RLS, Cox MJ, Peddle D, Cavanaugh T, Young JD, Behm DG.

Eur J Appl Physiol. 2019 Sep;119(9):1943-1949. doi: 10.1007/s00421-019-04182-x. Epub 2019 Jun 24.


Strategic application of wildland fire suppression in the southwestern United States.

Young JD, Thode AE, Huang CH, Ager AA, Fulé PZ.

J Environ Manage. 2019 Sep 1;245:504-518. doi: 10.1016/j.jenvman.2019.01.003. Epub 2019 May 29.


Patient centred variables with univariate associations with unplanned ICU admission: a systematic review.

Malycha J, Bonnici T, Clifton DA, Ludbrook G, Young JD, Watkinson PJ.

BMC Med Inform Decis Mak. 2019 May 15;19(1):98. doi: 10.1186/s12911-019-0820-1.


Mapping sources of noise in an intensive care unit.

Darbyshire JL, Müller-Trapet M, Cheer J, Fazi FM, Young JD.

Anaesthesia. 2019 Aug;74(8):1018-1025. doi: 10.1111/anae.14690. Epub 2019 May 7.


Hormetic Effects of Phytochemicals on Health and Longevity.

Martel J, Ojcius DM, Ko YF, Ke PY, Wu CY, Peng HH, Young JD.

Trends Endocrinol Metab. 2019 Jun;30(6):335-346. doi: 10.1016/j.tem.2019.04.001. Epub 2019 May 3. Review.


Availability and performance of image-based, non-contact methods of monitoring heart rate, blood pressure, respiratory rate, and oxygen saturation: a systematic review.

Harford M, Catherall J, Gerry S, Young JD, Watkinson P.

Physiol Meas. 2019 Jul 3;40(6):06TR01. doi: 10.1088/1361-6579/ab1f1d.


The effect of fractional inspired oxygen concentration on early warning score performance: A database analysis.

Malycha J, Farajidavar N, Pimentel MAF, Redfern O, Clifton DA, Tarassenko L, Meredith P, Prytherch D, Ludbrook G, Young JD, Watkinson PJ.

Resuscitation. 2019 Jun;139:192-199. doi: 10.1016/j.resuscitation.2019.04.002. Epub 2019 Apr 18.


Impact of abstinence and of reducing illicit drug use without abstinence on HIV viral load.

Nance RM, Trejo MEP, Whitney BM, Delaney JAC, Altice F, Beckwith CG, Chander G, Chandler R, Christopoulous K, Cunningham C, Cunningham WE, Del Rio C, Donovan D, Eron JJ, Fredericksen RJ, Kahana S, Kitahata MM, Kronmal R, Kuo I, Kurth A, Mathews WC, Mayer KH, Moore RD, Mugavero MJ, Ouellet LJ, Quan VM, Saag MS, Simoni JM, Springer S, Strand L, Taxman F, Young JD, Crane HM.

Clin Infect Dis. 2019 Apr 17. pii: ciz299. doi: 10.1093/cid/ciz299. [Epub ahead of print]



Young JD.

J Gen Intern Med. 2019 May;34(5):762-763. doi: 10.1007/s11606-019-04890-2. No abstract available.


Unilateral Knee and Ankle Joint Fatigue Induce Similar Impairment to Bipedal Balance in Judo Athletes.

Ghram A, Young JD, Soori R, Behm DG.

J Hum Kinet. 2019 Mar 27;66:7-18. doi: 10.2478/hukin-2018-0063. eCollection 2019 Mar.


Mechanistic identification of biofluid metabolite changes as markers of acetaminophen-induced liver toxicity in rats.

Pannala VR, Vinnakota KC, Rawls KD, Estes SK, O'Brien TP, Printz RL, Papin JA, Reifman J, Shiota M, Young JD, Wallqvist A.

Toxicol Appl Pharmacol. 2019 Jun 1;372:19-32. doi: 10.1016/j.taap.2019.04.001. Epub 2019 Apr 8.


Energy- and conformer-dependent excited-state relaxation of an E/Z photoswitchable thienyl-ethene.

Young JD, Honick CR, Zhou J, Pitts CR, Ghorbani F, Peters GM, Lectka T, Tovar JD, Bragg AE.

Phys Chem Chem Phys. 2019 Jul 14;21(26):14440-14452. doi: 10.1039/c9cp01226e. Epub 2019 Mar 28.


Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells.

Huang TT, Lan YW, Chen CM, Ko YF, Ojcius DM, Martel J, Young JD, Chong KY.

Sci Rep. 2019 Mar 26;9(1):5145. doi: 10.1038/s41598-019-41653-9.


Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat.

Vinnakota KC, Pannala VR, Wall ML, Rahim M, Estes SK, Trenary I, O'Brien TP, Printz RL, Reifman J, Shiota M, Young JD, Wallqvist A.

Front Physiol. 2019 Mar 1;10:161. doi: 10.3389/fphys.2019.00161. eCollection 2019.


Tuning the properties of tris(hydroxypyridinone) ligands: efficient 68Ga chelators for PET imaging.

Imberti C, Chen YL, Foley CA, Ma MT, Paterson BM, Wang Y, Young JD, Hider RC, Blower PJ.

Dalton Trans. 2019 Mar 26;48(13):4299-4313. doi: 10.1039/c8dt04454f.


Infectious Diseases Society of America Position Statement on Telehealth and Telemedicine as Applied to the Practice of Infectious Diseases.

Young JD, Abdel-Massih R, Herchline T, McCurdy L, Moyer KJ, Scott JD, Wood BR, Siddiqui J.

Clin Infect Dis. 2019 Apr 24;68(9):1437-1443. doi: 10.1093/cid/ciy907.


Protocol for a mixed-methods exploratory investigation of care following intensive care discharge: the REFLECT study.

Vollam S, Gustafson O, Hinton L, Morgan L, Pattison N, Thomas H, Young JD, Watkinson P.

BMJ Open. 2019 Jan 25;9(1):e027838. doi: 10.1136/bmjopen-2018-027838.


Antiaging effects of bioactive molecules isolated from plants and fungi.

Martel J, Ojcius DM, Ko YF, Chang CJ, Young JD.

Med Res Rev. 2019 Sep;39(5):1515-1552. doi: 10.1002/med.21559. Epub 2019 Jan 15. Review.


Glutamate-oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux.

Egnatchik RA, Leamy AK, Sacco SA, Cheah YE, Shiota M, Young JD.

J Biol Chem. 2019 Mar 1;294(9):3081-3090. doi: 10.1074/jbc.RA118.004869. Epub 2018 Dec 18.


Shake Rattle & Roll - Design and rationale for a pragmatic trial to improve blood pressure control among blacks with persistent hypertension.

Nguyen-Huynh MN, Young JD, Alexeeff S, Hatfield MK, Sidney S.

Contemp Clin Trials. 2019 Jan;76:85-92. doi: 10.1016/j.cct.2018.11.012. Epub 2018 Nov 28.


Risk of neurosyphilis in HIV-infected persons with syphilis lacking signs or symptoms of central nervous system infection.

Rotman L, Luo X, Thompson A, Mackesy-Amiti ME, Young LR, Young JD.

HIV Med. 2019 Jan;20(1):27-32. doi: 10.1111/hiv.12677. Epub 2018 Nov 7.


In vitro inhibition of human nucleoside transporters and uptake of azacitidine by an isocitrate dehydrogenase-2 inhibitor enasidenib and its metabolite AGI-16903.

Tong Z, Yerramilli U, Yao S, Young JD, Hoffmann M, Surapaneni S.

Xenobiotica. 2019 Oct;49(10):1229-1236. doi: 10.1080/00498254.2018.1539783. Epub 2018 Nov 29.


Using the experience-based co-design method to design a teaching package.

Darbyshire JL, Hinton L, Young JD, Greig PR.

Med Educ. 2018 Nov;52(11):1198. doi: 10.1111/medu.13720. No abstract available.


Automated symptom and treatment side effect monitoring for improved quality of life among adults with diabetic peripheral neuropathy in primary care: a pragmatic, cluster, randomized, controlled trial.

Adams AS, Schmittdiel JA, Altschuler A, Bayliss EA, Neugebauer R, Ma L, Dyer W, Clark J, Cook B, Willyoung D, Jaffe M, Young JD, Kim E, Boggs JM, Prosser LA, Wittenberg E, Callaghan B, Shainline M, Hippler RM, Grant RW.

Diabet Med. 2019 Jan;36(1):52-61. doi: 10.1111/dme.13840. Epub 2018 Nov 7.


Changes in health-related quality of life after discharge from an intensive care unit: a systematic review.

Gerth AMJ, Hatch RA, Young JD, Watkinson PJ.

Anaesthesia. 2019 Jan;74(1):100-108. doi: 10.1111/anae.14444. Epub 2018 Oct 6.


Acoustic source localization with microphone arrays for remote noise monitoring in an Intensive Care Unit.

Müller-Trapet M, Cheer J, Fazi FM, Darbyshire J, Young JD.

Appl Acoust. 2018 Oct;139:93-100. doi: 10.1016/j.apacoust.2018.04.019.


Role of cysteine 416 in N-ethylmaleimide sensitivity of human equilibrative nucleoside transporter 1 (hENT1).

Yao SYM, Ng AML, Cass CE, Young JD.

Biochem J. 2018 Oct 31;475(20):3293-3309. doi: 10.1042/BCJ20180543.


Risk factors for new-onset atrial fibrillation on the general adult ICU: protocol for a systematic review.

Bedford J, Harford M, Petrinic T, Young JD, Watkinson PJ.

BMJ Open. 2018 Sep 4;8(9):e024640. doi: 10.1136/bmjopen-2018-024640.


Metabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat.

Pannala VR, Wall ML, Estes SK, Trenary I, O'Brien TP, Printz RL, Vinnakota KC, Reifman J, Shiota M, Young JD, Wallqvist A.

Sci Rep. 2018 Aug 3;8(1):11678. doi: 10.1038/s41598-018-30149-7.


NK Cell-Derived IFN-γ Protects against Nontuberculous Mycobacterial Lung Infection.

Lai HC, Chang CJ, Lin CS, Wu TR, Hsu YJ, Wu TS, Lu JJ, Martel J, Ojcius DM, Ku CL, Young JD, Lu CC.

J Immunol. 2018 Sep 1;201(5):1478-1490. doi: 10.4049/jimmunol.1800123. Epub 2018 Jul 30.


Comprehensive organic profiling of biological particles derived from blood.

Wu CY, Martel J, Young JD.

Sci Rep. 2018 Jul 27;8(1):11310. doi: 10.1038/s41598-018-29573-6.


Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis.

Wu TR, Lin CS, Chang CJ, Lin TL, Martel J, Ko YF, Ojcius DM, Lu CC, Young JD, Lai HC.

Gut. 2019 Feb;68(2):248-262. doi: 10.1136/gutjnl-2017-315458. Epub 2018 Jul 14.


Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis.

Vollam S, Dutton S, Lamb S, Petrinic T, Young JD, Watkinson P.

Intensive Care Med. 2018 Jul;44(7):1115-1129. doi: 10.1007/s00134-018-5245-2. Epub 2018 Jun 25. Review.


Global Training Effects of Trained and Untrained Muscles With Youth Can be Maintained During 4 Weeks of Detraining.

Chaouachi A, Ben Othman A, Makhlouf I, Young JD, Granacher U, Behm DG.

J Strength Cond Res. 2019 Oct;33(10):2788-2800. doi: 10.1519/JSC.0000000000002606.


xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.

Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP.

Oncogene. 2018 Sep;37(36):5007-5019. doi: 10.1038/s41388-018-0307-z. Epub 2018 May 23.

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