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Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.

Stockmann C, Reilly CA, Fassl B, Gaedigk R, Nkoy F, Stone B, Roberts JK, Uchida DA, Leeder JS, Sherwin CM, Spigarelli MG, Yost GS, Ward RM.

J Allergy Clin Immunol. 2015 Aug;136(2):505-7. doi: 10.1016/j.jaci.2015.02.009. Epub 2015 Mar 29. No abstract available.


Low-dose paroxetine exposure causes lifetime declines in male mouse body weight, reproduction and competitive ability as measured by the novel organismal performance assay.

Gaukler SM, Ruff JS, Galland T, Kandaris KA, Underwood TK, Liu NM, Young EL, Morrison LC, Yost GS, Potts WK.

Neurotoxicol Teratol. 2015 Jan-Feb;47:46-53. doi: 10.1016/ Epub 2014 Nov 12.


Regulation of CYP3A genes by glucocorticoids in human lung cells.

Roberts JK, Moore CD, Romero EG, Ward RM, Yost GS, Reilly CA.

Version 2. F1000Res. 2013 Aug 13 [revised 2013 Jan 1];2:173. doi: 10.12688/f1000research.2-173.v2. eCollection 2013.


Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes.

Roberts JK, Moore CD, Ward RM, Yost GS, Reilly CA.

J Pharmacol Exp Ther. 2013 May;345(2):308-16. doi: 10.1124/jpet.112.202556. Epub 2013 Mar 19.


Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control.

Stockmann C, Fassl B, Gaedigk R, Nkoy F, Uchida DA, Monson S, Reilly CA, Leeder JS, Yost GS, Ward RM.

J Pediatr. 2013 Jun;162(6):1222-7, 1227.e1-2. doi: 10.1016/j.jpeds.2012.11.031. Epub 2013 Jan 3.


Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.

Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS.

Drug Metab Dispos. 2013 Feb;41(2):379-89. doi: 10.1124/dmd.112.046318. Epub 2012 Nov 9.


Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes.

Reilly CA, Henion F, Bugni TS, Ethirajan M, Stockmann C, Pramanik KC, Srivastava SK, Yost GS.

Chem Res Toxicol. 2013 Jan 18;26(1):55-66. doi: 10.1021/tx300366k. Epub 2012 Nov 6.


Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli.

Behrendorff JB, Moore CD, Kim KH, Kim DH, Smith CA, Johnston WA, Yun CH, Yost GS, Gillam EM.

Chem Res Toxicol. 2012 Sep 17;25(9):1964-74. doi: 10.1021/tx300281g. Epub 2012 Aug 29.


Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen.

Shahrokh K, Cheatham TE 3rd, Yost GS.

Biochim Biophys Acta. 2012 Oct;1820(10):1605-17. doi: 10.1016/j.bbagen.2012.05.011. Epub 2012 Jun 4.


Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.

Zhou X, D'Agostino J, Li L, Moore CD, Yost GS, Ding X.

Drug Metab Dispos. 2012 Apr;40(4):642-7. doi: 10.1124/dmd.111.044081. Epub 2012 Jan 6.


Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material.

Deering-Rice CE, Johansen ME, Roberts JK, Thomas KC, Romero EG, Lee J, Yost GS, Veranth JM, Reilly CA.

Mol Pharmacol. 2012 Mar;81(3):411-9. doi: 10.1124/mol.111.076067. Epub 2011 Dec 9.


Quantum mechanically derived AMBER-compatible heme parameters for various states of the cytochrome P450 catalytic cycle.

Shahrokh K, Orendt A, Yost GS, Cheatham TE 3rd.

J Comput Chem. 2012 Jan 15;33(2):119-33. doi: 10.1002/jcc.21922. Epub 2011 Oct 14.


Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury.

Thomas KC, Roberts JK, Deering-Rice CE, Romero EG, Dull RO, Lee J, Yost GS, Reilly CA.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L111-9. doi: 10.1152/ajplung.00231.2011. Epub 2011 Sep 23.


Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP.

Deering-Rice CE, Romero EG, Shapiro D, Hughen RW, Light AR, Yost GS, Veranth JM, Reilly CA.

Chem Res Toxicol. 2011 Jun 20;24(6):950-9. doi: 10.1021/tx200123z. Epub 2011 May 25.


Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity.

Thomas KC, Ethirajan M, Shahrokh K, Sun H, Lee J, Cheatham TE 3rd, Yost GS, Reilly CA.

J Pharmacol Exp Ther. 2011 May;337(2):400-10. doi: 10.1124/jpet.110.178491. Epub 2011 Feb 22.


Improved cytochrome P450 3A4 molecular models accurately predict the Phe215 requirement for raloxifene dehydrogenation selectivity.

Moore CD, Shahrokh K, Sontum SF, Cheatham TE 3rd, Yost GS.

Biochemistry. 2010 Oct 19;49(41):9011-9. doi: 10.1021/bi101139q.


Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK.

Weems JM, Lamb JG, D'Agostino J, Ding X, Yost GS.

Chem Res Toxicol. 2010 Nov 15;23(11):1682-90. doi: 10.1021/tx100147z. Epub 2010 Aug 26.


The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme.

Murai T, Reilly CA, Ward RM, Yost GS.

Chem Res Toxicol. 2010 Aug 16;23(8):1356-64. doi: 10.1021/tx100124k.


CYP3A4-Mediated oxygenation versus dehydrogenation of raloxifene.

Moore CD, Reilly CA, Yost GS.

Biochemistry. 2010 Jun 1;49(21):4466-75. doi: 10.1021/bi902213r.


3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively.

Weems JM, Yost GS.

Chem Res Toxicol. 2010 Mar 15;23(3):696-704. doi: 10.1021/tx9004506.


3-Methylindole is mutagenic and a possible pulmonary carcinogen.

Weems JM, Cutler NS, Moore C, Nichols WK, Martin D, Makin E, Lamb JG, Yost GS.

Toxicol Sci. 2009 Nov;112(1):59-67. doi: 10.1093/toxsci/kfp201. Epub 2009 Aug 21.


The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract.

D'Agostino J, Zhuo X, Shadid M, Morgan DG, Zhang X, Humphreys WG, Shu YZ, Yost GS, Ding X.

Drug Metab Dispos. 2009 Oct;37(10):2018-27. doi: 10.1124/dmd.109.027300. Epub 2009 Jul 16.


Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions.

Sun H, Moore C, Dansette PM, Kumar S, Halpert JR, Yost GS.

Drug Metab Dispos. 2009 Mar;37(3):672-84. doi: 10.1124/dmd.108.022707. Epub 2008 Dec 12.


A novel method to detect unlabeled inorganic nanoparticles and submicron particles in tissue by sedimentation field-flow fractionation.

Deering CE, Tadjiki S, Assemi S, Miller JD, Yost GS, Veranth JM.

Part Fibre Toxicol. 2008 Dec 3;5:18. doi: 10.1186/1743-8977-5-18.


Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

Kartha JS, Skordos KW, Sun H, Hall C, Easterwood LM, Reilly CA, Johnson EF, Yost GS.

Biochemistry. 2008 Sep 16;47(37):9756-70. doi: 10.1021/bi8005658. Epub 2008 Aug 22.


Human lung epithelial cells express a functional cold-sensing TRPM8 variant.

Sabnis AS, Shadid M, Yost GS, Reilly CA.

Am J Respir Cell Mol Biol. 2008 Oct;39(4):466-74. doi: 10.1165/rcmb.2007-0440OC. Epub 2008 May 5.


Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures.

Sabnis AS, Reilly CA, Veranth JM, Yost GS.

Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L194-200. doi: 10.1152/ajplung.00072.2008. Epub 2008 Apr 25.


Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action.

Bogen KT, Benson JM, Yost GS, Morris JB, Dahl AR, Clewell HJ 3rd, Krishnan K, Omiecinski CJ.

Regul Toxicol Pharmacol. 2008 Jul;51(2 Suppl):S27-36. doi: 10.1016/j.yrtph.2007.10.018. Epub 2007 Nov 22.


Effects of cell type and culture media on Interleukin-6 secretion in response to environmental particles.

Veranth JM, Cutler NS, Kaser EG, Reilly CA, Yost GS.

Toxicol In Vitro. 2008 Mar;22(2):498-509. doi: 10.1016/j.tiv.2007.10.011. Epub 2007 Nov 5.


Mechanism-based inactivation of lung-selective cytochrome P450 CYP2F enzymes.

Kartha JS, Yost GS.

Drug Metab Dispos. 2008 Jan;36(1):155-62. Epub 2007 Oct 25.


Transcription factor binding to a putative double E-box motif represses CYP3A4 expression in human lung cells.

Biggs JS, Wan J, Cutler NS, Hakkola J, Uusimäki P, Raunio H, Yost GS.

Mol Pharmacol. 2007 Sep;72(3):514-25. Epub 2007 Jun 4.


Dehydrogenation of indoline by cytochrome P450 enzymes: a novel "aromatase" process.

Sun H, Ehlhardt WJ, Kulanthaivel P, Lanza DL, Reilly CA, Yost GS.

J Pharmacol Exp Ther. 2007 Aug;322(2):843-51. Epub 2007 May 14.


Acute interstitial pneumonia in feedlot cattle: effects of feeding feather meal or vitamin E.

Stanford K, McAllister TA, Ayroud M, Bray TM, Yost GS.

Can J Vet Res. 2007 Apr;71(2):152-6.


Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells.

Thomas KC, Sabnis AS, Johansen ME, Lanza DL, Moos PJ, Yost GS, Reilly CA.

J Pharmacol Exp Ther. 2007 Jun;321(3):830-8. Epub 2007 Mar 1.


Metabolism and bioactivation of 3-methylindole by human liver microsomes.

Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.

Chem Res Toxicol. 2007 Jan;20(1):140-8.


Effect of dietary melengestrol acetate on the incidence of acute interstitial pneumonia in feedlot heifers.

Stanford K, McAllister TA, Ayroud M, Bray TM, Yost GS.

Can J Vet Res. 2006 Jul;70(3):218-25.


Localization of CYP4B1 in the rat nasal cavity and analysis of CYPs as secreted proteins.

Genter MB, Yost GS, Rettie AE.

J Biochem Mol Toxicol. 2006;20(3):139-41.


Correlation of in vitro cytokine responses with the chemical composition of soil-derived particulate matter.

Veranth JM, Moss TA, Chow JC, Labban R, Nichols WK, Walton JC, Watson JG, Yost GS.

Environ Health Perspect. 2006 Mar;114(3):341-9.


Effects of the differentiated keratinocyte phenotype on expression levels of CYP1-4 family genes in human skin cells.

Du L, Neis MM, Ladd PA, Lanza DL, Yost GS, Keeney DS.

Toxicol Appl Pharmacol. 2006 Jun 1;213(2):135-44. Epub 2005 Nov 22.


Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.

Kassahun K, Skordos K, McIntosh I, Slaughter D, Doss GA, Baillie TA, Yost GS.

Chem Res Toxicol. 2005 Sep;18(9):1427-37.


Molecular mechanisms regulating human CYP4B1 lung-selective expression.

Poch MT, Cutler NS, Yost GS, Hines RN.

Drug Metab Dispos. 2005 Aug;33(8):1174-84. Epub 2005 May 17.


Sp1 and Sp3 regulate basal transcription of the human CYP2F1 gene.

Wan J, Carr BA, Cutler NS, Lanza DL, Hines RN, Yost GS.

Drug Metab Dispos. 2005 Aug;33(8):1244-53. Epub 2005 Apr 28.


Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.

Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.

Drug Metab Dispos. 2004 Sep;32(9):1032-9.


Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles.

Veranth JM, Reilly CA, Veranth MM, Moss TA, Langelier CR, Lanza DL, Yost GS.

Toxicol Sci. 2004 Nov;82(1):88-96. Epub 2004 Aug 13.

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