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The Prospective Huntington At-Risk Observational Study (PHAROS): The Emotional Well-Being, Safety and Feasibility of Long-Term Research Participation.

Kayson E, Eberly S, Anderson KE, Marder K, Shoulson I, Oakes D, Young AB, Biglan K, Hersch S; Huntington Study Group PHAROS Investigators.

J Huntingtons Dis. 2019;8(4):435-441. doi: 10.3233/JHD-190365.


Phenotype-genotype discrepancies in the prospective Huntington at-risk observational study.

Shoulson I, Eberly S, Oakes D, Kayson E, Young AB; PHAROS Investigators.

Ann Clin Transl Neurol. 2019 May 1;6(6):1046-1052. doi: 10.1002/acn3.781. eCollection 2019 Jun.


Thaw circles around tree trunks provide spring ephemeral plants with a big head start on the growing season.

Vellend M, Young AB, Letendre G, Rivest S.

Ecology. 2017 Dec;98(12):3224-3226. doi: 10.1002/ecy.2024. Epub 2017 Nov 15. No abstract available.


The Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.

Tippett LJ, Waldvogel HJ, Snell RG, Vonsattel JP, Young AB, Faull RLM.

Adv Neurobiol. 2017;15:129-161. doi: 10.1007/978-3-319-57193-5_5. Review.


The ratio of HLA-DR and VNN2+ expression on CD14+ myeloid derived suppressor cells can distinguish glioblastoma from radiation necrosis patients.

Soler DC, Young AB, Cooper KD, Kerstetter-Fogle A, Barnholtz-Sloan JS, Gittleman H, McCormick TS, Sloan AE.

J Neurooncol. 2017 Aug;134(1):189-196. doi: 10.1007/s11060-017-2508-7. Epub 2017 May 27.


Antibody and cytokine levels in humans fed on by the common bedbug, Cimex lectularius L.

Sheele JM, Ridge GE, Coppolino K, Bonfield T, Young AB, Gaines SL, McCormick TS.

Parasite Immunol. 2017 Mar;39(3). doi: 10.1111/pim.12411.


Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice.

Fritz Y, Klenotic PA, Swindell WR, Yin ZQ, Groft SG, Zhang L, Baliwag J, Camhi MI, Diaconu D, Young AB, Foster AM, Johnston A, Gudjonsson JE, McCormick TS, Ward NL.

J Invest Dermatol. 2017 Mar;137(3):696-705. doi: 10.1016/j.jid.2016.10.021. Epub 2016 Oct 27.


LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.

Chopra V, Quinti L, Khanna P, Paganetti P, Kuhn R, Young AB, Kazantsev AG, Hersch S.

J Huntingtons Dis. 2016 Dec 15;5(4):347-355.


Risk Factors for Suicidal Ideation in People at Risk for Huntington's Disease.

Anderson KE, Eberly S, Groves M, Kayson E, Marder K, Young AB, Shoulson I; PHAROS Investigators.

J Huntingtons Dis. 2016 Dec 15;5(4):389-394.


Increased, but Functionally Impaired, CD14(+) HLA-DR(-/low) Myeloid-Derived Suppressor Cells in Psoriasis: A Mechanism of Dysregulated T Cells.

Soler DC, Young AB, Fiessinger L, Galimberti F, Debanne S, Groft S, McCormick TS, Cooper KD.

J Invest Dermatol. 2016 Apr;136(4):798-808. doi: 10.1016/j.jid.2015.12.036. Epub 2016 Jan 22.


Polarization Engineering in Photonic Crystal Waveguides for Spin-Photon Entanglers.

Young AB, Thijssen AC, Beggs DM, Androvitsaneas P, Kuipers L, Rarity JG, Hughes S, Oulton R.

Phys Rev Lett. 2015 Oct 9;115(15):153901. doi: 10.1103/PhysRevLett.115.153901. Epub 2015 Oct 6.


Massachusetts Alzheimer's Disease Research Center: progress and challenges.

Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR Jr, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, Selkoe DJ, Sperling RA, St George-Hyslop P, Tanzi RE, Yap L, Young AB, Phelps CH, McCaffrey PG.

Alzheimers Dement. 2015 Oct;11(10):1241-5. doi: 10.1016/j.jalz.2015.06.1887. Epub 2015 Aug 19. No abstract available.


Oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function.

Zhou L, Sun WL, Young AB, Lee K, McGinty JF, See RE.

Int J Neuropsychopharmacol. 2014 Oct 31;18(1). pii: pyu009. doi: 10.1093/ijnp/pyu009.


Assessment of a proposed "three-criteria" cocaine addiction model for use in reinstatement studies with rats.

Waters RP, Moorman DE, Young AB, Feltenstein MW, See RE.

Psychopharmacology (Berl). 2014 Aug;231(16):3197-205. doi: 10.1007/s00213-014-3497-2. Epub 2014 Mar 11.


HTRF analysis of soluble huntingtin in PHAROS PBMCs.

Moscovitch-Lopatin M, Goodman RE, Eberly S, Ritch JJ, Rosas HD, Matson S, Matson W, Oakes D, Young AB, Shoulson I, Hersch SM; Huntington Study Group PHAROS Investigators.

Neurology. 2013 Sep 24;81(13):1134-40. doi: 10.1212/WNL.0b013e3182a55ede. Epub 2013 Aug 21.


Psoriasis patients exhibit impairment of the high potency CCR5(+) T regulatory cell subset.

Soler DC, Sugiyama H, Young AB, Massari JV, McCormick TS, Cooper KD.

Clin Immunol. 2013 Oct;149(1):111-8. doi: 10.1016/j.clim.2013.06.007. Epub 2013 Jul 6.


Sex differences in methamphetamine seeking in rats: impact of oxytocin.

Cox BM, Young AB, See RE, Reichel CM.

Psychoneuroendocrinology. 2013 Oct;38(10):2343-53. doi: 10.1016/j.psyneuen.2013.05.005. Epub 2013 Jun 12.


Characterization of the Huntington intermediate CAG repeat expansion phenotype in PHAROS.

Killoran A, Biglan KM, Jankovic J, Eberly S, Kayson E, Oakes D, Young AB, Shoulson I.

Neurology. 2013 May 28;80(22):2022-7. doi: 10.1212/WNL.0b013e318294b304. Epub 2013 Apr 26.


Gamma Knife surgery for the management of glomus tumors: a multicenter study.

Sheehan JP, Tanaka S, Link MJ, Pollock BE, Kondziolka D, Mathieu D, Duma C, Young AB, Kaufmann AM, McBride H, Weisskopf PA, Xu Z, Kano H, Yang HC, Lunsford LD.

J Neurosurg. 2012 Aug;117(2):246-54. doi: 10.3171/2012.4.JNS11214. Epub 2012 Jun 8.


Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.

Sapp E, Valencia A, Li X, Aronin N, Kegel KB, Vonsattel JP, Young AB, Wexler N, DiFiglia M.

J Biol Chem. 2012 Apr 13;287(16):13487-99. doi: 10.1074/jbc.M111.286609. Epub 2012 Feb 27.


Metabotropic glutamate receptor 1 (mGluR1): antibody specificity and receptor expression in cultured primary neurons.

Ayala R, Kett LR, Leach TL, Young AB, Dunah AW, Orlando LR.

J Neurosci Methods. 2012 Mar 15;204(2):221-6. doi: 10.1016/j.jneumeth.2011.11.014. Epub 2011 Dec 2.


Impact of endoscopic surgical techniques on efficiency in pituitary surgery.

Comer BT, Young AB, Gal TJ.

Otolaryngol Head Neck Surg. 2011 Nov;145(5):732-6. doi: 10.1177/0194599811416753. Epub 2011 Jul 22.


Milestones in huntington disease.

Shoulson I, Young AB.

Mov Disord. 2011 May;26(6):1127-33. doi: 10.1002/mds.23685. Review.


Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).

Chan DV, Somani AK, Young AB, Massari JV, Ohtola J, Sugiyama H, Garaczi E, Babineau D, Cooper KD, McCormick TS.

BMC Biochem. 2011 May 26;12:27. doi: 10.1186/1471-2091-12-27.


Stat3 phosphorylation mediates resistance of primary human T cells to regulatory T cell suppression.

Goodman WA, Young AB, McCormick TS, Cooper KD, Levine AD.

J Immunol. 2011 Mar 15;186(6):3336-45. doi: 10.4049/jimmunol.1001455. Epub 2011 Feb 9.


3,4-Methylenedioxymethamphetamine (MDMA) alters acute gammaherpesvirus burden and limits interleukin 27 responses in a mouse model of viral infection.

Nelson DA, Singh SJ, Young AB, Tolbert MD, Bost KL.

Drug Alcohol Depend. 2011 Jul 1;116(1-3):211-21. doi: 10.1016/j.drugalcdep.2010.12.019. Epub 2011 Jan 26.


Causative agents of osteomyelitis induce death domain-containing TNF-related apoptosis-inducing ligand receptor expression on osteoblasts.

Young AB, Cooley ID, Chauhan VS, Marriott I.

Bone. 2011 Apr 1;48(4):857-63. doi: 10.1016/j.bone.2010.11.015. Epub 2010 Dec 3.


Levodopa-induced dyskinesia is associated with increased thyrotropin releasing hormone in the dorsal striatum of hemi-parkinsonian rats.

Cantuti-Castelvetri I, Hernandez LF, Keller-McGandy CE, Kett LR, Landy A, Hollingsworth ZR, Saka E, Crittenden JR, Nillni EA, Young AB, Standaert DG, Graybiel AM.

PLoS One. 2010 Nov 10;5(11):e13861. doi: 10.1371/journal.pone.0013861.


PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR; Global PD Gene Expression (GPEX) Consortium.

Sci Transl Med. 2010 Oct 6;2(52):52ra73. doi: 10.1126/scitranslmed.3001059.


Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.

Zucker B, Kama JA, Kuhn A, Thu D, Orlando LR, Dunah AW, Gokce O, Taylor DM, Lambeck J, Friedrich B, Lindenberg KS, Faull RL, Weiller C, Young AB, Luthi-Carter R.

J Neuropathol Exp Neurol. 2010 Sep;69(9):880-95. doi: 10.1097/NEN.0b013e3181ed7a41.


NOD2 mediates inflammatory responses of primary murine glia to Streptococcus pneumoniae.

Liu X, Chauhan VS, Young AB, Marriott I.

Glia. 2010 May;58(7):839-47. doi: 10.1002/glia.20968.


Four decades of neurodegenerative disease research: how far we have come!

Young AB.

J Neurosci. 2009 Oct 14;29(41):12722-8. doi: 10.1523/JNEUROSCI.3767-09.2009. No abstract available.


Fragmentation of doubly-protonated Pro-His-Xaa tripeptides: formation of b(2)(2+) ions.

Knapp-Mohammady M, Young AB, Paizs B, Harrison AG.

J Am Soc Mass Spectrom. 2009 Nov;20(11):2135-43. doi: 10.1016/j.jasms.2009.07.002. Epub 2009 Jul 10.


Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5.

Orlando LR, Ayala R, Kett LR, Curley AA, Duffner J, Bragg DC, Tsai LH, Dunah AW, Young AB.

J Neurochem. 2009 Jul;110(2):557-69. doi: 10.1111/j.1471-4159.2009.06139.x. Epub 2009 Apr 30.


From the homefront to the frontlines.

Young AB.

Midwifery Today Int Midwife. 2008 Winter;(88):44-5, 68. No abstract available.


Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy.

Crittenden JR, Cantuti-Castelvetri I, Saka E, Keller-McGandy CE, Hernandez LF, Kett LR, Young AB, Standaert DG, Graybiel AM.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2892-6. doi: 10.1073/pnas.0812822106. Epub 2009 Jan 26.


NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens.

Chauhan VS, Sterka DG Jr, Furr SR, Young AB, Marriott I.

Glia. 2009 Mar;57(4):414-23. doi: 10.1002/glia.20770.


Interferences and contaminants encountered in modern mass spectrometry.

Keller BO, Sui J, Young AB, Whittal RM.

Anal Chim Acta. 2008 Oct 3;627(1):71-81. doi: 10.1016/j.aca.2008.04.043. Epub 2008 Apr 25. Review.


Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications.

Brocklebank D, Gayán J, Andresen JM, Roberts SA, Young AB, Snodgrass SR, Penney JB, Ramos-Arroyo MA, Cha JJ, Rosas HD, Hersch SM, Feigin A, Cherny SS, Wexler NS, Housman DE, Cardon LR; International-Venezuela Collaborative Research Group.

Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):425-9. doi: 10.1002/ajmg.b.30826.


Long-term hearing results in gamma knife radiosurgery for acoustic neuromas.

Bush ML, Shinn JB, Young AB, Jones RO.

Laryngoscope. 2008 Jun;118(6):1019-22. doi: 10.1097/MLG.0b013e31816b8cc7.


A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9. Epub 2007 Oct 9.


Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death.

McCall SH, Sahraei M, Young AB, Worley CS, Duncan JA, Ting JP, Marriott I.

J Bone Miner Res. 2008 Jan;23(1):30-40.


Fragmentation of protonated dipeptides containing arginine. Effect of activation method.

Forbes MW, Jockusch RA, Young AB, Harrison AG.

J Am Soc Mass Spectrom. 2007 Nov;18(11):1959-66. Epub 2007 Aug 14.


Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.

Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG.

Science. 2007 Jul 27;317(5837):516-9. Epub 2007 Jun 21.


Myopathy as a first symptom of Huntington's disease in a Marathon runner.

Kosinski CM, Schlangen C, Gellerich FN, Gizatullina Z, Deschauer M, Schiefer J, Young AB, Landwehrmeyer GB, Toyka KV, Sellhaus B, Lindenberg KS.

Mov Disord. 2007 Aug 15;22(11):1637-40.


Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal.

Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, Young AB.

J Neurosurg. 2007 Apr;106(4):614-20.


Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments.

Coufal M, Maxwell MM, Russel DE, Amore AM, Altmann SM, Hollingsworth ZR, Young AB, Housman DE, Kazantsev AG.

J Biomol Screen. 2007 Apr;12(3):351-60. Epub 2007 Mar 22.


Common threads in neurodegenerative disorders of aging.

Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, Wetzel R, Wexler NS, Young AB, Bain L.

Alzheimers Dement. 2006 Oct;2(4):322-6. doi: 10.1016/j.jalz.2006.08.008. No abstract available.


Scrambling of sequence information in collision-induced dissociation of peptides.

Harrison AG, Young AB, Bleiholder C, Suhai S, Paizs B.

J Am Chem Soc. 2006 Aug 16;128(32):10364-5.


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