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Items: 1 to 50 of 148

1.

Simulated biological fluid exposure changes nanoceria's surface properties but not its biological response.

Yokel RA, Hancock ML, Cherian B, Brooks AJ, Ensor ML, Vekaria HJ, Sullivan PG, Grulke EA.

Eur J Pharm Biopharm. 2019 Nov;144:252-265. doi: 10.1016/j.ejpb.2019.09.023. Epub 2019 Sep 26.

PMID:
31563633
2.

Surface-controlled dissolution rates: a case study of nanoceria in carboxylic acid solutions.

Grulke EA, Beck MJ, Yokel RA, Unrine JM, Graham UM, Hancock ML.

Environ Sci Nano. 2019 May 1;6(5):1478-1492. doi: 10.1039/C9EN00222G. Epub 2019 Apr 4.

3.

Imatinib mesylate effects on zebrafish reproductive success: Gonadal development, gamete quality, fertility, embryo-larvae viability and development, and related genes.

Ahmadi N, Samaee SM, Yokel RA, Tehrani A.

Toxicol Appl Pharmacol. 2019 Sep 15;379:114645. doi: 10.1016/j.taap.2019.114645. Epub 2019 Jul 3.

PMID:
31278918
4.

Carboxylic acids accelerate acidic environment-mediated nanoceria dissolution.

Yokel RA, Hancock ML, Grulke EA, Unrine JM, Dozier AK, Graham UM.

Nanotoxicology. 2019 May;13(4):455-475. doi: 10.1080/17435390.2018.1553251. Epub 2019 Feb 7.

PMID:
30729879
5.

Methods to Quantify Nanomaterial Association with, and Distribution Across, the Blood-Brain Barrier In Vivo.

Yokel RA.

Methods Mol Biol. 2019;1894:281-299. doi: 10.1007/978-1-4939-8916-4_16.

PMID:
30547467
6.

Morphometric characteristics and time to hatch as efficacious indicators for potential nanotoxicity assay in zebrafish.

Samaee SM, Manteghi N, Yokel RA, Mohajeri-Tehrani MR.

Environ Toxicol Chem. 2018 Dec;37(12):3063-3076. doi: 10.1002/etc.4266. Epub 2018 Nov 19.

PMID:
30183097
7.

Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics.

Carlander U, Moto TP, Desalegn AA, Yokel RA, Johanson G.

Int J Nanomedicine. 2018 May 1;13:2631-2646. doi: 10.2147/IJN.S157210. eCollection 2018.

8.

Analytical High-resolution Electron Microscopy Reveals Organ-specific Nanoceria Bioprocessing.

Graham UM, Yokel RA, Dozier AK, Drummy L, Mahalingam K, Tseng MT, Birch E, Fernback J.

Toxicol Pathol. 2018 Jan;46(1):47-61. doi: 10.1177/0192623317737254. Epub 2017 Nov 16.

9.

Biokinetics of Nanomaterials: the Role of Biopersistence.

Laux P, Riebeling C, Booth AM, Brain JD, Brunner J, Cerrillo C, Creutzenberg O, Estrela-Lopis I, Gebel T, Johanson G, Jungnickel H, Kock H, Tentschert J, Tlili A, Schäffer A, Sips AJAM, Yokel RA, Luch A.

NanoImpact. 2017 Apr;6:69-80. doi: 10.1016/j.impact.2017.03.003. Epub 2017 Mar 22.

10.

Toxic and Essential Trace Element Content of Commonly Administered Pediatric Oral Medications.

Yokel RA, Seger SE, Unrine JM.

J Pediatr Pharmacol Ther. 2017 May-Jun;22(3):193-202. doi: 10.5863/1551-6776-22.3.193.

11.

From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity.

Graham UM, Jacobs G, Yokel RA, Davis BH, Dozier AK, Birch ME, Tseng MT, Oberdörster G, Elder A, DeLouise L.

Adv Exp Med Biol. 2017;947:71-100. doi: 10.1007/978-3-319-47754-1_4. Review.

12.

Physicochemical properties of engineered nanomaterials that influence their nervous system distribution and effects.

Yokel RA.

Nanomedicine. 2016 Oct;12(7):2081-2093. doi: 10.1016/j.nano.2016.05.007. Epub 2016 May 24. Review.

PMID:
27228902
13.

Aluminum and Phthalates in Calcium Gluconate: Contribution From Glass and Plastic Packaging.

Yokel RA, Unrine JM.

J Pediatr Gastroenterol Nutr. 2017 Jan;64(1):109-114. doi: 10.1097/MPG.0000000000001243.

PMID:
27111341
14.

Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood-brain barrier primary triple coculture model.

Xu L, Dan M, Shao A, Cheng X, Zhang C, Yokel RA, Takemura T, Hanagata N, Niwa M, Watanabe D.

Int J Nanomedicine. 2015 Sep 29;10:6105-18. doi: 10.2147/IJN.S85265. eCollection 2015.

15.

In Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free-Radical Scavenging Activity and Oxidative Stress.

Graham UM, Tseng MT, Jasinski JB, Yokel RA, Unrine JM, Davis BH, Dozier AK, Hardas SS, Sultana R, Grulke EA, Butterfield DA.

Chempluschem. 2014 Aug;79(8):1083-1088.

16.

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model.

Lee TJ, Haque F, Shu D, Yoo JY, Li H, Yokel RA, Horbinski C, Kim TH, Kim SH, Kwon CH, Nakano I, Kaur B, Guo P, Croce CM.

Oncotarget. 2015 Jun 20;6(17):14766-76.

17.

Alternating magnetic field-induced hyperthermia increases iron oxide nanoparticle cell association/uptake and flux in blood-brain barrier models.

Dan M, Bae Y, Pittman TA, Yokel RA.

Pharm Res. 2015 May;32(5):1615-25. doi: 10.1007/s11095-014-1561-6. Epub 2014 Nov 7.

18.

A Filtration System That Greatly Reduces Aluminum in Calcium Gluconate Injection, USP Used to Prepare Parenteral Nutrition Solutions.

Yokel RA, Harris WR, Spilling CD, Abramov VP, Lone JM, Kuhn RJ.

J Pediatr Pharmacol Ther. 2014 Jul;19(3):189-95. doi: 10.5863/1551-6776-19.3.189.

19.

The Yin: An adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity.

Yokel RA, Hussain S, Garantziotis S, Demokritou P, Castranova V, Cassee FR.

Environ Sci Nano. 2014 Oct 1;1(5):406-428.

20.

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts.

Willhite CC, Karyakina NA, Yokel RA, Yenugadhati N, Wisniewski TM, Arnold IM, Momoli F, Krewski D.

Crit Rev Toxicol. 2014 Oct;44 Suppl 4:1-80. doi: 10.3109/10408444.2014.934439. Review.

21.

Applying accelerator mass spectrometry for low-level detection of complex engineered nanoparticles in biological media.

Wang B, Jackson GS, Yokel RA, Grulke EA.

J Pharm Biomed Anal. 2014 Aug;97:81-7. doi: 10.1016/j.jpba.2014.04.003. Epub 2014 Apr 19.

PMID:
24819451
22.

Rat hippocampal responses up to 90 days after a single nanoceria dose extends a hierarchical oxidative stress model for nanoparticle toxicity.

Hardas SS, Sultana R, Warrier G, Dan M, Wu P, Grulke EA, Tseng MT, Unrine JM, Graham UM, Yokel RA, Butterfield DA.

Nanotoxicology. 2014 Aug;8 Suppl 1:155-66. doi: 10.3109/17435390.2013.868059. Epub 2013 Dec 18.

PMID:
24350865
23.

Binding, transcytosis and biodistribution of anti-PECAM-1 iron oxide nanoparticles for brain-targeted delivery.

Dan M, Cochran DB, Yokel RA, Dziubla TD.

PLoS One. 2013 Nov 20;8(11):e81051. doi: 10.1371/journal.pone.0081051. eCollection 2013.

24.

Persistent hepatic structural alterations following nanoceria vascular infusion in the rat.

Tseng MT, Fu Q, Lor K, Fernandez-Botran GR, Deng ZB, Graham U, Butterfield DA, Grulke EA, Yokel RA.

Toxicol Pathol. 2014 Aug;42(6):984-96. doi: 10.1177/0192623313505780. Epub 2013 Oct 31.

PMID:
24178579
25.

Assessing nanoparticle risk poses prodigious challenges.

MacPhail RC, Grulke EA, Yokel RA.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jul-Aug;5(4):374-87. doi: 10.1002/wnan.1216. Epub 2013 Apr 8. Review.

PMID:
23568806
26.

Block copolymer cross-linked nanoassemblies improve particle stability and biocompatibility of superparamagnetic iron oxide nanoparticles.

Dan M, Scott DF, Hardy PA, Wydra RJ, Hilt JZ, Yokel RA, Bae Y.

Pharm Res. 2013 Feb;30(2):552-61. doi: 10.1007/s11095-012-0900-8. Epub 2012 Oct 19.

27.

Biodistribution and biopersistence of ceria engineered nanomaterials: size dependence.

Yokel RA, Tseng MT, Dan M, Unrine JM, Graham UM, Wu P, Grulke EA.

Nanomedicine. 2013 Apr;9(3):398-407. doi: 10.1016/j.nano.2012.08.002. Epub 2012 Sep 5.

PMID:
22960425
28.

Brain microvascular endothelial cell association and distribution of a 5 nm ceria engineered nanomaterial.

Dan M, Tseng MT, Wu P, Unrine JM, Grulke EA, Yokel RA.

Int J Nanomedicine. 2012;7:4023-36. doi: 10.2147/IJN.S32526. Epub 2012 Jul 27.

29.

Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure.

Hardas SS, Sultana R, Warrier G, Dan M, Florence RL, Wu P, Grulke EA, Tseng MT, Unrine JM, Graham UM, Yokel RA, Butterfield DA.

Neurotoxicology. 2012 Oct;33(5):1147-55. doi: 10.1016/j.neuro.2012.06.007. Epub 2012 Jun 28.

PMID:
22750192
30.

Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria.

Tseng MT, Lu X, Duan X, Hardas SS, Sultana R, Wu P, Unrine JM, Graham U, Butterfield DA, Grulke EA, Yokel RA.

Toxicol Appl Pharmacol. 2012 Apr 15;260(2):173-82. doi: 10.1016/j.taap.2012.02.008. Epub 2012 Feb 20.

PMID:
22373796
31.

Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats.

Yokel RA, Au TC, MacPhail R, Hardas SS, Butterfield DA, Sultana R, Goodman M, Tseng MT, Dan M, Haghnazar H, Unrine JM, Graham UM, Wu P, Grulke EA.

Toxicol Sci. 2012 May;127(1):256-68. doi: 10.1093/toxsci/kfs067. Epub 2012 Feb 23.

PMID:
22367688
32.

The neurotoxic potential of engineered nanomaterials.

Boyes WK, Chen R, Chen C, Yokel RA.

Neurotoxicology. 2012 Aug;33(4):902-10. doi: 10.1016/j.neuro.2011.12.013. Epub 2011 Dec 21.

PMID:
22198707
33.

Ceria-engineered nanomaterial distribution in, and clearance from, blood: size matters.

Dan M, Wu P, Grulke EA, Graham UM, Unrine JM, Yokel RA.

Nanomedicine (Lond). 2012 Jan;7(1):95-110. doi: 10.2217/nnm.11.103.

PMID:
22191779
34.

Engineered nanomaterials: exposures, hazards, and risk prevention.

Yokel RA, Macphail RC.

J Occup Med Toxicol. 2011 Mar 21;6:7. doi: 10.1186/1745-6673-6-7.

35.

Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceria.

Hardas SS, Butterfield DA, Sultana R, Tseng MT, Dan M, Florence RL, Unrine JM, Graham UM, Wu P, Grulke EA, Yokel RA.

Toxicol Sci. 2010 Aug;116(2):562-76. doi: 10.1093/toxsci/kfq137. Epub 2010 May 10.

PMID:
20457660
36.

Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS viruses.

Al-Ghananeem AM, Saeed H, Florence R, Yokel RA, Malkawi AH.

J Drug Target. 2010 Jun;18(5):381-8. doi: 10.3109/10611860903483396.

PMID:
20001275
37.

Manganese flux across the blood-brain barrier.

Yokel RA.

Neuromolecular Med. 2009;11(4):297-310. doi: 10.1007/s12017-009-8101-2. Epub 2009 Nov 10. Review.

PMID:
19902387
38.

1,6-Dimethyl-4-hydroxy-3-pyridinecarboxylic acid and 4-hydroxy-2-methyl-3-pyridinecarboxylic acid as new possible chelating agents for iron and aluminium.

Dean A, Ferlin MG, Brun P, Castagliuolo I, Yokel RA, Badocco D, Pastore P, Venzo A, Bombi GG, Di Marco VB.

Dalton Trans. 2009 Mar 14;(10):1815-24. doi: 10.1039/b819148d. Epub 2009 Jan 27.

PMID:
19240917
39.

Aluminum bioavailability from tea infusion.

Yokel RA, Florence RL.

Food Chem Toxicol. 2008 Dec;46(12):3659-63. doi: 10.1016/j.fct.2008.09.041. Epub 2008 Sep 21.

40.

Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature.

Chen L, Yokel RA, Hennig B, Toborek M.

J Neuroimmune Pharmacol. 2008 Dec;3(4):286-95. doi: 10.1007/s11481-008-9131-5. Epub 2008 Oct 1.

41.

Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells.

Dey S, Bakthavatchalu V, Tseng MT, Wu P, Florence RL, Grulke EA, Yokel RA, Dhar SK, Yang HS, Chen Y, St Clair DK.

Carcinogenesis. 2008 Oct;29(10):1920-9. doi: 10.1093/carcin/bgn175. Epub 2008 Aug 1.

42.

Aluminum bioavailability from basic sodium aluminum phosphate, an approved food additive emulsifying agent, incorporated in cheese.

Yokel RA, Hicks CL, Florence RL.

Food Chem Toxicol. 2008 Jun;46(6):2261-6. doi: 10.1016/j.fct.2008.03.004. Epub 2008 Mar 10.

43.

The influence of citrate, maltolate and fluoride on the gastrointestinal absorption of aluminum at a drinking water-relevant concentration: A 26Al and 14C study.

Zhou Y, Harris WR, Yokel RA.

J Inorg Biochem. 2008 Apr;102(4):798-808. doi: 10.1016/j.jinorgbio.2007.11.019. Epub 2007 Dec 14.

PMID:
18207247
44.

Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide.

Krewski D, Yokel RA, Nieboer E, Borchelt D, Cohen J, Harry J, Kacew S, Lindsay J, Mahfouz AM, Rondeau V.

J Toxicol Environ Health B Crit Rev. 2007;10 Suppl 1:1-269. Review. No abstract available. Erratum in: J Toxicol Environ Health B Crit Rev. 2008 Feb;11(2):147.

45.
47.

The speciation of metals in mammals influences their toxicokinetics and toxicodynamics and therefore human health risk assessment.

Yokel RA, Lasley SM, Dorman DC.

J Toxicol Environ Health B Crit Rev. 2006 Jan-Feb;9(1):63-85. Review.

PMID:
16393870
48.

Aluminium content of some foods and food products in the USA, with aluminium food additives.

Saiyed SM, Yokel RA.

Food Addit Contam. 2005 Mar;22(3):234-44.

PMID:
16019791
49.

Manganese distribution across the blood-brain barrier. IV. Evidence for brain influx through store-operated calcium channels.

Crossgrove JS, Yokel RA.

Neurotoxicology. 2005 Jun;26(3):297-307. Epub 2004 Nov 11.

PMID:
15935202
50.

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