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Items: 46


The era of immunogenomics/immunopharmacogenomics.

Zewde M, Kiyotani K, Park JH, Fang H, Yap KL, Yew PY, Alachkar H, Kato T, Mai TH, Ikeda Y, Matsuda T, Liu X, Ren L, Deng B, Harada M, Nakamura Y.

J Hum Genet. 2018 Jul;63(8):865-875. doi: 10.1038/s10038-018-0468-1. Epub 2018 May 21. Review.


Immunoglobulin profiling identifies unique signatures in patients with Kawasaki disease during intravenous immunoglobulin treatment.

Ko TM, Kiyotani K, Chang JS, Park JH, Yew PY, Chen YT, Wu JY, Nakamura Y.

Hum Mol Genet. 2018 May 16. doi: 10.1093/hmg/ddy176. [Epub ahead of print]


Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro.

Tsuruta M, Ueda S, Yew PY, Fukuda I, Yoshimura S, Kishi H, Hamana H, Hirayama M, Yatsuda J, Irie A, Senju S, Yuba E, Kamba T, Eto M, Nakayama H, Nishimura Y.

Oncoimmunology. 2018 Jan 5;7(4):e1415687. doi: 10.1080/2162402X.2017.1415687. eCollection 2018.


Characterization of the B-cell receptor repertoires in peanut allergic subjects undergoing oral immunotherapy.

Kiyotani K, Mai TH, Yamaguchi R, Yew PY, Kulis M, Orgel K, Imoto S, Miyano S, Burks AW, Nakamura Y.

J Hum Genet. 2018 Feb;63(2):239-248. doi: 10.1038/s10038-017-0364-0. Epub 2017 Nov 30.


Low T-cell Receptor Diversity, High Somatic Mutation Burden, and High Neoantigen Load as Predictors of Clinical Outcome in Muscle-invasive Bladder Cancer.

Choudhury NJ, Kiyotani K, Yap KL, Campanile A, Antic T, Yew PY, Steinberg G, Park JH, Nakamura Y, O'Donnell PH.

Eur Urol Focus. 2016 Oct;2(4):445-452. doi: 10.1016/j.euf.2015.09.007. Epub 2015 Oct 9.


Clinical significance of T cell clonality and expression levels of immune-related genes in endometrial cancer.

Ikeda Y, Kiyotani K, Yew PY, Sato S, Imai Y, Yamaguchi R, Miyano S, Fujiwara K, Hasegawa K, Nakamura Y.

Oncol Rep. 2017 May;37(5):2603-2610. doi: 10.3892/or.2017.5536. Epub 2017 Mar 29.


Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.

Kim NH, Livi CB, Yew PR, Boyer TG.

BMC Dev Biol. 2016 May 17;16(1):17. doi: 10.1186/s12861-016-0114-0.


Characterization of T-cell Receptor Repertoire in Inflamed Tissues of Patients with Crohn's Disease Through Deep Sequencing.

Chapman CG, Yamaguchi R, Tamura K, Weidner J, Imoto S, Kwon J, Fang H, Yew PY, Marino SR, Miyano S, Nakamura Y, Kiyotani K.

Inflamm Bowel Dis. 2016 Jun;22(6):1275-85. doi: 10.1097/MIB.0000000000000752.


Germline PARP4 mutations in patients with primary thyroid and breast cancers.

Ikeda Y, Kiyotani K, Yew PY, Kato T, Tamura K, Yap KL, Nielsen SM, Mester JL, Eng C, Nakamura Y, Grogan RH.

Endocr Relat Cancer. 2016 Mar;23(3):171-9. doi: 10.1530/ERC-15-0359. Epub 2015 Dec 23.


Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation.

Leisegang M, Engels B, Schreiber K, Yew PY, Kiyotani K, Idel C, Arina A, Duraiswamy J, Weichselbaum RR, Uckert W, Nakamura Y, Schreiber H.

Clin Cancer Res. 2016 Jun 1;22(11):2734-43. doi: 10.1158/1078-0432.CCR-15-2361. Epub 2015 Dec 14.


Characterization of T cell repertoire of blood, tumor, and ascites in ovarian cancer patients using next generation sequencing.

Jang M, Yew PY, Hasegawa K, Ikeda Y, Fujiwara K, Fleming GF, Nakamura Y, Park JH.

Oncoimmunology. 2015 Apr 14;4(11):e1030561. eCollection 2015 Nov.


Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients.

Yew PY, Alachkar H, Yamaguchi R, Kiyotani K, Fang H, Yap KL, Liu HT, Wickrema A, Artz A, van Besien K, Imoto S, Miyano S, Bishop MR, Stock W, Nakamura Y.

Bone Marrow Transplant. 2015 Sep;50(9):1227-34. doi: 10.1038/bmt.2015.133. Epub 2015 Jun 8.


Quantitative T cell repertoire analysis by deep cDNA sequencing of T cell receptor α and β chains using next-generation sequencing (NGS).

Fang H, Yamaguchi R, Liu X, Daigo Y, Yew PY, Tanikawa C, Matsuda K, Imoto S, Miyano S, Nakamura Y.

Oncoimmunology. 2015 Jan 7;3(12):e968467. eCollection 2014 Dec.


Report of an outbreak of Clostridium difficile infection caused by ribotype 053 in a neurosurgery unit.

Nagar A, Yew P, Fairley D, Hanrahan M, Cooke S, Thompson I, Elbaz W.

J Infect Prev. 2015 May;16(3):126-130. doi: 10.1177/1757177414560250. Epub 2014 Dec 16.


Small-molecule high-throughput screening utilizing Xenopus egg extract.

Broadus MR, Yew PR, Hann SR, Lee E.

Methods Mol Biol. 2015;1263:63-73. doi: 10.1007/978-1-4939-2269-7_5.


Analysis of the increasing prevalence of necrotising fasciitis referrals to a regional plastic surgery unit: a retrospective case series.

Hodgins N, Damkat-Thomas L, Shamsian N, Yew P, Lewis H, Khan K.

J Plast Reconstr Aesthet Surg. 2015 Mar;68(3):304-11. doi: 10.1016/j.bjps.2014.11.003. Epub 2014 Nov 20.


Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent mutations of UNC5C and prognostic importance of DNA repair gene mutations on survival.

Yap KL, Kiyotani K, Tamura K, Antic T, Jang M, Montoya M, Campanile A, Yew PY, Ganshert C, Fujioka T, Steinberg GD, O'Donnell PH, Nakamura Y.

Clin Cancer Res. 2014 Dec 15;20(24):6605-17. doi: 10.1158/1078-0432.CCR-14-0257. Epub 2014 Oct 14.


Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes.

Hu L, Kim TM, Son MY, Kim SA, Holland CL, Tateishi S, Kim DH, Yew PR, Montagna C, Dumitrache LC, Hasty P.

Nature. 2013 Sep 26;501(7468):569-72. doi: 10.1038/nature12500. Epub 2013 Sep 8.


Two cases of importation of New Delhi Metallo-β-lactamase 1 into Northern Ireland.

Nagar A, Yew P, Ong G, Black C, Fogarty B, Christie S, Hedderwick S, Kealey D, Livermore DM.

Ulster Med J. 2012 Sep;81(3):154-5. No abstract available.


Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation.

Zhu XN, Kim DH, Lin HR, Budhavarapu VN, Rosenbaum HB, Mueller PR, Yew PR.

Cell Div. 2013 Apr 22;8(1):5. doi: 10.1186/1747-1028-8-5.


The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation.

Lu Y, Li J, Cheng D, Parameswaran B, Zhang S, Jiang Z, Yew PR, Peng J, Ye Q, Hu Y.

J Biol Chem. 2012 Nov 30;287(49):41014-22. doi: 10.1074/jbc.M112.407106. Epub 2012 Oct 18.


Identification of a functional variant in SPLUNC1 associated with nasopharyngeal carcinoma susceptibility among Malaysian Chinese.

Yew PY, Mushiroda T, Kiyotani K, Govindasamy GK, Yap LF, Teo SH, Lim PV, Govindaraju S, Ratnavelu K, Sam CK, Yap YY, Khoo AS, Pua KC, Nakamura Y; Malaysian NPC Study Group, Ng CC.

Mol Carcinog. 2012 Oct;51 Suppl 1:E74-82. doi: 10.1002/mc.21857. Epub 2011 Dec 27.


Acute respiratory distress syndrome caused by Mycoplasma pneumoniae diagnosed by polymerase chain reaction.

Yew P, Farren D, Curran T, Coyle PV, McCaughey C, McGarvey L.

Ulster Med J. 2012 Jan;81(1):28-9.


Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1.

Nair BC, Nair SS, Chakravarty D, Challa R, Manavathi B, Yew PR, Kumar R, Tekmal RR, Vadlamudi RK.

Cancer Res. 2010 Sep 15;70(18):7166-75. doi: 10.1158/0008-5472.CAN-10-0628. Epub 2010 Aug 31.


The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA.

Kim DH, Budhavarapu VN, Herrera CR, Nam HW, Kim YS, Yew PR.

Mol Cell Biol. 2010 Sep;30(17):4120-33. doi: 10.1128/MCB.01135-09. Epub 2010 Jul 6.


A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma.

Ng CC, Yew PY, Puah SM, Krishnan G, Yap LF, Teo SH, Lim PV, Govindaraju S, Ratnavelu K, Sam CK, Takahashi A, Kubo M, Kamatani N, Nakamura Y, Mushiroda T.

J Hum Genet. 2009 Jul;54(7):392-7. doi: 10.1038/jhg.2009.49. Epub 2009 May 29.


The Xenopus cell cycle: an overview.

Philpott A, Yew PR.

Mol Biotechnol. 2008 May;39(1):9-19. doi: 10.1007/s12033-008-9033-z. Epub 2008 Feb 12. Review.


The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle.

Boix-Perales H, Horan I, Wise H, Lin HR, Chuang LC, Yew PR, Philpott A.

Neural Dev. 2007 Dec 14;2:27.


Ubiquitination of cyclin-dependent kinase inhibitor, Xic1, is mediated by the Xenopus F-box protein xSkp2.

Lin HR, Chuang LC, Boix-Perales H, Philpott A, Yew PR.

Cell Cycle. 2006 Feb;5(3):304-14. Epub 2006 Feb 8.


The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain.

Block K, Appikonda S, Lin HR, Bloom J, Pagano M, Yew PR.

Cell Cycle. 2005 Oct;4(10):1421-7. Epub 2005 Oct 26.


The C-terminal domain of the Xenopus cyclin-dependent kinase inhibitor, p27Xic1, is both necessary and sufficient for phosphorylation-independent proteolysis.

Chuang LC, Zhu XN, Herrera CR, Tseng HM, Pfleger CM, Block K, Yew PR.

J Biol Chem. 2005 Oct 21;280(42):35290-8. Epub 2005 Aug 23.


The Xenopus cell cycle: an overview.

Philpott A, Yew PR.

Methods Mol Biol. 2005;296:95-112. Review.


Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.

Chauhan D, Li G, Hideshima T, Podar K, Shringarpure R, Mitsiades C, Munshi N, Yew PR, Anderson KC.

Oncogene. 2004 Apr 29;23(20):3597-602.


Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2.

Block K, Boyer TG, Yew PR.

J Biol Chem. 2001 Nov 2;276(44):41049-58. Epub 2001 Sep 6.


Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators.

Yew PR.

J Cell Physiol. 2001 Apr;187(1):1-10. Review.


Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27.

Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M.

Science. 1995 Aug 4;269(5224):682-5.


Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

Yew PR, Liu X, Berk AJ.

Genes Dev. 1994 Jan;8(2):190-202.


NIH3T3 transforming gene not a general feature of atherosclerotic plaque DNA (atherosclerosis/oncogene/NIH3T3 transfection assay).

Yew PR, Rajavashisth TB, Forrester J, Barath P, Lusis AJ.

Biochem Biophys Res Commun. 1989 Dec 29;165(3):1067-71.


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