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Items: 1 to 50 of 93

1.

Metabolomic study of saxitoxin analogues and biosynthetic intermediates in dinoflagellates using 15N-labelled sodium nitrate as a nitrogen source.

Cho Y, Tsuchiya S, Omura T, Koike K, Oikawa H, Konoki K, Oshima Y, Yotsu-Yamashita M.

Sci Rep. 2019 Mar 5;9(1):3460. doi: 10.1038/s41598-019-39708-y.

2.

Total Syntheses and Determination of Absolute Configurations of Cep-212 and Cep-210, Predicted Biosynthetic Intermediates of Tetrodotoxin Isolated from Toxic Newt.

Adachi M, Miyasaka T, Kudo Y, Sugimoto K, Yotsu-Yamashita M, Nishikawa T.

Org Lett. 2019 Feb 1;21(3):780-784. doi: 10.1021/acs.orglett.8b04043. Epub 2019 Jan 10.

PMID:
30628790
3.

Lack of alkaloids and tetrodotoxin in the neotropical frogs Allobates spp. (Aromobatidae) and Silverstoneia flotator (Dendrobatidae).

Mebs D, Yotsu-Yamashita M, Pogoda W, Vargas Alvarez J, Ernst R, Köhler G, Toennes SW.

Toxicon. 2018 Sep 15;152:103-105. doi: 10.1016/j.toxicon.2018.07.027. Epub 2018 Aug 4.

PMID:
30081062
4.

A Novel Compound, "FA-1" Isolated from Prunus mume, Protects Human Bronchial Epithelial Cells and Keratinocytes from Cigarette Smoke Extract-Induced Damage.

Jang AJ, Lee JH, Yotsu-Yamashita M, Park J, Kye S, Benza RL, Passineau MJ, Jeon YJ, Nyunoya T.

Sci Rep. 2018 Jul 31;8(1):11504. doi: 10.1038/s41598-018-29701-2.

5.
6.

Geographic range expansion of tetrodotoxin in amphibians - First record in Atelopus hoogmoedi from the Guiana Shield.

Mebs D, Lorentz M, Yotsu-Yamashita M, Rößler DC, Ernst R, Lötters S.

Toxicon. 2018 Aug;150:175-179. doi: 10.1016/j.toxicon.2018.05.011. Epub 2018 May 19.

PMID:
29782950
7.

Spiro Bicyclic Guanidino Compounds from Pufferfish: Possible Biosynthetic Intermediates of Tetrodotoxin in Marine Environments.

Ueyama N, Sugimoto K, Kudo Y, Onodera KI, Cho Y, Konoki K, Nishikawa T, Yotsu-Yamashita M.

Chemistry. 2018 May 17;24(28):7250-7258. doi: 10.1002/chem.201801006. Epub 2018 Apr 30.

PMID:
29504641
8.

Effects of 4,9-anhydrotetrodotoxin on voltage-gated Na+ channels of mouse vas deferens myocytes and recombinant NaV1.6 channels.

Takahara K, Yamamoto T, Uchida K, Zhu HL, Shibata A, Inai T, Noguchi M, Yotsu-Yamashita M, Teramoto N.

Naunyn Schmiedebergs Arch Pharmacol. 2018 May;391(5):489-499. doi: 10.1007/s00210-018-1476-6. Epub 2018 Feb 16.

PMID:
29453527
9.

Six domoic acid related compounds from the red alga, Chondria armata, and domoic acid biosynthesis by the diatom, Pseudo-nitzschia multiseries.

Maeno Y, Kotaki Y, Terada R, Cho Y, Konoki K, Yotsu-Yamashita M.

Sci Rep. 2018 Jan 10;8(1):356. doi: 10.1038/s41598-017-18651-w.

10.

Total Synthesis of Polycavernosides A and B, Two Lethal Toxins from Red Alga.

Iwasaki K, Sasaki S, Kasai Y, Kawashima Y, Sasaki S, Ito T, Yotsu-Yamashita M, Sasaki M.

J Org Chem. 2017 Dec 15;82(24):13204-13219. doi: 10.1021/acs.joc.7b02293. Epub 2017 Nov 27.

PMID:
29124933
11.

Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Nav 1.1 to Nav 1.7).

Tsukamoto T, Chiba Y, Wakamori M, Yamada T, Tsunogae S, Cho Y, Sakakibara R, Imazu T, Tokoro S, Satake Y, Adachi M, Nishikawa T, Yotsu-Yamashita M, Konoki K.

Br J Pharmacol. 2017 Nov;174(21):3881-3892. doi: 10.1111/bph.13985. Epub 2017 Sep 20.

12.

Dietary administration of tetrodotoxin and its putative biosynthetic intermediates to the captive-reared non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster.

Kudo Y, Chiba C, Konoki K, Cho Y, Yotsu-Yamashita M.

Toxicon. 2017 Oct;137:78-82. doi: 10.1016/j.toxicon.2017.07.016. Epub 2017 Jul 20.

PMID:
28734983
13.

Tetrodotoxin in Asian newts (Salamandridae).

Yotsu-Yamashita M, Toennes SW, Mebs D.

Toxicon. 2017 Aug;134:14-17. doi: 10.1016/j.toxicon.2017.05.014. Epub 2017 May 17.

PMID:
28528177
14.

Synthesis and Identification of Key Biosynthetic Intermediates for the Formation of the Tricyclic Skeleton of Saxitoxin.

Tsuchiya S, Cho Y, Yoshioka R, Konoki K, Nagasawa K, Oshima Y, Yotsu-Yamashita M.

Angew Chem Int Ed Engl. 2017 May 2;56(19):5327-5331. doi: 10.1002/anie.201612461. Epub 2017 Mar 31.

PMID:
28370934
15.

Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B.

Tsukamoto T, Chiba Y, Nakazaki A, Ishikawa Y, Nakane Y, Cho Y, Yotsu-Yamashita M, Nishikawa T, Wakamori M, Konoki K.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1247-1251. doi: 10.1016/j.bmcl.2017.01.054. Epub 2017 Jan 19.

PMID:
28143690
16.

Column switching combined with hydrophilic interaction chromatography-tandem mass spectrometry for the analysis of saxitoxin analogues, and their biosynthetic intermediates in dinoflagellates.

Cho Y, Tsuchiya S, Yoshioka R, Omura T, Konoki K, Oshima Y, Yotsu-Yamashita M.

J Chromatogr A. 2016 Nov 25;1474:109-120. doi: 10.1016/j.chroma.2016.10.065. Epub 2016 Oct 29.

PMID:
27817832
17.

A new sarasinoside congener, sarasinoside M2, from a marine sponge collected in the Solomon Islands.

Puilingi CG, Kudo Y, Cho Y, Konoki K, Yotsu-Yamashita M.

Biosci Biotechnol Biochem. 2017 Feb;81(2):222-225. doi: 10.1080/09168451.2016.1246172. Epub 2016 Oct 20.

PMID:
27760495
18.

Diastereoselective Ring-Closing Metathesis as a Means to Construct Medium-Sized Cyclic Ethers: Application to the Synthesis of a Photoactivatable Gambierol Derivative.

Onodera Y, Hirota K, Suga Y, Konoki K, Yotsu-Yamashita M, Sasaki M, Fuwa H.

J Org Chem. 2016 Sep 16;81(18):8234-52. doi: 10.1021/acs.joc.6b01302. Epub 2016 Sep 2.

PMID:
27529493
19.

Total Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory Activity on Voltage-Gated Sodium Channels.

Wang C, Oki M, Nishikawa T, Harada D, Yotsu-Yamashita M, Nagasawa K.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11600-3. doi: 10.1002/anie.201604155. Epub 2016 Aug 11.

20.

Two Cytochrome P450 Monooxygenases Catalyze Early Hydroxylation Steps in the Potato Steroid Glycoalkaloid Biosynthetic Pathway.

Umemoto N, Nakayasu M, Ohyama K, Yotsu-Yamashita M, Mizutani M, Seki H, Saito K, Muranaka T.

Plant Physiol. 2016 Aug;171(4):2458-67. doi: 10.1104/pp.16.00137. Epub 2016 Jun 15.

21.

Cyclic Guanidine Compounds from Toxic Newts Support the Hypothesis that Tetrodotoxin is Derived from a Monoterpene.

Kudo Y, Yasumoto T, Mebs D, Cho Y, Konoki K, Yotsu-Yamashita M.

Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8728-31. doi: 10.1002/anie.201602971. Epub 2016 Jun 1.

PMID:
27248052
22.

Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid.

Furumochi S, Onoda T, Cho Y, Fuwa H, Sasaki M, Yotsu-Yamashita M, Konoki K.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):2992-2996. doi: 10.1016/j.bmcl.2016.05.027. Epub 2016 May 12.

PMID:
27231127
23.

Asymmetric synthesis of crambescin A-C carboxylic acids and their inhibitory activity on voltage-gated sodium channels.

Nakazaki A, Nakane Y, Ishikawa Y, Yotsu-Yamashita M, Nishikawa T.

Org Biomol Chem. 2016 Jun 21;14(23):5304-9. doi: 10.1039/c6ob00914j. Epub 2016 May 24.

PMID:
27215973
24.

The voltage-gated sodium ion channel inhibitory activities of a new tetrodotoxin analogue, 4,4a-anhydrotetrodotoxin, and three other analogues evaluated by colorimetric cell-based assay.

Saruhashi S, Konoki K, Yotsu-Yamashita M.

Toxicon. 2016 Sep 1;119:72-6. doi: 10.1016/j.toxicon.2016.05.012. Epub 2016 May 19.

PMID:
27212630
25.

Biosynthetic route towards saxitoxin and shunt pathway.

Tsuchiya S, Cho Y, Konoki K, Nagasawa K, Oshima Y, Yotsu-Yamashita M.

Sci Rep. 2016 Feb 4;6:20340. doi: 10.1038/srep20340.

26.

Identification of okadaic acid binding protein 2 in reconstituted sponge cell clusters from Halichondria okadai and its contribution to the detoxification of okadaic acid.

Konoki K, Okada K, Kohama M, Matsuura H, Saito K, Cho Y, Nishitani G, Miyamoto T, Fukuzawa S, Tachibana K, Yotsu-Yamashita M.

Toxicon. 2015 Dec 15;108:38-45. doi: 10.1016/j.toxicon.2015.09.026. Epub 2015 Sep 28.

PMID:
26424103
27.
28.

Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS.

Kudo Y, Chiba C, Konoki K, Cho Y, Yotsu-Yamashita M.

Toxicon. 2015 Jul;101:101-5. doi: 10.1016/j.toxicon.2015.05.008. Epub 2015 May 16.

PMID:
25986913
29.

Synthesis of a tricyclic bisguanidine compound structurally related to saxitoxin and its identification in paralytic shellfish toxin-producing microorganisms.

Tsuchiya S, Cho Y, Konoki K, Nagasawa K, Oshima Y, Yotsu-Yamashita M.

Chemistry. 2015 May 18;21(21):7835-40. doi: 10.1002/chem.201500064. Epub 2015 Apr 14.

PMID:
25873235
30.
31.

Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity.

Konoki K, Suga Y, Fuwa H, Yotsu-Yamashita M, Sasaki M.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):514-8. doi: 10.1016/j.bmcl.2014.12.022. Epub 2014 Dec 13.

PMID:
25556093
32.

C5-C10 directly bonded tetrodotoxin analogues: possible biosynthetic precursors of tetrodotoxin from newts.

Kudo Y, Yamashita Y, Mebs D, Cho Y, Konoki K, Yasumoto T, Yotsu-Yamashita M.

Angew Chem Int Ed Engl. 2014 Dec 22;53(52):14546-9. doi: 10.1002/anie.201408913. Epub 2014 Nov 7.

PMID:
25382791
33.

Expression of recombinant alpha and beta tubulins from the yew Taxus cuspidata and analysis of the microtubule assembly in the presence of taxol.

Kudo Y, Abe A, Ito K, Cho Y, Yotsu-Yamashita M, Konoki K.

Biosci Biotechnol Biochem. 2014;78(11):1887-94. doi: 10.1080/09168451.2014.940837. Epub 2014 Jul 29.

PMID:
25070196
34.

A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.

Mori T, Hidaka M, Ikuji H, Yoshizawa I, Toyohara H, Okuda T, Uchida C, Asano T, Yotsu-Yamashita M, Uchida T.

Biosci Biotechnol Biochem. 2014;78(5):832-8. doi: 10.1080/09168451.2014.905189. Epub 2014 Apr 17.

PMID:
25035986
35.

Synthesis of 5- and 8-deoxytetrodotoxin.

Satake Y, Adachi M, Tokoro S, Yotsu-Yamashita M, Isobe M, Nishikawa T.

Chem Asian J. 2014 Jul;9(7):1922-32. doi: 10.1002/asia.201402202. Epub 2014 May 26.

PMID:
24861489
36.

Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2).

Tsuchiya S, Cho Y, Konoki K, Nagasawa K, Oshima Y, Yotsu-Yamashita M.

Org Biomol Chem. 2014 May 21;12(19):3016-20. doi: 10.1039/c4ob00071d.

PMID:
24718696
37.

Isolation of 6-deoxytetrodotoxin from the pufferfish, Takifugu pardalis, and a comparison of the effects of the C-6 and C-11 hydroxy groups of tetrodotoxin on its activity.

Kudo Y, Finn J, Fukushima K, Sakugawa S, Cho Y, Konoki K, Yotsu-Yamashita M.

J Nat Prod. 2014 Apr 25;77(4):1000-4. doi: 10.1021/np401097n. Epub 2014 Mar 21.

PMID:
24654947
38.

Synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channels.

Nakazaki A, Ishikawa Y, Sawayama Y, Yotsu-Yamashita M, Nishikawa T.

Org Biomol Chem. 2014 Jan 7;12(1):53-6. doi: 10.1039/c3ob42017e. Epub 2013 Nov 11. Erratum in: Org Biomol Chem. 2014 Sep 7;12(33):6530.

PMID:
24216693
39.

The binding of okadaic acid analogs to recombinant OABP2.1 originally isolated from the marine sponge Halichondria okadai.

Konoki K, Onoda T, Furumochi S, Cho Y, Yotsu-Yamashita M, Yasumoto T.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5833-5. doi: 10.1016/j.bmcl.2013.08.099. Epub 2013 Sep 6.

PMID:
24054121
40.

Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels.

Akimoto T, Masuda A, Yotsu-Yamashita M, Hirokawa T, Nagasawa K.

Org Biomol Chem. 2013 Oct 14;11(38):6642-9. doi: 10.1039/c3ob41398e. Epub 2013 Aug 30.

PMID:
23989458
41.

First identification of 5,11-dideoxytetrodotoxin in marine animals, and characterization of major fragment ions of tetrodotoxin and its analogs by high resolution ESI-MS/MS.

Yotsu-Yamashita M, Abe Y, Kudo Y, Ritson-Williams R, Paul VJ, Konoki K, Cho Y, Adachi M, Imazu T, Nishikawa T, Isobe M.

Mar Drugs. 2013 Aug 6;11(8):2799-813. doi: 10.3390/md11082799.

42.

Localization of pufferfish saxitoxin and tetrodotoxin binding protein (PSTBP) in the tissues of the pufferfish, Takifugu pardalis, analyzed by immunohistochemical staining.

Yotsu-Yamashita M, Okoshi N, Watanabe K, Araki N, Yamaki H, Shoji Y, Terakawa T.

Toxicon. 2013 Sep;72:23-8. doi: 10.1016/j.toxicon.2013.06.002. Epub 2013 Jun 13.

PMID:
23769753
43.

Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements.

Fuwa H, Kawakami M, Noto K, Muto T, Suga Y, Konoki K, Yotsu-Yamashita M, Sasaki M.

Chemistry. 2013 Jun 17;19(25):8100-10. doi: 10.1002/chem.201300664. Epub 2013 Apr 19.

PMID:
23606326
44.

Total synthesis and biological evaluation of (+)-gambieric acid A and its analogues.

Ishigai K, Fuwa H, Hashizume K, Fukazawa R, Cho Y, Yotsu-Yamashita M, Sasaki M.

Chemistry. 2013 Apr 22;19(17):5276-88. doi: 10.1002/chem.201204303. Epub 2013 Mar 28.

PMID:
23554126
45.

In vitro acylation of okadaic acid in the presence of various bivalves' extracts.

Konoki K, Onoda T, Watanabe R, Cho Y, Kaga S, Suzuki T, Yotsu-Yamashita M.

Mar Drugs. 2013 Jan 29;11(2):300-15. doi: 10.3390/md11020300.

46.

Isolation and structural determination of two novel phlorotannins from the brown alga Ecklonia kurome Okamura, and their radical scavenging activities.

Yotsu-Yamashita M, Kondo S, Segawa S, Lin YC, Toyohara H, Ito H, Konoki K, Cho Y, Uchida T.

Mar Drugs. 2013 Jan 18;11(1):165-83. doi: 10.3390/md11010165.

47.

Resurgent-like currents in mouse vas deferens myocytes are mediated by NaV1.6 voltage-gated sodium channels.

Teramoto N, Zhu HL, Yotsu-Yamashita M, Inai T, Cunnane TC.

Pflugers Arch. 2012 Nov;464(5):493-502. doi: 10.1007/s00424-012-1153-4. Epub 2012 Sep 18.

PMID:
22986623
48.
49.

Tetrodotoxin does not protect red-spotted newts, Notophthalmus viridescens, from intestinal parasites.

Mebs D, Yotsu-Yamashita M, Seitz HM, Arakawa O.

Toxicon. 2012 Jul;60(1):66-9. doi: 10.1016/j.toxicon.2012.03.017. Epub 2012 Mar 28.

PMID:
22480787
50.

Variability of tetrodotoxin and of its analogues in the red-spotted newt, Notophthalmus viridescens (Amphibia: Urodela: Salamandridae).

Yotsu-Yamashita M, Gilhen J, Russell RW, Krysko KL, Melaun C, Kurz A, Kauferstein S, Kordis D, Mebs D.

Toxicon. 2012 Feb;59(2):257-64. doi: 10.1016/j.toxicon.2011.12.004. Epub 2011 Dec 16.

PMID:
22197660

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