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Items: 40

1.

Functional confirmation that the R1488* variant in SCN9A results in complete loss-of-function of Nav1.7.

He W, Young GT, Zhang B, Cox PJ, Cho LT, John S, Paciga SA, Wood LS, Danziger N, Scollen S, Vangjeli C.

BMC Med Genet. 2018 Jul 23;19(1):124. doi: 10.1186/s12881-018-0643-4.

2.

An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.

Cho LT, Alexandrou AJ, Torella R, Knafels J, Hobbs J, Taylor T, Loucif A, Konopacka A, Bell S, Stevens EB, Pandit J, Horst R, Withka JM, Pryde DC, Liu S, Young GT.

Structure. 2018 Apr 3;26(4):533-544.e3. doi: 10.1016/j.str.2018.02.017. Epub 2018 Mar 22.

3.

Unraveling a model of TCL/RhoJ allosterism using TC10 reverse chimeras.

Florke RR, Young GT, Hamann MJ.

Small GTPases. 2017 Jul 11:1-8. doi: 10.1080/21541248.2017.1347599. [Epub ahead of print]

PMID:
28696829
4.

A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV).

Shaikh SS, Chen YC, Halsall SA, Nahorski MS, Omoto K, Young GT, Phelan A, Woods CG.

Hum Mutat. 2017 Jan;38(1):55-63. doi: 10.1002/humu.23123. Epub 2016 Nov 26.

5.

Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception.

Chen YC, Auer-Grumbach M, Matsukawa S, Zitzelsberger M, Themistocleous AC, Strom TM, Samara C, Moore AW, Cho LT, Young GT, Weiss C, Schabhüttl M, Stucka R, Schmid AB, Parman Y, Graul-Neumann L, Heinritz W, Passarge E, Watson RM, Hertz JM, Moog U, Baumgartner M, Valente EM, Pereira D, Restrepo CM, Katona I, Dusl M, Stendel C, Wieland T, Stafford F, Reimann F, von Au K, Finke C, Willems PJ, Nahorski MS, Shaikh SS, Carvalho OP, Nicholas AK, Karbani G, McAleer MA, Cilio MR, McHugh JC, Murphy SM, Irvine AD, Jensen UB, Windhager R, Weis J, Bergmann C, Rautenstrauss B, Baets J, De Jonghe P, Reilly MM, Kropatsch R, Kurth I, Chrast R, Michiue T, Bennett DL, Woods CG, Senderek J.

Nat Genet. 2015 Aug;47(8):962. doi: 10.1038/ng0815-962b. No abstract available.

PMID:
26220135
6.

Transcriptional regulator PRDM12 is essential for human pain perception.

Chen YC, Auer-Grumbach M, Matsukawa S, Zitzelsberger M, Themistocleous AC, Strom TM, Samara C, Moore AW, Cho LT, Young GT, Weiss C, Schabhüttl M, Stucka R, Schmid AB, Parman Y, Graul-Neumann L, Heinritz W, Passarge E, Watson RM, Hertz JM, Moog U, Baumgartner M, Valente EM, Pereira D, Restrepo CM, Katona I, Dusl M, Stendel C, Wieland T, Stafford F, Reimann F, von Au K, Finke C, Willems PJ, Nahorski MS, Shaikh SS, Carvalho OP, Nicholas AK, Karbani G, McAleer MA, Cilio MR, McHugh JC, Murphy SM, Irvine AD, Jensen UB, Windhager R, Weis J, Bergmann C, Rautenstrauss B, Baets J, De Jonghe P, Reilly MM, Kropatsch R, Kurth I, Chrast R, Michiue T, Bennett DL, Woods CG, Senderek J.

Nat Genet. 2015 Jul;47(7):803-8. doi: 10.1038/ng.3308. Epub 2015 May 25. Erratum in: Nat Genet. 2015 Aug;47(8):962.

PMID:
26005867
7.

Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels.

Young GT, Emery EC, Mooney ER, Tsantoulas C, McNaughton PA.

Pain. 2014 Sep;155(9):1708-19. doi: 10.1016/j.pain.2014.05.021. Epub 2014 May 23.

PMID:
24861581
8.

Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.

Young GT, Gutteridge A, Fox H, Wilbrey AL, Cao L, Cho LT, Brown AR, Benn CL, Kammonen LR, Friedman JH, Bictash M, Whiting P, Bilsland JG, Stevens EB.

Mol Ther. 2014 Aug;22(8):1530-1543. doi: 10.1038/mt.2014.86. Epub 2014 May 15.

9.

HCN2 ion channels: an emerging role as the pacemakers of pain.

Emery EC, Young GT, McNaughton PA.

Trends Pharmacol Sci. 2012 Aug;33(8):456-63. doi: 10.1016/j.tips.2012.04.004. Epub 2012 May 19. Review.

PMID:
22613784
10.

HCN2 ion channels play a central role in inflammatory and neuropathic pain.

Emery EC, Young GT, Berrocoso EM, Chen L, McNaughton PA.

Science. 2011 Sep 9;333(6048):1462-6. doi: 10.1126/science.1206243.

11.

Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.

Collins T, Young GT, Millar NS.

Neuropharmacology. 2011 Dec;61(8):1306-13. doi: 10.1016/j.neuropharm.2011.07.035. Epub 2011 Jul 30.

12.

Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

Gill JK, Savolainen M, Young GT, Zwart R, Sher E, Millar NS.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5867-72. doi: 10.1073/pnas.1017975108. Epub 2011 Mar 21.

13.

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

Young GT, Zwart R, Walker AS, Sher E, Millar NS.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14686-91. doi: 10.1073/pnas.0804372105. Epub 2008 Sep 12.

14.

Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating.

Young GT, Broad LM, Zwart R, Astles PC, Bodkin M, Sher E, Millar NS.

Mol Pharmacol. 2007 Feb;71(2):389-97. Epub 2006 Oct 25.

PMID:
17065235
15.

Ratings of perceived exertion and muscle activity during the bench press exercise in recreational and novice lifters.

Lagally KM, McCaw ST, Young GT, Medema HC, Thomas DQ.

J Strength Cond Res. 2004 May;18(2):359-64.

PMID:
15142009
16.

Association of antibiotic utilization measures and reduced incidence of infections with extended-spectrum beta-lactamase-producing organisms.

Lan CK, Hsueh PR, Wong WW, Fung CP, Lau YT, Yeung JY, Young GT, Su CC.

J Microbiol Immunol Infect. 2003 Sep;36(3):182-6.

PMID:
14582562
17.

[7-Methyltryptophan9]-beta-corticotropin-(1-24): a hyperactive Synacthen analogue.

Allen MC, Bailey PD, Brundish DE, Jones JH, Wade R, Young GT.

Int J Pept Protein Res. 1984 Nov;24(5):529-31.

PMID:
6097558
18.

Marketing employee assistance programs to industry.

Goldman RL, Reyes JG, Young GT, Barsamian S, Thomas A, Thuss M.

Health Mark Q. 1983-1984 Winter-Spring;1(2-3):91-8. No abstract available.

PMID:
10266219
19.

Amino-acids and peptides. Part 48. Synthesis of bradykinyl-chloromethane.

Aplin RT, Christiansen J, Young GT.

Int J Pept Protein Res. 1983 May;21(5):555-61.

PMID:
6885241
20.

Hydroxy- and amino-protection based on the 4-dimethylcarbamoylbenzyl group.

Chauhan VS, Ratcliffe SJ, Young GT.

Int J Pept Protein Res. 1980 Feb;15(2):96-101.

PMID:
6768684
21.

Amino-acids and peptides. Part XXXIX. Synthesis of analogues of bradykinin with modifications in positions 1, 6, and 9.

Pinker TG, Young GT, Elliott DF, Wade R.

J Chem Soc Perkin 1. 1976;(2):220-8. No abstract available.

PMID:
942961
23.
25.

Amino-acids and peptides. XXXVI. The synthesis of analogues of bradykinin by the picolyl ester method.

Fletcher GA, Young GT.

J Chem Soc Perkin 1. 1972;14:1867-74. No abstract available.

PMID:
4672445
26.

Amino-acids and peptides. XXXIV. Anchimerically assisted coupling reactions: the use of 2-pyridyl thiolesters.

Lloyd K, Young GT.

J Chem Soc Perkin 1. 1971;17:2890-6. No abstract available.

PMID:
5166756
27.

Facilitation of peptide synthesis by the use of 4-picolyl esters: synthesis of va15-angiotensin II.

Garner R, Young GT.

Nature. 1969 Apr 12;222(5189):177-8. No abstract available.

PMID:
4304928
28.

Novel facilitation of peptide synthesis.

Camble R, Garner R, Young GT.

Nature. 1968 Jan 20;217(5125):247-8. No abstract available.

PMID:
5639128
29.

Amino-acids and peptides. XXIX. The use of S-benzylthiomethyl-L-cysteine in peptide synthesis: synthesis of glutathione and homoglutathione.

Camble R, Purkayastha R, Young GT.

J Chem Soc Perkin 1. 1968;10:1219-24. No abstract available.

PMID:
5689746
30.
31.

Amino-acids and peptides. XXVII. Further studies on esters of 1-hydroxypiperidine.

Jones JH, Young GT.

J Chem Soc Perkin 1. 1968;1:53-61. No abstract available.

PMID:
5688879
32.

Amino-acids and peptides. XXVI. The use of 1-piperidyl esters in peptide synthesis: further studies.

Jones JH, Liberek B, Young GT.

J Chem Soc Perkin 1. 1967;22:2371-4. No abstract available.

PMID:
6070195
33.

Amino-acids and peptides. XXV. The mechanism of the base-catalysed racemisation of the p-nitrophenyl esters of acylpeptides.

Antonovics I, Young GT.

J Chem Soc Perkin 1. 1967;7:595-601. No abstract available.

PMID:
6068262
34.
35.

Amino-acids and peptides. 23. The synthesis of peptides related to arginine-vasopressin.

Cox ME, Garg HG, Hollowood J, Hugo JM, Scopes PM, Young GT.

J Chem Soc Perkin 1. 1965 Dec:6806-13. No abstract available.

PMID:
5892021
36.

AMINO-ACIDS AND PEPTIDES. XXII. SYNTHESIS OF N-ALPHA-L-ARGINYL-L-LYSYLGLYCINE.

WALSHAW KB, YOUNG GT.

J Chem Soc. 1965 Jan;47:786-8. No abstract available.

PMID:
14275665
37.

AMINO-ACIDS AND PEPTIDES. XXI. REMOVAL OF THE NITRO-GROUP FROM NITROARGININE AND PEPTIDES OF NITROARGININE BY ELECTROLYTIC REDUCTION.

SCOPES PM, WALSHAW KB, WELFORD M, YOUNG GT.

J Chem Soc. 1965 Jan;47:782-6. No abstract available.

PMID:
14275664
38.

The synthesis of some peptides containing glutamic acid.

ROWLANDS DA, YOUNG GT.

Biochem J. 1957 Mar;65(3):516-9. No abstract available.

39.

Determination of chemical purity.

HUGHES IW, YOUNG GT.

Nature. 1949 Sep 17;164(4168):503. No abstract available.

PMID:
18140466
40.

Synthesis of gamma-glutamyl peptides.

LE QUESNE WJ, YOUNG GT.

Nature. 1949 Apr 16;163(4146):604. No abstract available.

PMID:
18224957

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