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BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pathogenesis.

Yogalingam G, Luu AR, Prill H, Lo MJ, Yip B, Holtzinger J, Christianson T, Aoyagi-Scharber M, Lawrence R, Crawford BE, LeBowitz JH.

PLoS One. 2019 Jan 18;14(1):e0207836. doi: 10.1371/journal.pone.0207836. eCollection 2019.


Multimorbidity in middle age predicts more subsequent hospital admissions than in older age: A nine-year retrospective cohort study of 121,188 discharged in-patients.

Lai FTT, Wong SYS, Yip BHK, Guthrie B, Mercer SW, Chung RY, Chung GKK, Chau PYK, Wong ELY, Woo J, Yeoh EK.

Eur J Intern Med. 2018 Dec 20. pii: S0953-6205(18)30466-7. doi: 10.1016/j.ejim.2018.12.001. [Epub ahead of print]


PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age-related clonal hematopoiesis and myeloid neoplasia.

Chase A, Pellagatti A, Singh S, Score J, Tapper WJ, Lin F, Hoade Y, Bryant C, Trim N, Yip BH, Zoi K, Rasi C, Forsberg LA, Dumanski JP, Boultwood J, Cross NCP.

Leukemia. 2018 Dec 20. doi: 10.1038/s41375-018-0340-5. [Epub ahead of print]


Clinic-Based Patellar Mobilization Therapy for Knee Osteoarthritis: A Randomized Clinical Trial.

Sit RWS, Chan KKW, Zou D, Chan DCC, Yip BHK, Zhang DD, Chan YH, Chung VCH, Reeves KD, Wong SYS.

Ann Fam Med. 2018 Nov;16(6):521-529. doi: 10.1370/afm.2320.


Effects of a mindfulness-based intervention (MYmind) for children with ADHD and their parents: protocol for a randomised controlled trial.

Chan SKC, Zhang D, Bögels SM, Chan CS, Lai KYC, Lo HHM, Yip BHK, Lau ENS, Gao TT, Wong SYS.

BMJ Open. 2018 Nov 12;8(11):e022514. doi: 10.1136/bmjopen-2018-022514.


Socioeconomic disparity in mortality risks widened across generations during rapid economic development in Hong Kong: an age-period-cohort analysis from 1976 to 2010.

Chung RY, Lai FTT, Chung GKK, Yip BHK, Wong SYS, Yeoh EK.

Ann Epidemiol. 2018 Nov;28(11):743-752.e4. doi: 10.1016/j.annepidem.2018.06.004. Epub 2018 Jun 14.


Identifying Risk of Viral Failure in Treated HIV-Infected Patients Using Different Measures of Adherence: The Antiretroviral Therapy Cohort Collaboration.

Ingle SM, Crane HM, Glass TR, Yip B, Lima VD, Gill MJ, Hanhoff N, Ammassari A, Mugavero MJ, Tate JP, Guest J, Turner NL, May MT, Sterne JAC.

J Clin Med. 2018 Oct 5;7(10). pii: E328. doi: 10.3390/jcm7100328.


Dependence on size and shape of non-nature amino acids in the enhancement of lipopolysaccharide (LPS) neutralizing activities of antimicrobial peptides.

Chih YH, Wang SY, Yip BS, Cheng KT, Hsu SY, Wu CL, Yu HY, Cheng JW.

J Colloid Interface Sci. 2019 Jan 1;533:492-502. doi: 10.1016/j.jcis.2018.08.042. Epub 2018 Aug 14.


Nurse-led repeat prescription for patients with controlled hypertension: a randomised controlled trial.

Yip BH, Lee EK, Sit RW, Wong C, Li X, Wong EL, Wong MC, Chung RY, Chung VC, Kung K, Wong SY.

Hong Kong Med J. 2018 Aug;24 Suppl 4(4):4-7. No abstract available.


Report from the 19th annual Western Canadian Gastrointestinal Cancer Consensus Conference; Winnipeg, Manitoba; 29-30 September 2017.

Kim CA, Ahmed S, Ahmed S, Brunet B, Chalchal H, Deobald R, Doll C, Dupre MP, Gordon V, Lee-Ying RM, Lim H, Liu D, Loree JM, McGhie JP, Mulder K, Park J, Yip B, Wong RP, Zaidi A; Western Canadian Gastrointestinal Cancer Group.

Curr Oncol. 2018 Aug;25(4):275-284. doi: 10.3747/co.25.4109. Epub 2018 Aug 14.


Nurse-led hypertension management was well accepted and non-inferior to physician consultation in a Chinese population: a randomized controlled trial.

Yip BHK, Lee EKP, Sit RWS, Wong C, Li X, Wong ELY, Wong MCS, Chung RYN, Chung VCH, Kung K, Wong SYS.

Sci Rep. 2018 Jul 9;8(1):10302. doi: 10.1038/s41598-018-28721-2.


Adoption of the reference framework for diabetes care by primary care physicians.

Wong MC, Tsang KW, Kung K, Wong C, Chung VC, Wang HH, Yip BH, Chung RY, Chan JC.

Hong Kong Med J. 2018 Feb;24 Suppl 2(1):21-23. No abstract available.


Trial Protocol: The use of mindfulness-based intervention for improving bracing compliance for adolescent idiopathic scoliosis patients: protocol for a randomised, controlled trial.

Yip BHK, Li X, Leung CHY, Gao T, Chung VCH, Yu FWP, Lam TP, Cheng JCY, Wong SYS.

J Physiother. 2018 Jul;64(3):193. doi: 10.1016/j.jphys.2018.02.019. Epub 2018 Jun 12.


L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients.

Bello E, Kerry J, Singh S, Yip BH, Kušec R, Killick S, Raynaud S, Boultwood J, Pellagatti A.

Haematologica. 2018 Nov;103(11):e496-e500. doi: 10.3324/haematol.2018.190447. Epub 2018 Jun 14. No abstract available.


Normative Standards for HRpQCT Parameters in Chinese Men and Women.

Zhu TY, Yip BH, Hung VW, Choy CW, Cheng KL, Kwok TC, Cheng JC, Qin L.

J Bone Miner Res. 2018 Oct;33(10):1889-1899. doi: 10.1002/jbmr.3481. Epub 2018 Jul 4.


Cost-effectiveness of osteoporosis screening strategies for hip fracture prevention in older Chinese people: a decision tree modeling study in the Mr. OS and Ms. OS cohort in Hong Kong.

Su Y, Lai FTT, Yip BHK, Leung JCS, Kwok TCY.

Osteoporos Int. 2018 Aug;29(8):1793-1805. doi: 10.1007/s00198-018-4543-4. Epub 2018 May 17.


Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial.

Sit RWS, Wu RWK, Reeves KD, Rabago D, Chan DCC, Yip BHK, Chung VCH, Wong SYS.

BMC Complement Altern Med. 2018 May 15;18(1):157. doi: 10.1186/s12906-018-2226-5.


The impact of HCV co-infection status on healthcare-related utilization among people living with HIV in British Columbia, Canada: a retrospective cohort study.

Ma H, Villalobos CF, St-Jean M, Eyawo O, Lavergne MR, Ti L, Hull MW, Yip B, Wu L, Hogg RS, Barrios R, Shoveller JA, Montaner JSG, Lima VD.

BMC Health Serv Res. 2018 May 2;18(1):319. doi: 10.1186/s12913-018-3119-5.


Mindfulness-Based Stress Reduction (MBSR) or Psychoeducation for the Reduction of Menopausal Symptoms: A Randomized, Controlled Clinical Trial.

Wong C, Yip BH, Gao T, Lam KYY, Woo DMS, Yip ALK, Chin CY, Tang WPY, Choy MMT, Tsang KWK, Ho SC, Ma HSW, Wong SYS.

Sci Rep. 2018 Apr 26;8(1):6609. doi: 10.1038/s41598-018-24945-4.


Utilization of psychiatric care and antidepressants among people with different severity of depression: a population-based cohort study in Stockholm, Sweden.

Sun Y, Möller J, Lundin A, Wong SYS, Yip BHK, Forsell Y.

Soc Psychiatry Psychiatr Epidemiol. 2018 Jun;53(6):607-615. doi: 10.1007/s00127-018-1515-0. Epub 2018 Apr 12.


High Level Expression and Purification of the Clinically Active Antimicrobial Peptide P-113 in Escherichia coli.

Cheng KT, Wu CL, Yip BS, Yu HY, Cheng HT, Chih YH, Cheng JW.

Molecules. 2018 Mar 30;23(4). pii: E800. doi: 10.3390/molecules23040800.


Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS).

Tonoyama Y, Shinya M, Toyoda A, Kitano T, Oga A, Nishimaki T, Katsumura T, Oota H, Wan MT, Yip BWP, Helen MOL, Chisada S, Deguchi T, Au DWT, Naruse K, Kamei Y, Taniguchi Y.

Comp Biochem Physiol C Toxicol Pharmacol. 2018 Jul;209:54-62. doi: 10.1016/j.cbpc.2018.03.006. Epub 2018 Mar 19.


Clinical effectiveness of patella mobilisation therapy versus a waiting list control for knee osteoarthritis: a protocol for a pragmatic randomised clinical trial.

Sit RWS, Chan KKW, Yip BHK, Zhang DD, Reeves KD, Chan YH, Chung VCH, Wong SYS.

BMJ Open. 2018 Mar 14;8(3):e019103. doi: 10.1136/bmjopen-2017-019103.


Treating Subthreshold Depression in Primary Care: A Randomized Controlled Trial of Behavioral Activation With Mindfulness.

Wong SYS, Sun YY, Chan ATY, Leung MKW, Chao DVK, Li CCK, Chan KKH, Tang WK, Mazzucchelli T, Au AML, Yip BHK.

Ann Fam Med. 2018 Mar;16(2):111-119. doi: 10.1370/afm.2206.


Adverse drug reactions to integrase strand transfer inhibitors.

Lepik KJ, Yip B, Ulloa AC, Wang L, Toy J, Akagi L, Lima VD, Guillemi S, Montaner JSG, Barrios R.

AIDS. 2018 Apr 24;32(7):903-912. doi: 10.1097/QAD.0000000000001781.


Trends in discharges from the HIV/AIDS ward at a tertiary Canadian Hospital from 2005 to 2014.

Jaworsky D, Phillips P, Cui Z, Chau W, Colley G, Dutta R, Yip B, Kremer H, Eyawo O, Montaner JS, Hull MW.

AIDS Care. 2018 Sep;30(9):1099-1106. doi: 10.1080/09540121.2018.1434121. Epub 2018 Feb 4.


Screening for latent and active tuberculosis infection in the elderly at admission to residential care homes: A cost-effectiveness analysis in an intermediate disease burden area.

Li J, Yip BHK, Leung C, Chung W, Kwok KO, Chan EYY, Yeoh E, Chung P.

PLoS One. 2018 Jan 2;13(1):e0189531. doi: 10.1371/journal.pone.0189531. eCollection 2018.


Peer Education Group Intervention to Reduce Psychological Insulin Resistance: A Pilot Mixed-Method Study in a Chinese Population.

Or KY, Yip BH, Lau CH, Chen HH, Chan YW, Lee KP.

Diabetes Ther. 2018 Feb;9(1):113-124. doi: 10.1007/s13300-017-0347-3. Epub 2017 Dec 7.


Incidence and mortality of kidney cancer: temporal patterns and global trends in 39 countries.

Wong MCS, Goggins WB, Yip BHK, Fung FDH, Leung C, Fang Y, Wong SYS, Ng CF.

Sci Rep. 2017 Nov 16;7(1):15698. doi: 10.1038/s41598-017-15922-4.


Heritable Variation, With Little or No Maternal Effect, Accounts for Recurrence Risk to Autism Spectrum Disorder in Sweden.

Yip BHK, Bai D, Mahjani B, Klei L, Pawitan Y, Hultman CM, Grice DE, Roeder K, Buxbaum JD, Devlin B, Reichenberg A, Sandin S.

Biol Psychiatry. 2018 Apr 1;83(7):589-597. doi: 10.1016/j.biopsych.2017.09.007. Epub 2017 Sep 21.


Zika virus structural biology and progress in vaccine development.

Lin HH, Yip BS, Huang LM, Wu SC.

Biotechnol Adv. 2018 Jan - Feb;36(1):47-53. doi: 10.1016/j.biotechadv.2017.09.004. Epub 2017 Sep 12. Review.


In-hospital 'CODE STEMI' improves door-to-balloon time in patients undergoing primary percutaneous coronary intervention.

Koh JQ, Tong DC, Sriamareswaran R, Yeap A, Yip B, Wu S, Perera P, Menon S, Noaman SA, Layland J.

Emerg Med Australas. 2018 Apr;30(2):222-227. doi: 10.1111/1742-6723.12855. Epub 2017 Sep 12.


The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.

Yip BH, Steeples V, Repapi E, Armstrong RN, Llorian M, Roy S, Shaw J, Dolatshad H, Taylor S, Verma A, Bartenstein M, Vyas P, Cross NC, Malcovati L, Cazzola M, Hellström-Lindberg E, Ogawa S, Smith CW, Pellagatti A, Boultwood J.

J Clin Invest. 2017 Sep 1;127(9):3557. doi: 10.1172/JCI96202. Epub 2017 Sep 1. No abstract available.


A Pilot Cross-Sectional Study of Postpartum Wrist Pain in an Urban Chinese Population: Its Prevalence and Risk Factors.

Sit RWS, Tam WH, Chan DCC, Yip BHK, Tam LWY, Chow LLY, Chung VCH, Chung RY, Wong SYS.

Pain Physician. 2017 Jul;20(5):E711-E719.


Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice.

Aoyagi-Scharber M, Crippen-Harmon D, Lawrence R, Vincelette J, Yogalingam G, Prill H, Yip BK, Baridon B, Vitelli C, Lee A, Gorostiza O, Adintori EG, Minto WC, Van Vleet JL, Yates B, Rigney S, Christianson TM, Tiger PMN, Lo MJ, Holtzinger J, Fitzpatrick PA, LeBowitz JH, Bullens S, Crawford BE, Bunting S.

Mol Ther Methods Clin Dev. 2017 Jun 6;6:43-53. doi: 10.1016/j.omtm.2017.05.009. eCollection 2017 Sep 15.


Comparing the Effects of Mindfulness-Based Cognitive Therapy and Sleep Psycho-Education with Exercise on Chronic Insomnia: A Randomised Controlled Trial.

Wong SY, Zhang DX, Li CC, Yip BH, Chan DC, Ling YM, Lo CS, Woo DM, Sun YY, Ma H, Mak WW, Gao T, Lee TM, Wing YK.

Psychother Psychosom. 2017;86(4):241-253. doi: 10.1159/000470847. Epub 2017 Jun 24.


Systematic Review of Guidelines on Managing Patients with Harmful Use of Alcohol in Primary Healthcare Settings.

Zhang DX, Li ST, Lee QK, Chan KH, Kim JH, Yip BH, Chung RY, Wong AH, Fang Y, Liang M, Wong MC.

Alcohol Alcohol. 2017 Sep 1;52(5):595-609. doi: 10.1093/alcalc/agx034. Review.


Amplification of mixed lineage leukemia gene perturbs hematopoiesis and cooperates with partial tandem duplication to induce acute myeloid leukemia.

Yip BH, Tsai CT, Rane JK, Vetharoy W, Anguita E, Dong S, Caligiuri MA, So CWE.

Haematologica. 2017 Aug;102(8):e300-e304. doi: 10.3324/haematol.2016.161406. Epub 2017 May 18. No abstract available.


Is there a rural/urban gap in the quality of HIV care for treatment-naïve HIV-positive individuals initiating antiretroviral therapy in British Columbia?

MacKenzie LJ, Hull MW, Samji H, Lima VD, Yip B, Zhang W, Lourenço L, Colley G, Hogg RS, Montaner JSG.

AIDS Care. 2017 Oct;29(10):1218-1226. doi: 10.1080/09540121.2017.1322678. Epub 2017 May 4.


The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.

Yip BH, Steeples V, Repapi E, Armstrong RN, Llorian M, Roy S, Shaw J, Dolatshad H, Taylor S, Verma A, Bartenstein M, Vyas P, Cross NC, Malcovati L, Cazzola M, Hellström-Lindberg E, Ogawa S, Smith CW, Pellagatti A, Boultwood J.

J Clin Invest. 2017 Jun 1;127(6):2206-2221. doi: 10.1172/JCI91363. Epub 2017 Apr 24. Erratum in: J Clin Invest. 2017 Sep 1;127(9):3557.


Impact of MCA stenosis on the early outcome in acute ischemic stroke patients.

Jeng JS, Hsieh FI, Yeh HL, Chen WH, Chiu HC, Tang SC, Liu CH, Lin HJ, Hsu SP, Lo YK, Chan L, Chen CH, Lin RT, Chen YW, Lee JT, Yeh CH, Sun MH, Lai TC, Sun Y, Sun MC, Chen PL, Chiang TR, Lin SK, Yip BS, Chen CI, Bai CH, Chen ST, Chiou HY, Lien LM, Hsu CY; Taiwan Stroke Registry Investigators.

PLoS One. 2017 Apr 7;12(4):e0175434. doi: 10.1371/journal.pone.0175434. eCollection 2017.


Emergent drug resistance with integrase strand transfer inhibitor-based regimens.

Lepik KJ, Harrigan PR, Yip B, Wang L, Robbins MA, Zhang WW, Toy J, Akagi L, Lima VD, Guillemi S, Montaner JSG, Barrios R.

AIDS. 2017 Jun 19;31(10):1425-1434. doi: 10.1097/QAD.0000000000001494.


Endoscopic treatment of a pancreaticopleural fistula associated with a tension hydrothorax.

Wee E, Anastassiades C, Yip BC.

J Dig Dis. 2017 May;18(5):309-312. doi: 10.1111/1751-2980.12467. No abstract available.


Role of β-naphthylalanine end-tags in the enhancement of antiendotoxin activities: Solution structure of the antimicrobial peptide S1-Nal-Nal in complex with lipopolysaccharide.

Yu HY, Chen YA, Yip BS, Wang SY, Wei HJ, Chih YH, Chen KH, Cheng JW.

Biochim Biophys Acta Biomembr. 2017 Jun;1859(6):1114-1123. doi: 10.1016/j.bbamem.2017.03.007. Epub 2017 Mar 10.


Exploring cross-generational adult drinking patterns and physical child maltreatment: a study of Hong Kong adults.

Kim JH, Leung MC, Yip BH, Su X, Griffiths SM.

Public Health. 2017 Mar;144:143-146. doi: 10.1016/j.puhe.2017.01.014. Epub 2017 Feb 16. No abstract available.


The adherence gap: a longitudinal examination of men's and women's antiretroviral therapy adherence in British Columbia, 2000-2014.

Puskas CM, Kaida A, Miller CL, Zhang W, Yip B, Pick N, Montaner JS, Hogg RS.

AIDS. 2017 Mar 27;31(6):827-833. doi: 10.1097/QAD.0000000000001408.


Endoscopic Ultrasound-Guided Ethanol Ablation for Control of Local-Regional Metastatic Insulinoma.

Mittal M, Yip B, Lee JG.

Pancreas. 2017 Mar;46(3):e17-e18. doi: 10.1097/MPA.0000000000000788. No abstract available.


C-Reactive Protein Predicts Incidence of Dementia in an Elderly Asian Community Cohort.

Hsu PF, Pan WH, Yip BS, Chen RC, Cheng HM, Chuang SY.

J Am Med Dir Assoc. 2017 Mar 1;18(3):277.e7-277.e11. doi: 10.1016/j.jamda.2016.12.006. Epub 2017 Jan 31.


Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging.

Yip BW, Mok HO, Peterson DR, Wan MT, Taniguchi Y, Ge W, Au DW.

Mar Pollut Bull. 2017 Nov 30;124(2):701-709. doi: 10.1016/j.marpolbul.2017.01.021. Epub 2017 Jan 24.


Caesarean section and risk of autism across gestational age: a multi-national cohort study of 5 million births.

Yip BHK, Leonard H, Stock S, Stoltenberg C, Francis RW, Gissler M, Gross R, Schendel D, Sandin S.

Int J Epidemiol. 2017 Apr 1;46(2):429-439. doi: 10.1093/ije/dyw336.

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