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Outflanking immunodominance to target subdominant broadly neutralizing epitopes.

Angeletti D, Kosik I, Santos JJS, Yewdell WT, Boudreau CM, Mallajosyula VVA, Mankowski MC, Chambers M, Prabhakaran M, Hickman HD, McDermott AB, Alter G, Chaudhuri J, Yewdell JW.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13474-13479. doi: 10.1073/pnas.1816300116. Epub 2019 Jun 18.


A SIINFEKL-Based System to Measure MHC Class I Antigen Presentation Efficiency and Kinetics.

Dersh D, Yewdell JW, Wei J.

Methods Mol Biol. 2019;1988:109-122. doi: 10.1007/978-1-4939-9450-2_9.


Influenza A Virus Infection Induces Viral and Cellular Defective Ribosomal Products Encoded by Alternative Reading Frames.

Zanker DJ, Oveissi S, Tscharke DC, Duan M, Wan S, Zhang X, Xiao K, Mifsud NA, Gibbs J, Izzard L, Dlugolenski D, Faou P, Laurie KL, Vigneron N, Barr IG, Stambas J, Van den Eynde BJ, Bennink JR, Yewdell JW, Chen W.

J Immunol. 2019 Jun 15;202(12):3370-3380. doi: 10.4049/jimmunol.1900070. Epub 2019 May 15.


Influenza Hemagglutinin and Neuraminidase: Yin⁻Yang Proteins Coevolving to Thwart Immunity.

Kosik I, Yewdell JW.

Viruses. 2019 Apr 16;11(4). pii: E346. doi: 10.3390/v11040346. Review.


Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit.

Altman MO, Angel M, Košík I, Trovão NS, Zost SJ, Gibbs JS, Casalino L, Amaro RE, Hensley SE, Nelson MI, Yewdell JW.

MBio. 2019 Apr 2;10(2). pii: e00204-19. doi: 10.1128/mBio.00204-19.


Lymph node conduits transport virions for rapid T cell activation.

Reynoso GV, Weisberg AS, Shannon JP, McManus DT, Shores L, Americo JL, Stan RV, Yewdell JW, Hickman HD.

Nat Immunol. 2019 May;20(5):602-612. doi: 10.1038/s41590-019-0342-0. Epub 2019 Mar 18.


Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.

Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B.

JCI Insight. 2019 Feb 21;4(4). pii: 126047. doi: 10.1172/jci.insight.126047. eCollection 2019 Feb 21.


Casting a wider net: Immunosurveillance by nonclassical MHC molecules.

D'Souza MP, Adams E, Altman JD, Birnbaum ME, Boggiano C, Casorati G, Chien YH, Conley A, Eckle SBG, Früh K, Gondré-Lewis T, Hassan N, Huang H, Jayashankar L, Kasmar AG, Kunwar N, Lavelle J, Lewinsohn DM, Moody B, Picker L, Ramachandra L, Shastri N, Parham P, McMichael AJ, Yewdell JW.

PLoS Pathog. 2019 Feb 21;15(2):e1007567. doi: 10.1371/journal.ppat.1007567. eCollection 2019 Feb. Review.


Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance.

Wei J, Kishton RJ, Angel M, Conn CS, Dalla-Venezia N, Marcel V, Vincent A, Catez F, Ferré S, Ayadi L, Marchand V, Dersh D, Gibbs JS, Ivanov IP, Fridlyand N, Couté Y, Diaz JJ, Qian SB, Staudt LM, Restifo NP, Yewdell JW.

Mol Cell. 2019 Mar 21;73(6):1162-1173.e5. doi: 10.1016/j.molcel.2018.12.020. Epub 2019 Jan 31.


Neuraminidase inhibition contributes to influenza A virus neutralization by anti-hemagglutinin stem antibodies.

Kosik I, Angeletti D, Gibbs JS, Angel M, Takeda K, Kosikova M, Nair V, Hickman HD, Xie H, Brooke CB, Yewdell JW.

J Exp Med. 2019 Feb 4;216(2):304-316. doi: 10.1084/jem.20181624. Epub 2019 Jan 25.


Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem.

Tan HX, Jegaskanda S, Juno JA, Esterbauer R, Wong J, Kelly HG, Liu Y, Tilmanis D, Hurt AC, Yewdell JW, Kent SJ, Wheatley AK.

J Clin Invest. 2019 Feb 1;129(2):850-862. doi: 10.1172/JCI123366. Epub 2019 Jan 22.


Flu DRiPs in MHC Class I Immunosurveillance.

Wei J, Yewdell JW.

Virol Sin. 2019 Apr;34(2):162-167. doi: 10.1007/s12250-018-0061-y. Epub 2018 Nov 19. Review.


Correction: Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance.

Hickman HD, Mays JW, Gibbs J, Kosik I, Magadán JG, Takeda K, Das S, Reynoso GV, Ngudiankama BF, Wei J, Shannon JP, McManus D, Yewdell JW.

J Immunol. 2018 Oct 1;201(7):2187. doi: 10.4049/jimmunol.1801100. Epub 2018 Aug 24. No abstract available.


Peptide secretion triggers diabetes.

Wei J, Yewdell JW.

Nature. 2018 Aug;560(7716):33-34. doi: 10.1038/d41586-018-05710-z. No abstract available.


Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance.

Hickman HD, Mays JW, Gibbs J, Kosik I, Magadán JG, Takeda K, Das S, Reynoso GV, Ngudiankama BF, Wei J, Shannon JP, McManus D, Yewdell JW.

J Immunol. 2018 Aug 15;201(4):1222-1228. doi: 10.4049/jimmunol.1800586. Epub 2018 Jul 16. Erratum in: J Immunol. 2018 Oct 1;201(7):2187.


Correction: Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs.

Kosik I, Ince WL, Gentles LE, Oler AJ, Kosikova M, Angel M, Magadán JG, Xie H, Brooke CB, Yewdell JW.

PLoS Pathog. 2018 Jun 20;14(6):e1007141. doi: 10.1371/journal.ppat.1007141. eCollection 2018 Jun.


Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature.

Morel JD, Paatero AO, Wei J, Yewdell JW, Guenin-Macé L, Van Haver D, Impens F, Pietrosemoli N, Paavilainen VO, Demangel C.

Mol Cell Proteomics. 2018 Sep;17(9):1750-1765. doi: 10.1074/mcp.RA118.000824. Epub 2018 Jun 18.


What's Fair Is Fair: Leveling the Playing Field for Young Scientists.

Yewdell JW.

Vaccines (Basel). 2018 May 31;6(2). pii: E33. doi: 10.3390/vaccines6020033.


Understanding and Manipulating Viral Immunity: Antibody Immunodominance Enters Center Stage.

Angeletti D, Yewdell JW.

Trends Immunol. 2018 Jul;39(7):549-561. doi: 10.1016/ Epub 2018 May 19. Review.


The RiboPuromycylation Method (RPM): an Immunofluorescence Technique to Map Translation Sites at the Sub-cellular Level.

Bastide A, Yewdell JW, David A.

Bio Protoc. 2018 Jan 5;8(1). pii: e2669. doi: 10.21769/BioProtoc.2669.


Determining Ribosome Translational Status by Ribo-ELISA.

Bastide A, Yewdell JW, David A.

Bio Protoc. 2018 Jan 5;8(1). pii: e2670. doi: 10.21769/BioProtoc.2670.


Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes.

Jegaskanda S, Mason RD, Andrews SF, Wheatley AK, Zhang R, Reynoso GV, Ambrozak DR, Santos CP, Luke CJ, Matsuoka Y, Brenchley JM, Hickman HD, Talaat KR, Permar SR, Liao HX, Yewdell JW, Koup RA, Roederer M, McDermott AB, Subbarao K.

J Virol. 2018 Apr 13;92(9). pii: e01970-17. doi: 10.1128/JVI.01970-17. Print 2018 May 1.


Enhancing responses to cancer immunotherapy.

Kvistborg P, Yewdell JW.

Science. 2018 Feb 2;359(6375):516-517. doi: 10.1126/science.aar6574. Epub 2018 Feb 1. No abstract available.


Immunoribosomes: Where's there's fire, there's fire.

Wei J, Yewdell JW.

Mol Immunol. 2018 Jan 17. pii: S0161-5890(17)30628-4. doi: 10.1016/j.molimm.2017.12.026. [Epub ahead of print]


Antibody Immunodominance: The Key to Understanding Influenza Virus Antigenic Drift.

Altman MO, Angeletti D, Yewdell JW.

Viral Immunol. 2018 Mar;31(2):142-149. doi: 10.1089/vim.2017.0129. Epub 2018 Jan 22. Review.


Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs.

Kosik I, Ince WL, Gentles LE, Oler AJ, Kosikova M, Angel M, Magadán JG, Xie H, Brooke CB, Yewdell JW.

PLoS Pathog. 2018 Jan 18;14(1):e1006796. doi: 10.1371/journal.ppat.1006796. eCollection 2018 Jan. Erratum in: PLoS Pathog. 2018 Jun 20;14(6):e1007141.


Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance.

Rosshart SP, Vassallo BG, Angeletti D, Hutchinson DS, Morgan AP, Takeda K, Hickman HD, McCulloch JA, Badger JH, Ajami NJ, Trinchieri G, Pardo-Manuel de Villena F, Yewdell JW, Rehermann B.

Cell. 2017 Nov 16;171(5):1015-1028.e13. doi: 10.1016/j.cell.2017.09.016. Epub 2017 Oct 19.


Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens.

Arbuckle JH, Gardina PJ, Gordon DN, Hickman HD, Yewdell JW, Pierson TC, Myers TG, Kristie TM.

MBio. 2017 Aug 15;8(4). pii: e01141-17. doi: 10.1128/mBio.01141-17.


Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Outflanking Antibody Immunodominance on the Road to Universal Influenza Vaccination.

Angeletti D, Yewdell JW.

Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7). pii: a028852. doi: 10.1101/cshperspect.a028852. Review.


Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity.

Angeletti D, Frank GM, Yewdell JW.

Methods Mol Biol. 2017;1623:181-189. doi: 10.1007/978-1-4939-7095-7_15.


Autoimmune T cell recognition of alternative-reading-frame-encoded peptides.

Wei J, Yewdell JW.

Nat Med. 2017 Apr 7;23(4):409-410. doi: 10.1038/nm.4317. No abstract available.


Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands.

Wei J, Zanker D, Di Carluccio AR, Smelkinson MG, Takeda K, Seedhom MO, Dersh D, Gibbs JS, Yang N, Jadhav A, Chen W, Yewdell JW.

J Immunol. 2017 May 15;198(10):3835-3845. doi: 10.4049/jimmunol.1602122. Epub 2017 Mar 31.


Editorial overview: Viral immunology: Dealing with bad news.

Yewdell JW, Rimmelzwaan GF.

Curr Opin Virol. 2017 Feb;22:viii-x. doi: 10.1016/j.coviro.2017.02.002. No abstract available.


Defining B cell immunodominance to viruses.

Angeletti D, Gibbs JS, Angel M, Kosik I, Hickman HD, Frank GM, Das SR, Wheatley AK, Prabhakaran M, Leggat DJ, McDermott AB, Yewdell JW.

Nat Immunol. 2017 Apr;18(4):456-463. doi: 10.1038/ni.3680. Epub 2017 Feb 13.


The aryl hydrocarbon receptor controls cell-fate decisions in B cells.

Vaidyanathan B, Chaudhry A, Yewdell WT, Angeletti D, Yen WF, Wheatley AK, Bradfield CA, McDermott AB, Yewdell JW, Rudensky AY, Chaudhuri J.

J Exp Med. 2017 Jan;214(1):197-208. doi: 10.1084/jem.20160789. Epub 2016 Dec 23.


I've got algorithm: predicting tumor and autoimmune peptide targets for CD8+ T cells.

Dersh D, Yewdell JW.

J Clin Invest. 2016 Dec 1;126(12):4399-4401. doi: 10.1172/JCI91302. Epub 2016 Nov 14.


Influenza A virus hemagglutinin specific antibodies interfere with virion neuraminidase activity via two distinct mechanisms.

Kosik I, Yewdell JW.

Virology. 2017 Jan;500:178-183. doi: 10.1016/j.virol.2016.10.024. Epub 2016 Nov 5.


Protein Translation Activity: A New Measure of Host Immune Cell Activation.

Seedhom MO, Hickman HD, Wei J, David A, Yewdell JW.

J Immunol. 2016 Aug 15;197(4):1498-506. doi: 10.4049/jimmunol.1600088. Epub 2016 Jul 6.


Generation and Protective Ability of Influenza Virus-Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge.

Jegaskanda S, Luke C, Hickman HD, Sangster MY, Wieland-Alter WF, McBride JM, Yewdell JW, Wright PF, Treanor J, Rosenberger CM, Subbarao K.

J Infect Dis. 2016 Sep 15;214(6):945-52. doi: 10.1093/infdis/jiw262. Epub 2016 Jun 28.


Defining Viral Defective Ribosomal Products: Standard and Alternative Translation Initiation Events Generate a Common Peptide from Influenza A Virus M2 and M1 mRNAs.

Yang N, Gibbs JS, Hickman HD, Reynoso GV, Ghosh AK, Bennink JR, Yewdell JW.

J Immunol. 2016 May 1;196(9):3608-17. doi: 10.4049/jimmunol.1502303. Epub 2016 Mar 25.


Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread.

Cush SS, Reynoso GV, Kamenyeva O, Bennink JR, Yewdell JW, Hickman HD.

PLoS Pathog. 2016 Mar 18;12(3):e1005493. doi: 10.1371/journal.ppat.1005493. eCollection 2016 Mar.


Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity.

Altman MO, Bennink JR, Yewdell JW, Herrin BR.

Elife. 2015 Aug 7;4. doi: 10.7554/eLife.07467.


A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus.

Frank GM, Angeletti D, Ince WL, Gibbs JS, Khurana S, Wheatley AK, Max EE, McDermott AB, Golding H, Stevens J, Bennink JR, Yewdell JW.

MBio. 2015 Aug 4;6(4):e01156. doi: 10.1128/mBio.01156-15.


Ubiquitous Autofragmentation of Fluorescent Proteins Creates Abundant Defective Ribosomal Products (DRiPs) for Immunosurveillance.

Wei J, Gibbs JS, Hickman HD, Cush SS, Bennink JR, Yewdell JW.

J Biol Chem. 2015 Jun 26;290(26):16431-9. doi: 10.1074/jbc.M115.658062. Epub 2015 May 13.


Editorial overview: Antigen processing and presentation: Where cellular immunity begins.

Shastri N, Yewdell JW.

Curr Opin Immunol. 2015 Jun;34:v-vii. doi: 10.1016/j.coi.2015.04.004. Epub 2015 May 8. No abstract available.


CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.

Hickman HD, Reynoso GV, Ngudiankama BF, Cush SS, Gibbs J, Bennink JR, Yewdell JW.

Immunity. 2015 Mar 17;42(3):524-37. doi: 10.1016/j.immuni.2015.02.009. Epub 2015 Mar 10.


Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility.

Brooke CB, Ince WL, Wei J, Bennink JR, Yewdell JW.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16854-9. doi: 10.1073/pnas.1415396111. Epub 2014 Nov 10.


Applying the ribopuromycylation method to detect nuclear translation.

David A, Yewdell JW.

Methods Mol Biol. 2015;1228:133-42. doi: 10.1007/978-1-4939-1680-1_11.


Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes.

Magadán JG, Altman MO, Ince WL, Hickman HD, Stevens J, Chevalier A, Baker D, Wilson PC, Ahmed R, Bennink JR, Yewdell JW.

PLoS Pathog. 2014 Jun 12;10(6):e1004204. doi: 10.1371/journal.ppat.1004204. eCollection 2014 Jun.


Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors.

Antón LC, Yewdell JW.

J Leukoc Biol. 2014 Apr;95(4):551-62. doi: 10.1189/jlb.1113599. Epub 2014 Feb 14. Review.

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