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Items: 1 to 50 of 149

1.

Genotypes and allele frequencies of buried SNPs in a bovine single-nucleotide polymorphism array in Japanese Black cattle.

Sasaki S, Muraki E, Inoue Y, Suezawa R, Nikadori H, Yoshida Y, Nariai S, Hideshima R, Moriwaki S, Nakashima R, Uchiyama K, Yoshinari K, Takeda M, Kojima T.

Anim Sci J. 2019 Oct 10. doi: 10.1111/asj.13293. [Epub ahead of print]

PMID:
31599477
2.

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes.

Fujino C, Watanabe Y, Sanoh S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.

Heliyon. 2019 Sep 12;5(9):e02466. doi: 10.1016/j.heliyon.2019.e02466. eCollection 2019 Sep.

3.

Functional Interaction between Pregnane X Receptor and Yes-Associated Protein in Xenobiotic-Dependent Liver Hypertrophy and Drug Metabolism.

Abe T, Shizu R, Sasaki T, Shimizu Y, Hosaka T, Kodama S, Matsuzawa A, Yoshinari K.

J Pharmacol Exp Ther. 2019 Dec;371(3):590-601. doi: 10.1124/jpet.119.258632. Epub 2019 Sep 18.

PMID:
31533970
4.

Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARα-mediated transcriptional activation.

Fujino C, Watanabe Y, Sanoh S, Hattori S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.

Food Chem Toxicol. 2019 Nov;133:110792. doi: 10.1016/j.fct.2019.110792. Epub 2019 Aug 28.

PMID:
31472229
5.

Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis.

Yoshinari K.

Biol Pharm Bull. 2019;42(8):1243-1252. doi: 10.1248/bpb.b19-00267.

6.

Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro.

Okamura M, Shizu R, Hosaka T, Sasaki T, Yoshinari K.

Drug Metab Pharmacokinet. 2019 Aug;34(4):272-279. doi: 10.1016/j.dmpk.2019.04.005. Epub 2019 Apr 19.

PMID:
31280915
7.
8.

[In silico prediction models of the induction of drug-metabolizing enzymes for drug discovery].

Yoshinari K, Nagai M.

Nihon Yakurigaku Zasshi. 2019;153(4):186-191. doi: 10.1254/fpj.153.186. Japanese.

PMID:
30971659
9.

Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors.

Kojima H, Takeuchi S, Sanoh S, Okuda K, Kitamura S, Uramaru N, Sugihara K, Yoshinari K.

Toxicology. 2019 Feb 1;413:48-55. doi: 10.1016/j.tox.2018.12.001. Epub 2018 Dec 21.

PMID:
30582956
10.

Relationship between call rate per individual and genotyping accuracy of bovine single-nucleotide polymorphism array using deoxyribonucleic acid of various qualities.

Sasaki S, Yoshinari K, Uchiyama K, Takeda M, Kojima T.

Anim Sci J. 2018 Nov;89(11):1533-1539. doi: 10.1111/asj.13110. Epub 2018 Sep 19.

PMID:
30230122
11.

Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5.

Nihira K, Nan-Ya KI, Kakuni M, Ono Y, Yoshikawa Y, Ota T, Hiura M, Yoshinari K.

Toxicol Sci. 2019 Jan 1;167(1):190-201. doi: 10.1093/toxsci/kfy228.

PMID:
30202993
12.

Sensitive and Comprehensive LC-MS/MS Analyses of Chiral Pharmaceuticals and Their Hepatic Metabolites Using Ovomucoid Column.

Todoroki K, Kudoh Y, Nakamura M, Shimizu Y, Sasaki T, Otsuki H, Wada K, Min JZ, Mizuno H, Yoshinari K, Toyo'oka T.

Anal Sci. 2018 Sep 10;34(9):1011-1015. doi: 10.2116/analsci.18SCP05. Epub 2018 Jul 20.

13.

Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR.

Yoshimaru S, Shizu R, Tsuruta S, Amaike Y, Kano M, Hosaka T, Sasaki T, Yoshinari K.

J Toxicol Sci. 2018;43(7):443-450. doi: 10.2131/jts.43.443.

14.

Role of YAP Activation in Nuclear Receptor CAR-Mediated Proliferation of Mouse Hepatocytes.

Abe T, Amaike Y, Shizu R, Takahashi M, Kano M, Hosaka T, Sasaki T, Kodama S, Matsuzawa A, Yoshinari K.

Toxicol Sci. 2018 Oct 1;165(2):408-419. doi: 10.1093/toxsci/kfy149.

PMID:
29893953
15.

Characterization of CYP2C Induction in Cryopreserved Human Hepatocytes and Its Application in the Prediction of the Clinical Consequences of the Induction.

Nagai M, Hosaka T, Satsukawa M, Yoshinari K.

J Pharm Sci. 2018 Sep;107(9):2479-2488. doi: 10.1016/j.xphs.2018.05.008. Epub 2018 May 23.

PMID:
29802934
16.

Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system.

Yamazoe Y, Yoshinari K.

Drug Metab Pharmacokinet. 2017 Oct;32(5):229-247. doi: 10.1016/j.dmpk.2017.05.004. Epub 2017 May 29.

PMID:
28801182
17.

Effect of health foods on cytochrome P450-mediated drug metabolism.

Sasaki T, Sato Y, Kumagai T, Yoshinari K, Nagata K.

J Pharm Health Care Sci. 2017 May 10;3:14. doi: 10.1186/s40780-017-0083-x. eCollection 2017.

18.

Construction of the Database of Rat Repeated-dose Toxicity Tests of Pesticides for the Toxicological Characterization of Hepatocyte Hypertrophy.

Masuda A, Masuda M, Kawano T, Kitsunai Y, Nakayama H, Nakajima H, Kojima H, Kitamura S, Uramaru N, Hosaka T, Sasaki T, Yoshinari K.

Yakugaku Zasshi. 2017;137(5):611-622. doi: 10.1248/yakushi.16-00259. Japanese.

19.

Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation.

Kodama S, Shimura T, Kuribayashi H, Abe T, Yoshinari K.

Toxicol Lett. 2017 Apr 5;271:58-65. doi: 10.1016/j.toxlet.2017.02.018. Epub 2017 Feb 22.

PMID:
28237809
20.

Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.

Liu S, Kawamoto T, Morita O, Yoshinari K, Honda H.

Toxicol Appl Pharmacol. 2017 Mar 1;318:79-87. doi: 10.1016/j.taap.2017.01.006. Epub 2017 Jan 18.

PMID:
28108177
21.

Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.

Abe T, Takahashi M, Kano M, Amaike Y, Ishii C, Maeda K, Kudoh Y, Morishita T, Hosaka T, Sasaki T, Kodama S, Matsuzawa A, Kojima H, Yoshinari K.

Arch Toxicol. 2017 Jun;91(6):2365-2374. doi: 10.1007/s00204-016-1888-3. Epub 2016 Nov 10.

PMID:
27832320
22.

Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities.

Fujino C, Tamura Y, Tange S, Nakajima H, Sanoh S, Watanabe Y, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S.

J Toxicol Sci. 2016;41(5):677-91. doi: 10.2131/jts.41.677.

23.

Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 1. Focusing on polycyclic arenes and the related chemicals.

Yamazoe Y, Ito K, Yamamura Y, Iwama R, Yoshinari K.

Drug Metab Pharmacokinet. 2016 Oct;31(5):363-384. doi: 10.1016/j.dmpk.2016.07.005. Epub 2016 Aug 10.

PMID:
27665699
24.

Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element.

Sasaki T, Inami K, Numata Y, Funakoshi K, Yoshida M, Kumagai T, Kanno S, Matsui S, Toriyabe T, Yamazoe Y, Yoshinari K, Nagata K.

J Pharmacol Exp Ther. 2016 Oct;359(1):102-9. doi: 10.1124/jpet.115.231589. Epub 2016 Aug 9.

PMID:
27507784
25.

Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds.

Nagai M, Konno Y, Satsukawa M, Yamashita S, Yoshinari K.

Drug Metab Dispos. 2016 Aug;44(8):1390-8. doi: 10.1124/dmd.115.068619. Epub 2016 May 20.

PMID:
27208383
26.

Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents.

Kawada H, Ebiike H, Tsukazaki M, Yamamoto S, Koyama K, Nakamura M, Morikami K, Yoshinari K, Yoshida M, Ogawa K, Shimma N, Tsukuda T, Ohwada J.

Bioorg Med Chem. 2016 Jul 1;24(13):2897-2906. doi: 10.1016/j.bmc.2016.04.060. Epub 2016 Apr 28.

PMID:
27189888
27.

Preface. Analytical chemistry for ADMET research: Recent advances and future directions in LC-MS/MS and omics approaches.

Yoshinari K, Yamashita K.

Drug Metab Pharmacokinet. 2016 Feb;31(1):1-2. doi: 10.1016/j.dmpk.2015.12.006. Epub 2016 Jan 6. No abstract available.

PMID:
26852145
28.

Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability.

Kawada H, Ebiike H, Tsukazaki M, Yamamoto S, Koyama K, Nakamura M, Morikami K, Yoshinari K, Yoshida M, Ogawa K, Shinma N, Tsukuda T, Ohwada J.

Bioorg Med Chem. 2015 Dec 15;23(24):7650-60. doi: 10.1016/j.bmc.2015.11.009. Epub 2015 Nov 11.

PMID:
26613634
29.

PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.

Shizu R, Abe T, Benoki S, Takahashi M, Kodama S, Miayata M, Matsuzawa A, Yoshinari K.

Biochem J. 2016 Feb 1;473(3):257-66. doi: 10.1042/BJ20150734. Epub 2015 Nov 16.

PMID:
26574435
30.

A novel and sensitive assay for heme oxygenase activity.

Iwamori S, Sato E, Saigusa D, Yoshinari K, Ito S, Sato H, Takahashi N.

Am J Physiol Renal Physiol. 2015 Oct 1;309(7):F667-71. doi: 10.1152/ajprenal.00210.2015. Epub 2015 Jul 29.

31.

[Basic principles of interpretation of hepatocellular hypertrophy in risk assessment in Japan].

Yoshida M, Umemura T, Kojima H, Inoue K, Takahashi M, Uramaru N, Kitamura S, Abe K, Tohkin M, Ozawa S, Yoshinari K.

Shokuhin Eiseigaku Zasshi. 2015;56(2):42-8. doi: 10.3358/shokueishi.56.42. Review. Japanese.

32.

Antibacterial drug treatment increases intestinal bile acid absorption via elevated levels of ileal apical sodium-dependent bile acid transporter but not organic solute transporter α protein.

Miyata M, Hayashi K, Yamakawa H, Yamazoe Y, Yoshinari K.

Biol Pharm Bull. 2015;38(3):493-6. doi: 10.1248/bpb.b14-00640. Epub 2014 Dec 27.

33.

Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning.

Aoki T, Hyohdoh I, Furuichi N, Ozawa S, Watanabe F, Matsushita M, Sakaitani M, Morikami K, Takanashi K, Harada N, Tomii Y, Shiraki K, Furumoto K, Tabo M, Yoshinari K, Ori K, Aoki Y, Shimma N, Iikura H.

ACS Med Chem Lett. 2014 Jan 22;5(4):309-14. doi: 10.1021/ml400379x. eCollection 2014 Apr 10.

34.

Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties.

Hyohdoh I, Furuichi N, Aoki T, Itezono Y, Shirai H, Ozawa S, Watanabe F, Matsushita M, Sakaitani M, Ho PS, Takanashi K, Harada N, Tomii Y, Yoshinari K, Ori K, Tabo M, Aoki Y, Shimma N, Iikura H.

ACS Med Chem Lett. 2013 Sep 22;4(11):1059-63. doi: 10.1021/ml4002419. eCollection 2013 Nov 14.

35.

Regression of metastatic colon tumour from primary adenocarcinoma of the lung due to fistulisation to the bowel lumen.

Iwamuro M, Miyabe Y, Hanae K, Yoshinari K, Katsuyoshi T, Murakami T, Hirofumi M, Yamamoto K.

Ecancermedicalscience. 2014 Mar 20;8:412. doi: 10.3332/ecancer.2014.412. eCollection 2014.

36.

SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells.

Miyata M, Hata T, Yamazoe Y, Yoshinari K.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):477-82. doi: 10.1016/j.bbrc.2013.11.126. Epub 2013 Dec 7.

PMID:
24321096
37.

The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors.

Aoki T, Hyohdoh I, Furuichi N, Ozawa S, Watanabe F, Matsushita M, Sakaitani M, Ori K, Takanashi K, Harada N, Tomii Y, Tabo M, Yoshinari K, Aoki Y, Shimma N, Iikura H.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6223-7. doi: 10.1016/j.bmcl.2013.10.001. Epub 2013 Oct 9.

PMID:
24157370
38.

Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids.

Miyata M, Yamakawa H, Hayashi K, Kuribayashi H, Yamazoe Y, Yoshinari K.

Eur J Pharmacol. 2013 Aug 15;714(1-3):507-14. doi: 10.1016/j.ejphar.2013.06.036. Epub 2013 Jul 18.

PMID:
23872411
39.

Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.

Watanabe K, Sakurai K, Tsuchiya Y, Yamazoe Y, Yoshinari K.

Biochem Pharmacol. 2013 Aug 1;86(3):428-36. doi: 10.1016/j.bcp.2013.05.016. Epub 2013 May 31.

PMID:
23732298
40.

Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.

Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.

PLoS One. 2013 Apr 23;8(4):e61802. doi: 10.1371/journal.pone.0061802. Print 2013.

41.

New parameter that supports speculation on the possible mechanism of hypothyroidism induced by chemical substances in repeated-dose toxicity studies.

Yamada T, Hasegawa R, Nishikawa S, Sakuratani Y, Yamada J, Yamashita T, Yoshinari K, Yamazoe Y, Kamata E, Ono A, Hirose A, Hayashi M.

J Toxicol Sci. 2013;38(2):291-9.

42.

Coordinated roles of pregnane X receptor and constitutive androstane receptor in autoinduction of voriconazole metabolism in mice.

Ohbuchi M, Yoshinari K, Kaneko H, Matsumoto S, Inoue A, Kawamura A, Usui T, Yamazoe Y.

Antimicrob Agents Chemother. 2013 Mar;57(3):1332-8. doi: 10.1128/AAC.01900-12. Epub 2012 Dec 28.

43.
44.

Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation.

Kawada H, Ebiike H, Tsukazaki M, Nakamura M, Morikami K, Yoshinari K, Yoshida M, Ogawa K, Shimma N, Tsukuda T, Ohwada J.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):673-8. doi: 10.1016/j.bmcl.2012.11.112. Epub 2012 Dec 3.

PMID:
23265889
45.

Enterobacteria-mediated deconjugation of taurocholic acid enhances ileal farnesoid X receptor signaling.

Kuribayashi H, Miyata M, Yamakawa H, Yoshinari K, Yamazoe Y.

Eur J Pharmacol. 2012 Dec 15;697(1-3):132-8. doi: 10.1016/j.ejphar.2012.09.048. Epub 2012 Oct 7.

PMID:
23051670
46.

Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes.

Araki K, Watanabe K, Yamazoe Y, Yoshinari K.

Toxicol Lett. 2012 Nov 23;215(1):16-24. doi: 10.1016/j.toxlet.2012.09.021. Epub 2012 Oct 4.

PMID:
23041609
47.

Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19.

Miyata M, Hata T, Yamakawa H, Kagawa T, Yoshinari K, Yamazoe Y.

J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):41-7. doi: 10.1016/j.jsbmb.2012.04.008. Epub 2012 May 3.

PMID:
22561792
48.

Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice.

Miyata M, Sakaida Y, Matsuzawa H, Yoshinari K, Yamazoe Y.

Biol Pharm Bull. 2011;34(12):1885-9.

49.

Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase.

Yoshinari K, Ohno H, Benoki S, Yamazoe Y.

Toxicol Lett. 2012 Jan 25;208(2):185-91. doi: 10.1016/j.toxlet.2011.11.003. Epub 2011 Nov 11.

PMID:
22101211
50.

Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes.

Benoki S, Yoshinari K, Chikada T, Imai J, Yamazoe Y.

Arch Biochem Biophys. 2012 Jan 15;517(2):123-30. doi: 10.1016/j.abb.2011.10.014. Epub 2011 Nov 10.

PMID:
22093699

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