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Multimorbidity in middle age predicts more subsequent hospital admissions than in older age: A nine-year retrospective cohort study of 121,188 discharged in-patients.

Lai FTT, Wong SYS, Yip BHK, Guthrie B, Mercer SW, Chung RY, Chung GKK, Chau PYK, Wong ELY, Woo J, Yeoh EK.

Eur J Intern Med. 2018 Dec 20. pii: S0953-6205(18)30466-7. doi: 10.1016/j.ejim.2018.12.001. [Epub ahead of print]


PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia.

Chase A, Pellagatti A, Singh S, Score J, Tapper WJ, Lin F, Hoade Y, Bryant C, Trim N, Yip BH, Zoi K, Rasi C, Forsberg LA, Dumanski JP, Boultwood J, Cross NCP.

Leukemia. 2018 Dec 20. doi: 10.1038/s41375-018-0340-5. [Epub ahead of print]


Clinic-Based Patellar Mobilization Therapy for Knee Osteoarthritis: A Randomized Clinical Trial.

Sit RWS, Chan KKW, Zou D, Chan DCC, Yip BHK, Zhang DD, Chan YH, Chung VCH, Reeves KD, Wong SYS.

Ann Fam Med. 2018 Nov;16(6):521-529. doi: 10.1370/afm.2320.


Effects of a mindfulness-based intervention (MYmind) for children with ADHD and their parents: protocol for a randomised controlled trial.

Chan SKC, Zhang D, Bögels SM, Chan CS, Lai KYC, Lo HHM, Yip BHK, Lau ENS, Gao TT, Wong SYS.

BMJ Open. 2018 Nov 12;8(11):e022514. doi: 10.1136/bmjopen-2018-022514.


Socioeconomic disparity in mortality risks widened across generations during rapid economic development in Hong Kong: an age-period-cohort analysis from 1976 to 2010.

Chung RY, Lai FTT, Chung GKK, Yip BHK, Wong SYS, Yeoh EK.

Ann Epidemiol. 2018 Nov;28(11):743-752.e4. doi: 10.1016/j.annepidem.2018.06.004. Epub 2018 Jun 14.


Nurse-led repeat prescription for patients with controlled hypertension: a randomised controlled trial.

Yip BH, Lee EK, Sit RW, Wong C, Li X, Wong EL, Wong MC, Chung RY, Chung VC, Kung K, Wong SY.

Hong Kong Med J. 2018 Aug;24 Suppl 4(4):4-7. No abstract available.


Nurse-led hypertension management was well accepted and non-inferior to physician consultation in a Chinese population: a randomized controlled trial.

Yip BHK, Lee EKP, Sit RWS, Wong C, Li X, Wong ELY, Wong MCS, Chung RYN, Chung VCH, Kung K, Wong SYS.

Sci Rep. 2018 Jul 9;8(1):10302. doi: 10.1038/s41598-018-28721-2.


Adoption of the reference framework for diabetes care by primary care physicians.

Wong MC, Tsang KW, Kung K, Wong C, Chung VC, Wang HH, Yip BH, Chung RY, Chan JC.

Hong Kong Med J. 2018 Feb;24 Suppl 2(1):21-23. No abstract available.


Trial Protocol: The use of mindfulness-based intervention for improving bracing compliance for adolescent idiopathic scoliosis patients: protocol for a randomised, controlled trial.

Yip BHK, Li X, Leung CHY, Gao T, Chung VCH, Yu FWP, Lam TP, Cheng JCY, Wong SYS.

J Physiother. 2018 Jul;64(3):193. doi: 10.1016/j.jphys.2018.02.019. Epub 2018 Jun 12.


L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients.

Bello E, Kerry J, Singh S, Yip BH, Kušec R, Killick S, Raynaud S, Boultwood J, Pellagatti A.

Haematologica. 2018 Nov;103(11):e496-e500. doi: 10.3324/haematol.2018.190447. Epub 2018 Jun 14. No abstract available.


Normative Standards for HRpQCT Parameters in Chinese Men and Women.

Zhu TY, Yip BH, Hung VW, Choy CW, Cheng KL, Kwok TC, Cheng JC, Qin L.

J Bone Miner Res. 2018 Oct;33(10):1889-1899. doi: 10.1002/jbmr.3481. Epub 2018 Jul 4.


Cost-effectiveness of osteoporosis screening strategies for hip fracture prevention in older Chinese people: a decision tree modeling study in the Mr. OS and Ms. OS cohort in Hong Kong.

Su Y, Lai FTT, Yip BHK, Leung JCS, Kwok TCY.

Osteoporos Int. 2018 Aug;29(8):1793-1805. doi: 10.1007/s00198-018-4543-4. Epub 2018 May 17.


Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial.

Sit RWS, Wu RWK, Reeves KD, Rabago D, Chan DCC, Yip BHK, Chung VCH, Wong SYS.

BMC Complement Altern Med. 2018 May 15;18(1):157. doi: 10.1186/s12906-018-2226-5.


Mindfulness-Based Stress Reduction (MBSR) or Psychoeducation for the Reduction of Menopausal Symptoms: A Randomized, Controlled Clinical Trial.

Wong C, Yip BH, Gao T, Lam KYY, Woo DMS, Yip ALK, Chin CY, Tang WPY, Choy MMT, Tsang KWK, Ho SC, Ma HSW, Wong SYS.

Sci Rep. 2018 Apr 26;8(1):6609. doi: 10.1038/s41598-018-24945-4.


Utilization of psychiatric care and antidepressants among people with different severity of depression: a population-based cohort study in Stockholm, Sweden.

Sun Y, Möller J, Lundin A, Wong SYS, Yip BHK, Forsell Y.

Soc Psychiatry Psychiatr Epidemiol. 2018 Jun;53(6):607-615. doi: 10.1007/s00127-018-1515-0. Epub 2018 Apr 12.


Clinical effectiveness of patella mobilisation therapy versus a waiting list control for knee osteoarthritis: a protocol for a pragmatic randomised clinical trial.

Sit RWS, Chan KKW, Yip BHK, Zhang DD, Reeves KD, Chan YH, Chung VCH, Wong SYS.

BMJ Open. 2018 Mar 14;8(3):e019103. doi: 10.1136/bmjopen-2017-019103.


Treating Subthreshold Depression in Primary Care: A Randomized Controlled Trial of Behavioral Activation With Mindfulness.

Wong SYS, Sun YY, Chan ATY, Leung MKW, Chao DVK, Li CCK, Chan KKH, Tang WK, Mazzucchelli T, Au AML, Yip BHK.

Ann Fam Med. 2018 Mar;16(2):111-119. doi: 10.1370/afm.2206.


Screening for latent and active tuberculosis infection in the elderly at admission to residential care homes: A cost-effectiveness analysis in an intermediate disease burden area.

Li J, Yip BHK, Leung C, Chung W, Kwok KO, Chan EYY, Yeoh E, Chung P.

PLoS One. 2018 Jan 2;13(1):e0189531. doi: 10.1371/journal.pone.0189531. eCollection 2018.


Peer Education Group Intervention to Reduce Psychological Insulin Resistance: A Pilot Mixed-Method Study in a Chinese Population.

Or KY, Yip BH, Lau CH, Chen HH, Chan YW, Lee KP.

Diabetes Ther. 2018 Feb;9(1):113-124. doi: 10.1007/s13300-017-0347-3. Epub 2017 Dec 7.


Incidence and mortality of kidney cancer: temporal patterns and global trends in 39 countries.

Wong MCS, Goggins WB, Yip BHK, Fung FDH, Leung C, Fang Y, Wong SYS, Ng CF.

Sci Rep. 2017 Nov 16;7(1):15698. doi: 10.1038/s41598-017-15922-4.


Heritable Variation, With Little or No Maternal Effect, Accounts for Recurrence Risk to Autism Spectrum Disorder in Sweden.

Yip BHK, Bai D, Mahjani B, Klei L, Pawitan Y, Hultman CM, Grice DE, Roeder K, Buxbaum JD, Devlin B, Reichenberg A, Sandin S.

Biol Psychiatry. 2018 Apr 1;83(7):589-597. doi: 10.1016/j.biopsych.2017.09.007. Epub 2017 Sep 21.


The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.

Yip BH, Steeples V, Repapi E, Armstrong RN, Llorian M, Roy S, Shaw J, Dolatshad H, Taylor S, Verma A, Bartenstein M, Vyas P, Cross NC, Malcovati L, Cazzola M, Hellström-Lindberg E, Ogawa S, Smith CW, Pellagatti A, Boultwood J.

J Clin Invest. 2017 Sep 1;127(9):3557. doi: 10.1172/JCI96202. Epub 2017 Sep 1. No abstract available.


A Pilot Cross-Sectional Study of Postpartum Wrist Pain in an Urban Chinese Population: Its Prevalence and Risk Factors.

Sit RWS, Tam WH, Chan DCC, Yip BHK, Tam LWY, Chow LLY, Chung VCH, Chung RY, Wong SYS.

Pain Physician. 2017 Jul;20(5):E711-E719.


Comparing the Effects of Mindfulness-Based Cognitive Therapy and Sleep Psycho-Education with Exercise on Chronic Insomnia: A Randomised Controlled Trial.

Wong SY, Zhang DX, Li CC, Yip BH, Chan DC, Ling YM, Lo CS, Woo DM, Sun YY, Ma H, Mak WW, Gao T, Lee TM, Wing YK.

Psychother Psychosom. 2017;86(4):241-253. doi: 10.1159/000470847. Epub 2017 Jun 24.


Systematic Review of Guidelines on Managing Patients with Harmful Use of Alcohol in Primary Healthcare Settings.

Zhang DX, Li ST, Lee QK, Chan KH, Kim JH, Yip BH, Chung RY, Wong AH, Fang Y, Liang M, Wong MC.

Alcohol Alcohol. 2017 Sep 1;52(5):595-609. doi: 10.1093/alcalc/agx034. Review.


Amplification of mixed lineage leukemia gene perturbs hematopoiesis and cooperates with partial tandem duplication to induce acute myeloid leukemia.

Yip BH, Tsai CT, Rane JK, Vetharoy W, Anguita E, Dong S, Caligiuri MA, So CWE.

Haematologica. 2017 Aug;102(8):e300-e304. doi: 10.3324/haematol.2016.161406. Epub 2017 May 18. No abstract available.


The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.

Yip BH, Steeples V, Repapi E, Armstrong RN, Llorian M, Roy S, Shaw J, Dolatshad H, Taylor S, Verma A, Bartenstein M, Vyas P, Cross NC, Malcovati L, Cazzola M, Hellström-Lindberg E, Ogawa S, Smith CW, Pellagatti A, Boultwood J.

J Clin Invest. 2017 Jun 1;127(6):2206-2221. doi: 10.1172/JCI91363. Epub 2017 Apr 24. Erratum in: J Clin Invest. 2017 Sep 1;127(9):3557.


Exploring cross-generational adult drinking patterns and physical child maltreatment: a study of Hong Kong adults.

Kim JH, Leung MC, Yip BH, Su X, Griffiths SM.

Public Health. 2017 Mar;144:143-146. doi: 10.1016/j.puhe.2017.01.014. Epub 2017 Feb 16. No abstract available.


Caesarean section and risk of autism across gestational age: a multi-national cohort study of 5 million births.

Yip BHK, Leonard H, Stock S, Stoltenberg C, Francis RW, Gissler M, Gross R, Schendel D, Sandin S.

Int J Epidemiol. 2017 Apr 1;46(2):429-439. doi: 10.1093/ije/dyw336.


Prognostic Value of Bone Mineral Density on Curve Progression: A Longitudinal Cohort Study of 513 Girls with Adolescent Idiopathic Scoliosis.

Yip BH, Yu FW, Wang Z, Hung VW, Lam TP, Ng BK, Zhu F, Cheng JC.

Sci Rep. 2016 Dec 19;6:39220. doi: 10.1038/srep39220.


Characteristics and Methodological Quality of Meta-Analyses on Hypertension Treatments-A Cross-Sectional Study.

Wu XY, Du XJ, Ho RS, Lee CC, Yip BH, Wong MC, Wong SY, Chung VC.

J Clin Hypertens (Greenwich). 2017 Feb;19(2):137-142. doi: 10.1111/jch.12889. Epub 2016 Aug 6.


Epidemiological characteristics and methodological quality of meta-analyses on diabetes mellitus treatment: a systematic review.

Wu XY, Lam VC, Yu YF, Ho RS, Feng Y, Wong CH, Yip BH, Tsoi KK, Wong SY, Chung VC.

Eur J Endocrinol. 2016 Nov;175(5):353-60. doi: 10.1530/EJE-16-0172. Epub 2016 Aug 4. Review.


The association between types of regular primary care and hospitalization among people with and without multimorbidity: A household survey on 25,780 Chinese.

Chung RY, Mercer SW, Yip BH, Chan SW, Lai FT, Wang HH, Wong MC, Wong CK, Sit RW, Yeoh EK, Wong SY.

Sci Rep. 2016 Jul 20;6:29758. doi: 10.1038/srep29758.


A reliability and validity study for Scolioscan: a radiation-free scoliosis assessment system using 3D ultrasound imaging.

Zheng YP, Lee TT, Lai KK, Yip BH, Zhou GQ, Jiang WW, Cheung JC, Wong MS, Ng BK, Cheng JC, Lam TP.

Scoliosis Spinal Disord. 2016 May 31;11:13. doi: 10.1186/s13013-016-0074-y. eCollection 2016.


Electroacupuncture and splinting versus splinting alone to treat carpal tunnel syndrome: a randomized controlled trial.

Chung VC, Ho RS, Liu S, Chong MK, Leung AW, Yip BH, Griffiths SM, Zee BC, Wu JC, Sit RW, Lau AY, Wong SY.

CMAJ. 2016 Sep 6;188(12):867-75. doi: 10.1503/cmaj.151003. Epub 2016 Jun 6.


Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes.

Dolatshad H, Pellagatti A, Liberante FG, Llorian M, Repapi E, Steeples V, Roy S, Scifo L, Armstrong RN, Shaw J, Yip BH, Killick S, Kušec R, Taylor S, Mills KI, Savage KI, Smith CW, Boultwood J.

Leukemia. 2016 Dec;30(12):2322-2331. doi: 10.1038/leu.2016.149. Epub 2016 May 23.


A Critical Comparison Between Two Scanning Protocols of High-Resolution Peripheral Quantitative Computed Tomography at the Distal Radius in Adolescents.

Cheuk KY, Tam EM, Yu FW, Yip BH, Hung VW, Wang X, Ghasem-Zadeh A, Zhu TY, Qin L, Cheng JC, Lam TP.

J Clin Densitom. 2016 Jul-Sep;19(3):305-15. doi: 10.1016/j.jocd.2016.04.002. Epub 2016 Apr 27.


Patient Perceptions of Expression of Empathy From Chinese Medicine Clinicians in a Chinese Population: A Cross-Sectional Study.

Chung VC, Yip BH, Yu EL, Liu S, Ho RS, Sit RW, Leung AW, Wu JC, Wong SY.

Medicine (Baltimore). 2016 Apr;95(17):e3316. doi: 10.1097/MD.0000000000003316.


Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes.

Yip BH, Dolatshad H, Roy S, Pellagatti A, Boultwood J.

Curr Pharm Des. 2016;22(16):2333-44. Review.


Mindfulness-based cognitive therapy v. group psychoeducation for people with generalised anxiety disorder: randomised controlled trial.

Wong SY, Yip BH, Mak WW, Mercer S, Cheung EY, Ling CY, Lui WW, Tang WK, Lo HH, Wu JC, Lee TM, Gao T, Griffiths SM, Chan PH, Ma HS.

Br J Psychiatry. 2016 Jul;209(1):68-75. doi: 10.1192/bjp.bp.115.166124. Epub 2016 Feb 4.


Defining the bone morphometry, micro-architecture and volumetric density profile in osteopenic vs non-osteopenic adolescent idiopathic scoliosis.

Wang ZW, Lee WY, Lam TP, Yip BH, Yu FW, Yu WS, Zhu F, Ng BK, Qiu Y, Cheng JC.

Eur Spine J. 2017 Jun;26(6):1586-1594. doi: 10.1007/s00586-016-4422-7. Epub 2016 Feb 5.


Help-seeking and antibiotic prescribing for acute cough in a Chinese primary care population: a prospective multicentre observational study.

Wong CK, Liu Z, Butler CC, Wong SY, Fung A, Chan D, Yip BH, Kung K.

NPJ Prim Care Respir Med. 2016 Jan 21;26:15080. doi: 10.1038/npjpcrm.2015.80.


Association between multiple skin tags and metabolic syndrome: A multicentre cross-sectional study in primary care.

Hui ES, Yip BH, Tsang KW, Lai FT, Kung K, Wong SY.

Diabetes Metab. 2016 Apr;42(2):126-9. doi: 10.1016/j.diabet.2015.11.004. Epub 2015 Dec 22. No abstract available.


Patients' experience of Chinese Medicine Primary Care Services: Implications on Improving Coordination and Continuity of Care.

Chung VCh, Yip BH, Griffiths SM, Yu EL, Liu S, Ho RS, Wu X, Leung AW, Sit RW, Wu JC, Wong SY.

Sci Rep. 2015 Dec 21;5:18853. doi: 10.1038/srep18853.


The Association of Types of Training and Practice Settings with Doctors' Empathy and Patient Enablement among Patients with Chronic Illness in Hong Kong.

Yu FS, Yip BH, Kung K, Fung CS, Wong CK, Lam AT, Mercer SW, Wong SY.

PLoS One. 2015 Dec 14;10(12):e0144492. doi: 10.1371/journal.pone.0144492. eCollection 2015.


ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts.

Valletta S, Dolatshad H, Bartenstein M, Yip BH, Bello E, Gordon S, Yu Y, Shaw J, Roy S, Scifo L, Schuh A, Pellagatti A, Fulga TA, Verma A, Boultwood J.

Oncotarget. 2015 Dec 29;6(42):44061-71. doi: 10.18632/oncotarget.6392.


Socioeconomic Determinants of Multimorbidity: A Population-Based Household Survey of Hong Kong Chinese.

Chung RY, Mercer S, Lai FT, Yip BH, Wong MC, Wong SY.

PLoS One. 2015 Oct 9;10(10):e0140040. doi: 10.1371/journal.pone.0140040. eCollection 2015.


Application of genome editing technologies to the study and treatment of hematological disease.

Pellagatti A, Dolatshad H, Yip BH, Valletta S, Boultwood J.

Adv Biol Regul. 2016 Jan;60:122-134. doi: 10.1016/j.jbior.2015.09.005. Epub 2015 Sep 26. Review.



Chung RY, Yip BH, Chan SS, Wong SY.

Depress Anxiety. 2016 Jun;33(6):558-66. doi: 10.1002/da.22431. Epub 2015 Sep 28.


Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells.

Dolatshad H, Pellagatti A, Fernandez-Mercado M, Yip BH, Malcovati L, Attwood M, Przychodzen B, Sahgal N, Kanapin AA, Lockstone H, Scifo L, Vandenberghe P, Papaemmanuil E, Smith CW, Campbell PJ, Ogawa S, Maciejewski JP, Cazzola M, Savage KI, Boultwood J.

Leukemia. 2015 Aug;29(8):1798. doi: 10.1038/leu.2015.178. No abstract available.

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