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Items: 1 to 50 of 70

1.

Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila.

Green HJ, Griffiths AG, Ylänne J, Brown NH.

Elife. 2018 Jul 20;7. pii: e35783. doi: 10.7554/eLife.35783.

2.

Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms.

Antenucci L, Hytönen VP, Ylänne J.

J Biol Chem. 2018 Mar 30;293(13):4591-4602. doi: 10.1074/jbc.RA117.000660. Epub 2018 Feb 12.

3.

Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing.

Seppälä J, Bernardi RC, Haataja TJK, Hellman M, Pentikäinen OT, Schulten K, Permi P, Ylänne J, Pentikäinen U.

Sci Rep. 2017 Jun 26;7(1):4218. doi: 10.1038/s41598-017-04441-x.

4.

Evidence for the mechanosensor function of filamin in tissue development.

Huelsmann S, Rintanen N, Sethi R, Brown NH, Ylänne J.

Sci Rep. 2016 Sep 6;6:32798. doi: 10.1038/srep32798.

5.

Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21.

Seppälä J, Tossavainen H, Rodic N, Permi P, Pentikäinen U, Ylänne J.

PLoS One. 2015 Aug 31;10(8):e0136969. doi: 10.1371/journal.pone.0136969. eCollection 2015.

6.

Small-angle X-ray scattering reveals compact domain-domain interactions in the N-terminal region of filamin C.

Sethi R, Ylänne J.

PLoS One. 2014 Sep 22;9(9):e107457. doi: 10.1371/journal.pone.0107457. eCollection 2014.

7.

A novel structural unit in the N-terminal region of filamins.

Sethi R, Seppälä J, Tossavainen H, Ylilauri M, Ruskamo S, Pentikäinen OT, Pentikäinen U, Permi P, Ylänne J.

J Biol Chem. 2014 Mar 21;289(12):8588-98. doi: 10.1074/jbc.M113.537456. Epub 2014 Jan 27.

8.

Filopodia-like actin cables position nuclei in association with perinuclear actin in Drosophila nurse cells.

Huelsmann S, Ylänne J, Brown NH.

Dev Cell. 2013 Sep 30;26(6):604-15. doi: 10.1016/j.devcel.2013.08.014.

9.

Dynamic force sensing of filamin revealed in single-molecule experiments.

Rognoni L, Stigler J, Pelz B, Ylänne J, Rief M.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19679-84. doi: 10.1073/pnas.1211274109. Epub 2012 Nov 13.

10.

Negative regulators of integrin activity.

Pouwels J, Nevo J, Pellinen T, Ylänne J, Ivaska J.

J Cell Sci. 2012 Jul 15;125(Pt 14):3271-80. doi: 10.1242/jcs.093641. Epub 2012 Jul 20.

11.

The C-terminal rod 2 fragment of filamin A forms a compact structure that can be extended.

Ruskamo S, Gilbert R, Hofmann G, Jiang P, Campbell ID, Ylänne J, Pentikäinen U.

Biochem J. 2012 Sep 1;446(2):261-9. doi: 10.1042/BJ20120361.

PMID:
22676060
12.

Binding properties and stability of the Ras-association domain of Rap1-GTP interacting adapter molecule (RIAM).

Takala H, Ylänne J.

PLoS One. 2012;7(4):e31955. doi: 10.1371/journal.pone.0031955. Epub 2012 Apr 16.

13.

Model of a six immunoglobulin-like domain fragment of filamin A (16-21) built using residual dipolar couplings.

Tossavainen H, Koskela O, Jiang P, Ylänne J, Campbell ID, Kilpeläinen I, Permi P.

J Am Chem Soc. 2012 Apr 18;134(15):6660-72. doi: 10.1021/ja2114882. Epub 2012 Apr 10.

PMID:
22452512
14.

Filamins in mechanosensing and signaling.

Razinia Z, Mäkelä T, Ylänne J, Calderwood DA.

Annu Rev Biophys. 2012;41:227-46. doi: 10.1146/annurev-biophys-050511-102252. Epub 2012 Feb 23. Review.

15.

Assembly of a filamin four-domain fragment and the influence of splicing variant-1 on the structure.

Pentikäinen U, Jiang P, Takala H, Ruskamo S, Campbell ID, Ylänne J.

J Biol Chem. 2011 Jul 29;286(30):26921-30. doi: 10.1074/jbc.M110.195958. Epub 2011 Jun 2.

16.

Structure of the human filamin A actin-binding domain.

Ruskamo S, Ylänne J.

Acta Crystallogr D Biol Crystallogr. 2009 Nov;65(Pt 11):1217-21. doi: 10.1107/S0907444909037330. Epub 2009 Oct 22.

PMID:
19923718
17.

The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin.

Pentikäinen U, Ylänne J.

J Mol Biol. 2009 Oct 30;393(3):644-57. doi: 10.1016/j.jmb.2009.08.035. Epub 2009 Aug 20.

PMID:
19699211
18.

1H, 13C and 15N resonance assignments of the human filamin A tandem immunoglobulin-like domains 16-17 and 18-19.

Heikkinen O, Permi P, Koskela H, Ylänne J, Kilpeläinen I.

Biomol NMR Assign. 2009 Jun;3(1):53-6. doi: 10.1007/s12104-008-9140-6. Epub 2009 Jan 4.

PMID:
19636946
19.

Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin.

Heikkinen OK, Ruskamo S, Konarev PV, Svergun DI, Iivanainen T, Heikkinen SM, Permi P, Koskela H, Kilpeläinen I, Ylänne J.

J Biol Chem. 2009 Sep 11;284(37):25450-8. doi: 10.1074/jbc.M109.019661. Epub 2009 Jul 21.

20.

Solution structure of the first immunoglobulin domain of human myotilin.

Heikkinen O, Permi P, Koskela H, Carpén O, Ylänne J, Kilpeläinen I.

J Biomol NMR. 2009 Jun;44(2):107-12. doi: 10.1007/s10858-009-9320-4. Epub 2009 May 6.

PMID:
19418025
21.

Characterization of the interaction between Actinin-Associated LIM Protein (ALP) and the rod domain of alpha-actinin.

Klaavuniemi T, Alho N, Hotulainen P, Kelloniemi A, Havukainen H, Permi P, Mattila S, Ylänne J.

BMC Cell Biol. 2009 Mar 27;10:22. doi: 10.1186/1471-2121-10-22.

22.

Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.

Nakamura F, Heikkinen O, Pentikäinen OT, Osborn TM, Kasza KE, Weitz DA, Kupiainen O, Permi P, Kilpeläinen I, Ylänne J, Hartwig JH, Stossel TP.

PLoS One. 2009;4(3):e4928. doi: 10.1371/journal.pone.0004928. Epub 2009 Mar 18.

23.

Novel structural insights into F-actin-binding and novel functions of calponin homology domains.

Sjöblom B, Ylänne J, Djinović-Carugo K.

Curr Opin Struct Biol. 2008 Dec;18(6):702-8. doi: 10.1016/j.sbi.2008.10.003. Epub 2008 Nov 13. Review.

PMID:
18952167
24.

Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.

Lad Y, Jiang P, Ruskamo S, Harburger DS, Ylänne J, Campbell ID, Calderwood DA.

J Biol Chem. 2008 Dec 12;283(50):35154-63. doi: 10.1074/jbc.M802592200. Epub 2008 Sep 30.

25.

Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding.

Takala H, Nurminen E, Nurmi SM, Aatonen M, Strandin T, Takatalo M, Kiema T, Gahmberg CG, Ylänne J, Fagerholm SC.

Blood. 2008 Sep 1;112(5):1853-62. doi: 10.1182/blood-2007-12-127795. Epub 2008 Jun 12.

26.

Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.

Lad Y, Kiema T, Jiang P, Pentikäinen OT, Coles CH, Campbell ID, Calderwood DA, Ylänne J.

EMBO J. 2007 Sep 5;26(17):3993-4004. Epub 2007 Aug 9.

27.

Backbone NMR assignment of the internal interaction site of ALP.

Alho N, Klaavuniemi T, Ylänne J, Permi P, Mattila S.

Biomol NMR Assign. 2007 Jul;1(1):85-7. doi: 10.1007/s12104-007-9024-1. Epub 2007 Jul 20.

PMID:
19636834
28.

Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer.

Sjekloća L, Pudas R, Sjöblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylänne J, Djinović Carugo K.

J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20.

PMID:
17379241
29.

Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets.

Schwarz M, Meade G, Stoll P, Ylanne J, Bassler N, Chen YC, Hagemeyer CE, Ahrens I, Moran N, Kenny D, Fitzgerald D, Bode C, Peter K.

Circ Res. 2006 Jul 7;99(1):25-33. Epub 2006 Jun 15.

PMID:
16778135
30.

Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin--analysis of patient mutations.

Klaavuniemi T, Ylänne J.

Exp Cell Res. 2006 May 1;312(8):1299-311. Epub 2006 Feb 14.

PMID:
16476425
31.

The molecular basis of filamin binding to integrins and competition with talin.

Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, Campbell ID, Ylänne J, Calderwood DA.

Mol Cell. 2006 Feb 3;21(3):337-47.

32.

The structure of the GPIb-filamin A complex.

Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpeläinen I, Munday AD, Hartwig JH, Stossel TP, Ylänne J.

Blood. 2006 Mar 1;107(5):1925-32. Epub 2005 Nov 17.

33.
34.

Structural basis for vertebrate filamin dimerization.

Pudas R, Kiema TR, Butler PJ, Stewart M, Ylänne J.

Structure. 2005 Jan;13(1):111-9.

35.

Expression, purification and preliminary crystallographic characterization of a novel segment from the neurofibromatosis type 1 protein.

Bonneau F, D'Angelo I, Welti S, Stier G, Ylänne J, Scheffzek K.

Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2364-7. Epub 2004 Nov 26.

PMID:
15583390
36.
37.

Involvement of the beta3 E749ATSTFTN756 region in stabilizing integrin alphaIIbbeta3-ligand interaction.

Litjens PE, Gorter G, Ylänne J, Akkerman JW, van Willigen G.

J Thromb Haemost. 2003 Oct;1(10):2216-24.

38.

Adhesion of monocytes to medical steel as used for vascular stents is mediated by the integrin receptor Mac-1 (CD11b/CD18; alphaM beta2) and can be inhibited by semiconductor coating.

Schuler P, Assefa D, Ylänne J, Basler N, Olschewski M, Ahrens I, Nordt T, Bode C, Peter K.

Cell Commun Adhes. 2003 Jan-Feb;10(1):17-26.

PMID:
12881037
39.

Actin binding of a minispectrin.

Raae AJ, Bañuelos S, Ylänne J, Olausson T, Goldie KN, Wendt T, Hoenger A, Saraste M.

Biochim Biophys Acta. 2003 Mar 21;1646(1-2):67-76.

PMID:
12637013
40.

Pathways and intermediates in forced unfolding of spectrin repeats.

Altmann SM, Grünberg RG, Lenne PF, Ylänne J, Raae A, Herbert K, Saraste M, Nilges M, Hörber JK.

Structure. 2002 Aug;10(8):1085-96.

41.

The spectrin repeat: a structural platform for cytoskeletal protein assemblies.

Djinovic-Carugo K, Gautel M, Ylänne J, Young P.

FEBS Lett. 2002 Feb 20;513(1):119-23. Review.

42.

Crystal Structure of the alpha-Actinin Rod: Four Spectrin Repeats Forming a Thight Dimer.

Ylänne J, Scheffzek K, Young P, Saraste M.

Cell Mol Biol Lett. 2001;6(2):234. No abstract available.

PMID:
11544685
43.

Crystal structure of the alpha-actinin rod reveals an extensive torsional twist.

Ylänne J, Scheffzek K, Young P, Saraste M.

Structure. 2001 Jul 3;9(7):597-604.

44.

The NITY motif of the beta-chain cytoplasmic domain is involved in stimulated internalization of the beta3 integrin A isoform.

Gawaz M, Besta F, Ylänne J, Knorr T, Dierks H, Böhm T, Kolanus W.

J Cell Sci. 2001 Mar;114(Pt 6):1101-13.

45.

UNC-87 is an actin-bundling protein.

Kranewitter WJ, Ylanne J, Gimona M.

J Biol Chem. 2001 Mar 2;276(9):6306-12. Epub 2000 Nov 28.

46.

Effects of mutations in the cytoplasmic domain of integrin beta(1) to talin binding and cell spreading.

Kääpä A, Peter K, Ylänne J.

Exp Cell Res. 1999 Aug 1;250(2):524-34.

PMID:
10413605
47.

Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (alphaIIbbeta3) inhibitors.

Peter K, Schwarz M, Ylänne J, Kohler B, Moser M, Nordt T, Salbach P, Kübler W, Bode C.

Blood. 1998 Nov 1;92(9):3240-9.

48.

Conserved functions of the cytoplasmic domains of integrin beta subunits.

Ylänne J.

Front Biosci. 1998 Aug 5;3:d877-86. Review.

PMID:
9693157
49.

Expression of megakaryocytic and erythroid properties in human leukemic cells.

Tani T, Ylänne J, Virtanen I.

Exp Hematol. 1996 Feb;24(2):158-68.

PMID:
8641337
50.

The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.

Hughes PE, O'Toole TE, Ylänne J, Shattil SJ, Ginsberg MH.

J Biol Chem. 1995 May 26;270(21):12411-7.

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