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Items: 1 to 50 of 157

1.

Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation.

Carr PD, Ewens CL, Dai J, Ollis DL, Murphy JM, Jackson CJ, Young IG.

Biochem J. 2014 Nov 1;463(3):393-403. doi: 10.1042/BJ20140863.

PMID:
25137390
2.

Identification of microRNAs regulating the developmental pathways of bone marrow derived mast cells.

Xiang Y, Eyers F, Young IG, Rosenberg HF, Foster PS, Yang M.

PLoS One. 2014 May 21;9(5):e98139. doi: 10.1371/journal.pone.0098139. eCollection 2014.

3.

Expression profiling of differentiating eosinophils in bone marrow cultures predicts functional links between microRNAs and their target mRNAs.

Yang M, Eyers F, Xiang Y, Guo M, Young IG, Rosenberg HF, Foster PS.

PLoS One. 2014 May 13;9(5):e97537. doi: 10.1371/journal.pone.0097537. eCollection 2014.

4.

High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties.

Hercus TR, Barry EF, Dottore M, McClure BJ, Webb AI, Lopez AF, Young IG, Murphy JM.

PLoS One. 2013 Aug 26;8(8):e74376. doi: 10.1371/journal.pone.0074376. eCollection 2013.

5.

Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution.

Yao S, Young IG, Norton RS, Murphy JM.

Biochemistry. 2011 Apr 5;50(13):2464-77. doi: 10.1021/bi101810f. Epub 2011 Mar 2.

PMID:
21329364
6.

The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.

Mirza S, Chen J, Murphy JM, Young IG.

J Biol Chem. 2010 Aug 6;285(32):24759-68. doi: 10.1074/jbc.M109.097881. Epub 2010 Jun 1.

7.

Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.

Mirza S, Chen J, Wen B, Ewens CL, Dai J, Murphy JM, Young IG.

J Biol Chem. 2010 Jul 16;285(29):22370-81. doi: 10.1074/jbc.M110.117465. Epub 2010 May 14.

8.

The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation.

Mirza S, Walker A, Chen J, Murphy JM, Young IG.

Biochem J. 2010 Feb 24;426(3):307-17. doi: 10.1042/BJ20091745.

PMID:
20078425
9.

A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity.

Murphy JM, Metcalf D, Young IG, Hilton DJ.

Growth Factors. 2010 Apr;28(2):104-10. doi: 10.3109/08977190903443048.

PMID:
19961363
10.

A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode.

Chen J, Olsen J, Ford S, Mirza S, Walker A, Murphy JM, Young IG.

J Biol Chem. 2009 Feb 27;284(9):5763-73. doi: 10.1074/jbc.M808197200. Epub 2008 Dec 24.

11.

Clarification of the role of N-glycans on the common beta-subunit of the human IL-3, IL-5 and GM-CSF receptors and the murine IL-3 beta-receptor in ligand-binding and receptor activation.

Murphy JM, Soboleva TA, Mirza S, Ford SC, Olsen JE, Chen J, Young IG.

Cytokine. 2008 May;42(2):234-242. doi: 10.1016/j.cyto.2008.02.010. Epub 2008 Apr 18.

PMID:
18374598
12.
13.

Expression and evolution of the mammalian brain gene Ttyh1.

Matthews CA, Shaw JE, Hooper JA, Young IG, Crouch MF, Campbell HD.

J Neurochem. 2007 Feb;100(3):693-707. Epub 2006 Nov 20.

14.

IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor.

Murphy JM, Young IG.

Vitam Horm. 2006;74:1-30. Review.

PMID:
17027509
15.

An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope.

Carr PD, Conlan F, Ford S, Ollis DL, Young IG.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 1;62(Pt 6):509-13. Epub 2006 May 31.

16.

A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes.

Wang J, Shannon MF, Young IG.

Int Immunol. 2006 Feb;18(2):313-23. Epub 2005 Dec 22.

PMID:
16373364
17.

Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.

Murphy JM, Ford SC, Olsen JE, Gustin SE, Jeffrey PD, Ollis DL, Young IG.

J Biol Chem. 2004 Jun 18;279(25):26500-8. Epub 2004 Apr 1.

18.

Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity.

Yang M, Hogan SP, Mahalingam S, Pope SM, Zimmermann N, Fulkerson P, Dent LA, Young IG, Matthaei KI, Rothenberg ME, Foster PS.

J Allergy Clin Immunol. 2003 Nov;112(5):935-43.

PMID:
14610483
19.
20.

Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma.

Mattes J, Yang M, Mahalingam S, Kuehr J, Webb DC, Simson L, Hogan SP, Koskinen A, McKenzie AN, Dent LA, Rothenberg ME, Matthaei KI, Young IG, Foster PS.

J Exp Med. 2002 Jun 3;195(11):1433-44.

21.

Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development.

Campbell HD, Fountain S, McLennan IS, Berven LA, Crouch MF, Davy DA, Hooper JA, Waterford K, Chen KS, Lupski JR, Ledermann B, Young IG, Matthaei KI.

Mol Cell Biol. 2002 May;22(10):3518-26.

22.

Interleukin-5 and eosinophils as therapeutic targets for asthma.

Foster PS, Hogan SP, Yang M, Mattes J, Young IG, Matthaei KI, Kumar RK, Mahalingam S, Webb DC.

Trends Mol Med. 2002 Apr;8(4):162-7.

PMID:
11927273
23.

Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin.

Yang M, Hogan SP, Henry PJ, Matthaei KI, McKenzie AN, Young IG, Rothenberg ME, Foster PS.

Am J Respir Cell Mol Biol. 2001 Oct;25(4):522-30.

PMID:
11694459
24.

Expression, crystallization and derivatization of the complete extracellular domain of the beta(c) subunit of the human IL-5, IL-3 and GM-CSF receptors.

Gustin SE, Church AP, Ford SC, Mann DA, Carr PD, Ollis DL, Young IG.

Eur J Biochem. 2001 May;268(10):2905-11.

25.
26.

Elemental signals regulating eosinophil accumulation in the lung.

Foster PS, Mould AW, Yang M, Mackenzie J, Mattes J, Hogan SP, Mahalingam S, Mckenzie AN, Rothenberg ME, Young IG, Matthaei KI, Webb DC.

Immunol Rev. 2001 Feb;179:173-81. Review.

PMID:
11292021
27.

Eosinophilia is attenuated in experimental colitis induced in IL-5 deficient mice.

Stevceva L, Pavli P, Husband A, Matthaei KI, Young IG, Doe WF.

Genes Immun. 2000 Feb;1(3):213-8.

28.

Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration.

Carr PD, Gustin SE, Church AP, Murphy JM, Ford SC, Mann DA, Woltring DM, Walker I, Ollis DL, Young IG.

Cell. 2001 Jan 26;104(2):291-300.

29.

The mitochondrial benzodiazepine receptor and avoidance learning in the day-old chick.

Freeman FM, Young IG.

Pharmacol Biochem Behav. 2000 Oct;67(2):355-62.

PMID:
11124401
30.

Uterine eosinophils and reproductive performance in interleukin 5-deficient mice.

Robertson SA, Mau VJ, Young IG, Matthaei KI.

J Reprod Fertil. 2000 Nov;120(2):423-32.

PMID:
11058459
31.

Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections.

Vallance BA, Matthaei KI, Sanovic S, Young IG, Collins SM.

Parasite Immunol. 2000 Oct;22(10):487-92.

32.

Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins.

Campbell HD, Kamei M, Claudianos C, Woollatt E, Sutherland GR, Suzuki Y, Hida M, Sugano S, Young IG.

Genomics. 2000 Aug 15;68(1):89-92.

PMID:
10950931
33.
34.

Fliih, the murine homologue of the Drosophila melanogaster flightless I gene: nucleotide sequence, chromosomal mapping and overlap with Llglh.

Campbell HD, Fountain S, Young IG, Weitz S, Lichter P, Hoheisel JD.

DNA Seq. 2000;11(1-2):29-40.

PMID:
10902907
35.

A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo.

Apostolopoulos V, McKenzie IF, Lees C, Matthaei KI, Young IG.

Eur J Immunol. 2000 Jun;30(6):1733-9.

36.

Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma.

Foster PS, Ming Y, Matthei KI, Young IG, Temelkovski J, Kumar RK.

Lab Invest. 2000 May;80(5):655-62.

38.
39.

The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity.

Mould AW, Ramsay AJ, Matthaei KI, Young IG, Rothenberg ME, Foster PS.

J Immunol. 2000 Feb 15;164(4):2142-50.

40.

Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response.

Simeonovic CJ, Townsend MJ, Karupiah G, Wilson JD, Zarb JC, Mann DA, Young IG.

Cell Transplant. 1999 Jul-Aug;8(4):365-73.

PMID:
10478716
41.

IL-5 contributes to worm expulsion and muscle hypercontractility in a primary T. spiralis infection.

Vallance BA, Blennerhassett PA, Deng Y, Matthaei KI, Young IG, Collins SM.

Am J Physiol. 1999 Aug;277(2):G400-8. doi: 10.1152/ajpgi.1999.277.2.G400.

PMID:
10444455
42.

Immune mechanisms associated with the rejection of fetal murine proislet allografts and pig proislet xenografts: comparison of intragraft cytokine mRNA profiles.

Simeonovic CJ, Townsend MJ, Morris CF, Hapel AJ, Fung MC, Mann DA, Young IG, Wilson JD.

Transplantation. 1999 Apr 15;67(7):963-71.

PMID:
10221479
43.

Chloramphenicol-induced amnesia for passive avoidance training in the day-old chick.

Freeman FM, Young IG.

Neurobiol Learn Mem. 1999 Jan;71(1):80-93.

PMID:
9889074
44.

Regulation of primary Strongyloides ratti infections in mice: a role for interleukin-5.

Ovington KS, McKie K, Matthaei KI, Young IG, Behm CA.

Immunology. 1998 Nov;95(3):488-93.

45.

Cellular and molecular regulation of eosinophil trafficking to the lung.

Hogan SP, Mould AW, Young JM, Rothenberg ME, Ramsay AJ, Matthaei K, Young IG, Foster PS.

Immunol Cell Biol. 1998 Oct;76(5):454-60.

PMID:
9797467
46.

Intestinal IgA plasma cells of the B1 lineage are IL-5 dependent.

Bao S, Beagley KW, Murray AM, Caristo V, Matthaei KI, Young IG, Husband AJ.

Immunology. 1998 Jun;94(2):181-8.

48.

A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5.

Hogan SP, Matthaei KI, Young JM, Koskinen A, Young IG, Foster PS.

J Immunol. 1998 Aug 1;161(3):1501-9.

49.

Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice.

Hogan SP, Koskinen A, Matthaei KI, Young IG, Foster PS.

Am J Respir Crit Care Med. 1998 Jan;157(1):210-8.

PMID:
9445302

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