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Items: 1 to 50 of 85


Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.

Hale AT, Brown RE, Luka Z, Hudson BH, Matta P, Williams CS, York JD.

Adv Biol Regul. 2020 Jan 26:100694. doi: 10.1016/j.jbior.2020.100694. [Epub ahead of print]


Metabolic Labeling of Inositol Phosphates and Phosphatidylinositols in Yeast and Mammalian Cells.

Hale AT, Clarke BP, York JD.

Methods Mol Biol. 2020;2091:83-92. doi: 10.1007/978-1-0716-0167-9_7.


A synthetic biological approach to reconstitution of inositide signaling pathways in bacteria.

Clarke BP, Logeman BL, Hale AT, Luka Z, York JD.

Adv Biol Regul. 2019 Aug;73:100637. doi: 10.1016/j.jbior.2019.100637. Epub 2019 Jul 30.


Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.

McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T.

Cell Chem Biol. 2019 Jun 20;26(6):863-877.e7. doi: 10.1016/j.chembiol.2019.03.010. Epub 2019 Apr 25.


MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.

Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE.

Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. Epub 2018 Jun 7.


Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis.

Hudson BH, Hale AT, Irving RP, Li S, York JD.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3000-3005. doi: 10.1073/pnas.1715302115. Epub 2018 Mar 5.


Inositol phosphate multikinase dependent transcriptional control.

Hatch AJ, Odom AR, York JD.

Adv Biol Regul. 2017 May;64:9-19. doi: 10.1016/j.jbior.2017.03.001. Epub 2017 Mar 21.


Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.

Hargrove TY, Friggeri L, Wawrzak Z, Qi A, Hoekstra WJ, Schotzinger RJ, York JD, Guengerich FP, Lepesheva GI.

J Biol Chem. 2017 Apr 21;292(16):6728-6743. doi: 10.1074/jbc.M117.778308. Epub 2017 Mar 3.


Balloon-Occluded Retrograde Transvenous Obliteration of a Gastric Vascular Malformation: An Innovative Approach to Treatment of a Rare Condition.

Hansing CE, Marquardt JP, Sutton DM, York JD.

Cardiovasc Intervent Radiol. 2017 Feb;40(2):310-314. doi: 10.1007/s00270-016-1470-7. Epub 2016 Sep 26.


A tribute to Philip W. Majerus.

York JD, Vagelos PR.

J Clin Invest. 2016 Sep 1;126(9):3161-4. doi: 10.1172/JCI89724. Epub 2016 Sep 1. No abstract available.


Blast Injuries: From Improvised Explosive Device Blasts to the Boston Marathon Bombing.

Singh AK, Ditkofsky NG, York JD, Abujudeh HH, Avery LA, Brunner JF, Sodickson AD, Lev MH.

Radiographics. 2016 Jan-Feb;36(1):295-307. doi: 10.1148/rg.2016150114. Review.


Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila.

Seeds AM, Tsui MM, Sunu C, Spana EP, York JD.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15660-5. doi: 10.1073/pnas.1514684112. Epub 2015 Dec 8.


Structural basis of lipid binding for the membrane-embedded tetraacyldisaccharide-1-phosphate 4'-kinase LpxK.

Emptage RP, Tonthat NK, York JD, Schumacher MA, Zhou P.

J Biol Chem. 2014 Aug 29;289(35):24059-68. doi: 10.1074/jbc.M114.589986. Epub 2014 Jul 14.


Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.

Pulloor NK, Nair S, McCaffrey K, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN.

PLoS Pathog. 2014 Feb 27;10(2):e1003981. doi: 10.1371/journal.ppat.1003981. eCollection 2014 Feb. Erratum in: PLoS Pathog. 2014 Mar;10(3):e1004095. PLoS Pathog. 2014 Oct;10(10):e1004519. McCaffrey, Kathleen [added].


Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture.

Hudson BH, York JD.

Adv Biol Regul. 2014 Jan;54:208-13. doi: 10.1016/j.jbior.2013.11.002. Epub 2013 Nov 21.


Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis.

Hudson BH, Frederick JP, Drake LY, Megosh LC, Irving RP, York JD.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5040-5. doi: 10.1073/pnas.1205001110. Epub 2013 Mar 11.


Mechanistic characterization of the tetraacyldisaccharide-1-phosphate 4'-kinase LpxK involved in lipid A biosynthesis.

Emptage RP, Pemble CW 4th, York JD, Raetz CR, Zhou P.

Biochemistry. 2013 Apr 2;52(13):2280-90. doi: 10.1021/bi400097z. Epub 2013 Mar 19.


Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae.

Banfic H, Bedalov A, York JD, Visnjic D.

J Biol Chem. 2013 Jan 18;288(3):1717-25. doi: 10.1074/jbc.M112.412288. Epub 2012 Nov 24.


Structural studies and protein engineering of inositol phosphate multikinase.

Endo-Streeter S, Tsui MK, Odom AR, Block J, York JD.

J Biol Chem. 2012 Oct 12;287(42):35360-9. doi: 10.1074/jbc.M112.365031. Epub 2012 Aug 15.


Roles for nucleotide phosphatases in sulfate assimilation and skeletal disease.

Hudson BH, York JD.

Adv Biol Regul. 2012 Jan;52(1):229-38. Review. No abstract available.


SnapShot: Inositol phosphates.

Hatch AJ, York JD.

Cell. 2010 Dec 10;143(6):1030-1030.e1. doi: 10.1016/j.cell.2010.11.045. No abstract available.


Prosthetic treatment of hip fractures in the elderly patient.

York JD, Allen PG, Smith BP, Jinnah RH.

J Surg Orthop Adv. 2010 Summer;19(2):98-103.


Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cells.

Otto JC, York JD.

Methods Mol Biol. 2010;645:47-60. doi: 10.1007/978-1-60327-175-2_3.


Inositol phosphate synthesis and the nuclear processes they affect.

Monserrate JP, York JD.

Curr Opin Cell Biol. 2010 Jun;22(3):365-73. doi: 10.1016/ Epub 2010 Mar 30. Review.


Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes.

Tsui MM, York JD.

Adv Enzyme Regul. 2010;50(1):324-37. doi: 10.1016/j.advenzreg.2009.12.002. Epub 2009 Dec 16. Review. No abstract available.


Research reporting standards for image-guided ablation of bone and soft tissue tumors.

Callstrom MR, York JD, Gaba RC, Gemmete JJ, Gervais DA, Millward SF, Brown DB, Dupuy D, Goldberg SN, Kundu S, Rose SC, Thomas JJ, Cardella JF; Technology Assessment Committee of Society of Interventional Radiology.

J Vasc Interv Radiol. 2009 Dec;20(12):1527-40. doi: 10.1016/j.jvir.2009.08.009. Epub 2009 Oct 27. No abstract available.


Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.

Padmanabhan U, Dollins DE, Fridy PC, York JD, Downes CP.

J Biol Chem. 2009 Apr 17;284(16):10571-82. doi: 10.1074/jbc.M900752200. Epub 2009 Feb 10.


Phosphoinositide phosphatases and disease.

Majerus PW, York JD.

J Lipid Res. 2009 Apr;50 Suppl:S249-54. doi: 10.1194/jlr.R800072-JLR200. Epub 2008 Nov 11.


Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.

Lin H, Fridy PC, Ribeiro AA, Choi JH, Barma DK, Vogel G, Falck JR, Shears SB, York JD, Mayr GW.

J Biol Chem. 2009 Jan 16;284(3):1863-72. doi: 10.1074/jbc.M805686200. Epub 2008 Nov 3.


A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation.

Frederick JP, Tafari AT, Wu SM, Megosh LC, Chiou ST, Irving RP, York JD.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11605-12. doi: 10.1073/pnas.0801182105. Epub 2008 Aug 11.


Alcohol cosurfactants in hydrate antiagglomeration.

York JD, Firoozabadi A.

J Phys Chem B. 2008 Aug 28;112(34):10455-65. doi: 10.1021/jp8017265. Epub 2008 Jul 31.


Comparing effectiveness of rhamnolipid biosurfactant with a quaternary ammonium salt surfactant for hydrate anti-agglomeration.

York JD, Firoozabadi A.

J Phys Chem B. 2008 Jan 24;112(3):845-51. doi: 10.1021/jp077271h. Epub 2008 Jan 3.


IP7 guards the CDK gate.

York JD, Lew DJ.

Nat Chem Biol. 2008 Jan;4(1):16-7. No abstract available.


Biochemical analysis of inositol phosphate kinases.

Otto JC, Mulugu S, Fridy PC, Chiou ST, Armbruster BN, Ribeiro AA, York JD.

Methods Enzymol. 2007;434:171-85.


Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases.

Otto JC, Kelly P, Chiou ST, York JD.

Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15653-8. Epub 2007 Sep 25.


Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases.

Fridy PC, Otto JC, Dollins DE, York JD.

J Biol Chem. 2007 Oct 19;282(42):30754-62. Epub 2007 Aug 9.


Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.

Seeds AM, Frederick JP, Tsui MM, York JD.

Adv Enzyme Regul. 2007;47:10-25. Epub 2007 Jan 5. Review. No abstract available.


Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.

Lee YS, Mulugu S, York JD, O'Shea EK.

Science. 2007 Apr 6;316(5821):109-12.


A conserved family of enzymes that phosphorylate inositol hexakisphosphate.

Mulugu S, Bai W, Fridy PC, Bastidas RJ, Otto JC, Dollins DE, Haystead TA, Ribeiro AA, York JD.

Science. 2007 Apr 6;316(5821):106-9.


Inositol polyphosphate kinases: regulators of nuclear function.

Seeds AM, York JD.

Biochem Soc Symp. 2007;(74):183-97. Review.


Inositol phosphate metabolomics: merging genetic perturbation with modernized radiolabeling methods.

Stevenson-Paulik J, Chiou ST, Frederick JP, dela Cruz J, Seeds AM, Otto JC, York JD.

Methods. 2006 Jun;39(2):112-21. Review.


Regulation of nuclear processes by inositol polyphosphates.

York JD.

Biochim Biophys Acta. 2006 May-Jun;1761(5-6):552-9. Epub 2006 May 13. Review.


Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases.

Stevenson-Paulik J, Bastidas RJ, Chiou ST, Frye RA, York JD.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12612-7. Epub 2005 Aug 17.


An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production.

Frederick JP, Mattiske D, Wofford JA, Megosh LC, Drake LY, Chiou ST, Hogan BL, York JD.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8454-9. Epub 2005 Jun 6.


A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

Winter-Vann AM, Baron RA, Wong W, dela Cruz J, York JD, Gooden DM, Bergo MO, Young SG, Toone EJ, Casey PJ.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4336-41.


Signal transduction. Unexpected mediators of protein phosphorylation.

York JD, Hunter T.

Science. 2004 Dec 17;306(5704):2053-5. No abstract available.


Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism.

Spiegelberg BD, Dela Cruz J, Law TH, York JD.

J Biol Chem. 2005 Feb 18;280(7):5400-5. Epub 2004 Dec 6.


Inositol diphosphate signaling regulates telomere length.

York SJ, Armbruster BN, Greenwell P, Petes TD, York JD.

J Biol Chem. 2005 Feb 11;280(6):4264-9. Epub 2004 Nov 23.

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