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Items: 17

1.

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.

Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH.

J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.

PMID:
30366982
2.

Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria.

Yien YY, Ducamp S, van der Vorm LN, Kardon JR, Manceau H, Kannengiesser C, Bergonia HA, Kafina MD, Karim Z, Gouya L, Baker TA, Puy H, Phillips JD, Nicolas G, Paw BH.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8045-E8052. doi: 10.1073/pnas.1700632114. Epub 2017 Sep 5.

3.

Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes.

Seguin A, Takahashi-Makise N, Yien YY, Huston NC, Whitman JC, Musso G, Wallace JA, Bradley T, Bergonia HA, Kafina MD, Matsumoto M, Igarashi K, Phillips JD, Paw BH, Kaplan J, Ward DM.

J Biol Chem. 2017 Sep 29;292(39):16284-16299. doi: 10.1074/jbc.M117.797415. Epub 2017 Aug 14.

4.

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals.

Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD.

Science. 2017 May 12;356(6338):608-616. doi: 10.1126/science.aah3862.

5.

Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.

Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH.

J Biol Chem. 2017 Feb 10;292(6):2556. doi: 10.1074/jbc.A114.564625. No abstract available.

6.

A role for iron deficiency in dopaminergic neurodegeneration.

Yien YY, Paw BH.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3417-8. doi: 10.1073/pnas.1601976113. Epub 2016 Mar 16. No abstract available.

7.

Mitochondrial transport of protoporphyrinogen IX in erythroid cells.

Yien YY, Ringel AR, Paw BH.

Oncotarget. 2015 Aug 28;6(25):20742-3.

8.

Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis.

Kardon JR, Yien YY, Huston NC, Branco DS, Hildick-Smith GJ, Rhee KY, Paw BH, Baker TA.

Cell. 2015 May 7;161(4):858-67. doi: 10.1016/j.cell.2015.04.017.

9.

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.

Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH.

Sci Signal. 2015 Apr 14;8(372):ra34. doi: 10.1126/scisignal.aaa5903.

10.

Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues.

Yien YY, Gnanapragasam MN, Gupta R, Rivella S, Bieker JJ.

Exp Hematol. 2015 Jan;43(1):65-70. doi: 10.1016/j.exphem.2014.08.007. Epub 2014 Oct 2.

11.

TMEM14C is required for erythroid mitochondrial heme metabolism.

Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, Kingsley PD, Garone C, Hattangadi SM, Huang H, Chen W, Keenan EM, Shah DI, Schlaeger TM, DiMauro S, Orkin SH, Cantor AB, Palis J, Koehler CM, Lodish HF, Kaplan J, Ward DM, Dailey HA, Phillips JD, Peters LL, Paw BH.

J Clin Invest. 2014 Oct;124(10):4294-304. doi: 10.1172/JCI76979. Epub 2014 Aug 26.

12.

Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.

Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH.

J Biol Chem. 2014 Aug 1;289(31):21312-24. doi: 10.1074/jbc.M114.564625. Epub 2014 Jun 6. Erratum in: J Biol Chem. 2017 Feb 10;292(6):2556.

13.

Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4.

Hildick-Smith GJ, Cooney JD, Garone C, Kremer LS, Haack TB, Thon JN, Miyata N, Lieber DS, Calvo SE, Akman HO, Yien YY, Huston NC, Branco DS, Shah DI, Freedman ML, Koehler CM, Italiano JE Jr, Merkenschlager A, Beblo S, Strom TM, Meitinger T, Freisinger P, Donati MA, Prokisch H, Mootha VK, DiMauro S, Paw BH.

Am J Hum Genet. 2013 Nov 7;93(5):906-14. doi: 10.1016/j.ajhg.2013.09.011. Epub 2013 Oct 10.

14.

Snx3 regulates recycling of the transferrin receptor and iron assimilation.

Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, Freedman ML, Kingsley PD, Palis J, Hattangadi SM, Lodish HF, Ward DM, Kaplan J, Maeda T, Ponka P, Paw BH.

Cell Metab. 2013 Mar 5;17(3):343-52. doi: 10.1016/j.cmet.2013.01.013. Epub 2013 Feb 14.

15.

EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination.

Yien YY, Bieker JJ.

Mol Cell Biol. 2013 Jan;33(1):4-13. doi: 10.1128/MCB.01058-12. Epub 2012 Oct 22. Review.

16.

Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ.

Yien YY, Bieker JJ.

J Biol Chem. 2012 May 4;287(19):15193-204. doi: 10.1074/jbc.M112.350496. Epub 2012 Mar 5.

17.

Crystallization of a novel alpha-amylase, AmyB, from the thermophilic halophile Halothermothrix orenii.

Tan TC, Yien YY, Patel BK, Mijts BN, Swaminathan K.

Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2257-8. Epub 2003 Nov 27.

PMID:
14646087

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