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Items: 40

1.

In vitro and in vivo metabolism of a potent and selective integrin alpha v beta 3 antagonist in rats, dogs, and monkeys.

Cui D, Subramanian R, Shou M, Yu X, Wallace MA, Braun MP, Arison BH, Yergey JA, Prueksaritanont T.

Drug Metab Dispos. 2004 Aug;32(8):848-61.

PMID:
15258111
2.

Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.

Leblanc Y, Roy P, Wang Z, Li CS, Chauret N, Nicoll-Griffith DA, Silva JM, Aubin Y, Yergey JA, Chan CC, Riendeau D, Brideau C, Gordon R, Xu L, Webb J, Visco DM, Prasit P.

Bioorg Med Chem Lett. 2002 Nov 18;12(22):3317-20.

PMID:
12392741
3.

Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.

Guengerich FP, Miller GP, Hanna IH, Martin MV, Léger S, Black C, Chauret N, Silva JM, Trimble LA, Yergey JA, Nicoll-Griffith DA.

Biochemistry. 2002 Sep 10;41(36):11025-34.

PMID:
12206675
4.

Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding.

Chauret N, Guay D, Li C, Day S, Silva J, Blouin M, Ducharme Y, Yergey JA, Nicoll-Griffith DA.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2149-52.

PMID:
12127525
5.

Enzyme kinetics of cytochrome P450-mediated reactions.

Shou M, Lin Y, Lu P, Tang C, Mei Q, Cui D, Tang W, Ngui JS, Lin CC, Singh R, Wong BK, Yergey JA, Lin JH, Pearson PG, Baillie TA, Rodrigues AD, Rushmore TH.

Curr Drug Metab. 2001 Mar;2(1):17-36. Review.

PMID:
11465149
6.

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).

Chauret N, Yergey JA, Brideau C, Friesen RW, Mancini J, Riendeau D, Silva J, Styhler A, Trimble LA, Nicoll-Griffith DA.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):1059-62.

PMID:
11327589
7.

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.

Yergey JA, Trimble LA, Silva J, Chauret N, Li C, Therien M, Grimm E, Nicoll-Griffith DA.

Drug Metab Dispos. 2001 May;29(5):638-44.

PMID:
11302928
8.

Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization.

Li C, Chauret N, Trimble LA, Nicoll-Griffith DA, Silva JM, MacDonald D, Perrier H, Yergey JA, Parton T, Alexander RP, Warrellow GJ.

Drug Metab Dispos. 2001 Mar;29(3):232-41.

PMID:
11181489
9.

Application of rat hepatocyte culture to predict in vivo metabolic auto-induction: studies with DFP, a cyclooxygenase-2 inhibitor.

Nicoll-Griffith DA, Silva JM, Chauret N, Day S, Leblanc Y, Roy P, Yergey JA, Dixit R, Patrick D.

Drug Metab Dispos. 2001 Feb;29(2):159-65.

PMID:
11159806
10.

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).

Nicoll-Griffith DA, Yergey JA, Trimble LA, Silva JM, Li C, Chauret N, Gauthier JY, Grimm E, Léger S, Roy P, Thérien M, Wang Z, Prasit P, Zamboni R, Young RN, Brideau C, Chan CC, Mancini J, Riendeau D.

Bioorg Med Chem Lett. 2000 Dec 4;10(23):2683-6.

PMID:
11128651
11.

Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe.

Chauret N, Tremblay N, Lackman RL, Gauthier JY, Silva JM, Marois J, Yergey JA, Nicoll-Griffith DA.

Anal Biochem. 1999 Dec 15;276(2):215-26.

PMID:
10603245
12.

Mass spectrometric analysis of arachidonyl-containing phospholipids in human U937 cells.

Li C, McClory A, Wong E, Yergey JA.

J Mass Spectrom. 1999 May;34(5):521-36.

PMID:
10390857
13.

Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor.

Nicoll-Griffith DA, Falgueyret JP, Silva JM, Morin PE, Trimble L, Chan CC, Clas S, Leger S, Wang Z, Yergey JA, Riendeau D.

Drug Metab Dispos. 1999 Mar;27(3):403-9.

PMID:
10064573
14.

Refinement of an in vitro cell model for cytochrome P450 induction.

Silva JM, Morin PE, Day SH, Kennedy BP, Payette P, Rushmore T, Yergey JA, Nicoll-Griffith DA.

Drug Metab Dispos. 1998 May;26(5):490-6.

PMID:
9571231
15.

Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.

Kargman S, Wong E, Greig GM, Falgueyret JP, Cromlish W, Ethier D, Yergey JA, Riendeau D, Evans JF, Kennedy B, Tagari P, Francis DA, O'Neill GP.

Biochem Pharmacol. 1996 Oct 11;52(7):1113-25.

PMID:
8831731
16.

Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.

Delorme D, Ducharme Y, Brideau C, Chan CC, Chauret N, Desmarais S, Dubé D, Falgueyret JP, Fortin R, Guay J, Hamel P, Jones TR, Lépine C, Li C, McAuliffe M, McFarlane CS, Nicoll-Griffith DA, Riendeau D, Yergey JA, Girard Y.

J Med Chem. 1996 Sep 27;39(20):3951-70.

PMID:
8831761
17.

Verlukast (MK-0679) conjugation with glutathione by rat liver and kidney cytosols and excretion in the bile.

Nicoll-Griffith DA, Gupta N, Twa SP, Williams H, Trimble LA, Yergey JA.

Drug Metab Dispos. 1995 Oct;23(10):1085-93.

PMID:
8654196
18.

Integrated application of capillary HPLC/continuous-flow liquid secondary ion mass spectrometry to discovery stage metabolism studies.

Li C, Chauret N, Ducharme Y, Trimble LA, Nicoll-Griffith DA, Yergey JA.

Anal Chem. 1995 Sep 1;67(17):2931-6.

PMID:
8779418
19.

In vitro and in vivo biotransformations of the naphthalenic lignan lactone 5-lipoxygenase inhibitor, L-702,539.

Chauret N, Li C, Ducharme Y, Trimble LA, Yergey JA, Ramachandran C, Nicoll-Griffith DA.

Drug Metab Dispos. 1995 Jan;23(1):65-71.

PMID:
7720527
20.

Purification and characterization of recombinant human cyclooxygenase-2.

Percival MD, Ouellet M, Vincent CJ, Yergey JA, Kennedy BP, O'Neill GP.

Arch Biochem Biophys. 1994 Nov 15;315(1):111-8.

PMID:
7979387
21.

Lipoxygenase stimulating effects of hydroxylated docosahexaenoates produced by human platelets.

Karanian JW, Kim HY, Yergey JA, Salem N Jr.

Prostaglandins Leukot Essent Fatty Acids. 1994 May;50(5):271-8.

PMID:
8066103
22.

Enhancement of mass spectrometric detection of LTC4, LTD 4, and LTE 4 by derivatization.

Mamer OA, Just G, Li CS, Préville P, Watson S, Young R, Yergey JA.

J Am Soc Mass Spectrom. 1994 Apr;5(4):292-8. doi: 10.1016/1044-0305(94)85019-4.

PMID:
24222566
23.

Respiratory tract eicosanoid measurement using microdialysis sampling and GC/MS detection.

Callaghan DH, Yergey JA, Rousseau P, Masson P.

Pulm Pharmacol. 1994 Feb;7(1):35-41.

PMID:
8003850
24.

CYP1A1 specificity of Verlukast epoxidation in mice, rats, rhesus monkeys, and humans.

Grossman SJ, Herold EG, Drey JM, Alberts DW, Umbenhauer DR, Patrick DH, Nicoll-Griffith D, Chauret N, Yergey JA.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1029-36.

PMID:
7905381
25.

Characterization of verlukast metabolites arising from an epoxide intermediate produced with hepatic microsomes from beta-naphthoflavone-treated rodents (P-4501A1).

Nicoll-Griffith DA, Chauret N, Yergey JA, Trimble LA, Favreau L, Zamboni R, Grossman SJ, Drey J, Herold E.

Drug Metab Dispos. 1993 Sep-Oct;21(5):861-7.

PMID:
7902249
26.

Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status.

Heyes MP, Brew BJ, Martin A, Price RW, Salazar AM, Sidtis JJ, Yergey JA, Mouradian MM, Sadler AE, Keilp J, et al.

Ann Neurol. 1991 Feb;29(2):202-9.

PMID:
1826418
27.

Brain and cerebrospinal fluid quinolinic acid concentrations in patients with intractable complex partial seizures.

Heyes MP, Wyler AR, Devinsky O, Yergey JA, Markey SP, Nadi NS.

Adv Exp Med Biol. 1991;294:683-6. No abstract available.

PMID:
1837698
28.

Stable isotope-labeled tryptophan as a precursor for studying the disposition of quinolinic acid in rabbits.

Boni RL, Heyes MP, Bacher JD, Yergey JA, Ji XD, Abramson FP, Markey SP.

Adv Exp Med Biol. 1991;294:481-4.

PMID:
1837688
29.

Mass spectrometric determinations of tryptophan and its metabolites.

Markey SP, Boni RL, Yergey JA, Heyes MP.

Adv Exp Med Biol. 1991;294:41-50. Review. No abstract available.

PMID:
1837685
30.

Quinolinic acid concentrations are increased in cerebrospinal fluid of Rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D.

Heyes MP, Gravell M, April M, Blackmore D, London WT, Yergey JA, Markey SP.

Adv Exp Med Biol. 1991;294:555-8. No abstract available.

PMID:
1663318
31.

Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D.

Heyes MP, Gravell M, London WT, Eckhaus M, Vickers JH, Yergey JA, April M, Blackmore D, Markey SP.

Brain Res. 1990 Oct 29;531(1-2):148-58.

PMID:
1963097
32.

Quinolinic acid concentrations in brain and cerebrospinal fluid of patients with intractable complex partial seizures.

Heyes MP, Wyler AR, Devinsky O, Yergey JA, Markey SP, Nadi NS.

Epilepsia. 1990 Mar-Apr;31(2):172-7.

PMID:
1690639
33.

Brain eicosanoid formation following acute penetration injury as studied by in vivo microdialysis.

Yergey JA, Heyes MP.

J Cereb Blood Flow Metab. 1990 Jan;10(1):143-6.

PMID:
2298831
34.

Prostaglandins in cerebrospinal fluid of healthy human volunteers, abstinent alcoholics and rhesus monkeys.

Yergey JA, Karanian JW, Salem N, Heyes MP, Ravitz B, Linnoila M.

Prostaglandins. 1989 Apr;37(4):505-17.

PMID:
2762559
35.

GC/MS assay of prostaglandins in cerebrospinal fluid from humans and monkeys.

Yergey JA, Salem N Jr, Karanian JW, Linnoila M.

Adv Alcohol Subst Abuse. 1988;7(3-4):125-9.

PMID:
3223427
36.

Smooth muscle effects of hydroxylated docosahexaenoates produced from human platelet.

Karanian JW, Kim HY, Shingu T, Yergey JA, Yoffe A, Salem N Jr.

Biomed Biochim Acta. 1988;47(10-11):S79-82.

PMID:
2977725
37.

Discovery of novel brain lipoxygenase products formed from docosahexaenoic acid (22:6w3).

Shingu T, Karanian JW, Kim HY, Yergey JA, Salem N Jr.

Adv Alcohol Subst Abuse. 1988;7(3-4):235-40.

PMID:
2975919
38.
39.
40.

Comparison of thermospray and fast atom bombardment mass spectrometry as solution-dependent ionization techniques.

Fenselau C, Liberato DJ, Yergey JA, Cotter RJ, Yergey AL.

Anal Chem. 1984 Dec;56(14):2759-62. No abstract available.

PMID:
6098190

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