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Items: 34

1.

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages.

Chua ACY, Ong JJY, Malleret B, Suwanarusk R, Kosaisavee V, Zeeman AM, Cooper CA, Tan KSW, Zhang R, Tan BH, Abas SN, Yip A, Elliot A, Joyner CJ, Cho JS, Breyer K, Baran S, Lange A, Maher SP, Nosten F, Bodenreider C, Yeung BKS, Mazier D, Galinski MR, Dereuddre-Bosquet N, Le Grand R, Kocken CHM, Rénia L, Kyle DE, Diagana TT, Snounou G, Russell B, Bifani P.

Nat Commun. 2019 Aug 12;10(1):3635. doi: 10.1038/s41467-019-11332-4.

2.

Hepatic spheroids used as an in vitro model to study malaria relapse.

Chua ACY, Ananthanarayanan A, Ong JJY, Wong JY, Yip A, Singh NH, Qu Y, Dembele L, McMillian M, Ubalee R, Davidson S, Tungtaeng A, Imerbsin R, Gupta K, Andolina C, Lee F, S-W Tan K, Nosten F, Russell B, Lange A, Diagana TT, Rénia L, Yeung BKS, Yu H, Bifani P.

Biomaterials. 2019 Sep;216:119221. doi: 10.1016/j.biomaterials.2019.05.032. Epub 2019 May 22.

3.

Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi.

Kosaisavee V, Suwanarusk R, Chua ACY, Kyle DE, Malleret B, Zhang R, Imwong M, Imerbsin R, Ubalee R, Sámano-Sánchez H, Yeung BKS, Ong JJY, Lombardini E, Nosten F, Tan KSW, Bifani P, Snounou G, Rénia L, Russell B.

Blood. 2017 Sep 14;130(11):1357-1363. doi: 10.1182/blood-2017-02-764787. Epub 2017 Jul 11.

4.

The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites.

Dembele L, Ang X, Chavchich M, Bonamy GMC, Selva JJ, Lim MY, Bodenreider C, Yeung BKS, Nosten F, Russell BM, Edstein MD, Straimer J, Fidock DA, Diagana TT, Bifani P.

Sci Rep. 2017 May 24;7(1):2325. doi: 10.1038/s41598-017-02440-6.

5.

Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit.

Kounde CS, Yeo HQ, Wang QY, Wan KF, Dong H, Karuna R, Dix I, Wagner T, Zou B, Simon O, Bonamy GMC, Yeung BKS, Yokokawa F.

Bioorg Med Chem Lett. 2017 Mar 15;27(6):1385-1389. doi: 10.1016/j.bmcl.2017.02.005. Epub 2017 Feb 4.

PMID:
28216045
6.

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes.

Lim MY, LaMonte G, Lee MCS, Reimer C, Tan BH, Corey V, Tjahjadi BF, Chua A, Nachon M, Wintjens R, Gedeck P, Malleret B, Renia L, Bonamy GMC, Ho PC, Yeung BKS, Chow ED, Lim L, Fidock DA, Diagana TT, Winzeler EA, Bifani P.

Nat Microbiol. 2016 Sep 19;1:16166. doi: 10.1038/nmicrobiol.2016.166.

7.

PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites.

Zeeman AM, Lakshminarayana SB, van der Werff N, Klooster EJ, Voorberg-van der Wel A, Kondreddi RR, Bodenreider C, Simon O, Sauerwein R, Yeung BK, Diagana TT, Kocken CH.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63. doi: 10.1128/AAC.03080-15. Print 2016 May.

8.

Drug discovery for the developing world: progress at the Novartis Institute for Tropical Diseases.

Jones CL, Yeung BK, Manjunatha U, Shi PY, Bodenreider C, Diagana TT.

Nat Rev Drug Discov. 2015 Jun;14(6):442-4. doi: 10.1038/nrd4001-c1. No abstract available.

PMID:
26027536
9.

Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model.

Lakshminarayana SB, Freymond C, Fischli C, Yu J, Weber S, Goh A, Yeung BK, Ho PC, Dartois V, Diagana TT, Rottmann M, Blasco F.

Antimicrob Agents Chemother. 2015 Feb;59(2):1200-10. doi: 10.1128/AAC.03274-14. Epub 2014 Dec 8.

10.

Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages.

Zou B, Nagle A, Chatterjee AK, Leong SY, Tan LJ, Sim WL, Mishra P, Guntapalli P, Tully DC, Lakshminarayana SB, Lim CS, Tan YC, Abas SN, Bodenreider C, Kuhen KL, Gagaring K, Borboa R, Chang J, Li C, Hollenbeck T, Tuntland T, Zeeman AM, Kocken CH, McNamara C, Kato N, Winzeler EA, Yeung BK, Diagana TT, Smith PW, Roland J.

ACS Med Chem Lett. 2014 Jul 6;5(8):947-50. doi: 10.1021/ml500244m. eCollection 2014 Aug 14.

11.

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro.

Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ, van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A, Sauerwein R, Gagaring K, Borboa R, Chen Z, Kuhen K, Glynne RJ, Chatterjee AK, Nagle A, Roland J, Winzeler EA, Leroy D, Campo B, Diagana TT, Yeung BK, Thomas AW, Kocken CH.

Antimicrob Agents Chemother. 2014;58(3):1586-95. doi: 10.1128/AAC.01927-13. Epub 2013 Dec 23.

12.

Targeting Plasmodium PI(4)K to eliminate malaria.

McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Nagle A, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA.

Nature. 2013 Dec 12;504(7479):248-253. doi: 10.1038/nature12782. Epub 2013 Nov 27.

13.

Progressing the global antimalarial portfolio: finding drugs which target multiple Plasmodium life stages.

Smith PW, Diagana TT, Yeung BK.

Parasitology. 2014 Jan;141(1):66-76. doi: 10.1017/S0031182013000747. Epub 2013 Jun 10. Review.

PMID:
23746048
14.

Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials.

Spillman NJ, Allen RJ, McNamara CW, Yeung BK, Winzeler EA, Diagana TT, Kirk K.

Cell Host Microbe. 2013 Feb 13;13(2):227-37. doi: 10.1016/j.chom.2012.12.006.

15.

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.

Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler EA, Diagana TT, Greenbaum DC.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21486-91. doi: 10.1073/pnas.1216016110. Epub 2012 Dec 11.

16.

Mechanistic study of the spiroindolones: a new class of antimalarials.

Zou B, Yap P, Sonntag LS, Leong SY, Yeung BK, Keller TH.

Molecules. 2012 Aug 24;17(9):10131-41. doi: 10.3390/molecules170910131.

17.

The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector.

van Pelt-Koops JC, Pett HE, Graumans W, van der Vegte-Bolmer M, van Gemert GJ, Rottmann M, Yeung BK, Diagana TT, Sauerwein RW.

Antimicrob Agents Chemother. 2012 Jul;56(7):3544-8. doi: 10.1128/AAC.06377-11. Epub 2012 Apr 16.

18.
19.

Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B.

Yeung BK.

Curr Opin Chem Biol. 2011 Aug;15(4):523-8. doi: 10.1016/j.cbpa.2011.05.019. Epub 2011 Jun 22. Review.

PMID:
21684798
20.

Spiroindolones, a potent compound class for the treatment of malaria.

Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT.

Science. 2010 Sep 3;329(5996):1175-80. doi: 10.1126/science.1193225.

21.

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C, Goh A, Schmitt EK, Krastel P, Francotte E, Kuhen K, Plouffe D, Henson K, Wagner T, Winzeler EA, Petersen F, Brun R, Dartois V, Diagana TT, Keller TH.

J Med Chem. 2010 Jul 22;53(14):5155-64. doi: 10.1021/jm100410f.

PMID:
20568778
22.

Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT.

Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. doi: 10.1128/AAC.01526-09. Epub 2010 Mar 29.

23.

Gram-scale syntheses of the (1-->3)-linked and (1-->4)-linked hyaluronan disaccharides.

Adamski-Werner SL, Yeung BK, Miller-Deist LA, Petillo PA.

Carbohydr Res. 2004 May 17;339(7):1255-62.

PMID:
15113662
24.
25.

Synthesis of isochrysohermidin-distamycin hybrids.

Yeung BK, Boger DL.

J Org Chem. 2003 Jun 27;68(13):5249-53.

PMID:
12816485
26.

Facile C1 Epimerization of alpha-1-sulfonamidyl-2-deoxy-2-iodo- glycopyranosides.

Owens JM, Yeung BK, Hill DC, Petillo PA.

J Org Chem. 2001 Feb 23;66(4):1484-6. No abstract available.

PMID:
11312984
27.

Surgical management of abdominal aortic aneurysm.

Yeung BK, Pearce WH.

Vasc Med. 2000;5(3):187-93. Review.

PMID:
11104301
28.
29.

The mild cleavage of 2-amino-2-deoxy-D-glucoside methoxycarbonyl derivatives.

Yeung BK, Adamski-Werner SL, Bernard JB, Poulenat G, Petillo PA.

Org Lett. 2000 Oct 5;2(20):3135-8.

PMID:
11009364
30.

Synthesis of two hyaluronan trisaccharides

Yeung BK, Hill DC, Janicka M, Petillo PA.

Org Lett. 2000 May 4;2(9):1279-82.

PMID:
10810727
31.

Cystic dysplasia of the testis associated with ipsilateral renal agenesis and high anorectal anomalies.

Ngai RL, Yeung BK, Tsui WM, Cheng FY.

J Pediatr Surg. 1998 May;33(5):787-8.

PMID:
9607503
32.

Caritas Medical Centre day surgery pilot study.

Yeung BK, Ngai RL, Mok FP.

Hong Kong Med J. 1997 Mar;3(1):113-116.

33.
34.

The Kapakahines, Cyclic Peptides from the Marine Sponge Cribrochalina olemda.

Yeung BK, Nakao Y, Kinnel RB, Carney JR, Yoshida WY, Scheuer PJ, Kelly-Borges M.

J Org Chem. 1996 Oct 4;61(20):7168-7173.

PMID:
11667621

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