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Items: 1 to 50 of 141

1.

Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate.

Halfon Y, Jimenez-Fernandez A, La Rosa R, Espinosa Portero R, Krogh Johansen H, Matzov D, Eyal Z, Bashan A, Zimmerman E, Belousoff M, Molin S, Yonath A.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22275-22281. doi: 10.1073/pnas.1909831116. Epub 2019 Oct 14.

2.

Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant.

Halfon Y, Matzov D, Eyal Z, Bashan A, Zimmerman E, Kjeldgaard J, Ingmer H, Yonath A.

Sci Rep. 2019 Aug 7;9(1):11460. doi: 10.1038/s41598-019-48019-1.

3.

Stress response as implemented by hibernating ribosomes: a structural overview.

Matzov D, Bashan A, Yap MF, Yonath A.

FEBS J. 2019 Sep;286(18):3558-3565. doi: 10.1111/febs.14968. Epub 2019 Jul 15. Review.

4.

Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.

Shalev-Benami M, Zhang Y, Rozenberg H, Nobe Y, Taoka M, Matzov D, Zimmerman E, Bashan A, Isobe T, Jaffe CL, Yonath A, Skiniotis G.

Nat Commun. 2017 Nov 17;8(1):1589. doi: 10.1038/s41467-017-01664-4.

5.

Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus.

Matzov D, Eyal Z, Benhamou RI, Shalev-Benami M, Halfon Y, Krupkin M, Zimmerman E, Rozenberg H, Bashan A, Fridman M, Yonath A.

Nucleic Acids Res. 2017 Sep 29;45(17):10284-10292. doi: 10.1093/nar/gkx658.

6.

The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus.

Matzov D, Aibara S, Basu A, Zimmerman E, Bashan A, Yap MF, Amunts A, Yonath AE.

Nat Commun. 2017 Sep 28;8(1):723. doi: 10.1038/s41467-017-00753-8.

7.

The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel.

Wekselman I, Zimmerman E, Davidovich C, Belousoff M, Matzov D, Krupkin M, Rozenberg H, Bashan A, Friedlander G, Kjeldgaard J, Ingmer H, Lindahl L, Zengel JM, Yonath A.

Structure. 2017 Aug 1;25(8):1233-1241.e3. doi: 10.1016/j.str.2017.06.004. Epub 2017 Jul 6.

8.

A Bright Future for Antibiotics?

Matzov D, Bashan A, Yonath A.

Annu Rev Biochem. 2017 Jun 20;86:567-583. doi: 10.1146/annurev-biochem-061516-044617. Review.

PMID:
28654325
9.

Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.

Belousoff MJ, Eyal Z, Radjainia M, Ahmed T, Bamert RS, Matzov D, Bashan A, Zimmerman E, Mishra S, Cameron D, Elmlund H, Peleg AY, Bhushan S, Lithgow T, Yonath A.

MBio. 2017 May 9;8(3). pii: e00395-17. doi: 10.1128/mBio.00395-17.

10.

A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism.

Eyal Z, Matzov D, Krupkin M, Paukner S, Riedl R, Rozenberg H, Zimmerman E, Bashan A, Yonath A.

Sci Rep. 2016 Dec 13;6:39004. doi: 10.1038/srep39004.

11.

The fluctuating ribosome: thermal molecular dynamics characterized by neutron scattering.

Zaccai G, Natali F, Peters J, Řihová M, Zimmerman E, Ollivier J, Combet J, Maurel MC, Bashan A, Yonath A.

Sci Rep. 2016 Nov 16;6:37138. doi: 10.1038/srep37138.

12.

Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.

Krupkin M, Wekselman I, Matzov D, Eyal Z, Diskin Posner Y, Rozenberg H, Zimmerman E, Bashan A, Yonath A.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6796-E6805. Epub 2016 Oct 19.

13.

2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.

Shalev-Benami M, Zhang Y, Matzov D, Halfon Y, Zackay A, Rozenberg H, Zimmerman E, Bashan A, Jaffe CL, Yonath A, Skiniotis G.

Cell Rep. 2016 Jul 12;16(2):288-294. doi: 10.1016/j.celrep.2016.06.014. Epub 2016 Jun 30.

14.

Ribosomal Antibiotics: Contemporary Challenges.

Auerbach-Nevo T, Baram D, Bashan A, Belousoff M, Breiner E, Davidovich C, Cimicata G, Eyal Z, Halfon Y, Krupkin M, Matzov D, Metz M, Rufayda M, Peretz M, Pick O, Pyetan E, Rozenberg H, Shalev-Benami M, Wekselman I, Zarivach R, Zimmerman E, Assis N, Bloch J, Israeli H, Kalaora R, Lim L, Sade-Falk O, Shapira T, Taha-Salaime L, Tang H, Yonath A.

Antibiotics (Basel). 2016 Jun 29;5(3). pii: E24. doi: 10.3390/antibiotics5030024. Review.

15.

Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.

Eyal Z, Matzov D, Krupkin M, Wekselman I, Paukner S, Zimmerman E, Rozenberg H, Bashan A, Yonath A.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5805-14. doi: 10.1073/pnas.1517952112. Epub 2015 Oct 13.

16.

A Recombinant Collagen-mRNA Platform for Controllable Protein Synthesis.

Sun L, Xiong Y, Bashan A, Zimmerman E, Shulman Daube S, Peleg Y, Albeck S, Unger T, Yonath H, Krupkin M, Matzov D, Yonath A.

Chembiochem. 2015 Jul 6;16(10):1415-9. doi: 10.1002/cbic.201500205. Epub 2015 May 26.

17.

A new system for naming ribosomal proteins.

Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, Ramakrishnan V, Spahn CM, Steitz TA, Tchorzewski M, Tollervey D, Warren AJ, Williamson JR, Wilson D, Yonath A, Yusupov M.

Curr Opin Struct Biol. 2014 Feb;24:165-9. doi: 10.1016/j.sbi.2014.01.002. Epub 2014 Feb 10. Review.

18.

Protoribosome by quantum kernel energy method.

Huang L, Krupkin M, Bashan A, Yonath A, Massa L.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14900-5. doi: 10.1073/pnas.1314112110. Epub 2013 Aug 26.

19.

[The three-dimensional structure of the ribosome].

Yonath A.

Harefuah. 2012 May;151(5):256. Hebrew. No abstract available.

PMID:
22844725
20.

An exit cavity was crucial to the polymerase activity of the early ribosome.

Fox GE, Tran Q, Yonath A.

Astrobiology. 2012 Jan;12(1):57-60. doi: 10.1089/ast.2011.0692. Epub 2011 Dec 22.

21.

Tough science.

Yonath AE.

Nature. 2011 Oct 12;478(7368):S6-7. doi: 10.1038/478S6a. No abstract available.

PMID:
21993826
22.

A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome.

Krupkin M, Matzov D, Tang H, Metz M, Kalaora R, Belousoff MJ, Zimmerman E, Bashan A, Yonath A.

Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27;366(1580):2972-8. doi: 10.1098/rstb.2011.0146.

23.

X-ray crystallography at the heart of life science.

Yonath A.

Curr Opin Struct Biol. 2011 Oct;21(5):622-6. doi: 10.1016/j.sbi.2011.07.005. Epub 2011 Aug 6.

PMID:
21824762
24.

Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.

Belousoff MJ, Shapira T, Bashan A, Zimmerman E, Rozenberg H, Arakawa K, Kinashi H, Yonath A.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2717-22. doi: 10.1073/pnas.1019406108. Epub 2011 Jan 31.

25.

The Proto-Ribosome: an ancient nano-machine for peptide bond formation.

Davidovich C, Belousoff M, Wekselman I, Shapira T, Krupkin M, Zimmerman E, Bashan A, Yonath A.

Isr J Chem. 2010 Jun 18;50(1):29-35.

26.

Polar bears, antibiotics, and the evolving ribosome (Nobel Lecture).

Yonath A.

Angew Chem Int Ed Engl. 2010 Jun 14;49(26):4341-54. doi: 10.1002/anie.201001297.

PMID:
20535730
27.

Ancient machinery embedded in the contemporary ribosome.

Belousoff MJ, Davidovich C, Zimmerman E, Caspi Y, Wekselman I, Rozenszajn L, Shapira T, Sade-Falk O, Taha L, Bashan A, Weiss MS, Yonath A.

Biochem Soc Trans. 2010 Apr;38(2):422-7. doi: 10.1042/BST0380422. Review.

PMID:
20298195
28.

The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics.

Auerbach T, Mermershtain I, Davidovich C, Bashan A, Belousoff M, Wekselman I, Zimmerman E, Xiong L, Klepacki D, Arakawa K, Kinashi H, Mankin AS, Yonath A.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1983-8. doi: 10.1073/pnas.0914100107. Epub 2010 Jan 11.

29.
30.

2009 Nobels: break or breakthrough for women? Interview by Jeffrey Mervis and Kate Travis.

Blackburn E, Greider C, Yonath A, Ostrom E.

Science. 2009 Oct 30;326(5953):656-8. doi: 10.1126/science.326_656. No abstract available.

PMID:
19900910
31.

Large facilities and the evolving ribosome, the cellular machine for genetic-code translation.

Yonath A.

J R Soc Interface. 2009 Oct 6;6 Suppl 5:S575-85. doi: 10.1098/rsif.2009.0167.focus. Epub 2009 Aug 5. Review.

32.

The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery.

Davidovich C, Belousoff M, Bashan A, Yonath A.

Res Microbiol. 2009 Sep;160(7):487-92. doi: 10.1016/j.resmic.2009.07.004. Epub 2009 Jul 18. Review.

PMID:
19619641
33.

Structural basis for cross-resistance to ribosomal PTC antibiotics.

Davidovich C, Bashan A, Yonath A.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20665-70. doi: 10.1073/pnas.0810826105. Epub 2008 Dec 19.

34.

Biological implications of the ribosome's stunning stereochemistry.

Zimmerman E, Yonath A.

Chembiochem. 2009 Jan 5;10(1):63-72. doi: 10.1002/cbic.200800554. Review. Erratum in: Chembiochem. 2009 Jan 26;10(2):198.

PMID:
19089882
35.

Ribosome's mode of function: myths, facts and recent results.

Wekselman I, Davidovich C, Agmon I, Zimmerman E, Rozenberg H, Bashan A, Berisio R, Yonath A.

J Pept Sci. 2009 Mar;15(3):122-30. doi: 10.1002/psc.1077. Review.

PMID:
19053078
36.

Correlating ribosome function with high-resolution structures.

Bashan A, Yonath A.

Trends Microbiol. 2008 Jul;16(7):326-35. doi: 10.1016/j.tim.2008.05.001. Epub 2008 Jun 9. Review.

PMID:
18547810
37.

Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity.

Davidovich C, Bashan A, Auerbach-Nevo T, Yaggie RD, Gontarek RR, Yonath A.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4291-6. Epub 2007 Mar 8.

38.

Molecular biology: triggering positive competition.

Yonath A.

Nature. 2006 Nov 23;444(7118):435-6. No abstract available.

PMID:
17122845
39.

Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center.

Sato NS, Hirabayashi N, Agmon I, Yonath A, Suzuki T.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15386-91. Epub 2006 Oct 10.

40.

The transition state for formation of the peptide bond in the ribosome.

Gindulyte A, Bashan A, Agmon I, Massa L, Yonath A, Karle J.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13327-32. Epub 2006 Aug 28. Erratum in: Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):3015.

41.

23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.

Berisio R, Corti N, Pfister P, Yonath A, Böttger EC.

Antimicrob Agents Chemother. 2006 Nov;50(11):3816-23. Epub 2006 Aug 21.

42.
43.
44.

Symmetry at the active site of the ribosome: structural and functional implications.

Agmon I, Bashan A, Zarivach R, Yonath A.

Biol Chem. 2005 Sep;386(9):833-44. Review.

PMID:
16164408
45.

Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action.

Baram D, Pyetan E, Sittner A, Auerbach-Nevo T, Bashan A, Yonath A.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12017-22. Epub 2005 Aug 9.

46.

A crevice adjoining the ribosome tunnel: hints for cotranslational folding.

Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A.

FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23.

47.

Reproducible growth of well diffracting ribosomal crystals.

Auerbach-Nevo T, Zarivach R, Peretz M, Yonath A.

Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):713-9. Epub 2005 May 26.

PMID:
15930627
48.
49.

23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.

Pfister P, Corti N, Hobbie S, Bruell C, Zarivach R, Yonath A, Böttger EC.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5180-5. Epub 2005 Mar 28.

50.

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