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Epstein-Barr virus detection using gastric biopsy specimens after rapid urease test for Helicobacter pylori.

Yanai H, Iizasa H, Chihara D, Murakami T, Nishikawa J, Yoshiyama H.

Endosc Int Open. 2019 Apr;7(4):E431-E432. doi: 10.1055/a-0859-7233. Epub 2019 Mar 21. No abstract available.


Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells.

Ichikawa T, Okuno Y, Sato Y, Goshima F, Yoshiyama H, Kanda T, Kimura H, Murata T.

mSphere. 2018 Nov 28;3(6). pii: e00478-18. doi: 10.1128/mSphere.00478-18.


EBV-associated gastric cancer evades T-cell immunity by PD-1/PD-L1 interactions.

Sasaki S, Nishikawa J, Sakai K, Iizasa H, Yoshiyama H, Yanagihara M, Shuto T, Shimokuri K, Kanda T, Suehiro Y, Yamasaki T, Sakaida I.

Gastric Cancer. 2019 May;22(3):486-496. doi: 10.1007/s10120-018-0880-4. Epub 2018 Sep 28.


Identification of Novel Mycobacterial Inhibitors Against Mycobacterial Protein Kinase G.

Kanehiro Y, Tomioka H, Pieters J, Tatano Y, Kim H, Iizasa H, Yoshiyama H.

Front Microbiol. 2018 Jul 12;9:1517. doi: 10.3389/fmicb.2018.01517. eCollection 2018.


The Role of Transforming Growth Factor β in Cell-to-Cell Contact-Mediated Epstein-Barr Virus Transmission.

Nanbo A, Ohashi M, Yoshiyama H, Ohba Y.

Front Microbiol. 2018 May 15;9:984. doi: 10.3389/fmicb.2018.00984. eCollection 2018.


Clinical Importance of Epstein⁻Barr Virus-Associated Gastric Cancer.

Nishikawa J, Iizasa H, Yoshiyama H, Shimokuri K, Kobayashi Y, Sasaki S, Nakamura M, Yanai H, Sakai K, Suehiro Y, Yamasaki T, Sakaida I.

Cancers (Basel). 2018 May 29;10(6). pii: E167. doi: 10.3390/cancers10060167. Review.


Non-malignant epithelial cells preferentially proliferate from nasopharyngeal carcinoma biopsy cultured under conditionally reprogrammed conditions.

Yu F, Lu Y, Tao L, Jiang YY, Lin DC, Wang L, Petersson F, Yoshiyama H, Koeffler PH, Goh BC, Loh KS.

Sci Rep. 2017 Dec 12;7(1):17359. doi: 10.1038/s41598-017-17628-z.


A case report of tuberculous peritonitis in rectal cancer diagnosed by staging laparoscopy and post-treatment status at laparoscopic low-anterior resection.

Aibara N, Hotchi M, Kotegawa H, Yoshiyama H, Watanabe M, Okikawa S, Kanzaki M, Kawasaki H.

Nihon Shokakibyo Gakkai Zasshi. 2017;114(8):1467-1473. doi: 10.11405/nisshoshi.114.1467. Japanese.


Herpesviral microRNAs in Cellular Metabolism and Immune Responses.

Kim H, Iizasa H, Kanehiro Y, Fekadu S, Yoshiyama H.

Front Microbiol. 2017 Jul 18;8:1318. doi: 10.3389/fmicb.2017.01318. eCollection 2017. Review.


The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer.

Nishikawa J, Iizasa H, Yoshiyama H, Nakamura M, Saito M, Sasaki S, Shimokuri K, Yanagihara M, Sakai K, Suehiro Y, Yamasaki T, Sakaida I.

Int J Mol Sci. 2017 Jul 25;18(8). pii: E1606. doi: 10.3390/ijms18081606. Review.


Five-weekly S-1 plus cisplatin therapy combined with trastuzumab therapy in HER2-positive gastric cancer: a phase II trial and biomarker study (WJOG7212G).

Miura Y, Sukawa Y, Hironaka S, Mori M, Nishikawa K, Tokunaga S, Okuda H, Sakamoto T, Taku K, Nishikawa K, Moriwaki T, Negoro Y, Kimura Y, Uchino K, Shinozaki K, Shinozaki H, Musha N, Yoshiyama H, Tsuda T, Miyata Y, Sugimoto N, Shirakawa T, Ito M, Yonesaka K, Yoshimura K, Boku N, Nosho K, Takano T, Hyodo I.

Gastric Cancer. 2018 Jan;21(1):84-95. doi: 10.1007/s10120-017-0725-6. Epub 2017 May 11.


Epstein-Barr virus infection-induced inflammasome activation in human monocytes.

Torii Y, Kawada JI, Murata T, Yoshiyama H, Kimura H, Ito Y.

PLoS One. 2017 Apr 3;12(4):e0175053. doi: 10.1371/journal.pone.0175053. eCollection 2017.


Epstein-Barr virus exploits host endocytic machinery for cell-to-cell viral transmission rather than a virological synapse.

Nanbo A, Kachi K, Yoshiyama H, Ohba Y.

J Gen Virol. 2016 Nov;97(11):2989-3006. doi: 10.1099/jgv.0.000605. Epub 2016 Sep 19.


Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor.

Murata T, Noda C, Narita Y, Watanabe T, Yoshida M, Ashio K, Sato Y, Goshima F, Kanda T, Yoshiyama H, Tsurumi T, Kimura H.

J Virol. 2016 Mar 28;90(8):3873-3889. doi: 10.1128/JVI.03227-15. Print 2016 Apr.


Dysbiotic infection in the stomach.

Iizasa H, Ishihara S, Richardo T, Kanehiro Y, Yoshiyama H.

World J Gastroenterol. 2015 Oct 28;21(40):11450-7. doi: 10.3748/wjg.v21.i40.11450. Review.


Demonstration of the disease activity by serial carotid artery ultrasonography, magnetic resonance imaging and 18-fluoro-deoxyglucose positron emission tomography in a Behçet's disease patient with carotid artery stenosis.

Igata S, Tahara N, Tahara A, Honda A, Nitta Y, Kusaba K, Niiyama H, Kaida H, Abe T, Yoshiyama H, Fukumoto Y.

Eur Heart J. 2015 Jul 1;36(25):1629. doi: 10.1093/eurheartj/ehv031. Epub 2015 Feb 24. No abstract available.


Ezetimibe ameliorates atherogenic lipids profiles, insulin resistance and hepatocyte growth factor in obese patients with hypercholesterolemia.

Adachi H, Nakano H, Yamamoto K, Nakata M, Bekki H, Honma T, Yoshiyama H, Nohara M; ERASE METS Study Investigators.

Lipids Health Dis. 2015 Jan 10;14:1. doi: 10.1186/1476-511X-14-1.


Epstein-barr virus in gastric carcinoma.

Nishikawa J, Yoshiyama H, Iizasa H, Kanehiro Y, Nakamura M, Nishimura J, Saito M, Okamoto T, Sakai K, Suehiro Y, Yamasaki T, Oga A, Yanai H, Sakaida I.

Cancers (Basel). 2014 Nov 7;6(4):2259-74. doi: 10.3390/cancers6042259. Review.


Colonization of an acid resistant Kingella denitrificans in the stomach may contribute to gastric dysbiosis by Helicobacter pylori.

Okamoto T, Hayashi Y, Mizuno H, Yanai H, Nishikawa J, Nakazawa T, Iizasa H, Jinushi M, Sakaida I, Yoshiyama H.

J Infect Chemother. 2014 Mar;20(3):169-74. doi: 10.1016/j.jiac.2013.09.007. Epub 2013 Dec 11.


TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.

Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M.

Immunity. 2013 Dec 12;39(6):1070-81. doi: 10.1016/j.immuni.2013.09.014. Epub 2013 Dec 5.


Enhanced susceptibility of B lymphoma cells to measles virus by Epstein-Barr virus type III latency that upregulates CD150/signaling lymphocytic activation molecule.

Takeda S, Kanbayashi D, Kurata T, Yoshiyama H, Komano J.

Cancer Sci. 2014 Feb;105(2):211-8. doi: 10.1111/cas.12324. Epub 2014 Jan 12.


Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells.

Nanbo A, Kawanishi E, Yoshida R, Yoshiyama H.

J Virol. 2013 Sep;87(18):10334-47. doi: 10.1128/JVI.01310-13. Epub 2013 Jul 17.


Putting the brakes on anticancer therapies: suppression of innate immune pathways by tumor-associated myeloid cells.

Jinushi M, Yagita H, Yoshiyama H, Tahara H.

Trends Mol Med. 2013 Sep;19(9):536-45. doi: 10.1016/j.molmed.2013.06.001. Epub 2013 Jun 27. Review.


Epstein-Barr Virus (EBV)-associated gastric carcinoma.

Iizasa H, Nanbo A, Nishikawa J, Jinushi M, Yoshiyama H.

Viruses. 2012 Dec;4(12):3420-39. Review.


Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas.

Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M.

Cancer Immunol Immunother. 2013 Apr;62(4):629-37. doi: 10.1007/s00262-012-1371-9. Epub 2012 Nov 10.


Regulation of cancer stem cell activities by tumor-associated macrophages.

Jinushi M, Baghdadi M, Chiba S, Yoshiyama H.

Am J Cancer Res. 2012;2(5):529-39. Epub 2012 Aug 20.


Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.

Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M.

Nat Immunol. 2012 Sep;13(9):832-42. doi: 10.1038/ni.2376. Epub 2012 Jul 29.


MFG-E8 regulates the immunogenic potential of dendritic cells primed with necrotic cell-mediated inflammatory signals.

Baghdadi M, Chiba S, Yamashina T, Yoshiyama H, Jinushi M.

PLoS One. 2012;7(6):e39607. doi: 10.1371/journal.pone.0039607. Epub 2012 Jun 25.


Unexpected instability of family of repeats (FR), the critical cis-acting sequence required for EBV latent infection, in EBV-BAC systems.

Kanda T, Shibata S, Saito S, Murata T, Isomura H, Yoshiyama H, Takada K, Tsurumi T.

PLoS One. 2011;6(11):e27758. doi: 10.1371/journal.pone.0027758. Epub 2011 Nov 16.


ATM-mediated DNA damage signals mediate immune escape through integrin-αvβ3-dependent mechanisms.

Jinushi M, Chiba S, Baghdadi M, Kinoshita I, Dosaka-Akita H, Ito K, Yoshiyama H, Yagita H, Uede T, Takaoka A.

Cancer Res. 2012 Jan 1;72(1):56-65. doi: 10.1158/0008-5472.CAN-11-2028. Epub 2011 Nov 17.


Identification and characterization of CCAAT enhancer-binding protein (C/EBP) as a transcriptional activator for Epstein-Barr virus oncogene latent membrane protein 1.

Noda C, Murata T, Kanda T, Yoshiyama H, Sugimoto A, Kawashima D, Saito S, Isomura H, Tsurumi T.

J Biol Chem. 2011 Dec 9;286(49):42524-33. doi: 10.1074/jbc.M111.271734. Epub 2011 Oct 19.


Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells.

Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12425-30. doi: 10.1073/pnas.1106645108. Epub 2011 Jul 11.


Cytokine signatures of transformed B cells with distinct Epstein-Barr virus latencies as a potential diagnostic tool for B cell lymphoma.

Miyauchi K, Urano E, Yoshiyama H, Komano J.

Cancer Sci. 2011 Jun;102(6):1236-41. doi: 10.1111/j.1349-7006.2011.01924.x. Epub 2011 Apr 1.


Dominant-negative derivative of EBNA1 represses EBNA1-mediated transforming gene expression during the acute phase of Epstein-Barr virus infection independent of rapid loss of viral genome.

Kariya Y, Hamatake M, Urano E, Yoshiyama H, Shimizu N, Komano J.

Cancer Sci. 2010 Apr;101(4):876-81. doi: 10.1111/j.1349-7006.2009.01474.x. Epub 2009 Dec 16.


New diarylmethanofullerene derivatives and their properties for organic thin-film solar cells.

Sukeguchi D, Singh SP, Reddy MR, Yoshiyama H, Afre RA, Hayashi Y, Inukai H, Soga T, Nakamura S, Shibata N, Toru T.

Beilstein J Org Chem. 2009 Feb 24;5:7. doi: 10.3762/bjoc.5.7.


Synthesis of trifluoroethoxy-coated binuclear phthalocyanines with click spacers and investigation of their clamshell behaviour.

Yoshiyama H, Shibata N, Sato T, Nakamura S, Toru T.

Org Biomol Chem. 2009 Jun 7;7(11):2265-9. doi: 10.1039/b902905b. Epub 2009 Apr 14.


Synthesis of covalently linked binuclear clamshell phthalocyanine by double-click reaction.

Yoshiyama H, Shibata N, Sato T, Nakamura S, Toru T.

Org Biomol Chem. 2008 Dec 21;6(24):4498-501. doi: 10.1039/b814169j. Epub 2008 Oct 23.


Synthesis and properties of trifluoroethoxy-coated binuclear phthalocyanine.

Yoshiyama H, Shibata N, Sato T, Nakamura S, Toru T.

Chem Commun (Camb). 2008 May 7;(17):1977-9. doi: 10.1039/b800918j. Epub 2008 Mar 28.


[Infection and mechanism of proliferation in herpes virus].

Yoshiyama H.

Nihon Rinsho. 2006 Mar;64 Suppl 3:43-8. Review. Japanese. No abstract available.


A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori.

Okamoto T, Yoshiyama H, Nakazawa T, Park ID, Chang MW, Yanai H, Okita K, Shirai M.

J Antimicrob Chemother. 2002 Dec;50(6):849-56.


Ammonia as an accelerator of tumor necrosis factor alpha-induced apoptosis of gastric epithelial cells in Helicobacter pylori infection.

Igarashi M, Kitada Y, Yoshiyama H, Takagi A, Miwa T, Koga Y.

Infect Immun. 2001 Feb;69(2):816-21.


A novel in vitro effect of the mucosal protective agent sofalcone--inhibition of chemotactic motility in Helicobacter pylori.

Yoshiyama H, Nakamura H, Okamoto T, Okita K, Nakazawa T.

Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:230-6.


Unique mechanism of Helicobacter pylori for colonizing the gastric mucus.

Yoshiyama H, Nakazawa T.

Microbes Infect. 2000 Jan;2(1):55-60. Review.


Chemotaxis and motility of Helicobacter pylori in a viscous environment.

Yoshiyama H, Nakamura H, Kimoto M, Okita K, Nakazawa T.

J Gastroenterol. 1999;34 Suppl 11:18-23.


Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis.

Yanai H, Murakami T, Yoshiyama H, Takeuchi H, Nishikawa J, Nakamura H, Okita K, Miura O, Shimizu N, Takada K.

J Clin Gastroenterol. 1999 Jul;29(1):39-43.


Chemotaxis of Helicobacter pylori: a urease-independent response.

Yoshiyama H, Mizote T, Nakamura H, Okita K, Nakazawa T.

J Gastroenterol. 1998;33 Suppl 10:1-5.


Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment.

Nakamura H, Yoshiyama H, Takeuchi H, Mizote T, Okita K, Nakazawa T.

Infect Immun. 1998 Oct;66(10):4832-7.


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