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Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex.

Chiner-Oms Á, Berney M, Boinett C, González-Candelas F, Young DB, Gagneux S, Jacobs WR Jr, Parkhill J, Cortes T, Comas I.

Nat Commun. 2019 Sep 5;10(1):3994. doi: 10.1038/s41467-019-11948-6.


Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival.

Cortes T, Schubert OT, Banaei-Esfahani A, Collins BC, Aebersold R, Young DB.

Sci Rep. 2017 Aug 15;7(1):8208. doi: 10.1038/s41598-017-08306-1.


A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity.

Schnettger L, Rodgers A, Repnik U, Lai RP, Pei G, Verdoes M, Wilkinson RJ, Young DB, Gutierrez MG.

Cell Host Microbe. 2017 May 10;21(5):619-628.e5. doi: 10.1016/j.chom.2017.04.004.


Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography.

Esmail H, Lai RP, Lesosky M, Wilkinson KA, Graham CM, Coussens AK, Oni T, Warwick JM, Said-Hartley Q, Koegelenberg CF, Walzl G, Flynn JL, Young DB, Barry Iii CE, O'Garra A, Wilkinson RJ.

Nat Med. 2016 Oct;22(10):1090-1093. doi: 10.1038/nm.4161. Epub 2016 Sep 5.


Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis.

Chenge J, Kavanagh ME, Driscoll MD, McLean KJ, Young DB, Cortes T, Matak-Vinkovic D, Levy CW, Rigby SE, Leys D, Abell C, Munro AW.

Sci Rep. 2016 May 26;6:26628. doi: 10.1038/srep26628.


6'6" United States Marine Seeks Treatment for Gynecomastia Only to Learn It Is All in His Head.

Young DB.

Mil Med. 2015 Dec;180(12):e1290-2. doi: 10.7205/MILMED-D-15-00248.


Comparison of the breadth and complexity of bovine viral diarrhea (BVDV) populations circulating in 34 persistently infected cattle generated in one outbreak.

Ridpath JF, Bayles DO, Neill JD, Falkenberg SM, Bauermann FV, Holler L, Braun LJ, Young DB, Kane SE, Chase CC.

Virology. 2015 Nov;485:297-304. doi: 10.1016/j.virol.2015.07.022. Epub 2015 Aug 28.


Admixture mapping of tuberculosis and pigmentation-related traits in an African-European hybrid cattle population.

Kassahun Y, Mattiangeli V, Ameni G, Hailu E, Aseffa A, Young DB, Hewinson RG, Vordermeier HM, Bradley DG.

Front Genet. 2015 Jun 15;6:210. doi: 10.3389/fgene.2015.00210. eCollection 2015.


Bovine viral diarrhea virus outbreak in a beef cow herd in South Dakota.

Kane SE, Holler LD, Braun LJ, Neill JD, Young DB, Ridpath JF, Chase CC.

J Am Vet Med Assoc. 2015 Jun 15;246(12):1358-62. doi: 10.2460/javma.246.12.1358.


Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis.

Young DB, Comas I, de Carvalho LP.

Front Mol Biosci. 2015 Mar 4;2:6. doi: 10.3389/fmolb.2015.00006. eCollection 2015. Review.


Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis.

Torres M, García-García L, Cruz-Hervert P, Guio H, Carranza C, Ferreyra-Reyes L, Canizales S, Molina S, Ferreira-Guerrero E, Téllez N, Montero-Campos R, Delgado-Sánchez G, Mongua-Rodriguez N, Sifuentes-Osornio J, Ponce-de Leon A, Sada E, Young DB, Wilkinson RJ.

Eur Respir J. 2015 Feb;45(2):473-82. doi: 10.1183/09031936.00123314. Epub 2014 Oct 30.


Genomic mapping of cAMP receptor protein (CRP Mt) in Mycobacterium tuberculosis: relation to transcriptional start sites and the role of CRPMt as a transcription factor.

Kahramanoglou C, Cortes T, Matange N, Hunt DM, Visweswariah SS, Young DB, Buxton RS.

Nucleic Acids Res. 2014 Jul;42(13):8320-9. doi: 10.1093/nar/gku548. Epub 2014 Jun 23.


The ongoing challenge of latent tuberculosis.

Esmail H, Barry CE 3rd, Young DB, Wilkinson RJ.

Philos Trans R Soc Lond B Biol Sci. 2014 May 12;369(1645):20130437. doi: 10.1098/rstb.2013.0437. Print 2014. Review.


Noncoding RNA in Mycobacteria.

Arnvig KB, Cortes T, Young DB.

Microbiol Spectr. 2014 Apr;2(2). doi: 10.1128/microbiolspec.MGM2-0029-2013. Review.


A small RNA encoded in the Rv2660c locus of Mycobacterium tuberculosis is induced during starvation and infection.

Houghton J, Cortes T, Schubert O, Rose G, Rodgers A, De Ste Croix M, Aebersold R, Young DB, Arnvig KB.

PLoS One. 2013 Dec 12;8(12):e80047. doi: 10.1371/journal.pone.0080047. eCollection 2013.


Analytical performance issues: quantifying response time in carbon monoxide monitors to produce high-resolution measurements.

Young DB, Jones RM.

J Occup Environ Hyg. 2014;11(1):D17-9. doi: 10.1080/15459624.2013.839880. No abstract available.


Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.

Everitt AR, Clare S, McDonald JU, Kane L, Harcourt K, Ahras M, Lall A, Hale C, Rodgers A, Young DB, Haque A, Billker O, Tregoning JS, Dougan G, Kellam P.

PLoS One. 2013 Nov 21;8(11):e80723. doi: 10.1371/journal.pone.0080723. eCollection 2013.


Genome-wide mapping of transcriptional start sites defines an extensive leaderless transcriptome in Mycobacterium tuberculosis.

Cortes T, Schubert OT, Rose G, Arnvig KB, Comas I, Aebersold R, Young DB.

Cell Rep. 2013 Nov 27;5(4):1121-31. doi: 10.1016/j.celrep.2013.10.031. Epub 2013 Nov 21. Erratum in: Cell Rep. 2014 Jan 30;6(2):415.


Mapping of genotype-phenotype diversity among clinical isolates of mycobacterium tuberculosis by sequence-based transcriptional profiling.

Rose G, Cortes T, Comas I, Coscolla M, Gagneux S, Young DB.

Genome Biol Evol. 2013;5(10):1849-62. doi: 10.1093/gbe/evt138.


Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA.

Schuessler DL, Cortes T, Fivian-Hughes AS, Lougheed KE, Harvey E, Buxton RS, Davis EO, Young DB.

Mol Microbiol. 2013 Oct;90(1):195-207. doi: 10.1111/mmi.12358. Epub 2013 Aug 23.


A restatement of the natural science evidence base relevant to the control of bovine tuberculosis in Great Britain.

Godfray HC, Donnelly CA, Kao RR, Macdonald DW, McDonald RA, Petrokofsky G, Wood JL, Woodroffe R, Young DB, McLean AR.

Proc Biol Sci. 2013 Aug 7;280(1768):20131634. doi: 10.1098/rspb.2013.1634. Print 2013 Oct 7.


Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus).

Via LE, Weiner DM, Schimel D, Lin PL, Dayao E, Tankersley SL, Cai Y, Coleman MT, Tomko J, Paripati P, Orandle M, Kastenmayer RJ, Tartakovsky M, Rosenthal A, Portevin D, Eum SY, Lahouar S, Gagneux S, Young DB, Flynn JL, Barry CE 3rd.

Infect Immun. 2013 Aug;81(8):2909-19. doi: 10.1128/IAI.00632-13. Epub 2013 May 28.


Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia.

Firdessa R, Berg S, Hailu E, Schelling E, Gumi B, Erenso G, Gadisa E, Kiros T, Habtamu M, Hussein J, Zinsstag J, Robertson BD, Ameni G, Lohan AJ, Loftus B, Comas I, Gagneux S, Tschopp R, Yamuah L, Hewinson G, Gordon SV, Young DB, Aseffa A.

Emerg Infect Dis. 2013 Mar;19(3):460-3. doi: 10.3201/eid1903.120256.


Bioinformatic and empirical analysis of novel hypoxia-inducible targets of the human antituberculosis T cell response.

Gideon HP, Wilkinson KA, Rustad TR, Oni T, Guio H, Sherman DR, Vordermeier HM, Robertson BD, Young DB, Wilkinson RJ.

J Immunol. 2012 Dec 15;189(12):5867-76. doi: 10.4049/jimmunol.1202281. Epub 2012 Nov 19.


Control of Cardiac Output.

Young DB.

San Rafael (CA): Morgan & Claypool Life Sciences; 2010.


Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.

Pitt JM, Stavropoulos E, Redford PS, Beebe AM, Bancroft GJ, Young DB, O'Garra A.

J Immunol. 2012 Oct 15;189(8):4079-87. doi: 10.4049/jimmunol.1201061. Epub 2012 Sep 12.


Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment.

Coussens AK, Wilkinson RJ, Hanifa Y, Nikolayevskyy V, Elkington PT, Islam K, Timms PM, Venton TR, Bothamley GH, Packe GE, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Mein CA, Bhaw-Rosun L, Nuamah R, Young DB, Drobniewski FA, Griffiths CJ, Martineau AR.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15449-54. Epub 2012 Sep 4.


Conserved immune recognition hierarchy of mycobacterial PE/PPE proteins during infection in natural hosts.

Vordermeier HM, Hewinson RG, Wilkinson RJ, Wilkinson KA, Gideon HP, Young DB, Sampson SL.

PLoS One. 2012;7(8):e40890. doi: 10.1371/journal.pone.0040890. Epub 2012 Aug 1.


OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection.

Snelgrove RJ, Cornere MM, Edwards L, Dagg B, Keeble J, Rodgers A, Lyonga DE, Stewart GR, Young DB, Walker B, Hussell T.

J Infect Dis. 2012 Mar 15;205(6):975-83. doi: 10.1093/infdis/jir868. Epub 2012 Feb 7.


The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia.

Vordermeier M, Ameni G, Berg S, Bishop R, Robertson BD, Aseffa A, Hewinson RG, Young DB.

Comp Immunol Microbiol Infect Dis. 2012 May;35(3):227-32. doi: 10.1016/j.cimid.2012.01.003. Epub 2012 Feb 1. Review.


Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis.

Arnvig KB, Comas I, Thomson NR, Houghton J, Boshoff HI, Croucher NJ, Rose G, Perkins TT, Parkhill J, Dougan G, Young DB.

PLoS Pathog. 2011 Nov;7(11):e1002342. doi: 10.1371/journal.ppat.1002342. Epub 2011 Nov 3.


Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles.

Krishnan N, Malaga W, Constant P, Caws M, Tran TH, Salmons J, Nguyen TN, Nguyen DB, Daffé M, Young DB, Robertson BD, Guilhot C, Thwaites GE.

PLoS One. 2011;6(9):e23870. doi: 10.1371/journal.pone.0023870. Epub 2011 Sep 8.


Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines.

Gideon HP, Wilkinson KA, Rustad TR, Oni T, Guio H, Kozak RA, Sherman DR, Meintjes G, Behr MA, Vordermeier HM, Young DB, Wilkinson RJ.

PLoS Pathog. 2010 Dec 23;6(12):e1001237. doi: 10.1371/journal.ppat.1001237.


Conversion from pure laparoscopy to hand-assisted laparoscopy for control of bleeding in renal surgery: an attractive alternative to open conversion.

Vricella GJ, Young DB, Boncher NA, Madi R.

J Endourol. 2011 Jan;25(1):81-4. doi: 10.1089/end.2010.0321. Epub 2010 Oct 7.


Field evaluation of the efficacy of Mycobacterium bovis bacillus Calmette-Guerin against bovine tuberculosis in neonatal calves in Ethiopia.

Ameni G, Vordermeier M, Aseffa A, Young DB, Hewinson RG.

Clin Vaccine Immunol. 2010 Oct;17(10):1533-8. doi: 10.1128/CVI.00222-10. Epub 2010 Aug 18.


Identification of small RNAs in Mycobacterium tuberculosis.

Arnvig KB, Young DB.

Mol Microbiol. 2009 Aug;73(3):397-408. doi: 10.1111/j.1365-2958.2009.06777.x. Epub 2009 Jun 22.


Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis.

Wilkinson KA, Newton SM, Stewart GR, Martineau AR, Patel J, Sullivan SM, Herrmann JL, Neyrolles O, Young DB, Wilkinson RJ.

BMC Microbiol. 2009 May 14;9:93. doi: 10.1186/1471-2180-9-93.


Eliminating latent tuberculosis.

Young DB, Gideon HP, Wilkinson RJ.

Trends Microbiol. 2009 May;17(5):183-8. doi: 10.1016/j.tim.2009.02.005. Epub 2009 Apr 16.


Molecular analysis of Mycobacterium tuberculosis strains with an intact pks15/1 gene in a rural community of Mexico.

Martinez-Gamboa A, Ponce-de-Leon A, Galindo-Fraga A, Bobadilla-del-Valle M, Kato-Maeda M, Robertson BD, Young DB, Small PM, Sifuentes-Osornio J.

Arch Med Res. 2008 Nov;39(8):809-14. doi: 10.1016/j.arcmed.2008.08.006.


The heat shock response of Mycobacterium tuberculosis: linking gene expression, immunology and pathogenesis.

Stewart GR, Wernisch L, Stabler R, Mangan JA, Hinds J, Laing KG, Butcher PD, Young DB.

Comp Funct Genomics. 2002;3(4):348-51. doi: 10.1002/cfg.183.


The development and validation of The Inquiry Science Observation Coding Sheet.

Brandon PR, Taum AK, Young DB, Pottenger FM 3rd.

Eval Program Plann. 2008 Aug;31(3):247-58. doi: 10.1016/j.evalprogplan.2008.03.007. Epub 2008 Apr 9.


Use of short tandem repeat sequences to study Mycobacterium leprae in leprosy patients in Malawi and India.

Young SK, Ponnighaus JM, Jain S, Lucas S, Suneetha S, Lockwood DN, Young DB, Fine PE.

PLoS Negl Trop Dis. 2008 Apr 9;2(4):e214. doi: 10.1371/journal.pntd.0000214.


Confronting the scientific obstacles to global control of tuberculosis.

Young DB, Perkins MD, Duncan K, Barry CE 3rd.

J Clin Invest. 2008 Apr;118(4):1255-65. doi: 10.1172/JCI34614. Review.


The effect of ultraviolet B-induced vitamin D levels on host resistance to Mycobacterium tuberculosis: a pilot study in immigrant Asian adults living in the United Kingdom.

Yesudian PD, Berry JL, Wiles S, Hoyle S, Young DB, Haylett AK, Rhodes LE, Davies P.

Photodermatol Photoimmunol Photomed. 2008 Apr;24(2):97-8. doi: 10.1111/j.1600-0781.2008.00339.x.


Effect of skin testing and segregation on the prevalence of bovine tuberculosis, and molecular typing of Mycobacterium bovis, in Ethiopia.

Ameni G, Aseffa A, Sirak A, Engers H, Young DB, Hewinson RG, Vordermeier MH, Gordon SV.

Vet Rec. 2007 Dec 8;161(23):782-6.


A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties.

Henao-Tamayo M, Junqueira-Kipnis AP, Ordway D, Gonzales-Juarrero M, Stewart GR, Young DB, Wilkinson RJ, Basaraba RJ, Orme IM.

Vaccine. 2007 Oct 10;25(41):7153-9. Epub 2007 Aug 13.


BCoR-L1 variation and breast cancer.

Lose F, Arnold J, Young DB, Brown CJ, Mann GJ, Pupo GM; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Khanna KK, Chenevix-Trench G, Spurdle AB.

Breast Cancer Res. 2007;9(4):R54. Erratum in: Breast Cancer Res. 2008;10(5):406.


A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP.

Pagan JK, Arnold J, Hanchard KJ, Kumar R, Bruno T, Jones MJ, Richard DJ, Forrest A, Spurdle A, Verdin E, Crossley M, Fanciulli M, Chenevix-Trench G, Young DB, Khanna KK.

J Biol Chem. 2007 May 18;282(20):15248-57. Epub 2007 Mar 22.


Unusual features of the cell cycle in mycobacteria: polar-restricted growth and the snapping-model of cell division.

Thanky NR, Young DB, Robertson BD.

Tuberculosis (Edinb). 2007 May;87(3):231-6. Epub 2007 Feb 6.


Systems biology and its impact on anti-infective drug development.

Stumpf MP, Robertson BD, Duncan K, Young DB.

Prog Drug Res. 2007;64:1, 3-20. Review.


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