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Items: 18


Solving the missing heritability problem.

Young AI.

PLoS Genet. 2019 Jun 24;15(6):e1008222. doi: 10.1371/journal.pgen.1008222. eCollection 2019 Jun. No abstract available.


Identifying loci affecting trait variability and detecting interactions in genome-wide association studies.

Young AI, Wauthier FL, Donnelly P.

Nat Genet. 2018 Nov;50(11):1608-1614. doi: 10.1038/s41588-018-0225-6. Epub 2018 Oct 15.


Relatedness disequilibrium regression estimates heritability without environmental bias.

Young AI, Frigge ML, Gudbjartsson DF, Thorleifsson G, Bjornsdottir G, Sulem P, Masson G, Thorsteinsdottir U, Stefansson K, Kong A.

Nat Genet. 2018 Sep;50(9):1304-1310. doi: 10.1038/s41588-018-0178-9. Epub 2018 Aug 13.


The nature of nurture: Effects of parental genotypes.

Kong A, Thorleifsson G, Frigge ML, Vilhjalmsson BJ, Young AI, Thorgeirsson TE, Benonisdottir S, Oddsson A, Halldorsson BV, Masson G, Gudbjartsson DF, Helgason A, Bjornsdottir G, Thorsteinsdottir U, Stefansson K.

Science. 2018 Jan 26;359(6374):424-428. doi: 10.1126/science.aan6877.


Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.

Young AI, Timpson P, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Cell Adh Migr. 2018;12(6):513-523. doi: 10.1080/19336918.2017.1393591. Epub 2017 Dec 21. Review.


Andy's Algorithms: new automated digital image analysis pipelines for FIJI.

Law AMK, Yin JXM, Castillo L, Young AIJ, Piggin C, Rogers S, Caldon CE, Burgess A, Millar EKA, O'Toole SA, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Sci Rep. 2017 Nov 16;7(1):15717. doi: 10.1038/s41598-017-15885-6.


A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.

Oakes SR, Gallego-Ortega D, Stanford PM, Junankar S, Au WWY, Kikhtyak Z, von Korff A, Sergio CM, Law AMK, Castillo LE, Allerdice SL, Young AIJ, Piggin C, Whittle B, Bertram E, Naylor MJ, Roden DL, Donovan J, Korennykh A, Goodnow CC, O'Bryan MK, Ormandy CJ.

PLoS Genet. 2017 Nov 8;13(11):e1007072. doi: 10.1371/journal.pgen.1007072. eCollection 2017 Nov.


Selection against variants in the genome associated with educational attainment.

Kong A, Frigge ML, Thorleifsson G, Stefansson H, Young AI, Zink F, Jonsdottir GA, Okbay A, Sulem P, Masson G, Gudbjartsson DF, Helgason A, Bjornsdottir G, Thorsteinsdottir U, Stefansson K.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E727-E732. doi: 10.1073/pnas.1612113114. Epub 2017 Jan 17.


MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib.

Young AI, Law AM, Castillo L, Chong S, Cullen HD, Koehler M, Herzog S, Brummer T, Lee EF, Fairlie WD, Lucas MC, Herrmann D, Allam A, Timpson P, Watkins DN, Millar EK, O'Toole SA, Gallego-Ortega D, Ormandy CJ, Oakes SR.

Breast Cancer Res. 2016 Dec 8;18(1):125.


Powerful decomposition of complex traits in a diploid model.

Hallin J, Märtens K, Young AI, Zackrisson M, Salinas F, Parts L, Warringer J, Liti G.

Nat Commun. 2016 Nov 2;7:13311. doi: 10.1038/ncomms13311.


Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index.

Young AI, Wauthier F, Donnelly P.

Nat Commun. 2016 Sep 6;7:12724. doi: 10.1038/ncomms12724.


ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.

Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhtyak Z, Cho C, Allerdice SL, Lee HJ, Valdes-Mora F, Herrmann D, Salomon R, Young AI, Lee BY, Sergio CM, Kaplan W, Piggin C, Conway JR, Rabinovich B, Millar EK, Oakes SR, Chtanova T, Swarbrick A, Naylor MJ, O'Toole S, Green AR, Timpson P, Gee JM, Ellis IO, Clark SJ, Ormandy CJ.

PLoS Biol. 2015 Dec 30;13(12):e1002330. doi: 10.1371/journal.pbio.1002330. eCollection 2015 Dec.


Estimation of epistatic variance components and heritability in founder populations and crosses.

Young AI, Durbin R.

Genetics. 2014 Dec;198(4):1405-16. doi: 10.1534/genetics.114.170795. Epub 2014 Oct 17.


Political attitudes bias the mental representation of a presidential candidate's face.

Young AI, Ratner KG, Fazio RH.

Psychol Sci. 2014 Feb;25(2):503-10. doi: 10.1177/0956797613510717. Epub 2013 Dec 23.


The use of a co-design model in improving timely bleed reporting by adults with haemophilia living in the Auckland region of New Zealand.

d'Young AI, Young L, Ockelford PA, Brasser M, Slavin K, Manson L, Preston S.

Haemophilia. 2014 May;20(3):388-97. doi: 10.1111/hae.12336. Epub 2013 Nov 29.


Conservative physiotherapeutic management of chronic haematomata and haemophilic pseudotumours: case study and comparison to historical management.

D'Young AI.

Haemophilia. 2009 Jan;15(1):253-60. doi: 10.1111/j.1365-2516.2008.01855.x. Epub 2008 Sep 8.


Domiciliary application of CryoCuff in severe haemophilia: qualitative questionnaire and clinical audit.

d'Young AI.

Haemophilia. 2008 Jul;14(4):823-7. doi: 10.1111/j.1365-2516.2008.01701.x. Epub 2008 May 7.


Megalocornea and mosaic dystrophy in identical twins.

Young AI.

Am J Ophthalmol. 1968 Oct;66(4):734-5. No abstract available.


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