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Snf1-Dependent Transcription Confers Glucose-Induced Decay upon the mRNA Product.

Braun KA, Dombek KM, Young ET.

Mol Cell Biol. 2015 Dec 14;36(4):628-44. doi: 10.1128/MCB.00436-15. Print 2016 Feb 15.


Yeast 14-3-3 protein functions as a comodulator of transcription by inhibiting coactivator functions.

Parua PK, Dombek KM, Young ET.

J Biol Chem. 2014 Dec 19;289(51):35542-60. doi: 10.1074/jbc.M114.592287. Epub 2014 Oct 29.


Coupling mRNA synthesis and decay.

Braun KA, Young ET.

Mol Cell Biol. 2014 Nov 15;34(22):4078-87. doi: 10.1128/MCB.00535-14. Epub 2014 Aug 25. Review.


Phosphoproteomic analysis identifies proteins involved in transcription-coupled mRNA decay as targets of Snf1 signaling.

Braun KA, Vaga S, Dombek KM, Fang F, Palmisano S, Aebersold R, Young ET.

Sci Signal. 2014 Jul 8;7(333):ra64. doi: 10.1126/scisignal.2005000.


Binding and transcriptional regulation by 14-3-3 (Bmh) proteins requires residues outside of the canonical motif.

Parua PK, Young ET.

Eukaryot Cell. 2014 Jan;13(1):21-30. doi: 10.1128/EC.00240-13. Epub 2013 Oct 18.


14-3-3 (Bmh) proteins regulate combinatorial transcription following RNA polymerase II recruitment by binding at Adr1-dependent promoters in Saccharomyces cerevisiae.

Braun KA, Parua PK, Dombek KM, Miner GE, Young ET.

Mol Cell Biol. 2013 Feb;33(4):712-24. doi: 10.1128/MCB.01226-12. Epub 2012 Dec 3.


The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae.

Young ET, Zhang C, Shokat KM, Parua PK, Braun KA.

J Biol Chem. 2012 Aug 17;287(34):29021-34. doi: 10.1074/jbc.M112.380147. Epub 2012 Jul 2.


Pichia pastoris 14-3-3 regulates transcriptional activity of the methanol inducible transcription factor Mxr1 by direct interaction.

Parua PK, Ryan PM, Trang K, Young ET.

Mol Microbiol. 2012 Jul;85(2):282-98. doi: 10.1111/j.1365-2958.2012.08112.x. Epub 2012 Jun 12.


Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter.

Abate G, Bastonini E, Braun KA, Verdone L, Young ET, Caserta M.

Biochim Biophys Acta. 2012 May;1819(5):419-27. doi: 10.1016/j.bbagrm.2012.01.009. Epub 2012 Jan 28.


Analysis of nucleosome positioning using a nucleosome-scanning assay.

Infante JJ, Law GL, Young ET.

Methods Mol Biol. 2012;833:63-87. doi: 10.1007/978-1-61779-477-3_5.


Toward a global analysis of metabolites in regulatory mutants of yeast.

Humston EM, Dombek KM, Tu BP, Young ET, Synovec RE.

Anal Bioanal Chem. 2011 Nov;401(8):2387-402. doi: 10.1007/s00216-011-4800-2. Epub 2011 Mar 17.


Activator-independent transcription of Snf1-dependent genes in mutants lacking histone tails.

Infante JJ, Law GL, Wang IT, Chang HW, Young ET.

Mol Microbiol. 2011 Apr;80(2):407-22. doi: 10.1111/j.1365-2958.2011.07583.x. Epub 2011 Mar 1.


14-3-3 (Bmh) proteins inhibit transcription activation by Adr1 through direct binding to its regulatory domain.

Parua PK, Ratnakumar S, Braun KA, Dombek KM, Arms E, Ryan PM, Young ET.

Mol Cell Biol. 2010 Nov;30(22):5273-83. doi: 10.1128/MCB.00715-10. Epub 2010 Sep 20.


Snf1 dependence of peroxisomal gene expression is mediated by Adr1.

Ratnakumar S, Young ET.

J Biol Chem. 2010 Apr 2;285(14):10703-14. doi: 10.1074/jbc.M109.079848. Epub 2010 Feb 6.


Cloudy with a chance of stars. Making a star is no easy thing.

Young ET.

Sci Am. 2010 Feb;302(2):34-41. No abstract available.


Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant of Saccharomyces cerevisiae.

Young ET, Yen K, Dombek KM, Law GL, Chang E, Arms E.

Mol Microbiol. 2009 Oct;74(2):364-83. doi: 10.1111/j.1365-2958.2009.06866.x. Epub 2009 Sep 2.


Snf1 controls the activity of adr1 through dephosphorylation of Ser230.

Ratnakumar S, Kacherovsky N, Arms E, Young ET.

Genetics. 2009 Jul;182(3):735-45. doi: 10.1534/genetics.109.103432. Epub 2009 Apr 27.


The disorderly study of ordered recruitment.

Biddick R, Young ET.

Yeast. 2009 Apr;26(4):205-20. doi: 10.1002/yea.1660. Review.


The transcriptional coactivators SAGA, SWI/SNF, and mediator make distinct contributions to activation of glucose-repressed genes.

Biddick RK, Law GL, Chin KK, Young ET.

J Biol Chem. 2008 Nov 28;283(48):33101-9. doi: 10.1074/jbc.M805258200. Epub 2008 Sep 30.


Time-dependent profiling of metabolites from Snf1 mutant and wild type yeast cells.

Humston EM, Dombek KM, Hoggard JC, Young ET, Synovec RE.

Anal Chem. 2008 Nov 1;80(21):8002-11. doi: 10.1021/ac800998j. Epub 2008 Oct 1.


Promoter binding by the Adr1 transcriptional activator may be regulated by phosphorylation in the DNA-binding region.

Kacherovsky N, Tachibana C, Amos E, Fox D 3rd, Young ET.

PLoS One. 2008 Sep 15;3(9):e3213. doi: 10.1371/journal.pone.0003213.


Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression.

Young ET, Tachibana C, Chang HW, Dombek KM, Arms EM, Biddick R.

Mol Cell Biol. 2008 Apr;28(8):2509-16. doi: 10.1128/MCB.00658-07. Epub 2008 Feb 4.


Adr1 and Cat8 mediate coactivator recruitment and chromatin remodeling at glucose-regulated genes.

Biddick RK, Law GL, Young ET.

PLoS One. 2008 Jan 16;3(1):e1436. doi: 10.1371/journal.pone.0001436.


Identification and evaluation of cycling yeast metabolites in two-dimensional comprehensive gas chromatography-time-of-flight-mass spectrometry data.

Mohler RE, Tu BP, Dombek KM, Hoggard JC, Young ET, Synovec RE.

J Chromatogr A. 2008 Apr 4;1186(1-2):401-11. Epub 2007 Oct 25.


A poised initiation complex is activated by SNF1.

Tachibana C, Biddick R, Law GL, Young ET.

J Biol Chem. 2007 Dec 28;282(52):37308-15. Epub 2007 Oct 31.


Cyclic changes in metabolic state during the life of a yeast cell.

Tu BP, Mohler RE, Liu JC, Dombek KM, Young ET, Synovec RE, McKnight SL.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16886-91. Epub 2007 Oct 16.


Comprehensive analysis of yeast metabolite GC x GC-TOFMS data: combining discovery-mode and deconvolution chemometric software.

Mohler RE, Dombek KM, Hoggard JC, Pierce KM, Young ET, Synovec RE.

Analyst. 2007 Aug;132(8):756-67. Epub 2007 May 22.


Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae.

Voronkova V, Kacherovsky N, Tachibana C, Yu D, Young ET.

Genetics. 2006 Apr;172(4):2123-38. Epub 2006 Jan 16.


Yeast mediator and its role in transcriptional regulation.

Biddick R, Young ET.

C R Biol. 2005 Sep;328(9):773-82. Epub 2005 Apr 20. Review.


Dexmedetomidine sedation in a pediatric cardiac patient scheduled for MRI.

Young ET.

Can J Anaesth. 2005 Aug-Sep;52(7):730-2.


Infrared echoes near the supernova remnant Cassiopeia A.

Krause O, Rieke GH, Birkmann SM, Le Floc'h E, Gordon KD, Egami E, Bieging J, Hughes JP, Young ET, Hinz JL, Quanz SP, Hines DC.

Science. 2005 Jun 10;308(5728):1604-6.


Combined global localization analysis and transcriptome data identify genes that are directly coregulated by Adr1 and Cat8.

Tachibana C, Yoo JY, Tagne JB, Kacherovsky N, Lee TI, Young ET.

Mol Cell Biol. 2005 Mar;25(6):2138-46.


Simultaneous multichannel mass-specific detection for high-performance liquid chromatography using an array detector sector-field mass spectrometer.

Barnes JH 4th, Schilling GD, Stone SF, Sperline RP, Denton MB, Young ET, Barinaga CJ, Koppenaal DW, Hieftje GM.

Anal Bioanal Chem. 2004 Sep;380(2):227-34. Epub 2004 Jul 28.


The Reg1-interacting proteins, Bmh1, Bmh2, Ssb1, and Ssb2, have roles in maintaining glucose repression in Saccharomyces cerevisiae.

Dombek KM, Kacherovsky N, Young ET.

J Biol Chem. 2004 Sep 10;279(37):39165-74. Epub 2004 Jun 25.


Characterization of a focal plane camera fitted to a Mattauch-Herzog geometry mass spectrograph. 2. Use with an inductively coupled plasma.

Barnes JH 4th, Schilling GD, Sperline R, Denton MB, Young ET, Barinaga CJ, Koppenaal DW, Hieftje GM.

Anal Chem. 2004 May 1;76(9):2531-6.


Genome-wide amplifications caused by chromosomal rearrangements play a major role in the adaptive evolution of natural yeast.

Infante JJ, Dombek KM, Rebordinos L, Cantoral JM, Young ET.

Genetics. 2003 Dec;165(4):1745-59.


Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8.

Young ET, Dombek KM, Tachibana C, Ideker T.

J Biol Chem. 2003 Jul 11;278(28):26146-58. Epub 2003 Apr 3.


Characterization of a focal plane camera fitted to a Mattauch-Herzog geometry mass spectrograph. 1. Use with a glow-discharge source.

Barnes JH 4th, Sperline R, Denton MB, Barinaga CJ, Koppenaal D, Young ET, Hieftje GM.

Anal Chem. 2002 Oct 15;74(20):5327-32.


Snf1 protein kinase regulates Adr1 binding to chromatin but not transcription activation.

Young ET, Kacherovsky N, Van Riper K.

J Biol Chem. 2002 Oct 11;277(41):38095-103. Epub 2002 Aug 6.


Hyperacetylation of chromatin at the ADH2 promoter allows Adr1 to bind in repressed conditions.

Verdone L, Wu J, van Riper K, Kacherovsky N, Vogelauer M, Young ET, Grunstein M, Di Mauro E, Caserta M.

EMBO J. 2002 Mar 1;21(5):1101-11.


Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg.

Cohen DJ, Ellerman DA, Busso D, Morgenfeld MM, Piazza AD, Hayashi M, Young ET, Kasahara M, Cuasnicu PS.

Biol Reprod. 2001 Oct;65(4):1000-5.


Evidence for a Graves' disease susceptibility locus at chromosome Xp11 in a United Kingdom population.

Imrie H, Vaidya B, Perros P, Kelly WF, Toft AD, Young ET, Kendall-Taylor P, Pearce SH.

J Clin Endocrinol Metab. 2001 Feb;86(2):626-30.


Evidence for a new Graves disease susceptibility locus at chromosome 18q21.

Vaidya B, Imrie H, Perros P, Young ET, Kelly WF, Carr D, Large DM, Toft AD, Kendall-Taylor P, Pearce SH.

Am J Hum Genet. 2000 May;66(5):1710-4. Epub 2000 Apr 3.


Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae.

Young ET, Sloan JS, Van Riper K.

Genetics. 2000 Mar;154(3):1053-68.


Evolution of a glucose-regulated ADH gene in the genus Saccharomyces.

Young ET, Sloan J, Miller B, Li N, van Riper K, Dombek KM.

Gene. 2000 Mar 21;245(2):299-309.


Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE-1) genes in sporadic autoimmune Addison's disease.

Vaidya B, Imrie H, Geatch DR, Perros P, Ball SG, Baylis PH, Carr D, Hurel SJ, James RA, Kelly WF, Kemp EH, Young ET, Weetman AP, Kendall-Taylor P, Pearce SH.

J Clin Endocrinol Metab. 2000 Feb;85(2):688-91.


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