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Items: 42


Streptococcus pneumoniae Cell Wall-Localized Trigger Factor Elicits a Protective Immune Response and Contributes to Bacterial Adhesion to the Host.

Cohen A, Troib S, Dotan S, Najmuldeen H, Yesilkaya H, Kushnir T, Shagan M, Portnoi M, Nachmani H, Benisty R, Tal M, Ellis R, Chalifa-Caspi V, Dagan R, Nebenzahl YM.

Sci Rep. 2019 Mar 12;9(1):4295. doi: 10.1038/s41598-019-40779-0.


Functional assessment of microbial superoxide dismutase isozymes suggests a differential role for each isozyme.

Najmuldeen H, Alghamdi R, Alghofaili F, Yesilkaya H.

Free Radic Biol Med. 2019 Apr;134:215-228. doi: 10.1016/j.freeradbiomed.2019.01.018. Epub 2019 Jan 15.


The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface.

Haleem KS, Ali YM, Yesilkaya H, Kohler T, Hammerschmidt S, Andrew PW, Schwaeble WJ, Lynch NJ.

Infect Immun. 2018 Dec 19;87(1). pii: e00742-18. doi: 10.1128/IAI.00742-18. Print 2019 Jan.


Function of BriC peptide in the pneumococcal competence and virulence portfolio.

Aggarwal SD, Eutsey R, West-Roberts J, Domenech A, Xu W, Abdullah IT, Mitchell AP, Veening JW, Yesilkaya H, Hiller NL.

PLoS Pathog. 2018 Oct 11;14(10):e1007328. doi: 10.1371/journal.ppat.1007328. eCollection 2018 Oct.


RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization.

Glanville DG, Han L, Maule AF, Woodacre A, Thanki D, Abdullah IT, Morrissey JA, Clarke TB, Yesilkaya H, Silvaggi NR, Ulijasz AT.

PLoS Pathog. 2018 May 11;14(5):e1007052. doi: 10.1371/journal.ppat.1007052. eCollection 2018 May.


Rgg-Shp regulators are important for pneumococcal colonization and invasion through their effect on mannose utilization and capsule synthesis.

Zhi X, Abdullah IT, Gazioglu O, Manzoor I, Shafeeq S, Kuipers OP, Hiller NL, Andrew PW, Yesilkaya H.

Sci Rep. 2018 Apr 23;8(1):6369. doi: 10.1038/s41598-018-24910-1.


Flavin Reductase Contributes to Pneumococcal Virulence by Protecting from Oxidative Stress and Mediating Adhesion and Elicits Protection Against Pneumococcal Challenge.

Morozov GI, Porat N, Kushnir T, Najmuldeen H, Adawi A, Chalifa-Caspi V, Benisty R, Ohayon A, Liron O, Azriel S, Malka I, Dotan S, Portnoi M, Piotrowski AA, Kafka D, Hajaj B, Fishilevich T, Shagan M, Tal M, Ellis R, Morrison DA, Mitchell AM, Mitchell TJ, Dagan R, Yesilkaya H, Nebenzahl YM.

Sci Rep. 2018 Jan 10;8(1):314. doi: 10.1038/s41598-017-18645-8.


Modulation of Quorum Sensing in a Gram-Positive Pathogen by Linear Molecularly Imprinted Polymers with Anti-infective Properties.

Motib A, Guerreiro A, Al-Bayati F, Piletska E, Manzoor I, Shafeeq S, Kadam A, Kuipers O, Hiller L, Cowen T, Piletsky S, Andrew PW, Yesilkaya H.

Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16555-16558. doi: 10.1002/anie.201709313. Epub 2017 Dec 1.


Activation of invariant natural killer T cells stimulated with microbial α-mannosyl glycolipids.

Shimamura M, Yamamura M, Nabeshima T, Kitano N, van den Elzen P, Yesilkaya H, Andrew P, Illarionov P.

Sci Rep. 2017 Aug 29;7(1):9703. doi: 10.1038/s41598-017-10309-x.


CodY Regulates Thiol Peroxidase Expression as Part of the Pneumococcal Defense Mechanism against H2O2 Stress.

Hajaj B, Yesilkaya H, Shafeeq S, Zhi X, Benisty R, Tchalah S, Kuipers OP, Porat N.

Front Cell Infect Microbiol. 2017 May 24;7:210. doi: 10.3389/fcimb.2017.00210. eCollection 2017.


Promiscuous signaling by a regulatory system unique to the pandemic PMEN1 pneumococcal lineage.

Kadam A, Eutsey RA, Rosch J, Miao X, Longwell M, Xu W, Woolford CA, Hillman T, Motib AS, Yesilkaya H, Mitchell AP, Hiller NL.

PLoS Pathog. 2017 May 18;13(5):e1006339. doi: 10.1371/journal.ppat.1006339. eCollection 2017 May.


Deacetylation of sialic acid by esterases potentiates pneumococcal neuraminidase activity for mucin utilization, colonization and virulence.

Kahya HF, Andrew PW, Yesilkaya H.

PLoS Pathog. 2017 Mar 3;13(3):e1006263. doi: 10.1371/journal.ppat.1006263. eCollection 2017 Mar.


Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase.

Al-Bayati FA, Kahya HF, Damianou A, Shafeeq S, Kuipers OP, Andrew PW, Yesilkaya H.

Sci Rep. 2017 Feb 27;7:43587. doi: 10.1038/srep43587.


Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence.

Robb M, Hobbs JK, Woodiga SA, Shapiro-Ward S, Suits MD, McGregor N, Brumer H, Yesilkaya H, King SJ, Boraston AB.

PLoS Pathog. 2017 Jan 5;13(1):e1006090. doi: 10.1371/journal.ppat.1006090. eCollection 2017 Jan.


Pneumococcal 6-Phospho-β-Glucosidase (BglA3) Is Involved in Virulence and Nutrient Metabolism.

Terra VS, Zhi X, Kahya HF, Andrew PW, Yesilkaya H.

Infect Immun. 2015 Nov 2;84(1):286-92. doi: 10.1128/IAI.01108-15. Print 2016 Jan.


Host glycan sugar-specific pathways in Streptococcus pneumoniae: galactose as a key sugar in colonisation and infection [corrected].

Paixão L, Oliveira J, Veríssimo A, Vinga S, Lourenço EC, Ventura MR, Kjos M, Veening JW, Fernandes VE, Andrew PW, Yesilkaya H, Neves AR.

PLoS One. 2015 Mar 31;10(3):e0121042. doi: 10.1371/journal.pone.0121042. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0127483.


Lactate dehydrogenase is the key enzyme for pneumococcal pyruvate metabolism and pneumococcal survival in blood.

Gaspar P, Al-Bayati FA, Andrew PW, Neves AR, Yesilkaya H.

Infect Immun. 2014 Dec;82(12):5099-109. doi: 10.1128/IAI.02005-14. Epub 2014 Sep 22.


Host stress hormone norepinephrine stimulates pneumococcal growth, biofilm formation and virulence gene expression.

Sandrini S, Alghofaili F, Freestone P, Yesilkaya H.

BMC Microbiol. 2014 Jul 4;14:180. doi: 10.1186/1471-2180-14-180.


Development and characterization of a long-term murine model of Streptococcus pneumoniae infection of the lower airways.

Haste L, Hulland K, Bolton S, Yesilkaya H, McKechnie K, Andrew PW.

Infect Immun. 2014 Aug;82(8):3289-98. doi: 10.1128/IAI.01623-14. Epub 2014 May 27.


[Cloning of Blastocystis sp subtype 3 small-subunit ribosomal DNA].

Şakalar Ç, Uyar Y, Yürürdurmaz MA, Tokar S, Yeşilkaya H, Gürbüz E, Kuk S, Yazar S.

Turkiye Parazitol Derg. 2013;37(1):13-8. doi: 10.5152/tpd.2013.04. Turkish.


Streptococcus pneumoniae and reactive oxygen species: an unusual approach to living with radicals.

Yesilkaya H, Andisi VF, Andrew PW, Bijlsma JJ.

Trends Microbiol. 2013 Apr;21(4):187-95. doi: 10.1016/j.tim.2013.01.004. Epub 2013 Feb 13. Review.


Thiol peroxidase is an important component of Streptococcus pneumoniae in oxygenated environments.

Hajaj B, Yesilkaya H, Benisty R, David M, Andrew PW, Porat N.

Infect Immun. 2012 Dec;80(12):4333-43. doi: 10.1128/IAI.00126-12. Epub 2012 Oct 1.


Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.

Kinjo Y, Illarionov P, Vela JL, Pei B, Girardi E, Li X, Li Y, Imamura M, Kaneko Y, Okawara A, Miyazaki Y, Gómez-Velasco A, Rogers P, Dahesh S, Uchiyama S, Khurana A, Kawahara K, Yesilkaya H, Andrew PW, Wong CH, Kawakami K, Nizet V, Besra GS, Tsuji M, Zajonc DM, Kronenberg M.

Nat Immunol. 2011 Sep 4;12(10):966-74. doi: 10.1038/ni.2096.


Treatment of tuberculosis in a region with high drug resistance: outcomes, drug resistance amplification and re-infection.

Bonnet M, Pardini M, Meacci F, Orrù G, Yesilkaya H, Jarosz T, Andrew PW, Barer M, Checchi F, Rinder H, Orefici G, Rüsch-Gerdes S, Fattorini L, Oggioni MR, Melzer J, Niemann S, Varaine F.

PLoS One. 2011;6(8):e23081. doi: 10.1371/journal.pone.0023081. Epub 2011 Aug 23.


The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae.

Shafeeq S, Yesilkaya H, Kloosterman TG, Narayanan G, Wandel M, Andrew PW, Kuipers OP, Morrissey JA.

Mol Microbiol. 2011 Sep;81(5):1255-70. doi: 10.1111/j.1365-2958.2011.07758.x. Epub 2011 Jul 19.


Characterization of novel beta-galactosidase activity that contributes to glycoprotein degradation and virulence in Streptococcus pneumoniae.

Terra VS, Homer KA, Rao SG, Andrew PW, Yesilkaya H.

Infect Immun. 2010 Jan;78(1):348-57. doi: 10.1128/IAI.00721-09. Epub 2009 Oct 19.


The pneumococcal response to oxidative stress includes a role for Rgg.

Bortoni ME, Terra VS, Hinds J, Andrew PW, Yesilkaya H.

Microbiology. 2009 Dec;155(Pt 12):4123-34. doi: 10.1099/mic.0.028282-0. Epub 2009 Sep 17.


Pyruvate formate lyase is required for pneumococcal fermentative metabolism and virulence.

Yesilkaya H, Spissu F, Carvalho SM, Terra VS, Homer KA, Benisty R, Porat N, Neves AR, Andrew PW.

Infect Immun. 2009 Dec;77(12):5418-27. doi: 10.1128/IAI.00178-09. Epub 2009 Sep 14.


Characteristics of drug-resistant tuberculosis in Abkhazia (Georgia), a high-prevalence area in Eastern Europe.

Pardini M, Niemann S, Varaine F, Iona E, Meacci F, Orrù G, Yesilkaya H, Jarosz T, Andrew P, Barer M, Checchi F, Rinder H, Orefici G, Rüsch-Gerdes S, Fattorini L, Oggioni MR, Bonnet M.

Tuberculosis (Edinb). 2009 Jul;89(4):317-24. doi: 10.1016/ Epub 2009 Jun 17.


The ability to utilize mucin affects the regulation of virulence gene expression in Streptococcus pneumoniae.

Yesilkaya H, Manco S, Kadioglu A, Terra VS, Andrew PW.

FEMS Microbiol Lett. 2008 Jan;278(2):231-5. Epub 2007 Dec 5.


Evaluation of molecular-Beacon, TaqMan, and fluorescence resonance energy transfer probes for detection of antibiotic resistance-conferring single nucleotide polymorphisms in mixed Mycobacterium tuberculosis DNA extracts.

Yesilkaya H, Meacci F, Niemann S, Hillemann D, Rüsch-Gerdes S; LONG DRUG Study Group, Barer MR, Andrew PW, Oggioni MR.

J Clin Microbiol. 2006 Oct;44(10):3826-9.


Identification of amino acids essential for catalytic activity of pneumococcal neuraminidase A.

Yesilkaya H, Soma-Haddrick S, Crennell SJ, Andrew PW.

Res Microbiol. 2006 Jul-Aug;157(6):569-74. Epub 2006 Feb 13.


Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis.

Manco S, Hernon F, Yesilkaya H, Paton JC, Andrew PW, Kadioglu A.

Infect Immun. 2006 Jul;74(7):4014-20.


Distribution and genomic location of active insertion sequences in the Burkholderia cepacia complex.

Kenna DT, Yesilkaya H, Forbes KJ, Barcus VA, Vandamme P, Govan JR.

J Med Microbiol. 2006 Jan;55(Pt 1):1-10.


The genetic portrait of an outbreak strain.

Yesilkaya H, Forbes KJ, Shafi J, Smith R, Dale JW, Rajakumar K, Barer MR, Andrew PW.

Tuberculosis (Edinb). 2006 Sep;86(5):357-62. Epub 2005 Dec 19.


An extremely rapid and simple DNA-release method for detection of M. tuberculosis from clinical specimens.

Thomson LM, Traore H, Yesilkaya H, Doig C, Steingrimsdottir H, Garcia L, Forbes KJ.

J Microbiol Methods. 2005 Oct;63(1):95-8.


Antibiotic resistance may affect alkali decontamination of specimens containing mycobacteria.

Yesilkaya H, Barer MR, Andrew PW.

Diagn Microbiol Infect Dis. 2004 Oct;50(2):153-5.


Locating transposable element polymorphisms in bacterial genomes.

Yesilkaya H, Thomson A, Doig C, Watt B, Dale JW, Forbes KJ.

J Microbiol Methods. 2003 Jun;53(3):355-63.


Evolutionary relationships among strains of Mycobacterium tuberculosis with few copies of IS6110.

Dale JW, Al-Ghusein H, Al-Hashmi S, Butcher P, Dickens AL, Drobniewski F, Forbes KJ, Gillespie SH, Lamprecht D, McHugh TD, Pitman R, Rastogi N, Smith AT, Sola C, Yesilkaya H.

J Bacteriol. 2003 Apr;185(8):2555-62.


Sensitivities of human monocytes and epithelial cells to pneumolysin are different.

Hirst RA, Yesilkaya H, Clitheroe E, Rutman A, Dufty N, Mitchell TJ, O'Callaghan C, Andrew PW.

Infect Immun. 2002 Feb;70(2):1017-22.


Role of manganese-containing superoxide dismutase in oxidative stress and virulence of Streptococcus pneumoniae.

Yesilkaya H, Kadioglu A, Gingles N, Alexander JE, Mitchell TJ, Andrew PW.

Infect Immun. 2000 May;68(5):2819-26.

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