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Items: 26

1.

Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling.

Yorgan TA, Peters S, Amling M, Schinke T.

Bone. 2019 Oct;127:155-163. doi: 10.1016/j.bone.2019.06.008. Epub 2019 Jun 14.

2.

Ultra-high matrix mineralization of sperm whale auditory ossicles facilitates high sound pressure and high-frequency underwater hearing.

Schmidt FN, Delsmann MM, Mletzko K, Yorgan TA, Hahn M, Siebert U, Busse B, Oheim R, Amling M, Rolvien T.

Proc Biol Sci. 2018 Dec 19;285(1893):20181820. doi: 10.1098/rspb.2018.1820.

PMID:
30963901
3.

Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand.

Luther J, Yorgan TA, Rolvien T, Ulsamer L, Koehne T, Liao N, Keller D, Vollersen N, Teufel S, Neven M, Peters S, Schweizer M, Trumpp A, Rosigkeit S, Bockamp E, Mundlos S, Kornak U, Oheim R, Amling M, Schinke T, David JP.

Sci Transl Med. 2018 Nov 7;10(466). pii: eaau7137. doi: 10.1126/scitranslmed.aau7137.

PMID:
30404864
4.

The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover.

Pohl S, Angermann A, Jeschke A, Hendrickx G, Yorgan TA, Makrypidi-Fraune G, Steigert A, Kuehn SC, Rolvien T, Schweizer M, Koehne T, Neven M, Winter O, Velho RV, Albers J, Streichert T, Pestka JM, Baldauf C, Breyer S, Stuecker R, Muschol N, Cox TM, Saftig P, Paganini C, Rossi A, Amling M, Braulke T, Schinke T.

J Bone Miner Res. 2018 Dec;33(12):2186-2201. doi: 10.1002/jbmr.3563. Epub 2018 Aug 24.

PMID:
30075049
5.

Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells.

Di Lorenzo G, Velho RV, Winter D, Thelen M, Ahmadi S, Schweizer M, De Pace R, Cornils K, Yorgan TA, Grüb S, Hermans-Borgmeyer I, Schinke T, Müller-Loennies S, Braulke T, Pohl S.

Mol Cell Proteomics. 2018 Aug;17(8):1612-1626. doi: 10.1074/mcp.RA118.000720. Epub 2018 May 17.

6.

Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis.

Hendrickx G, Borra VM, Steenackers E, Yorgan TA, Hermans C, Boudin E, Waterval JJ, Jansen IDC, Aydemir TB, Kamerling N, Behets GJ, Plumeyer C, D'Haese PC, Busse B, Everts V, Lammens M, Mortier G, Cousins RJ, Schinke T, Stokroos RJ, Manni JJ, Van Hul W.

PLoS Genet. 2018 Apr 5;14(4):e1007321. doi: 10.1371/journal.pgen.1007321. eCollection 2018 Apr.

7.

The high bone mass phenotype of Lrp5-mutant mice is not affected by megakaryocyte depletion.

Yorgan T, David JP, Amling M, Schinke T.

Biochem Biophys Res Commun. 2018 Mar 4;497(2):659-666. doi: 10.1016/j.bbrc.2018.02.127. Epub 2018 Feb 15.

PMID:
29454962
8.

Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice.

Brylka LJ, Köppert S, Babler A, Kratz B, Denecke B, Yorgan TA, Etich J, Costa IG, Brachvogel B, Boor P, Schinke T, Jahnen-Dechent W.

PLoS One. 2017 Oct 31;12(10):e0187030. doi: 10.1371/journal.pone.0187030. eCollection 2017.

9.

High Bone Turnover in Mice Carrying a Pathogenic Notch2 Mutation Causing Hajdu-Cheney Syndrome.

Vollersen N, Hermans-Borgmeyer I, Cornils K, Fehse B, Rolvien T, Triviai I, Jeschke A, Oheim R, Amling M, Schinke T, Yorgan TA.

J Bone Miner Res. 2018 Jan;33(1):70-83. doi: 10.1002/jbmr.3283. Epub 2017 Sep 20.

10.

Severe bone loss and multiple fractures in SCN8A-related epileptic encephalopathy.

Rolvien T, Butscheidt S, Jeschke A, Neu A, Denecke J, Kubisch C, Meisler MH, Pueschel K, Barvencik F, Yorgan T, Oheim R, Schinke T, Amling M.

Bone. 2017 Oct;103:136-143. doi: 10.1016/j.bone.2017.06.025. Epub 2017 Jul 1.

PMID:
28676440
11.

Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone.

Rolvien T, Krause M, Jeschke A, Yorgan T, Püschel K, Schinke T, Busse B, Demay MB, Amling M.

Bone. 2017 Oct;103:78-87. doi: 10.1016/j.bone.2017.06.022. Epub 2017 Jun 27.

PMID:
28666969
12.

Differential effects of Calca-derived peptides in male mice with diet-induced obesity.

Bartelt A, Jeschke A, Müller B, Gaziano I, Morales M, Yorgan T, Heckt T, Heine M, Gagel RF, Emeson RB, Amling M, Niemeier A, Heeren J, Schinke T, Keller J.

PLoS One. 2017 Jun 30;12(6):e0180547. doi: 10.1371/journal.pone.0180547. eCollection 2017.

13.

The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans.

Boudin E, Yorgan T, Fijalkowski I, Sonntag S, Steenackers E, Hendrickx G, Peeters S, De Maré A, Vervaet B, Verhulst A, Mortier G, D'Haese P, Schinke T, Van Hul W.

J Bone Miner Res. 2017 Aug;32(8):1739-1749. doi: 10.1002/jbmr.3160.

14.

The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta.

Gioia R, Tonelli F, Ceppi I, Biggiogera M, Leikin S, Fisher S, Tenedini E, Yorgan TA, Schinke T, Tian K, Schwartz JM, Forte F, Wagener R, Villani S, Rossi A, Forlino A.

Hum Mol Genet. 2017 Aug 1;26(15):2897-2911. doi: 10.1093/hmg/ddx171.

15.

The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone.

Milovanovic P, Zimmermann EA, Vom Scheidt A, Hoffmann B, Sarau G, Yorgan T, Schweizer M, Amling M, Christiansen S, Busse B.

Small. 2017 Jan;13(3). doi: 10.1002/smll.201602215. Epub 2016 Nov 7.

PMID:
28084694
16.

Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells.

Weinberger F, Breckwoldt K, Pecha S, Kelly A, Geertz B, Starbatty J, Yorgan T, Cheng KH, Lessmann K, Stolen T, Scherrer-Crosbie M, Smith G, Reichenspurner H, Hansen A, Eschenhagen T.

Sci Transl Med. 2016 Nov 2;8(363):363ra148.

PMID:
27807283
17.

Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton.

Yorgan T, Vollersen N, Riedel C, Jeschke A, Peters S, Busse B, Amling M, Schinke T.

Bone. 2016 Jun;87:136-46. doi: 10.1016/j.bone.2016.04.012. Epub 2016 Apr 14.

PMID:
27102824
18.

Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton.

Haffner-Luntzer M, Heilmann A, Heidler V, Liedert A, Schinke T, Amling M, Yorgan TA, Vom Scheidt A, Ignatius A.

J Orthop Res. 2016 Nov;34(11):1914-1921. doi: 10.1002/jor.23221. Epub 2016 Mar 14.

19.

Impaired bone remodeling and its correction by combination therapy in a mouse model of mucopolysaccharidosis-I.

Kuehn SC, Koehne T, Cornils K, Markmann S, Riedel C, Pestka JM, Schweizer M, Baldauf C, Yorgan TA, Krause M, Keller J, Neven M, Breyer S, Stuecker R, Muschol N, Busse B, Braulke T, Fehse B, Amling M, Schinke T.

Hum Mol Genet. 2015 Dec 15;24(24):7075-86. doi: 10.1093/hmg/ddv407. Epub 2015 Oct 1.

PMID:
26427607
20.

Immediate effects of retinoic acid on gene expression in primary murine osteoblasts.

Yorgan TA, Heckt T, Rendenbach C, Helmis C, Seitz S, Streichert T, Amling M, Schinke T.

J Bone Miner Metab. 2016 Mar;34(2):161-70. doi: 10.1007/s00774-015-0666-2. Epub 2015 May 9.

PMID:
25956707
21.

The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5.

Yorgan TA, Peters S, Jeschke A, Benisch P, Jakob F, Amling M, Schinke T.

J Bone Miner Res. 2015 Jul;30(7):1175-83. doi: 10.1002/jbmr.2461. Epub 2015 Jun 8.

22.

Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity.

Bartelt A, Beil FT, Müller B, Koehne T, Yorgan TA, Heine M, Yilmaz T, Rüther W, Heeren J, Schinke T, Niemeier A.

Bone. 2014 May;62:90-8. doi: 10.1016/j.bone.2014.01.001. Epub 2014 Jan 16.

PMID:
24440515
23.

Relevance of Wnt signaling for osteoanabolic therapy.

Yorgan TA, Schinke T.

Mol Cell Ther. 2014 Jul 14;2:22. doi: 10.1186/2052-8426-2-22. eCollection 2014. Review.

24.

Effects of extracellular phosphate on gene expression in murine osteoblasts.

Rendenbach C, Yorgan TA, Heckt T, Otto B, Baldauf C, Jeschke A, Streichert T, David JP, Amling M, Schinke T.

Calcif Tissue Int. 2014 May;94(5):474-83. doi: 10.1007/s00223-013-9831-6. Epub 2013 Dec 24.

PMID:
24366459
25.

Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.

Moreau C, Kirchberger T, Swarbrick JM, Bartlett SJ, Fliegert R, Yorgan T, Bauche A, Harneit A, Guse AH, Potter BV.

J Med Chem. 2013 Dec 27;56(24):10079-102. doi: 10.1021/jm401497a. Epub 2013 Dec 13.

26.

Increased Col10a1 expression is not causative for the phenotype of Phex-deficient Hyp mice.

Yorgan T, Rendenbach C, Jeschke A, Amling M, Cheah KS, Schinke T.

Biochem Biophys Res Commun. 2013 Dec 13;442(3-4):209-13. doi: 10.1016/j.bbrc.2013.11.033. Epub 2013 Nov 21.

PMID:
24269824

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