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Pretreatment predictive factors for feasibility of oral intake in adjuvant concurrent chemoradiotherapy for patients with locally advanced squamous cell carcinoma of the head and neck.

Kimura H, Hamauchi S, Kawai S, Onozawa Y, Yasui H, Yamashita A, Ogawa H, Onoe T, Kamijo T, Iida Y, Onitsuka T, Yokota T.

Int J Clin Oncol. 2019 Oct 16. doi: 10.1007/s10147-019-01560-5. [Epub ahead of print]


Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients.

Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T.

Sci Rep. 2019 Oct 11;9(1):14709. doi: 10.1038/s41598-019-51298-3.


Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes.

Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A.

Biochem Biophys Res Commun. 2019 Oct 1. pii: S0006-291X(19)31825-X. doi: 10.1016/j.bbrc.2019.09.095. [Epub ahead of print]


Pre- and post-serial metagenomic analysis of gut microbiota as a prognostic factor in patients undergoing haematopoietic stem cell transplantation.

Kusakabe S, Fukushima K, Maeda T, Motooka D, Nakamura S, Fujita J, Yokota T, Shibayama H, Oritani K, Kanakura Y.

Br J Haematol. 2019 Sep 30. doi: 10.1111/bjh.16205. [Epub ahead of print]


"Hierarchy" and "Holacracy"; A Paradigm of the Hematopoietic System.

Yokota T.

Cells. 2019 Sep 24;8(10). pii: E1138. doi: 10.3390/cells8101138. Review.


Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure.

Nakano I, Hori H, Fukushima A, Yokota T, Kinugawa S, Takada S, Yamanashi K, Obata Y, Kitaura Y, Kakutani N, Abe T, Anzai T.

J Card Fail. 2019 Sep 15. pii: S1071-9164(19)30416-6. doi: 10.1016/j.cardfail.2019.09.001. [Epub ahead of print]


A Highly Responsive Organic Image Sensor Based on a Two-Terminal Organic Photodetector with Photomultiplication.

Wu YL, Fukuda K, Yokota T, Someya T.

Adv Mater. 2019 Sep 9:e1903687. doi: 10.1002/adma.201903687. [Epub ahead of print]


Safety and efficacy of naldemedine in cancer patients with opioid-induced constipation: a pooled, subgroup analysis of two randomised controlled studies.

Osaka I, Ishiki H, Yokota T, Tada Y, Sato H, Okamoto M, Satomi E.

ESMO Open. 2019 Jul 31;4(4):e000527. doi: 10.1136/esmoopen-2019-000527. eCollection 2019.


Exons 45-55 Skipping Using Mutation-Tailored Cocktails of Antisense Morpholinos in the DMD Gene.

Echigoya Y, Lim KRQ, Melo D, Bao B, Trieu N, Mizobe Y, Maruyama R, Mamchaoui K, Tanihata J, Aoki Y, Takeda S, Mouly V, Duddy W, Yokota T.

Mol Ther. 2019 Jul 26. pii: S1525-0016(19)30325-9. doi: 10.1016/j.ymthe.2019.07.012. [Epub ahead of print]


[Successful treatment of unresectable advanced gastric cancer with bladder metastasis using mFOLFOX6:a case report].

Hirose Y, Kinoshita A, Ishii A, Ishimoto U, Shibata K, Yamaguchi R, Yokota T, Koike K, Saruta M.

Nihon Shokakibyo Gakkai Zasshi. 2019;116(8):676-684. doi: 10.11405/nisshoshi.116.676. Japanese.


Anatomical consideration of the cardiac plexus to prevent grave bradycardiac arrhythmias associated with lung cancer surgery: a case report.

Fukui K, Ikeda S, Yokota T, Hoshino T.

Surg Case Rep. 2019 Aug 8;5(1):129. doi: 10.1186/s40792-019-0686-6.


A 3-Year Overall Survival Update From a Phase 2 Study of Chemoselection With DCF and Subsequent Conversion Surgery for Locally Advanced Unresectable Esophageal Cancer.

Yokota T, Kato K, Hamamoto Y, Tsubosa Y, Ogawa H, Ito Y, Hara H, Ura T, Kojima T, Chin K, Hironaka S, Kii T, Kojima Y, Akutsu Y, Matsushita H, Kawakami K, Mori K, Makiuchi T, Nagumo R, Kitagawa Y.

Ann Surg Oncol. 2019 Aug 2. doi: 10.1245/s10434-019-07654-8. [Epub ahead of print]


ROCK2 regulates TGF-β-induced expression of CTGF and profibrotic genes via NF-κB and cytoskeleton dynamics in mesangial cells.

Nagai Y, Matoba K, Kawanami D, Takeda Y, Akamine T, Ishizawa S, Kanazawa Y, Yokota T, Utsunomiya K, Nishimura R.

Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F839-F851. doi: 10.1152/ajprenal.00596.2018. Epub 2019 Jul 31.


Highly Stretchable Metallic Nanowire Networks Reinforced by the Underlying Randomly Distributed Elastic Polymer Nanofibers via Interfacial Adhesion Improvement.

Jiang Z, Nayeem MOG, Fukuda K, Ding S, Jin H, Yokota T, Inoue D, Hashizume D, Someya T.

Adv Mater. 2019 Sep;31(37):e1903446. doi: 10.1002/adma.201903446. Epub 2019 Jul 24.


A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells.

Katayama T, Kinugawa S, Takada S, Furihata T, Fukushima A, Yokota T, Anzai T, Hibino M, Harashima H, Yamada Y.

Mitochondrion. 2019 Jul 19;49:66-72. doi: 10.1016/j.mito.2019.07.005. [Epub ahead of print]


Clinical background factors affecting outcomes of Helicobacter pylori eradication therapy in primary care.

Yokota N, Ae R, Amenomori M, Kitagawa K, Nakamura T, Yokota T, Masato K, Sasahara T, Matsubara Y, Kosami K, Nakamura Y.

J Gen Fam Med. 2019 Apr 10;20(4):139-145. doi: 10.1002/jgf2.245. eCollection 2019 Jul.


Safety of tapering tacrolimus dose in patients with well-controlled anti-acetylcholine receptor antibody-positive myasthenia gravis.

Nishida Y, Takahashi YK, Kanai T, Nose Y, Ishibashi S, Sanjo N, Uzawa A, Oda F, Ozawa Y, Kuwabara S, Noguchi E, Suzuki S, Nakahara J, Suzuki N, Ogawa T, Yokoyama K, Hattori N, Konno S, Fujioka T, Kawaguchi N, Hatanaka Y, Sonoo M, Kaneko J, Ogino M, Nishiyama K, Nomura K, Yokota T.

Eur J Neurol. 2019 Jul 15. doi: 10.1111/ene.14039. [Epub ahead of print]


Current understanding and treatment of cardiac and skeletal muscle pathology in laminin-α2 chain-deficient congenital muscular dystrophy.

Nguyen Q, Lim KRQ, Yokota T.

Appl Clin Genet. 2019 Jul 3;12:113-130. doi: 10.2147/TACG.S187481. eCollection 2019.


Olivary hypertrophy improved by steroid treatment: Two case reports with unique presentations.

Ohara M, Sanjo N, Hattori T, Oyama J, Hamada M, Ozaki K, Yokota T.

J Neuroimmunol. 2019 Sep 15;334:577003. doi: 10.1016/j.jneuroim.2019.577003. Epub 2019 Jul 5.


Three-dimensional surface models of autopsied human brains constructed from multiple photographs by photogrammetry.

Shintaku H, Yamaguchi M, Toru S, Kitagawa M, Hirokawa K, Yokota T, Uchihara T.

PLoS One. 2019 Jul 10;14(7):e0219619. doi: 10.1371/journal.pone.0219619. eCollection 2019.


Robust 3D image reconstruction of pancreatic cancer tumors from histopathological images with different stains and its quantitative performance evaluation.

Kugler M, Goto Y, Tamura Y, Kawamura N, Kobayashi H, Yokota T, Iwamoto C, Ohuchida K, Hashizume M, Shimizu A, Hontani H.

Int J Comput Assist Radiol Surg. 2019 Jul 2. doi: 10.1007/s11548-019-02019-8. [Epub ahead of print]


Real-time estimation of electric fields induced by transcranial magnetic stimulation with deep neural networks.

Yokota T, Maki T, Nagata T, Murakami T, Ugawa Y, Laakso I, Hirata A, Hontani H.

Brain Stimul. 2019 Jun 17. pii: S1935-861X(19)30266-9. doi: 10.1016/j.brs.2019.06.015. [Epub ahead of print]


Early Detection of Pancreatic Cancer in Patients With Chronic Liver Disease Under Hepatocellular Carcinoma Surveillance.

Kumagi T, Terao T, Yokota T, Azemoto N, Kuroda T, Imamura Y, Uesugi K, Kisaka Y, Tanaka Y, Shibata N, Koizumi M, Ohno Y, Yukimoto A, Tange K, Nishiyama M, Kanemitsu K, Miyake T, Miyata H, Ishii H, Hiasa Y; Ehime Pancreato-Cholangiology (EPOCH) Study Group.

Mayo Clin Proc. 2019 Oct;94(10):2004-2010. doi: 10.1016/j.mayocp.2018.12.034. Epub 2019 Jun 28.


C/EBPε ΔRS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A.

Muraoka M, Akagi T, Ueda A, Wada T, Koeffler HP, Yokota T, Yachie A.

Biochem Biophys Res Commun. 2019 Aug 13;516(1):293-299. doi: 10.1016/j.bbrc.2019.06.130. Epub 2019 Jun 27.


Highly Durable Nanofiber-Reinforced Elastic Conductors for Skin-Tight Electronic Textiles.

Jin H, Nayeem MOG, Lee S, Matsuhisa N, Inoue D, Yokota T, Hashizume D, Someya T.

ACS Nano. 2019 Jul 23;13(7):7905-7912. doi: 10.1021/acsnano.9b02297. Epub 2019 Jun 21.


Intrathecal IgG Synthesis and Persistent Inflammation are Associated with White Matter Lesions in HIV-negative Patients with Cryptococcal Meningoencephalitis.

Ohyagi M, Irioka T, Ohkubo T, Ishibashi S, Takahashi YK, Amano E, Machida A, Kuwahara H, Yokota T.

Intern Med. 2019 Jun 27. doi: 10.2169/internalmedicine.2338-18. [Epub ahead of print]


Detrimental Effect of Chronic Hypertension on Leptomeningeal Collateral Flow in Acute Ischemic Stroke.

Fujita K, Tanaka K, Yamagami H, Ide T, Ishiyama H, Sonoda K, Satow T, Takahashi JC, Ihara M, Koga M, Yokota T, Toyoda K.

Stroke. 2019 Jul;50(7):1751-1757. doi: 10.1161/STROKEAHA.119.025142. Epub 2019 May 16. Erratum in: Stroke. 2019 Sep;50(9):e280-e281.


The efficacy and safety of nab paclitaxel plus gemcitabine in elderly patients over 75 years with unresectable pancreatic cancer compared with younger patients.

Ishimoto U, Kinoshita A, Hirose Y, Shibata K, Ishii A, Shoji R, Yokota T, Iwaku A, Mizuno Y, Koike K, Saruta M.

Cancer Chemother Pharmacol. 2019 Sep;84(3):647-654. doi: 10.1007/s00280-019-03895-2. Epub 2019 Jun 22.


Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42.

Hashiguchi S, Doi H, Kunii M, Nakamura Y, Shimuta M, Suzuki E, Koyano S, Okubo M, Kishida H, Shiina M, Ogata K, Hirashima F, Inoue Y, Kubota S, Hayashi N, Nakamura H, Takahashi K, Katsumoto A, Tada M, Tanaka K, Sasaoka T, Miyatake S, Miyake N, Saitsu H, Sato N, Ozaki K, Ohta K, Yokota T, Mizusawa H, Mitsui J, Ishiura H, Yoshimura J, Morishita S, Tsuji S, Takeuchi H, Ishikawa K, Matsumoto N, Ishikawa T, Tanaka F.

Neurobiol Dis. 2019 Oct;130:104516. doi: 10.1016/j.nbd.2019.104516. Epub 2019 Jun 20.


Comparison of enteral nutrition with total parenteral nutrition for patients with locally advanced unresectable esophageal cancer harboring dysphagia in definitive chemoradiotherapy.

Furuta M, Yokota T, Tsushima T, Todaka A, Machida N, Hamauchi S, Yamazaki K, Fukutomi A, Kawai S, Kawabata T, Onozawa Y, Yasui H.

Jpn J Clin Oncol. 2019 Jun 20. pii: hyz089. doi: 10.1093/jjco/hyz089. [Epub ahead of print]


Highly efficient silencing of microRNA by heteroduplex oligonucleotides.

Yoshioka K, Kunieda T, Asami Y, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Hara RI, Nagata T, Wada T, Obika S, Yokota T.

Nucleic Acids Res. 2019 Aug 22;47(14):7321-7332. doi: 10.1093/nar/gkz492.


Afatinib vs Placebo as Adjuvant Therapy After Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck: A Randomized Clinical Trial.

Burtness B, Haddad R, Dinis J, Trigo J, Yokota T, de Souza Viana L, Romanov I, Vermorken J, Bourhis J, Tahara M, Martins Segalla JG, Psyrri A, Vasilevskaya I, Nangia CS, Chaves-Conde M, Kiyota N, Homma A, Holeckova P, Del Campo JM, Asarawala N, Nicolau UR, Rauch D, Even C, Wang B, Gibson N, Ehrnrooth E, Harrington K, Cohen EEW; LUX-Head & Neck 2 investigators.

JAMA Oncol. 2019 Jun 13. doi: 10.1001/jamaoncol.2019.1146. [Epub ahead of print]


A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition).

Head and Neck Cancer Study Group (HNCSG), Monden N, Asakage T, Kiyota N, Homma A, Matsuura K, Hanai N, Kodaira T, Zenda S, Fujii H, Tahara M, Yokota T, Akimoto T, Iwae S, Onitsuka T, Ogawa T, Okano S, Takahashi S, Shimizu Y, Yonezawa K, Hayashi R.

Jpn J Clin Oncol. 2019 Jul 1;49(7):589-595. doi: 10.1093/jjco/hyz052.


Development of demyelinating lesions in progressive multifocal leukoencephalopathy (PML): Comparison of magnetic resonance images and neuropathology of post-mortem brain.

Ono D, Shishido-Hara Y, Mizutani S, Mori Y, Ichinose K, Watanabe M, Tanizawa T, Yokota T, Uchihara T, Fujigasaki H.

Neuropathology. 2019 Aug;39(4):294-306. doi: 10.1111/neup.12562. Epub 2019 Jun 2.


Prognostic impact of body mass index and culprit lesion calcification in patients with acute myocardial infarction.

Yokoyama H, Higuma T, Endo T, Nishizaki F, Hanada K, Yokota T, Yamada M, Okumura K, Tomita H.

Heart Vessels. 2019 May 29. doi: 10.1007/s00380-019-01439-5. [Epub ahead of print]


Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease.

Uehara T, Choong CJ, Nakamori M, Hayakawa H, Nishiyama K, Kasahara Y, Baba K, Nagata T, Yokota T, Tsuda H, Obika S, Mochizuki H.

Sci Rep. 2019 May 21;9(1):7567. doi: 10.1038/s41598-019-43772-9.


Prevalence and clinicoradiological features of spinocerebellar ataxia type 34 in a Japanese ataxia cohort.

Ozaki K, Ansai A, Nobuhara K, Araki T, Kubodera T, Ishii T, Higashi M, Sato N, Soga K, Mizusawa H, Ishikawa K, Yokota T.

Parkinsonism Relat Disord. 2019 Aug;65:238-242. doi: 10.1016/j.parkreldis.2019.05.019. Epub 2019 May 13.


Selective Correction of Genotype Yield by Probucol in HDL-Deficient Mice Propagation.

Tsujita M, Akita N, Yokota T, Kobayashi F, Yokoyama S.

J Atheroscler Thromb. 2019 May 14. doi: 10.5551/jat.48967. [Epub ahead of print]


Cutaneous diffuse large B-cell lymphoma mimicking rheumatoid vasculitis.

Waki D, Nishimura K, Kadoba K, Yokota T.

Rheumatology (Oxford). 2019 May 12. pii: kez193. doi: 10.1093/rheumatology/kez193. [Epub ahead of print] No abstract available.


Anti-proliferative Activities towards Human Brain Glioma U251 Cells and Human Carcinoma Cells (KB3-1) of Some Twin-Drug Type Bivalent C2-Symmetrical Phenylboronic Acid Derivatives.

Furutachi M, Gondo T, Ikeda R, Yoshikawa N, Yokota T, Takeda Y, Yokomizo K, Zhou JR, Kashige N, Miake F, Sumoto K.

Biol Pharm Bull. 2019;42(5):833-836. doi: 10.1248/bpb.b18-00859.


Elevated lipid peaks during the recovery phase of Baló's concentric sclerosis: A case report.

Otsu S, Ishibashi S, Ozaki K, Yokota T.

eNeurologicalSci. 2019 Apr 9;15:100191. doi: 10.1016/j.ensci.2019.100191. eCollection 2019 Jun. No abstract available.


Efficacy of Plasma Exchange in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.

Nishimura K, Waki D, Kadoba K, Mukoyama H, Yokota T, Murabe H.

Ther Apher Dial. 2019 Jun;23(3):248-252. doi: 10.1111/1744-9987.12828. Epub 2019 May 30.


Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report.

Sakai T, Yahagi K, Hoshino T, Yokota T, Tanabe K, Mori M, Ikeda S.

Respir Med Case Rep. 2019 Apr 15;27:100839. doi: 10.1016/j.rmcr.2019.100839. eCollection 2019.


Cross-Sectional Area Analysis of the Head of the Caudate Nucleus in Huntington's Disease.

Furukawa F, Ishikawa K, Yokota T, Sanjo N.

Eur Neurol. 2019;81(1-2):13-18. doi: 10.1159/000499909. Epub 2019 Apr 23.


Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody.

Ebashi M, Toru S, Nakamura A, Kamei S, Yokota T, Hirokawa K, Uchihara T.

Acta Neuropathol. 2019 Jul;138(1):163-166. doi: 10.1007/s00401-019-02012-0. Epub 2019 Apr 20. No abstract available.


Usefulness of [11C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma.

Hashimoto S, Inaji M, Nariai T, Kobayashi D, Sanjo N, Yokota T, Ishii K, Taketoshi M.

Neurol Med Chir (Tokyo). 2019 May 15;59(5):176-183. doi: 10.2176/nmc.oa.2018-0287. Epub 2019 Apr 17.


Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation.

Guo L, Bertola DR, Takanohashi A, Saito A, Segawa Y, Yokota T, Ishibashi S, Nishida Y, Yamamoto GL, Franco JFDS, Honjo RS, Kim CA, Musso CM, Timmons M, Pizzino A, Taft RJ, Lajoie B, Knight MA, Fischbeck KH, Singleton AB, Ferreira CR, Wang Z, Yan L, Garbern JY, Simsek-Kiper PO, Ohashi H, Robey PG, Boyde A, Matsumoto N, Miyake N, Spranger J, Schiffmann R, Vanderver A, Nishimura G, Passos-Bueno MRDS, Simons C, Ishikawa K, Ikegawa S.

Am J Hum Genet. 2019 May 2;104(5):925-935. doi: 10.1016/j.ajhg.2019.03.004. Epub 2019 Apr 11.


The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Naldemedine.

Fukumura K, Yamada T, Yokota T, Kawasaki A.

Clin Pharmacol Drug Dev. 2019 Apr 12. doi: 10.1002/cpdd.690. [Epub ahead of print]


Antisense oligonucleotides for the treatment of cardiomyopathy in Duchenne muscular dystrophy.

Nguyen Q, Yokota T.

Am J Transl Res. 2019 Mar 15;11(3):1202-1218. eCollection 2019. Review.

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